Gladden Longevity Podcast

Dr. Gladden and Nikki Schultek explore the intricate links between Alzheimer's disease, infections, and the pathobiome. Nikki shares her personal journey through chronic illness and how it led her to advocate for a better understanding of the role of infections in autoimmune and neurodegenerative diseases. They discuss the importance of a systems biology approach to healthcare, emphasizing the need for collaboration among specialists to address complex health issues. The conversation highlights the interplay between genetics, infections, and chronic diseases, and the potential for future research to uncover new treatment avenues. In this conversation, Dr. Gladden and Nikki Schultek discuss...

In this episode, Dr. Gladden speaks with Dr. Hany Demian about the shift from reactive medicine to prevention, personalization, and longevity-focused care. Dr. Hany shares how his journey through breast surgery, emergency medicine, and chronic pain management led him to a more systems-based approach to health, aging, and healing. They discuss why aging may be better understood as a condition, how patient empowerment changes outcomes, and why nervous system regulation, stress reduction, and individualized care matter as much as diagnostics and therapies.

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Michael Clinton and Dr. Gladden explore the concept of longevity and the evolving perception of aging. They discuss the importance of viewing the second half of life as an opportunity for growth and adventure rather than a decline. The discussion covers the significance of role models, the idea of life layering to build identities beyond work, the necessity of movement and engagement, and the architectural approach to health through five circles. They also touch on the generational transfer of health and the importance of community and connection in combating loneliness and mental health issues. In this conversation, Michael Clinton...

In this conversation, Dr. Gladden and Annelie Smith explore the intersection of genetics and nutrition, emphasizing the importance of personalized approaches to health. They discuss the evolution of nutrigenomics, the role of AI in developing tailored health plans, and the complexities of hormonal balance as influenced by genetics. Annelie shares insights from her clinical experience, highlighting the need for a systems biology approach to understand the intricate relationships between genes, hormones, and overall health. The discussion also touches on future directions in genetic testing and the potential for more accessible and actionable insights for individuals. In this conversation, Dr...

In this episode of the Gladden Longevity Podcast, Dr. Gladden interviews Dr. Bill Rawls, who shares his transformative journey from conventional medicine to holistic healing. Bill discusses his struggles with chronic illness, particularly Lyme disease, and how he discovered the importance of cellular health and autophagy in recovery. He emphasizes the role of herbal therapies and adaptogens in promoting wellness and protecting cellular function, ultimately leading to a deeper understanding of chronic illness and aging. In this conversation, they explore the intricate connections between autoimmunity, chronic illness, and the role of microbial influences. They discuss the implications of long...

In this episode of the Gladden Longevity podcast, Dr. Gladden interviews Shaun Noorian from Empower Pharmacy, discussing the growth and mission of the pharmacy, the cost-effectiveness of compounding medications, quality standards in compounding, regulatory oversight, and the ongoing controversy surrounding peptides and FDA decisions. The conversation highlights the importance of personalized medicine and the challenges faced by compounding pharmacies in providing affordable and effective treatments for patients. In this conversation, Dr. Gladden and Shaun Noorian discuss the evolving landscape of compounding pharmacies and personalized medicine. They explore the regulatory challenges faced by compounding pharmacies, the promise of new medications...

In this episode, Dr. Marc Pietropaoli discusses his transition from traditional orthopedics to regenerative medicine, emphasizing the importance of repairing rather than replacing damaged joints. He shares insights on the components and sequencing of regenerative treatments, the role of genetic testing in nutrition, and his mission to eliminate the need for knee replacements by 2043. The conversation highlights the significance of prevention and proactive care in joint health. In this conversation, Dr. Marc Pietropaoli discusses various aspects of injury prevention, particularly focusing on ACL injuries and innovative surgical techniques. He emphasizes the importance of proper landing techniques, dynamic warm-ups, and...

In this conversation, Dr. Kevin R. Stone discusses his journey and innovations in cartilage regeneration, focusing on the importance of mindset, the role of anabolic therapies, and the significance of play in recovery and longevity. He emphasizes the need for a holistic approach to injury prevention and recovery, encouraging patients to view their injuries as opportunities for improvement rather than setbacks.

