Foodie Pharmacology Podcast

What if some of the plants farmers spend hours pulling out of their fields belong on our plates? In this episode, Dr. Cassandra Quave talks with agroecologists Dr. Roland Ebel (College of Agricultural and Environmental Education, Vienna) and Dr. Fabian Menalled (Montana State University) about edible weeds: the spontaneous plants that are wiped out in conventional farming but have long been valued as food in traditional farming systems, from Mexico’s quelites to the wild greens of southern Italy.

They start by asking what a weed actually is. From there they explain why traditional farmers often don’t se...

Did humans domesticate plants, or did plants domesticate us? Paleoethnobotanist Dr. Robert Spengler joins Dr. Cassandra Quave to explain why ancient farmers likely had no idea they were changing the course of evolution. Key traits like the tough rachis in wheat and barley took 2,000 to 3,000 years to take hold, far longer than any one person, or any one generation, could have planned for.

From there, they follow the Silk Road, which Dr. Spengler describes as the spokes of a wagon wheel with Central Asia at the center. They cover millet and wheat crossing Eurasia, apples hybridized by...

Why does “cheap” food cost us so much? In this episode of Foodie Pharmacology, Dr. Cassandra Quave talks with Kristine Root, founder of the branding and growth marketing agency Socha, about her new report, The End of Cheap Food. Kristine traces how U.S. farm policy and an all-out push for efficiency built a food system that looks inexpensive at the register. Along the way, the real costs moved into our healthcare systems, our soil, and our farmers’ livelihoods.

They dig into how what we grow and how we grow it shape the nutrition on our plates, from h...

Can bacteria be bred to feed crops, and do it for a fraction of the cost of chemical fertilizer? This week on the show, Dr. Cassandra Quave talks with Dr. Mariangela Hungria, a soil microbiologist at Embrapa (the Brazilian Agricultural Research Corporation), 2025 World Food Prize laureate, and one of TIME’s 100 Most Influential People of 2026. They discuss how nitrogen-fixing bacteria partner with legumes, grasses, and sugarcane, and why chemical fertilizers added to the soil drive water pollution and greenhouse gas emissions.

Dr. Hungria explains how her work with soybeans helped make Brazil a global leader in agricultural bi...

What can microbes living in the dark, mineral-rich corners of a cave tell us about the next generation of medicines?

In this episode of Foodie Pharmacology, Dr. Cassandra Quave talks with biomedical geoscientist Dr. Rachel Washburn, director of the Washburn CHAOS Lab (Complex Host and Abiotic Systems). Her team studies the whole system at once: which microbes are present, what chemistry they are making, and how minerals and water shape it. They take samples from wild caves, polluted caves, and tourist show caves across Kentucky.

Dr. Washburn explains how sequencing, geology, and metabolomics fit together...

Why do humans have a sweet tooth, and what does the glycemic index actually tell us about food? Dr. Cassandra Quave talks with University of Sydney nutrition scientist Dr. Jennie Brand-Miller about the role of fruit and sugar in human evolution, how different carbohydrates affect blood glucose, and why the type of rice you choose may matter more than whether it’s white or brown.

They also explore practical ways to build a balanced plate, what makes pasta a surprising low-GI food, and why Dr. Brand-Miller urges us to enjoy fruit rather than fear its sugar. It’s a...

What if the value of a farm were measured not only by what it produces, but also by the communities, skills, and ecosystems it sustains? This week on Foodie Pharmacology, Dr. Cassandra Quave welcomes environmental anthropologist Dr. Andrew Flachs back to the show to discuss his new book, Feeding the World as if People Mattered: How Small Farms Produce Value Beyond Yields.

Drawing on research in India, Bosnia, and the American Midwest, Andrew challenges the assumption that producing more food will solve hunger. Industrial agriculture can generate enormous quantities of inexpensive commodities while obscuring its social and...

Could centuries of traditional plant knowledge help scientists discover the next generation of medicines for the brain? In this episode of Foodie Pharmacology, Dr. Cassandra Quave speaks with chemist and neuroscientist Dr. Jacob Hooker, co-founder and CEO of Sensorium Therapeutics, about a new approach to finding treatments for anxiety and other neurological and psychiatric conditions.

Dr. Hooker explains how Sensorium combines ethnobotanical records, chemical data, medicinal chemistry, and artificial intelligence in a vast computational knowledge graph. By mapping relationships among plants, molecules, human experiences, and biological activity, researchers can uncover patterns and prioritize promising natural products for...

