MedEvidence Articles

In this week's episode, we take a first look at early-stage clinical trials for tooth regrowth in Japan. We look at some of the key molecules involved in tooth development, and why they are suppressed after our permanent teeth come in. Finally, we explore what happens when the protein that stops tooth growth is turned off.

References

Novacescu D, Dumitru CS, Zara F, Raica M, Suciu CS, Barb AC, Rakitovan M, Armega Anghelescu A, Cindrea AC, Diana S, Gaje PN. The Morphogenesis, Pathogenesis, and Molecular Regulation of Human Tooth Development—A...

On this week's episode, we’re talking about breakthroughs in Type 1 Diabetes management.

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On this week's episode, we look into one of the key benefits of clinical trials: that they tend to isolate against confounding variables. We look at what confounding variables are and look at the long-term example of reported links between sunscreen use and increased skin cancer rates. We look at why excessive sun exposure is dangerous, how sunscreen works, why rates of skin cancer appeared to increase as sunscreen was introduced.

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In this episode, we’re talking about the FDA’s push toward real-time clinical trials, and what that could mean for the pace, quality, and oversight of bringing new treatments to patients.

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In this episode, we look at the need for cheap, accurate screening tools for common diseases. To that end, we take the example of fatty liver disease. We review the "gold standard" diagnostic tool, liver biopsy, and why that shouldn't be the first line of detection for a fatty liver. We review some standard methods of screening before diving into transient elastography, also known as FibroScan. We look at what this method is, why it may be preferable to an MRI or CT scan, and how clinical researchers use transient elastography in trials.

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In this week's episode, guest author Maya Yanchuck explores the ins and outs of PCOS. We review what the condition is, symptoms, complications, and what is happening in the body. Finally, we look at treatments, from mental health to medicaitons.

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In this week's episode, written by guest author Christy Kestner, we explore the neuroscience of misinformation. We look inot what misinformation is, what happens inside the brain when we encounter misinformation, why misinformation can be so hard to correct, and some of the real-life consequences with misinformation - especialyl in relation to health. We close by discussing how we can combat misinformation, from correcting false ideas to protecting against inflammatory, misleading informaiton found online.

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In this week's episode, we explore the most common type of degenerative joint disease, osteoarthritis. We look at the risks of getting the disease, complications and symptoms, and what can be done about it. We also look at what may be next on the horizon; clinical trials targeting degenerative joint disease in myriad ways.

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In this week's episode, we explore new RNA interference technology and how it is being investigated for clinical research. We look at what high blood pressure is, one of the key underlining systems involved: RAAS, and how current blood pressure medications target this system. We then look at the theory behind RNA interference medicaitons and why they are so exciting for scientists.

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In this week's episode, we explore some of the roles receptors play in the body. We focus on Cannabanoid 1 (CB1) receptors, which regulate appetite and energy expenditure in the body, but can have effects in the brain as well. We look at how receptors can do different things depending on location and that the challenge of medications is in targeting right receptors in the right place.

References:

In this week's episode, we talk about Sjögren's disease, a relatively common autoimmune disease. We explore the risks of contracting the disease, who gets it, symptoms, and complications. We also explore how the disease works on a mechanical level inside the body by hijacking the immune system, and finish by looking at what treatment looks like today and what's coming down the clinical trial pipeline tomorrow.

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In this week's episode we explore gene therapies. We look at what genes are, why mutations can be dangerous, and what methods are being investigated to solve these problems. Then we focus on familial hypercholesterolemia as an example and look at what's being researched today to solve this problem.

References:

In this week's episode, we explore what happens when the body can't supply enough oxygen to cells. This condition, called anemia, is caused by a drop in red blood cells or the oxygen-carrying hemoglobin inside them. We dive into some of the risks, causes, complications, and treatments associated with anemia.

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In this week's episode, we take a look at bipolar disorder. Bipolar disorder is what happens when out-of-control brain chemicals cut our ability to regulate our mood. The condition results in uncontrollable mood swings that can last for weeks at a time, ranging from impuslive mania to debilitating depression.