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In this episode of the Gladden Longevity Podcast, Dr. Gladden and Leslie Kenny delve into the intricacies of aging, health, and the role of spermidine in promoting longevity. They discuss the hallmarks of aging, Leslie's personal journey with autoimmune conditions, and the importance of empowerment and curiosity in health management. The conversation emphasizes the interconnectedness of health factors and the need for a holistic approach to wellness. In this conversation, Leslie Kenny and Dr. Gladden explore the potential of spermidine as a breakthrough in aging research, discussing its effects on health, longevity, and cellular processes like autophagy. They share...

Dr. Pamela Cipriano shares her journey from being an ICU nurse to a trailblazer in functional medicine. She discusses her personal experiences with Lyme disease, the importance of hydration, nutrition, and the impact of chronic illnesses. Dr. Cipriano emphasizes the need for a holistic approach to health, focusing on root causes and lifestyle changes, while also sharing insights on the effects of COVID and the importance of proper diet and hydration. In this conversation, Dr. Pamela Cipriano discusses the implications of vaccination, particularly in relation to health concerns and the effects of spike proteins. She emphasizes the importance of...

In this episode of the Glad and Longevity Podcast, Jeff Gladden and Jonathan Roseland delve into the world of biohacking and nootropics. They discuss the inspiration behind Roseland's journey into cognitive enhancement, the quest for effective smart drugs, and the role of nicotine in boosting creativity. The conversation also touches on the importance of a systems biology approach to personal development, emphasizing the need for personalized strategies in optimizing cognitive function and overall health. In this conversation, Jonathan Roseland and Jeff Gladden explore the themes of risk-taking, spirituality, psychedelics, and memory enhancement. They discuss the importance of embracing risk...

In this conversation, Dr. Aleksandra Gajer shares her journey from emergency medicine to focusing on metabolic health and hormonal balance. She discusses the challenges faced during the COVID-19 pandemic, her transition to a new practice, and the importance of understanding metabolic health as a foundation for overall wellness. Dr. Gajer emphasizes the role of peptides in supporting health, the significance of body composition, and the therapeutic relationship with patients as essential for effective care.

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In this episode of the Gladden Longevity Podcast, Dr. Jeffrey Gladden speaks with Nicole Bell and Jennifer Miller from Galaxy Diagnostics about the challenges and advancements in diagnosing and treating tick-borne illnesses, particularly Lyme disease. They discuss the personal journey that led Nicole to become the CEO of Galaxy Diagnostics, the complexities of the immune response to Lyme, and the innovative diagnostic approaches being developed to improve patient outcomes. The conversation also touches on the implications of co-infections and the future of research in this critical area of health.

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In this conversation, Ashley James shares her journey as an anxiety cessation expert, discussing her personal experiences with ADHD and anxiety. She emphasizes the importance of personal growth and the tools she has developed over 20 years to help others manage their anxiety. The discussion covers the role of genetics, the physiological responses to stress, and the difference between excitement and anxiety. Ashley introduces various tools for managing anxiety, including techniques from Neurolinguistic Programming (NLP) and the significance of metacognition in understanding and controlling anxiety. In this conversation, Ashley James and Jeff Gladden explore the intricacies of anxiety, its impact...

In this episode, Dr. Gladden and nutrition expert Sarah Kennedy discuss Calocurb, a natural extract that uses evolutionary biology to suppress appetite. The discovery focuses on bitter taste receptors (T2Rs) located throughout the gastrointestinal tract, which historically served as a protective mechanism to slow the consumption of potentially toxic substances. By using a specific New Zealand hop extract, Calocurb triggers these receptors to signal the brain that the body is full. This process stimulates the natural release of satiety hormones—GLP-1, CCK, and PYY—effectively quieting "hunger noise" and reducing caloric intake without the need for synthetic pharmaceuticals.

In this episode of the Gladden Longevity Podcast, Garrett Salpeter discusses his journey in developing the NeuFit device, which combines principles of engineering and neuroscience to enhance healing and athletic performance. He shares insights on the role of the nervous system in recovery, the importance of neuromuscular reeducation, and how electrical stimulation can be used to balance muscle activation. The conversation also explores the innovative technology behind NeuFit, its applications in rehabilitation, and how it compares to other devices in the market. In this conversation, Garrett Salpeter discusses the advancements in recovery techniques post-surgery, the integration of neurological responses...

