Histamine Well Podcast: Exploring Histamine, Methylation & Holistic Health

Are “healthy” foods like broccoli, garlic, eggs, or red meat making you feel worse instead of better?

In this episode of The Histamine Well Podcast, Joanne breaks down one of the most overlooked root causes of food sensitivity, gut symptoms, and chronic fatigue: sulfur metabolism dysfunction.

If you’ve been struggling with histamine intolerance, unexplained food reactions, bloating, brain fog, or fatigue, this episode will help you understand what may really be going on beneath the surface.

🎧 In this episode, you’ll learn:

Do you find your anxiety worsening at night—or waking you suddenly between 2AM and 4AM with a racing heart and intrusive thoughts?

In this Clarity Session Q&A, Joanne explores one of the most common patterns seen in clinic: night-time anxiety and early morning wake-ups—and why this is often more than just a psychological issue.

This episode explains the physiological root causes of anxiety at night, including the critical role of blood sugar regulation, liver glycogen stores, and stress hormones like cortisol and adrenaline. When blood sugar drop...

Are you struggling with anxiety, overwhelm, or constant nervous system dysregulation—despite normal lab results?

In this episode of The Histamine Well Podcast, Joanne uncovers one of the most overlooked root causes of anxiety in women: blood sugar instability.

Learn how blood sugar spikes and crashes can trigger cortisol and adrenaline, creating symptoms that feel exactly like anxiety disorders. Joanne breaks down why this often goes undiagnosed, even when glucose, insulin, and HbA1c levels appear normal.

This episode explores the connection between blood sugar, hormones, histamine, gut health, and neurotransmitter production—and why...

If your blood tests are “normal”… why do you still feel inflamed?

In this Q&A Clarity Session of The Histamine Well Podcast, Joanne answers a deeply important and often overlooked question: why symptoms of inflammation can persist even when CRP and ESR markers come back normal.

Many people are told everything is “fine” based on standard blood work—yet continue to experience fatigue, brain fog, skin issues, gut dysfunction, and hormonal imbalances. This episode explains why that disconnect happens and what may actually be driving your symptoms.

CRP (C-reactive protein) and ESR (ery...

In this in-depth episode of The Histamine Well Podcast, Joanne explores why hormone symptoms often persist despite treatment, and what may be driving this beneath the surface.

Drawing on clinical observation and biochemistry, Joanne explains how chronic inflammation, histamine dysregulation, and methylation imbalances interact to disrupt hormonal signaling, ovulation, and recovery.

If you’ve tried supplements, improved your diet, and still experience symptoms like PMS, PMDD, anxiety, insomnia, migraines, or hormonal acne, this episode provides a deeper framework for understanding why.

What You’ll Learn

Are bioidentical hormones truly “natural”—or is that just clever marketing?

In this Q&A Clarity Session of The Histamine Well Podcast, Joanne breaks down one of the most common and misunderstood questions in women’s health: what bioidentical hormones actually are, where they come from, and how they differ from both synthetic hormones and herbal remedies.

Many women exploring hormone replacement therapy (HRT) feel uncertain about what they’re putting into their bodies—especially when terms like “natural,” “plant-based,” and “bioidentical” are used interchangeably. In this episode, we clarify the science in a simple, grounded way so you can...

Can’t tolerate HRT? This episode explores the connection between histamine intolerance, hormone replacement therapy (HRT), SIBO, gut health, menopause symptoms, and hormone imbalance in women.

Joanne Kennedy shares a clinical case study showing how histamine overload and gut dysfunction can worsen HRT side effects like brain fog, fatigue, mood swings, and skin reactions.

Learn how the estrogen-histamine connection, gut health, and inflammation impact hormone tolerance—and why addressing SIBO and histamine intolerance may help restore balance.

Perfect for women experiencing menopause symptoms, HRT intolerance, or ongoing hormone imbalances.

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In this Q&A Clarity Session of The Histamine Well Podcast, naturopath Joanne Kennedy explains the science behind sulforaphane and how it activates the NRF2 pathway, often referred to as the body’s “master switch” for protection and repair.

Rather than acting as a simple antioxidant, sulforaphane works at a deeper level—helping to switch on a network of protective genes responsible for detoxification, antioxidant production, inflammation control, and immune regulation 

This episode breaks down complex science into simple, practical insights—perfect for both practitioners and those navigating chronic health issu...

In this episode of The Histamine Well Podcast, Joanne speaks with nutritional biochemist Dr. Christine Houghton about the GEMM Protocol (Gut Ecology & Metabolic Modulation) — a science-based approach to restoring gut health by repairing the gut lining and activating protective genes.

Learn how sulforaphane, NRF2 activation, and targeted microbiome support can help improve gut inflammation, histamine intolerance, food sensitivities, and chronic illness.

In this episode, you’ll learn:

In this Q&A Clarity Session of The Histamine Well Podcast, Joanne answers a common and often confusing question: Should I take antibiotics for SIBO?

The truth is—it depends.

In this episode, Joanne breaks down the two distinct patient scenarios she commonly sees in clinical practice. She explains when antibiotics may be a practical and supportive option, especially for those with lifestyle limitations, and when a deeper, more comprehensive approach may be necessary to address the root causes of SIBO.