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On this week's episode we investigate the molecule amylin, a hormone that also affects the body and brain. Amylin is released in response to eating, and helps us know when we're full. We look at what amylin is, how it works, and how investigational versions of the hormone may help with obesity and weight loss.

References:

In this week's episode, we explore the concept of Carbs Last. This is an eating tactic where foods high in fiber and protein are eaten before sugary carbohydrates. A solid history of clinical research studies has shown that this method of eating smooths out spikes in blood glucose and is associated with better outcomes for diabetic patients. Tune in to learn about this fast, free method of helping your body process sugars!

References:

In this week's episode, we take a closer look at Neurotrophic Keratopathy (NK), a rare nerve condition affecting the eye. We explore how the eye works, the risks of developing NK, possible complications of the disease, and what is actually happening within the eye. We also dive into current treatments, including an new investigational class of medications being researched.

References: 

In this week's episode, we explore hypertriglyceridemia: high triglyceride levels in the blood. We look at what triglycerides are, why they might be elevated, and some of the risks and causes of hypertriglyceridemia. We also look at the pivotal role clinical research has and continues to play in controlling this dangerous condition, and give a powerful look at what's being investigated now in the research space.

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In this week's episode, we look at the surprising link between mouthwash use and high blood pressure. We explore what mouthwash does, how the bacteria in our mouths are beneficial, and how the products of those bacteria can indirectly affect blood pressure.

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This week we explore atopic dermatitis, oftne called eczema. This skin condition is common, long lasting, and can have serious effects on mental health and relationships. We explore who gets it, how it works in the body, and what treatments are available and on the horizon.

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On this week's episode, we show an increased drive into vagus nerve stimulation clinical research. This FDA-approved therapy for major depressive disorder (MDD) is undergoing further trials in an effort to get it approved by big insurance carriers like Medicaid.

On this week's episode, we look into the calculations being made to develop new obesity treatments. We go into the history, current best practices, body changes, and some possible new solutions in the weight loss field.

References:

In this week's episode, originally written in 2022, we look at some of the science behind creating and maintaining a successful New Year's resolition. We explore how language, habit, and brain science can all make a difference in makign a better you.

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In this week's episode, written by guest author Chase Berger, we explore the positive health benefits of clinical research beyond the obvious. We look at how those who can particiapte in clinical research have an alternative method of interacting with healthcare professionals that is quick, consistent, and pateint-oriented.

References:

Koren, M.J., Geddings, K., (17 November, 2025). Coordinated care through clinical research. On MedEvidence! Truth Behind the Data. [Podcast]. https://www.medevidence.com/coordinated-care-through-clinical-research

Koren, M.J., Collins, S., (3 December, 2025). Equity through clinical research. On MedEvidence! Truth Behind the Data. [Podcast]. https...

In this week's episode, which revisits a topic from several years ago, we go deep into the brain to explore what happens inside whe nwe give gifts. We explore a few studies which have looked at brain activity during gifting - including during diffrent types of gifting - and explore why giving gifts makes you feel good, connects you with friends, and acts as a prosocial activity.

References:

Aknin, L. B., Barrington-Leigh, C. P., Dunn, E. W., Helliwell, J. F., Burns, J., Biswas-Diener, R., ... & Norton, M. I. Prosocial Spending and Well-Being: Cross-Cultural...

In this episode we explore the less cheery side of the holidays: holiday heart syndrome. This syndrome is defined as irregular heartbeats that occur as a result of binge drinking, the type of which is frequently seen around the holidays. We explore the risks, outcomes, mechanics, and treatments of this not-so-happy heart syndrome.

References:

Jain, A., Yelamanchili, V. S., Brown, K. N., & Goel, A. (2024). Holiday heart syndrome. In StatPearls [Internet]. StatPearls Publishing. https://www.ncbi.nlm.nih.gov/books/NBK537185/

World Health Organization. (January 4, 2023). No level of alcohol consumption is...

In this week's episode, we explore the stream of causes that can lead to the painful inflammatory condition gout. We look at the risks, progression, mechanics, and solutions available for this most common inflammatory arthritis. The primary cause of gout is excessive urate in the the blood depositing itself, especially toes. We then look ahead to clinical trials that recently wrapped up or are currently underway and which target the underlying urate in the blood or the immune response to urate crystals in joints.