What if some of the most important foundations for lifelong health are established before a child’s second birthday? In this episode of Foodie Pharmacology, Dr. Cassandra Quave speaks with Yale-trained gastroenterologist and microbiome specialist Dr. Savita Srivastava about how the gut microbiome develops during the first 1,000 days of life.

They explore how birth, skin-to-skin contact, breastfeeding, antibiotics, environmental exposures, and the introduction of solid foods help shape a baby’s developing microbial community. Dr. Srivastava explains the differences among probiotics, prebiotics, and postbiotics; why metabolites such as butyrate matter for the gut barrier and immune system; and...

We’d once again like to thank Thermo Fisher Scientific Incorporated for their sponsorship of this episode.

What if a single tick bite could change the way you eat forever? In this episode, I sit down with allergy expert Gary Falcetano to explore alpha-gal syndrome, a strange and increasingly recognized condition triggered by tick bites that can lead to delayed allergic reactions to red meat and other mammalian products. We unpack the science behind this unusual immune response, why symptoms can emerge hours after eating, and why many cases go undiagnosed for years. From hidden sources of al...

Did you know that one of the most important organs shaping lifelong health is only temporary? In this episode of Foodie Pharmacology, I sit down with developmental biologist Dr. Cheryl Rosenfeld to explore the fascinating science of the placenta and its role as the communication hub between mother and developing baby. We discuss the emerging concept of the placenta-brain axis and discuss how maternal diet, the gut microbiome, environmental exposures, and even tiny molecular signals can influence fetal development long before birth. From serotonin and the microbiome to probiotics, inflammation, and the hidden impacts of modern life, this conversation...

Journey to Brazil to uncover the hidden roots of Candomblé, an Afro-Brazilian spiritual tradition shaped by African plant knowledge, resilience, and cultural memory. In this episode, I speak with ethnobotanist Dr. Bob Voeks to explore how enslaved Africans preserved sacred healing traditions and foodways across the Atlantic, transforming plants into powerful symbols of identity and survival. From spiritual cleansing rituals with sacred leaves to the fascinating story of caruru, a revered okra dish tied to twin deities, we trace the remarkable journey of African plants through the diaspora. Along the way, we uncover surprising connections linking Candomblé, callaloo, and ev...

Pet nutrition has undergone a dramatic shift over the past century, moving from whole foods to highly processed convenience diets, and not always for the better. This week on Foodie Pharmacology, Dr. Cassandra Quave speaks with Dr. Judy Morgan, a veterinarian with over 40 years of experience in integrative and holistic care, about what’s gone wrong in the modern pet food industry and how to rethink what we feed our animals. The conversation explores the rise of ultra-processed kibble, gaps in regulation, and the health consequences linked to highly processed diets, while offering practical guidance on incorporating fresher, more sp...

Antibiotic resistance is one of the most pressing challenges in modern medicine, raising the risk of a return to a pre-antibiotic era where common infections become life-threatening. This week on Foodie Pharmacology, Dr. Cassandra Quave speaks with Dr. Nadine Ziemert about how scientists are turning to microbial genomes to discover the next generation of antibiotics. A professor of translational genome mining at the University of Tübingen, Nadine explains how bacteria themselves are prolific chemists, producing complex natural products that can be harnessed to fight infection. The conversation explores why traditional discovery methods have slowed, how genome mining reveals h...

The health of our environment underpins everything from food systems to future medicines, yet much of the damage done to nature goes unaddressed. This week on Foodie Pharmacology, Dr. Cassandra Quave speaks with Jacob Phelps about a new approach to conservation that brings science into the courtroom. Together, they explore how environmental litigation can move beyond small fines and toward holding offenders accountable for restoring damaged ecosystems, from illegal mining and deforestation to wildlife trafficking. The conversation highlights the gap between strong environmental laws on paper and their limited use in practice, and how interdisciplinary teams of scientists and...

Spring is a time when many of us think about fresh starts and better health, including the well-being of our pets. This week on Foodie Pharmacology, Dr. Cassandra Quave speaks with Angela Ardolino about natural approaches to supporting aging dogs. Angela, a formulator and educator specializing in cannabinoids, medicinal mushrooms, and adaptogens, explains how these compounds interact with the endocannabinoid system to regulate inflammation, neurological function, and overall balance. They discuss the differences between full-spectrum hemp extracts and isolated compounds, how cannabinoids may support joint pain, seizures, and cognitive decline, and the growing interest in functional mushrooms like lion’s...