In this episode, I break down the three things that determine whether your supplement protocol is actually working or quietly wasting your time and money. Most people are worried they're not taking the right thing, not taking the right amount, or worse, taking something that's actively counteracting something else in their stack. That's not paranoia. It's a real problem. I walk through the first pillar, quality, and explain what to look for in terms of bioavailability, organic sourcing, fillers, and whether the supplement can actually integrate into your cells. Then I cover precision, which is the difference between guessing...

In this episode of the Gladden Longevity Podcast, Dr. Jeff Gladden, Dr. Oscar Coetzee, and Danielle Arnold delve into the complexities of the gut microbiome, discussing its role as an organ system, the importance of probiotics and prebiotics, and the impact of modern diets on gut health. They explore innovative technologies for enhancing gut health, the significance of microbiome diversity, and the future of gut health treatments, emphasizing the need for a holistic understanding of gut health through functional stool testing. In this conversation, experts discuss the complexities of gut health, focusing on the importance of a systematic approach...

In this episode of the Gladden Longevity Podcast, Jeff Gladden and Jason Sonners delve into the fascinating world of hyperbaric therapy. Jason shares his personal journey from experiencing a debilitating disc injury to discovering the profound benefits of hyperbaric oxygen therapy. They explore the science behind oxygen's role in cellular function, the therapeutic effects of hypoxia, and the importance of balancing various longevity strategies. The conversation also touches on recent studies regarding telomere length and the potential of hyperbaric therapy to promote cellular health. Finally, they discuss the risks associated with hyperbaric therapy and the importance of gradual exposure...

In this episode, I break down the major categories of medicine— allopathic, functional, naturopathic, ayurvedic, Chinese, homeopathy, and integrative—explaining what each does well and where each falls short. I then show why longevity medicine goes further by treating aging itself as the root cause. You'll learn how the 12–16 hallmarks of aging accelerate each other, why symptom management or root-cause treatment alone can't stop the process, and why measuring and addressing the hallmarks directly is essential. I share why we hold ourselves to the standard of a 30-year-old body and a 300-year-old mind, how stress speeds aging, and why the qu...

In this episode of the Gladden Longevity Podcast, Dr. Elizabeth Yurth shares her extensive journey in the longevity and regenerative medicine space, discussing the evolution and significance of peptides in healing and performance. She emphasizes the importance of understanding hormonal and peptide levels as we age, the role of mitochondria in energy production, and the critical aspects of immune regulation through the thymus gland. The conversation also covers the eight pillars of regeneration, highlighting the multifaceted approach needed for optimal health and healing. In this conversation, Dr. Yurth and Dr. Gladden discuss the importance of peptide therapy, particularly focusing...

In this conversation, Eli Israel shares his journey with longevity and optimization, focusing on his experiences with Crohn's disease, cancer, and the transformative impact of surgery. The discussion delves into the psychological burdens of chronic illness, the importance of mindset, and the role of courageous conversations in relationships. Mukti Devi emphasizes the significance of embracing uncertainty and the cues from our bodies in navigating life's challenges. Together, they explore the interplay between health, sexuality, and communication, highlighting the journey towards a fulfilling life. In this conversation, Mukti Devi and Eli Israel explore the themes of pleasure positivity, the role...

In this exciting episode of the Gladden Longevity Podcast, Dr. Jeffrey Gladden joins Kyle Trautmann to explore the fundamental electrical underpinnings of human vitality. Moving beyond basic biochemistry, they dive into energy literacy and the critical role of cellular energy in the pursuit of longevity. The conversation reveals how maintaining proper voltage within the body is essential for mitochondrial health and overall performance. By understanding quantum biology and the impact of electrolytes on our "internal battery," listeners can unlock a new level of health optimization. This deep dive into bioenergetics explains why managing your body's electrical frequency is the...

In this episode, Dr. Jeff Gladden walks through a live stress and nervous system assessment with Carlos, a 29-year-old patient who has survived five accidents including three serious ones. Dr. Gladden breaks down what heart rate variability actually measures, why your stress index reveals how fast you're aging, and what vagus nerve power means for longevity. He explains why all of life comes down to optimizing the nervous system, how stress is fundamentally a function of not feeling safe, and why no external achievement can ever create true safety. Dr. Gladden introduces the concept of the 300-year-old mind and...