References

Dalbeth, N., Choi, H. K...

In this week's episode, we talk about placebos, which are inert "medications" used to compare with active drugs. We talk about how the use of medications that "do nothing" can provide pain relief, change hormone balance int he body, and lower symptoms across a broad variety of diseases.

References:

Beecher, H. K. (1955). The powerful placebo. Journal of the American Medical Association, 159(17), 1602-1606. https://jamanetwork.com/journals/jama/article-abstract/303530

Wager, T. D., & Atlas, L. Y. (2015). The neuroscience of placebo effects: connecting context, learning and health. Nature Reviews Neuroscience, 16(7), 403-418. https://www...

In this week's episode, we explore some specific, actionable methods for increasing gratitude. These include gratitude journaling, gratitude letters, mental subtraction, and experiantial consumption. We go over what the methods are, how they work, and how expressing gratitude may help mental health.

References:

Allen, S. (2018). The science of gratitude (pp. 1217948920-1544632649). Conshohocken, PA: John Templeton Foundation. https://ggsc.berkeley.edu/images/uploads/GGSC-JTF_White_Paper-Gratitude-FINAL.pdf

Dickens, L. R. (2017). Using gratitude to promote positive change: A series of meta-analyses investigating the effectiveness of gratitude interventions. Basic and Applied Social Psychology, 39(4), 193...

On this week's episode, we talk about gratitude, and how it can affect mood, positive emotions, and even biological markers of health.

References:

Allen, S. (2018). The science of gratitude (pp. 1217948920-1544632649). Conshohocken, PA: John Templeton Foundation. 

Boggiss, A. L., Consedine, N. S., Brenton-Peters, J. M., Hofman, P. L., & Serlachius, A. S. (2020). A systematic review of gratitude interventions: Effects on physical health and health behaviors. Journal of Psychosomatic Research, 135, 110165. https://doi.org/10.1016/j.jpsychores.2020.110165

McCullough, M. E., Emmons, R. A., & Tsang, J. A. (2002). The grateful disposition: a conceptual and e...

In this week's episode, we talk about how targeting a specific immune cell called an eosinophil may help lower the burden of COPD (chronic obstructive pilmonary disease). We explore the epidemiology, pathophysiology, and treatment options for COPD, including targeting the eosinophil pathway.

References:

Bhatti, M. S. (1999). A historical look at chlorofluorocarbon refrigerants. ASHRAE Transactions, 105, 1186. https://www.osti.gov/biblio/20002388

Narendra, D. K., & Hanania, N. A. (2019). Targeting IL-5 in COPD. International journal of chronic obstructive pulmonary disease, 1045-1051. https://www.tandfonline.com/doi/full/10.2147/COPD.S155306

World Health Organization. (6...

In this episode, we explore the role of adjuvants in vaccines. These addatives help the immune response to a vaccine, making it more effective at stoping infection, complication, hospitalization, and or death. We discuss the need for better vaccines and how adjuvants may be able to help.

References:

Grohskopf, L. A. (2019). Prevention and control of seasonal influenza with vaccines: recommendations of the Advisory Committee on Immunization Practices—United States, 2019–20 influenza season. MMWR. Recommendations and Reports, 68. https://www.cdc.gov/mmwr/volumes/73/rr/rr7305a1.htm

Gross, P. A., Hermogenes, A. W...

In this week's episode we explore osteoporosis, a condition where there's "too little bone in the bone." We look at how bones work normally ,adn compare that to the risks, pathophysiology, and treatments available to those with osteoporosis.

References:

Marcus, R., Dempster, D. W., Cauley, J. A., & Feldman, D. (Eds.). (2013). Osteoporosis. Academic Press. 

Reginster, J. Y., & Burlet, N. (2006). Osteoporosis: a still increasing prevalence. Bone, 38(2), 4-9. https://www.sciencedirect.com/science/article/pii/S8756328205005272

Sarafrazi, N., Wambogo, E. A., & Shepherd, J. A. (2021). Osteoporosis or low bone mass in older a...

