Lipid Insights

From Cholesterol to Dyslipidemia: Translating the 2026 Multi-Society Guideline into Clinical Practice | Month 3 Podcast

Knowing the guidelines is one thing. Putting them into practice is another. In the third installment of this four-part CME/CE-accredited series, the conversation shifts from risk assessment to treatment — tackling the clinical decisions that define how we manage patients with dyslipidemia day to day.

This episode covers the new lipid treatment targets established by the 2026 Multi-Society Dyslipidemia Guideline, updated statin initiation thresholds, treatment goals across primary and secondary prevention, strategies for intensifying therapy when patients aren’t at goal, and the grow...

What do we really know about cholesterol... and what are we missing? In this Lipid Insights episode, host Peter H. Jones, MD, MNLA sits down with Thomas Dayspring, MD, FACP, MNLA — widely known as “Dr. Lipid” — for a deep dive into the world of sterols and what Dr. Dayspring has coined “sterology.”

Dr. Dayspring breaks down why cholesterol is so fundamentally important to cellular function, how cells defend against excess cholesterol buildup, how gut microflora influence cholesterol absorption, and the fascinating role of ABCG5 and ABCG8. Equal parts chemistry lesson and clinical revelation with Dr. Lipid!

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Two podcasts. One conversation. A meeting of minds at the intersection of lipidology and cardiovascular pharmacy.

In this special collaboration episode, Lipid Insights joins forces with The Tell-Tale Heart: The Pharmacist's Cardiovascular Digest for a wide-ranging discussion on where lipid management stands today and where it's heading. Host Craig J. Beavers, PharmD sits down with NLA Executive Council Chair Michael J. Wilkinson, MD, FNLA for a conversation that every cardiovascular clinician and pharmacist needs to hear right now. 

The discussion spans the 2026 Multi-Society Dyslipidemia Guideline and what i...

From Cholesterol to Dyslipidemia: Translating the 2026 Multi-Society Guideline into Clinical Practice | Month 2 Podcast

LDL-C alone doesn't tell the whole story, and the 2026 Multi-Society Dyslipidemia Guideline makes that clear. In the second installment of this four-part CME/CE-accredited series, host Kaye-Eileen Willard, MD, FNLA sits down with Jessica Peña, MD, FNLA and Ann Marie Navar, MD, PhD to dig into the biomarkers reshaping cardiovascular risk assessment: ApoB vs. LDL-C discordance, the role of Lp(a) in everyday practice, and how clinicians can effectively use CAC scoring to guide patient management.

This episode is a companion p...

In honor of FH Awareness Day, this special Lipid Insights episode features a conversation with Jose Lopez, MS, recipient of the Donald Hunninghake, MD, Familial Hypercholesterolemia (FH) Abstract Award at the 2026 NLA Scientific Sessions.

Guest host and Foundation of the NLA President Ann Liebeskind, MD, FNLA, FAAP sits down with Jose to discuss his award-winning abstract, "Early Detection of Familial Hypercholesterolemia Through Point of Care Testing in 2-Year-Olds" — exploring the promise of point-of-care lipid testing in very young children as a practical strategy for identifying FH.

A timely and important listen for...

The 2026 Multi-Society Dyslipidemia Guideline introduced significant changes; but, this episode isn't just about what's new. It's about why the field decided a change was necessary in the first place. 

In the first installment of this four-part CME/CE-accredited series, host Dave Dixon, PharmD, CLS, FNLA sits down with NLA President Dinesh Kalra, MD, FNLA and Salim Virani, MD to unpack the foundational shift from cholesterol-focused care to a broader dyslipidemia paradigm. The conversation covers why atherogenic lipoprotein exposure earlier in life matters, the key clinical misconceptions embedded in the prior guideline, and what clinicians most commonly misunderstand a...

Hot off the European Society of Cardiology Congress in Munich, this Lipid Insights episode takes a closer look at a significant announcement in triglyceride science and its implications for clinical practice. Host Peter H. Jones, MD, MNLA sits down with Christie M. Ballantyne, MD, MNLA to discuss the 12-month pivotal trial results from SHASTA-3 and SHASTA-4 — evaluating plozasiran in patients with severe hypertriglyceridemia. If you missed Munich, this is your catch-up.

Watch the video version on YouTube HERE.

The National Lipid Association Lipid Insights podcast series brings you engaging discussions on the most relevant, timely, an...

