The Science and Experience of Energy

Part I – MiSBIE Study rationale and protocol ⎸
Welcome
MiSBIE team, collaborators, partners – Martin Picard
Agenda for today’s MiSBIE progress meeting –
Caroline Trumpff
MiSBIE Study overview – Martin Picard
Rationale, primary hypotheses, scientific opportunities
The stress-disease cascade hypothesis
MiSBIE mother paper, website

Uploaded 22-01-26

The Mitochondrial Stress, Brain Imaging, and Epigenetics (MiSBIE) study was developed to understand the role of mitochondria and energy more generally in mind-body processes, as well as their potential relevance to people with mitochondrial diseases. At this Symposium, MiSBIE investigators and the international team of coll...

2025 MiSBIE Symposium
Part III – Immune cell bioenergetics
Session Chair – Darshana Kapri
Immune mitochondrial phenotypes – Jack Devine
Immune cell bioenergetics (seahorse) in mitochondrial diseases – Anna Monzel
Life adversity moderates the relationship between immune cell mitochondrial respiration and mood
symptoms – Cynthia Liu

Uploaded 22-01-26

The Mitochondrial Stress, Brain Imaging, and Epigenetics (MiSBIE) study was developed to understand the role of mitochondria and energy more generally in mind-body processes, as well as their potential relevance to people with mitochondrial diseases. At this Symposium, MiSBIE investigators and the international team of collaborators will share...

2025 MiSBIE Symposium
Part V – The energetics of acute stress reactivity
Session Chair – Evan Shaulson
The MiSBIE stress reactivity protocol and Physiological and neuroendocrine reactivity in health and mitochondrial disease –
Natalia Bobba-Alves (zoom)
Saliva and blood cell-free mtDNA reactivity to acute psychosocial stress –
David Shire
FGF21 reactivity to acute psychosocial stress – Mangesh Kurade
2:40 GDF15 reactivity to acute psychosocial stress – Caroline Trumpff
2:50 Novel pipelines to extract differences in proteome dynamics based on health status –
Alan Cohen

Uploaded 22-01-26

The Mitochondrial Stress, Brain Imaging, and Epigenetics (MiSBIE) study was deve...

What is the difference between something that is alive and something that isn’t? You may think that life is defined by cells, proteins, or DNA. In this video, I share how the flow of energy is the foundation for all living things. Energy constantly flows and transforms through our bodies and our brains—it is the essence of life as we know it. Seeing life and the human experience through an energetic lens can help us cultivate gratitude.

Uploaded 07-07-26

Learn more about the science of energy and mitochondria:
• Website - https://www.ma...

2025 MiSBIE Symposium at Columbia University
December 12, 2025
A fabulous and stimulating day distilled into eight minutes.

Uploaded 31-01-26

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2025 MiSBIE Symposium
Part III – Immune cell bioenergetics

Session Chair – Darshana Kapri
Immune mitochondrial phenotypes – Jack Devine
Immune cell bioenergetics (seahorse) in mitochondrial diseases – Anna Monzel
Life adversity moderates the relationship between immune cell mitochondrial respiration and mood
symptoms – Cynthia Liu

Uploaded 22-01-26

The Mitochondrial Stress, Brain Imaging, and Epigenetics (MiSBIE) study was developed to understand the role of mitochondria and energy more generally in mind-body processes, as well as their potential relevance to people with mitochondrial diseases. At this Symposium, MiSBIE investigators and the international team of collaborat...

Mitochondria do much more than just transform energy to power our cells. They serve as a portal between the small-scale physical-chemical processes that give rise to life, and larger-scale phenomena, like consciousness, that make us human. This video provides insight on the dynamic, social nature of mitochondria and the roles they play in transforming biochemical energy from food into signals, and into the human experience.

Uploaded 15-07-26

Learn more about the science of energy and mitochondria:
• Website - https://www.martinpicard.energy/

For more information, check out these articles on Substack:

Why do some people recover quickly from illness or injury, while others don’t? Throughout my life I have been fascinated by the healing process, and what we can do to achieve optimal health. In this video, I share a reflection about the human experience of healing that continues to inspire me in my research on mitochondria, energy, and human health.

Uploaded 06-08-26

Learn more about the science of energy and mitochondria:
• Website - https://www.martinpicard.energy/

For more information, check out these articles on Substack:
• My Passion for Energy...

2025 MiSBIE Symposium
Part VI – Opportunities and future directions
The energetic cost of mitochondrial disorders across day and night: MDEE – Evan Shaulson
Summary: Opportunities, collaborations, data sharing – Martin Picard

Uploaded 22-01-26

The Mitochondrial Stress, Brain Imaging, and Epigenetics (MiSBIE) study was developed to understand the role of mitochondria and energy more generally in mind-body processes, as well as their potential relevance to people with mitochondrial diseases. At this Symposium, MiSBIE investigators and the international team of collaborators will share findings addressing some of the hypotheses we originally set out to test, plus some u...