In this compelling episode of the Gladden Longevity Podcast, Dr. Jeffrey Gladden and Dr. Lloyd Glauberman explore how the subconscious mind fundamentally dictates our longevity. They dive deep into Hypno-Peripheral Processing (HPP), a unique method designed to bypass the conscious ego and install healthy lifestyle habits directly into the subconscious. By leveraging the brain's natural neuroplasticity, listeners can move beyond the exhausting struggle of willpower to achieve truly effortless behavior change.

The conversation reveals that true personal growth and total health optimization must start from within. Dr. Glauberman explains how reshaping your internal narrative can transform your...

In this transformative episode of the Gladden Longevity Podcast, Dr. Jeffrey Gladden and Sara Fisk dive deep into the essential connection between authentic relationships and long-term health. While many focus solely on physical biohacking, this conversation reveals that longevity is profoundly impacted by our ability to navigate societal expectations and foster meaningful connections.

Sara and Dr. Gladden discuss the unique challenges women face when breaking free from societal norms and the vital role of community support in driving personal transformation. You'll learn why courageous conversations and empathy in relationships are the true foundation of a long, fulfilling...

In this episode, I break down the six developments I'm watching in longevity for 2026 and why I believe we're closer than ever to cracking the code on aging. I explain how AI is already transforming personalized medicine (and how to prompt it for better results), introduce the Longevity Wingman app we're building to remove all friction from your health journey, and discuss why genetic testing is finally becoming truly actionable. I also cover the sequencing strategy behind regenerative procedures that most clinics get wrong, why nervous system optimization and shadow work may be the most underrated lever in longevity...

In this episode of the Gladden Longevity Podcast, Dr. Jeffrey Gladden and neurologist Dr. Majid Fotuhi discuss building an "Invincible Brain." Challenging the myth that cognitive decline is inevitable, Dr. Fotuhi outlines five pillars—exercise, sleep, nutrition, stress management, and brain training, proven to increase brain volume and neuroplasticity.

The discussion highlights how racket sports and balance training activate the cerebellum to boost overall function and reduce Alzheimer's risk. By consistently challenging the nervous system, you can shift the aging paradigm, achieving mental sharpness and vitality well into your 80s and 90s. This is the blueprint for li...

In this episode of the Gladden Longevity Podcast, Dr. Jeffrey Gladden sits down in person with fitness and nutrition expert Autumn Calabrese to unpack the full truth about GLP-1 agonists. With millions of people jumping on semaglutide, tirzepatide, and soon retatrutide, the conversation most doctors aren't having is about what's actually happening inside the body while the scale goes down. Dr. Gladden breaks down how GLP-1s suppress hunger, slow metabolism, and trigger muscle wasting when used without proper diagnostics or a supporting protocol. He explains the critical differences between GLP-1s, GLP-2s, and GLP-3s, reveals why...

In this episode of the Gladden Longevity Podcast, Dr. Jeffrey Gladden speaks with registered dietitian Ashley Koff about her personal journey with body image, trauma, and the importance of understanding weight health. They discuss the psychological aspects of health, the role of medications in weight management, and the significance of personalized nutrition. The conversation emphasizes the connection between gut health and overall wellness, the benefits of fasting, and the need for a holistic approach to health and longevity.

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In this episode of the Gladden Longevity Podcast, Dr. Jeffrey Gladden speaks with Dr. Anthony Beck about the evolving landscape of functional medicine and the importance of personalized health approaches. They discuss the challenges patients face in navigating conflicting health information, the significance of integrating multiple health assessments, and the role of genetics in understanding individual health. Dr. Beck emphasizes the need for collaboration among healthcare providers and the empowerment of patients in their health journeys, advocating for a comprehensive and individualized approach to wellness.

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In this episode of the Gladden Longevity Podcast, Dr. Jeffrey Gladden interviews Tamim Hamid, a biomedical engineer who transitioned from NASA to developing a revolutionary hair regrowth laser helmet. The conversation delves into the science of hair loss, the role of lasers in stimulating hair regrowth, and the impact of fungal infections on scalp health. Hamid explains the importance of using anti-fungal shampoos in conjunction with laser therapy for optimal results. He also discusses the limitations of traditional hair loss treatments like minoxidil and finasteride, highlighting the superior efficacy of his laser technology. The episode concludes with practical advice...