You’ll learn:

When antibiotics can be helpful—and when they m...

Is SIBO (Small Intestinal Bacterial Overgrowth) really the root cause of your bloating and food intolerances — or is it a downstream effect of deeper dysfunction?

In this episode of The Histamine Well Podcast, Joanne explains why SIBO rarely develops in isolation and why antibiotics or herbal antimicrobials alone often fail to prevent relapse.

If you’ve been stuck in the cycle of treating SIBO repeatedly without lasting improvement, this episode explores the underlying mechanisms that may be driving bacterial overgrowth in the first place.

Joanne unpacks how impaired gut motility, nervous system dysregulation, low...

In this Q&A episode, we explore how methylation affects mental health, including its impact on neurotransmitters like dopamine, serotonin, and norepinephrine. Learn how the methylation cycle regulates gene expression, hormone balance, histamine clearance, and stress resilience — and why low folate, vitamin B12, B6, and B2 can contribute to symptoms such as anxiety, depression, brain fog, fatigue, insomnia, and “wired but tired” patterns.

We also discuss slow COMT activity, the link between estrogen and histamine, and how imbalances can drive mood swings, palpitations, and poor stress tolerance. Discover how real-time methylation testing (Mood Sense saliva swab...

In this episode of The Histamine Well Podcast, Joanne explains how Helicobacter pylori (H. pylori) can quietly drive histamine intolerance, SIBO, and hormone imbalance — even without classic ulcer or reflux symptoms.

H. pylori produces urease, converting urea into ammonia and lowering stomach acid. This reduction in hydrochloric acid can impair protein digestion, weaken pathogen control, and disrupt digestive signaling — creating the perfect environment for small intestinal bacterial overgrowth (SIBO) and rising histamine levels. The result can be a “histamine storm” of inflammation and systemic symptoms.

Common signs may include:

In this short Clarity Session Q&A, Joanne explains the key differences between common magnesium forms and how to choose the right one for symptoms like anxiety, sleep issues, constipation, migraines, fatigue, muscle pain, or brain fog. Learn when each type may help—and when to avoid certain forms if you’re sensitive. 

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📘 New to this journey? Buy The Ultimate Bundle for Managing Histamine Intolerance—your step-by-step guide to manage your histamine intolerance effectively.

 🧪 Curious...

In this episode of The Histamine Well Podcast, Joanne explores how candida, yeast, and fungal overgrowth can worsen histamine intolerance and trigger ongoing mast cell symptoms.

She explains how fungal-driven gut inflammation increases histamine production by activating mast cells, upregulating histidine decarboxylase (HDC), and reducing DAO enzyme activity — making it harder for the body to break histamine down.

You’ll learn why antifungals alone often fail, how gut “terrain” factors like low stomach acid, poor bile flow, digestive enzyme insufficiency, microbiome imbalance, mold exposure, and chronic stress allow fungal overgrowth to persist, and how SIBO and SIFO...

In this short Clarity Session Q&A bonus episode of The Histamine Well Podcast, Joanne explains what antihistamines actually do, why symptoms often return when you stop them, and the common root causes behind histamine issues. Learn the difference between symptom suppression and true regulation of the gut, detox pathways, and nervous system. 

✨ Want more? Follow on Instagram, Facebook, and YouTube for updates and tips.

📘 New to this journey? Buy The Ultimate Bundle for Managing Histamine Intolerance—your step-by-step guide to manage your histamine intolerance effectively.

 🧪 Cur...

In this episode of the Histamine Well Podcast, Joanne speaks with Rachel Scott, who developed severe food intolerances, intense histamine reactions, and unexplained chronic symptoms following mold exposure.

After years of misdiagnosis and treatments that failed to address the root cause, Rachel’s health continued to deteriorate — until a simpler, more balanced approach was introduced. Rachel shares how targeted support using sulforaphane, digestive enzymes, and Epsom salt baths helped stabilize her system and gradually restore tolerance to food.

Joanne explains the biochemical drivers behind mold-related illness, including sulfur metabolism, detoxification pathways, and nervous system load, and...

In this Clarity Session, Joanne breaks down a common myth about the MTHFR gene, methylation, and detox. Does having an MTHFR variant mean your detox pathways are impaired? Learn how detoxification really works, how methylation fits in, and what actually supports healthy histamine balance, gut health, and energy. Perfect for anyone navigating MTHFR, chronic fatigue, or food sensitivities. 

✨ Want more? Follow on Instagram, Facebook, and YouTube for updates and tips.

📘 New to this journey? Buy The Ultimate Bundle for Managing Histamine Intolerance—your step-by-step guide to manage your his...

In this episode of The Histamine Well Podcast, Joanne takes a deep dive into MARCoNS (Multiple Antibiotic Resistant Coagulase-Negative Staphylococci)—a frequently overlooked bacterial colonization that can drive chronic inflammation, histamine intolerance, and persistent, unexplained symptoms.

Joanne explains how MARCoNS colonize the nasal passages, often in the context of mould-related illness, and why these bacteria are particularly difficult to eradicate due to their ability to form protective biofilms. She explores the connection between MARCoNS and symptoms such as fatigue, brain fog, migraines, an...