2025 MiSBIE Symposium
Part V – The energetics of acute stress reactivity
Session Chair – Evan Shaulson
The MiSBIE stress reactivity protocol and Physiological and neuroendocrine reactivity in health and mitochondrial disease –
Natalia Bobba-Alves (zoom)
Saliva and blood cell-free mtDNA reactivity to acute psychosocial stress –
David Shire
FGF21 reactivity to acute psychosocial stress – Mangesh Kurade
2:40 GDF15 reactivity to acute psychosocial stress – Caroline Trumpff
2:50 Novel pipelines to extract differences in proteome dynamics based on health status –
Alan Cohen

Uploaded 22-01-26

The Mitochondrial Stress, Brain Imaging, and Epigenetics (MiSBIE) study was deve...

2025 MiSBIE Symposium
Part II – Looking inside the brain’s mitochondria
Session Chair – Anna Monzel
MitoBrain MRI map – Michel Thiebaut de Schotten
Mitochondrial energy transformation capacity influences brain activation
during sensory, affective, and cognitive tasks – Ke Bo / Tor Wager

Uploaded 22-01-26

The Mitochondrial Stress, Brain Imaging, and Epigenetics (MiSBIE) study was developed to understand the role of mitochondria and energy more generally in mind-body processes, as well as their potential relevance to people with mitochondrial diseases. At this Symposium, MiSBIE investigators and the international team of collaborators will share findings addressing...

Part II – Looking inside the brain’s mitochondria
Session Chair - Anna Monzel
MitoBrain MRI map – Michel Thiebaut de Schotten (zoom)
Mitochondrial energy transformation capacity influences brain activation
during sensory, affective, and cognitive tasks – Ke Bo / Tor Wager

Uploaded 22-01-26

The Mitochondrial Stress, Brain Imaging, and Epigenetics (MiSBIE) study was developed to understand the role of mitochondria and energy more generally in mind-body processes, as well as their potential relevance to people with mitochondrial diseases. At this Symposium, MiSBIE investigators and the international team of collaborators will share findings addressing some of...

2026 MiSBIE Symposium
Part IV – Health indicators in mitochondrial disease

Session Chair – Caroline Trumpff
Mitochondrial biology and time perception – Darshana Kapri
Mitochondrial disease and allostatic load – Alex Junker

Uploaded 22-01-26

The Mitochondrial Stress, Brain Imaging, and Epigenetics (MiSBIE) study was developed to understand the role of mitochondria and energy more generally in mind-body processes, as well as their potential relevance to people with mitochondrial diseases. At this Symposium, MiSBIE investigators and the international team of collaborators will share findings addressing some of the hypotheses we originally set out to test, plus som...

2025 MiSBIE Symposium
Part VI – Opportunities and future directions
The energetic cost of mitochondrial disorders across day and night: MDEE – Evan Shaulson
Summary: Opportunities, collaborations, data sharing – Martin Picard

Uploaded 22-01-26

The Mitochondrial Stress, Brain Imaging, and Epigenetics (MiSBIE) study was developed to understand the role of mitochondria and energy more generally in mind-body processes, as well as their potential relevance to people with mitochondrial diseases. At this Symposium, MiSBIE investigators and the international team of collaborators will share findings addressing some of the hypotheses we originally set out to test, plus some u...

In April 2024, approximately 75 MiSBIE Team members, collaborators, partners, and broader international community members gathered to review the study rationale and design, 2-day protocol, and to share data, preliminary analyses, and some exciting initial results.

Uploaded 14-01-26

​This meeting marked the transition from the data collection phase to the analysis and learning phase of the MiSBIE study.

Please visit the Mitochondrial Psychobiology Group’s website at www.picardlab.org for more information on our research.

Learn more about your ad choices. Visit megaphone.fm/adchoices

2025 MiSBIE Symposium
Part IV – Health indicators in mitochondrial disease

Session Chair – Caroline Trumpff
Mitochondrial biology and time perception – Darshana Kapri
Mitochondrial disease and allostatic load – Alex Junker

Uploaded 22-01-26

The Mitochondrial Stress, Brain Imaging, and Epigenetics (MiSBIE) study was developed to understand the role of mitochondria and energy more generally in mind-body processes, as well as their potential relevance to people with mitochondrial diseases. At this Symposium, MiSBIE investigators and the international team of collaborators will share findings addressing some of the hypotheses we originally set out to test, plus som...