In this episode of the Gladden Longevity Podcast, Dr. Jeffrey Gladden engages in a heartfelt conversation with Elizabeth, Karen, and Mukti about the profound journey of grief and healing. Elizabeth shares her personal story of losing her husband and the subsequent struggle with despair, highlighting the importance of community support and coaching in her recovery. Karen provides insights into the role of grief education and the need for proactive approaches to healing. Mukti discusses the significance of understanding grief through a broader lens, emphasizing the importance of community in the healing process. Together, they explore themes of resilience, transformation...

In this episode of the Gladden Longevity Podcast, Dr. Jeffrey Gladden and Dr. Justin Marchegiani discuss the intricacies of functional medicine, focusing on thyroid health, hormone optimization, and the impact of environmental factors on overall health. They explore the importance of understanding root causes of health issues, the role of insulin resistance, and the significance of gut health in managing autoimmune conditions. The conversation emphasizes a holistic approach to health, integrating physical, emotional, and environmental aspects to optimize well-being and longevity.

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In this episode of the Gladden Longevity Podcast, Dr. Jeffrey Gladden engages in a deep conversation with Dylan Gemelli, exploring themes of personal transformation, accountability, and the interconnectedness of health and spirituality. Dylan shares his journey from struggles with addiction and incarceration to becoming a respected figure in the health and wellness space. The discussion emphasizes the importance of a growth mindset, the role of diet and exercise in longevity, and the significance of understanding the nervous system in achieving optimal health. Throughout the conversation, both speakers highlight the value of curiosity, vulnerability, and the power of asking questions...

In this episode of the Gladden Longevity Podcast, Dr. Jeffrey Gladden and Dr. Dan Pardi delve into the intricate relationship between longevity, cognitive enhancement, sleep, and stem cell health. They explore the science behind nootropics, the impact of sleep on cognitive function, and the role of stem cells in aging. The conversation highlights the importance of a healthy internal environment and the interplay of various biological systems in promoting longevity. They also discuss innovative approaches to support stem cell function and the significance of mindset in the healing process.

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In this episode of the Gladden Longevity Podcast, Dr. Jeffrey Gladden interviews Chloe Harrouche, who shares her transformative journey through a breast cancer diagnosis at a young age. Chloe discusses her initial admiration for the healthcare system, which shifted dramatically after her diagnosis. She explores the challenges of navigating post-treatment care, the limitations of traditional oncology, and her eventual turn to functional medicine. The conversation delves into the importance of understanding the nervous system's role in health, the societal pressures of stress, and the need for a more integrated approach to wellness in primary care. In this conversation, Chloe...

In this episode of the Gladden Longevity podcast, Dr. Jeffrey Gladden interviews Mark Fox, a former rocket scientist turned innovator in energy therapy. They discuss Mark's journey from working on the solid rocket boosters for NASA to developing devices that utilize pulsed electromagnetic fields (PEMF) for health benefits. The conversation covers the Challenger disaster, the potential of PEMF technology for treating PTSD, and the importance of vagus nerve stimulation. Mark shares insights on brainwave frequencies and the future of energy therapy devices, emphasizing the need for innovation in healing practices.

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In this episode of the Gladden Longevity podcast, Dr. Jeffrey Gladden interviews Dr. Bernard Straile, a chiropractic physician who has transitioned from traditional chiropractic methods to energy medicine. They discuss the connection between inflammation and various health issues, the importance of bio-energetic evaluations, and the role of genetic testing in understanding health. Dr. Straile explains his innovative IMATE system, which uses frequencies to address genetic expression and inflammation. The conversation also covers the significance of epigenetics, the therapeutic applications of frequency treatments, and the holistic approach to healing chronic conditions. Dr. Straile shares insights on treatment success rates and...

In this episode of the Gladden Longevity Podcast, Dr. Jeffrey Gladden and Kashif Khan discuss the intersection of genetics, health, and longevity. Kashif shares his personal journey from illness to founding the DNA company, emphasizing the importance of personalized medicine and genetic testing. They explore the unique health challenges faced by women, the impact of trauma and stress on health, and the need for individualized approaches in biohacking. The conversation highlights the significance of understanding hormone metabolism and the role of genetics in parenting, ultimately advocating for a comprehensive analysis of health to achieve optimal outcomes.