In this week's episode, we explore what monoclonal antibodies are, how they make things happen in the body, and how they can be used in medicine. We discuss how they can be used for identifying cells, delivering drugs to specific cells, or anything in between. Tune in to learn about monoclonal antibodies and hwo they relate to a cat who's a picky eater.

References:

Nelson, P. N., Reynolds, G. M., Waldron, E. E., Ward, E., Giannopoulos, K., & Murray, P. G. (2000). Demystified…: monoclonal antibodies. Molecular pathology, 53(3), 111. https://pmc.ncbi.nlm.nih.gov/articles/PM...

On this week's episode, we explore the ins and outs of chronic spontaneous urticaria. We discuss the signs, symptoms, complications, and how-it-works of the disease, including how linchpin molecules in the cell like Bruton's tyrosine kinase may be the key to tempering extreme reposnses from a hair-trigger immune system.

References:

Isachenkov, V. (2017, September 19). Stanislav Petrov, who averted nuclear war, dies at 77. The Associated Press. https://apnews.com/general-news-b9de4e3c9a5949e4a27e8ea601059f25

Zuberbier T, Abdul Latiff AH, Abuzakouk M, et al (2022) The international EAACI/GA²L...

In this week's episode we review fatty liver disease, called metabolic dysfunction–associated steatotic liver disease (MASLD) and its advanced form, metabolic dysfunction-associated steatohepatitis, or MASH. We look at the prevalence, risks, and complications of this dangerous disease. Then we get into the nuts and bolts of how MASLD and MASH work and some of the treatment options available.

References:

Allen, A. M., Younossi, Z. M., Diehl, A. M., Charlton, M. R., & Lazarus, J. V. (2024). Envisioning how to advance the MASH field. Nature Reviews Gastroenterology & Hepatology, 21(10), 726-738. https://www.nature.com/articles/s41575-024-00938-9...

In today's episode we discuss an immune-mediated disease, eosinophilic esophagitis, or EoE. We review the symptoms, risks, and damage this disease can cause. We also get into what happens inside the body during and what's being done in both standard medicine and clinical research to try to end EoE.

References:

[1] Muir, A., & Falk, G. W. (2021). Eosinophilic esophagitis: a review. Jama, 326(13), 1310-1318. https://pmc.ncbi.nlm.nih.gov/articles/PMC9045493/

[2] Nurko, S., & Furuta, G. T. (2006). Eosinophilic esophagitis. GI Motility online. https://www.nature.com/gimo/contents/pt1/full/gimo49.html

[3...

In this podcast, we explore Crohn's disease: who it affects, what it is, how it works in the body, and what you can do about it. We relate the disease to screens on windows, which can degrade over time, letting unwanted bugs in the house. Tune in for the who, how, and what can be done about Crohn's!

References:

Roda, G., Chien Ng, S., Kotze, P. G., Argollo, M., Panaccione, R., Spinelli, A., ... & Danese, S. (2020). Crohn’s disease. Nature reviews Disease primers, 6(1), 22. https://doi.org/10.1038/s41572-020-0156-2

Peyrin-Biroulet, L...

In this week's episode, we set sail to explore Attention-Deficit Hyperactivity Disorder, or ADHD. We cruise past the risks, symptoms, and what actually happens inside the brain to make increase impulsivity, inattentiveness, and hyperactivity. Finally, we shoot the breeze with various treatment options, including medical, therapy-based, and alternative.

References:

Norman, L. J., Sudre, G., Price, J., Shastri, G. G., & Shaw, P. (2023). Evidence from “big data” for the default-mode hypothesis of ADHD: a mega-analysis of multiple large samples. Neuropsychopharmacology, 48(2), 281-289. https://www.nature.com/articles/s41386-022-01408-z

Ayano, G., Deme...

In this episode we dive deep into new technologies in the ongoing attempt to get cholesterol levels under control worldwide. Heart disease remains the #1 killer in America, and much of the blame falls on high cholesterol. We go into what cholesterol is and some of the new targets and technologies being developed now to help keep the body in line producing the right amount of the right proteins for good cholesterol control.

References:

Occupational Safety and Health Administration. (2025). Accident search results: Keyword “Robot”. U.S. Department of Labor. Accessed 3 September, 2025. https://www.osha...