Seed oils are everywhere. From salad dressings to snack foods, they’ve become a quiet staple of the modern diet. But how did they get there, and what do we really know about their impact on human health?

This week on Foodie Pharmacology, Dr. Cassandra Quave sits down with nutritionist Cherie Calbom, MS, known as “The Juice Lady,” to unpack the rise of industrial seed oils and the debate surrounding them. Cherie shares her personal journey into nutrition, which began with a serious health crisis and led her to rethink the role of food in healing.

Tog...

Spring is here, and seasonal pollen along with it! This week on Foodie Pharmacology, Dr. Cassandra Quave speaks with Gary Falcetano, PA-C, AE-C, Senior Manager of Global Medical & Scientific Affairs in Allergy at Thermo Fisher Scientific and a longtime clinician and educator in asthma and immunologic disorders, about pollen food allergy syndrome and why certain fresh foods can suddenly cause itching or irritation during allergy season.

Also known as oral allergy syndrome, this condition stems from cross-reactivity between pollen proteins and similar proteins found in plant foods. Gary explains how this immune mix-up happens, why symptoms are...

What if the key to reducing food waste, strengthening community, and reconnecting with our food systems is already in your kitchen?

In this episode of Foodie Pharmacology, Dr. Cassandra Quave speaks with Dr. Julia Skinner, food writer, fermentation expert, and founder of the Culinary Curiosity School, to explore the practice of food preserving. From fermentation to freezing, Julia shares how preserving is not just a set of techniques but a way of thinking about food with intention and creativity.

They discuss her upcoming book, Essential Food Preserving, which takes an ingredient-first approach. Instead of rigid...

Flowers may seem delicate, but they have transformed the planet! In this episode of Foodie Pharmacology, Dr. Cassandra Quave speaks with Dr. David George Haskell, author of the new book How Flowers Made Our World, about the revolutionary rise of flowering plants. They discuss how grasses helped shape human evolution as “grass apes,” why orchids rely on intimate fungal partnerships, and how floral chemistry communicates with pollinators through scent and even electrical fields! From the endosperm that feeds much of humanity to the cultural and aesthetic power of flowers, this conversation examines how flowering plants engineered ecosystems, nourished civilizations, and...

What if the future of antimicrobial discovery lies buried in medieval manuscripts? In this episode of Foodie Pharmacology, Dr. Cassandra Quave speaks with microbiologist Dr. Freya Harrison of the University of Warwick about the emerging field of “Ancient-biotics”. They examine how early medieval remedies such as Bald’s eyesalve are being reconstructed and tested against modern antibiotic-resistant biofilms. Dr. Harrison explains how her lab builds infection models that mimic the human body, why biofilms are so difficult to treat, and how combinations of natural products like honey and vinegar may hold clues to new antimicrobial strategies. This conversation bridges microb...

Inflammation is essential for healing, but when it becomes chronic, it can quietly drive joint pain, blood sugar imbalance, autoimmune conditions, and long-term disease. In this episode of Foodie Pharmacology, Dr. Cassandra Quave speaks with Dr. Josh Redd, founder of RedRiver Health and Wellness and author of The 30-Day Inflammatory Reset, about the root causes of chronic inflammation. They discuss how ultra-processed diets, environmental exposures, stress, hormonal imbalance, and even trauma contribute to inflammatory load, and what practical steps individuals can take to support immune balance through nutrition and lifestyle change. Learn more about Josh’s work at DrJoshRedd.co...

Sake sits at the intersection of fermentation science, ritual, and food culture. In this episode of Foodie Pharmacology, Dr. Cassandra Quave is joined by Dr. Eric C. Rath, professor of history at the University of Kansas and author of Kanpai: The History of Sake. Together, they explore what sake really is, how fermentation with koji mold transforms rice into alcohol, and why sake has played such a central role in Japanese ritual, everyday life, and food culture. The conversation also traces the history of home brewing, the rise of izakaya gastropubs, and the emergence of American sake as both...

In the remote Alaskan wilderness, survival is not a simple metaphor. It is an act of daily practice. In this episode of Foodie Pharmacology, Dr. Cassandra Quave reconnects with Sue Aikens, best known from National Geographic’s Life Below Zero, to talk about her memoir North of Ordinary. Broadcasting from Alaska, Sue reflects on a life shaped by abandonment, fierce independence, and learning to endure both emotional and physical extremes—from brutal winters and isolation to surviving a grizzly bear attack. This conversation explores resilience, the role of helpers (human and animal), and what it means to build a sens...