Energy is the driving force of life that powers all of our complex biological functions, and all of these functions require resistance. Resistance is what transforms energy so it can do meaningful work in our bodies. This short explainer video provides an introduction to the Energy Resistance Principle (ERP).

Uploaded 28-05-26

Learn more about how resistance to energy flow shapes life in this article from The Science and Experience of Energy Substack:
https://tseenergy.substack.com/p/erp

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2025 MiSBIE Symposium
Part V – The energetics of acute stress reactivity
Session Chair – Evan Shaulson
The MiSBIE stress reactivity protocol and Physiological and neuroendocrine reactivity in health and mitochondrial disease –
Natalia Bobba-Alves (zoom)
Saliva and blood cell-free mtDNA reactivity to acute psychosocial stress –
David Shire
FGF21 reactivity to acute psychosocial stress – Mangesh Kurade
2:40 GDF15 reactivity to acute psychosocial stress – Caroline Trumpff
2:50 Novel pipelines to extract differences in proteome dynamics based on health status –
Alan Cohen

Uploaded 22-01-26

The Mitochondrial Stress, Brain Imaging, and Epigenetics (MiSBIE) study was deve...

Energy is the fundamental force that enables life, health, and healing. Approaches like genome sequencing provide static snapshots of the instructions encoded into our DNA. However, each person is unique, and genes don't fully determine when and how people develop common chronic illnesses. How we age and our ability to heal also are dynamic features that aren’t encoded in our genes. This video emphasizes the importance of understanding how these outcomes are shaped by dynamic biological and energetic processes that evolve over time.

Uploaded 22-07-26

Learn more about the science of energy and mi...

2025 MiSBIE Symposium
Part V – The energetics of acute stress reactivity
Session Chair – Evan Shaulson
The MiSBIE stress reactivity protocol and Physiological and neuroendocrine reactivity in health and mitochondrial disease –
Natalia Bobba-Alves (zoom)
Saliva and blood cell-free mtDNA reactivity to acute psychosocial stress –
David Shire
FGF21 reactivity to acute psychosocial stress – Mangesh Kurade
2:40 GDF15 reactivity to acute psychosocial stress – Caroline Trumpff
2:50 Novel pipelines to extract differences in proteome dynamics based on health status –
Alan Cohen

Uploaded 22-01-26

The Mitochondrial Stress, Brain Imaging, and Epigenetics (MiSBIE) study was deve...

2025 MiSBIE Symposium
Part III – Immune cell bioenergetics

Session Chair – Darshana Kapri
Immune mitochondrial phenotypes – Jack Devine
Immune cell bioenergetics (seahorse) in mitochondrial diseases – Anna Monzel
Life adversity moderates the relationship between immune cell mitochondrial respiration and mood
symptoms – Cynthia Liu

Uploaded 22-01-26

The Mitochondrial Stress, Brain Imaging, and Epigenetics (MiSBIE) study was developed to understand the role of mitochondria and energy more generally in mind-body processes, as well as their potential relevance to people with mitochondrial diseases. At this Symposium, MiSBIE investigators and the international team of collaborat...

2025 MiSBIE Symposium
Part V – The energetics of acute stress reactivity
Session Chair – Evan Shaulson
The MiSBIE stress reactivity protocol and Physiological and neuroendocrine reactivity in health and mitochondrial disease –
Natalia Bobba-Alves (zoom)
Saliva and blood cell-free mtDNA reactivity to acute psychosocial stress –
David Shire
FGF21 reactivity to acute psychosocial stress – Mangesh Kurade
2:40 GDF15 reactivity to acute psychosocial stress – Caroline Trumpff
2:50 Novel pipelines to extract differences in proteome dynamics based on health status –
Alan Cohen

Uploaded 22-01-26

The Mitochondrial Stress, Brain Imaging, and Epigenetics (MiSBIE) study was deve...

Our body is a dynamic collective. This is true at the level of our cells. And also at smaller scales, at the level of our mitochondria. In this video, I explore how the mitochondrial collective of a cell receives signals, integrates information, and helps shape cell fates. Mitochondria match cell behavior with the greater good of the whole body. Like a healthy family or society, the body depends on its individual parts coherently working well together toward a shared purpose. By reflecting on our mitochondria, we can appreciate how connection and cooperation contribute to our health and who we...

In this video, Martin Picard shares his tenure talk at Columbia University, including the origins of his research program. He describes progress that his lab has made across five research themes: mitochondrial disease, aging, cell-free mitochondrial DNA (cf-mtDNA), the brain, and technological innovation. Martin also describes future plans of the Mitochondrial Psychobiology Lab.

Uploaded 18-05-26

This video was recorded on January 6, 2022.

Please visit the Mitochondrial Psychobiology Group’s website at www.picardlab.org for more information on our research.

Learn more about your ad choices. Visit megaphone.fm/ad...