For decades, Alzheimer’s research has been shaped by a dominant hypothesis, enormous funding streams, and the promise of breakthrough cures. But what happens when the science itself is compromised? In this episode of Foodie Pharmacology, Dr. Cassandra Quave sits down with investigative science journalist Charles Piller to unpack the revelations behind his book Doctored: Fraud, Arrogance, and Tragedy in the Quest to Cure Alzheimer’s. We examine how image manipulation, groupthink, and institutional failures distorted the Alzheimer’s research landscape for years, shaping clinical trials, drug approvals, and patient expectations. This conversation goes beyond a single disease to examin...

This week on Foodie Pharmacology, we explore the cultural, scientific, and social dimensions of kava (Piper methysticum) with Douglas La Rose, Executive Director of the Kava Coalition. We discuss kava’s roots in Pacific Island traditions, how it’s prepared, what the new AHP monograph means for safety and standards, and why this non-alcoholic beverage is gaining global interest as a pro-social, calming alternative. Douglas shares insights from his work supporting education, responsible use, and sustainable industry growth, offering a grounded look at how this plant bridges community, culture, and modern wellness.

#FoodiePharmacology #Kava #Ethnobotany #PlantMedicine #WellnessCulture #Natu...

What makes ibogaine such a remarkable plant-derived compound? I sit down with Jonathan Dickinson, CEO and co-founder of Ambio Life Sciences, to explore the fascinating neuropharmacology of this alkaloid and its profound impact on the brain. Jonathan is an expert on ibogaine, with more than 15 years of experience spanning clinical care, traditional practice, and psychedelic research.

We discuss iboga’s deep cultural roots in Central and West Africa, its role in Bwiti spiritual traditions, and how modern science is uncovering its potential in treating addiction, trauma, and neurological disease. Jonathan also shares insights from his pioneering work in...

What if the future of egg farming could eliminate one of the industry’s most difficult animal welfare issues—male chick culling? Thanks to in-ovo sexing technology, that future is here.

This week on Foodie Pharmacology, I talk with Jasen Urena, Vice President of NestFresh, about the launch of their Humanely Hatched™ eggs—the first in the U.S. to ensure only female chicks are incubated. It’s a groundbreaking step that transforms both animal welfare and consumer choice.

Jasen shares his journey at NestFresh and how the company has been at the forefront of ethical in...

Plants are master chemists. From caffeine and nicotine to powerful drugs like colchicine, they manufacture an incredible array of molecules that defend against pests, attract pollinators, and sometimes even become lifesaving medicines for humans. But how exactly do plants build these complex compounds, and why do they make them in the first place?

This week, I sit down with Dr. Ryan Nett, Assistant Professor of Molecular and Cellular Biology at Harvard University, to explore the fascinating world of plant biosynthesis. We talk about how plants orchestrate molecular “assembly lines” using specialized enzymes, why some of the most prom...

Food allergies affect millions of children and adults worldwide—and the numbers are rising. This week on the show, Dr. Quave speaks with Dr. Sarita Patil, Assistant Professor of Medicine at Harvard Medical School and Co-Director of the MGH Food Allergy Center, to explore the science behind allergic reactions. They discuss the differences between food allergies and intolerances, the rise in childhood allergies, and how early exposure to allergenic foods can help prevent these conditions.

Dr. Patil shares insights from her latest research on peanut immunotherapy and the role of protective antibodies in reducing severe reactions. She al...

What if our future food security depended not on fields of grain, but on forests of trees? In this episode of Foodie Pharmacology, I sit down with Elspeth Hay, author of Feed Us with Trees: Nuts and the Future of Food and host of the Local Food Report on CAI NPR. Elspeth takes us on a journey through oak groves and chestnut stands to explore how nut-bearing trees once fed the world—and could again.

We unpack the ecological power of keystone species like oaks and the role of fire in maintaining these ancient foodscapes. Elspeth shares ho...

This week on the show, Dr. Quave speaks with Dr. Giulia Menichetti, a computational physicist at Harvard Medical School, about one of the most elusive frontiers in nutrition science: the “dark matter” of food. While most nutrition data is focused on a handful of known nutrients, Dr. Menichetti’s “Foodome” Project is charting the vast landscape of overlooked bioactive compounds hidden in everyday ingredients—and using artificial intelligence to unlock their therapeutic potential.

From network science and protein targets to AI-powered metabolomics and precision diets, this conversation uncovers how foods interact with our biology in ways we’re only beginn...

This week on the show, Dr. Quave speaks with conservation biologist Dr. Daniel Villar about the deep connections between culture, ecology, and traditional knowledge in the Central Andes. Their conversation centers on Lake Titicaca, one of the world’s highest navigable lakes, where Dr. Villar has studied how traditional ecological knowledge (TEK) shapes and responds to environmental change. 

They discuss the many uses of the totora sedge—a plant once used to build floating islands, craft artisanal goods, and provide food for people and livestock—and how its management reflects centuries of indigenous governance and adaptation. Dr. Villar...

What if your doctor prescribed kale instead of pills? This week on Foodie Pharmacology, Dr. Quave sits down with Dr. Steven Chen and Nat Irwin to discuss Recipe4Health, a pioneering “Food as Medicine” program transforming how we treat chronic disease. Based in Alameda County, CA, this initiative pairs regenerative and organic produce with health coaching—all covered by Medi-Cal (Medicaid).

Learn how fresh, regenerative produce is being prescribed to thousands of patients as part of a broader effort to improve outcomes for chronic conditions like diabetes and depression. This innovative model also delivers ripple effects beyond the cl...

Psilocybin and the Fountain of Youth with Dr. Louise Hecker

Could magic mushrooms hold the key to longer life? In this episode, Dr. Quave chats with Dr. Louise Hecker, Associate Professor at Baylor College of Medicine and Founder of Fibronox, about her groundbreaking research on psilocybin and aging. You may have seen the headlines—her team found that psilocybin slowed cellular aging, reduced oxidative stress, and even extended lifespan in mice. Dr. Hecker shares the origin story behind the study, which started with rooftop workouts and curiosity, and walks us through the science behind her findings. From ch...

Menus aren’t just lists of food—they’re time machines. This week on Foodie Pharmacology, Dr. Cassandra Quave returns to Season 7 with literary food historian Dr. Nathalie Cooke of McGill University. Together, they explore how menus offer rich clues into the cultural, economic, and even medical mindsets of past centuries.

From elephant soup on menus to how Coca-Cola and cigarettes once appeared as health tonics, you’ll hear surprising stories of how dining habits—and health claims—have evolved. Discover how art, identity, and even politics show up on the plate, and how modern “no-choice” tasting menus harken bac...

This week on the show, we speak with Dr. César Ojeda, an ethnobiologist specializing in fermentation, biocultural diversity, and microbial ecology. Dr. Ojeda shares his insights on traditional Mexican fermented beverages, particularly focusing on the science and cultural importance of these foods. We discuss the concept of ethnomicrobiology, the role of microbes in traditional agriculture, and how microbial communities impact the fermentation process. From lessons on prickly pear cactus fermented beverages and the significance of various fermentation containers, we cover a delightful array of fun food science topics!

#cactus #fermentation #pricklypear #microbiology 

This week on the show, we’re joined by Dr. Rosette Chakkalakal, an Associate Professor at Emory School of Medicine and Director of Preventive Medicine, and Kathy Taylor, Director of Medical Nutrition Therapy at Grady Health System. Dr. Chakkalakal and Taylor share insights into Grady’s innovative Food as Medicine program, which addresses food insecurity and chronic disease management through nutrition-based interventions. We discuss the critical role of fresh produce access, cooking education, and personalized nutrition counseling in improving health outcomes for patients with diabetes and hypertension. Our guests highlight how Grady’s approach is transforming patient care—helping to lower...

If you feel like you never have time to cook a healthy meal, this episode is for you! This week on the show, we’re joined by Sharon Palmer, known as the ‘Plant-powered Dietician.’ Sharon shares helpful tips on easy and healthy meal preparation and explores the intersection of nutrition and sustainability. Plants really are the best when it comes to supporting a healthy planet and a healthy you! Sharon also discusses her new book 'The Plant Powered Plan to Beat Diabetes' and shares valuable information on managing and preventing chronic diseases through dietary choices. Learn more about her work a...

Have you ever wondered what’s really in your food—beyond just vitamins, minerals, carbs, proteins, and fats—but also the antioxidant and anti-inflammatory compounds that impact health? This week on the show, our guest is Dr. Selena Ahmed, Global Director of the Periodic Table of Food Initiative (PTFI) and Dean of Food EDU at the American Heart Association. With her expertise in food systems research and sustainable agriculture, Dr. Ahmed delves into PTFI’s mission to transform our understanding of food composition and quality.

We discuss the importance of biodiversity, nutritional yields, and sustainable farming practices like agr...