Familial chylomicronemia syndrome (FCS) is one of the rarest and most challenging lipid disorders to manage, but the landscape is changing rapidly. In this Industry Innovations episode, guest host Kevin Maki, PhD, CLS, MNLA sits down with Archna Bajaj, MD, FNLA for a comprehensive and forward-looking conversation on FCS from every angle.

Dr. Bajaj walks through the realities of living with FCS — from diagnosis to the demands of a strict ultra-low-fat diet — before turning to what has the field buzzing: two landmark APOC3-targeting therapies and the clinical trial data behind them. A must-listen for any clinician cari...

In this Lipid Insights episode, host Peter H. Jones, MD, MNLA sits down with Thomas Dayspring, MD, FACP, MNLA — widely known as "Dr. Lipid" — for a deep dive into one of lipidology's most complex and frequently misrepresented topics: HDL-Cholesterol.

From the history of HDL and how our understanding of it has evolved over decades, to a true microscope-level look at HDL biochemistry and functionality, Dr. Dayspring does what he does best: peeling back the layers to reveal what HDL is really telling us and what it isn't.

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Th...

How do we move the needle on cardiovascular prevention — not just in the clinic, but across entire systems and communities? In this episode of Lipid Insights, host Alan S. Brown, MD, MHA, MNLA sits down with Nihar R. Desai, MD, MPH, FNLA for a forward-thinking conversation on long-term LDL exposure and what it truly means to practice longevity medicine.

From the power of imaging as a patient education tool to the momentum behind the 2026 dyslipidemia guidelines, Dr. Desai shares his vision for a healthcare landscape where patients are empowered, systems are hardwired to deliver better care, and pu...

What does your patient's lipid panel actually tell you and what is it missing? In this special National Lipid Day episode of Lipid Insights, host Peter H. Jones, MD, MNLA, sits down with Thomas Dayspring, MD, FACP, MNLA — widely known as "The Lipid Doctor" — for a conversation that challenges some of medicine's most entrenched assumptions about lipid risk assessment. From the clinical superiority of ApoB over LDL-C and the underrecognized atherogenic burden of Lipoprotein(a), to why HDL-C should no longer be treated as a therapeutic target, Dr. Dayspring delivers evidence-based truths that have direct implications for how clinicians asse...

In this episode of Lipid Insights, host Peter H. Jones, MD, MNLA sits down with Nivedita Patni, MD, of the Department of Pediatrics at UT Southwestern Medical Center in Dallas, TX, to explore the complex landscape of pediatric dyslipidemia. Dr. Patni walks through the critical importance of tailoring management to etiology, the long-term cardiovascular and metabolic risks that hang in the balance, and why early identification is everything.

Drawing on case studies and evidence-based management strategies, Dr. Patni shares practical implementation guidelines for clinicians navigating these challenging diagnoses — including the challenges that make ra...

Childhood obesity is one of the most pressing public health challenges of our time — and its long-term cardiovascular and metabolic consequences make it essential territory for lipidologists and clinicians alike.

In this episode of Lipid Insights, host Peter H. Jones, MD, MNLA sits down with Casey Berman, MD to explore the full picture: how childhood obesity is defined, why its prevalence continues to rise, and the behavioral, societal, and genetic factors fueling the epidemic. They also dive into associated comorbidities and the latest prevention and management strategies — from lifestyle modifications and pharmacotherapy to the...

Join host Dr. Peter H. Jones for a special episode of Lipid Insights discussing the 2026 ACC/AHA/Multisociety Guideline on the Management of Dyslipidemia. Dr. Jones is joined by guideline author and NLA Past President Dr. Joseph Saseen and NLA President-Elect Dr. Dinesh Kalra to break down what clinicians need to know.

From the restoration of LDL-C treatment goals and major conceptual shifts from the 2018 guideline, to primordial and primary prevention, risk assessment, special populations, and real-world implementation challenges, this episode covers it all. The panel also explores the guideline's expanded scope beyond LDL-C to...

In this episode of Lipid Insights, we explore the NLA's recent expert meta-analysis, "Low-density lipoprotein cholesterol lowering and risk of major adverse cardiovascular events in primary prevention trials."
 
Lead author Dinesh K. Kalra, MD, MBA and key author Kevin C. Maki, PhD, CLS, MNLA join host Alan S. Brown, MD, MHA, MNLA to examine the relationship between LDL-C reduction and major adverse cardiovascular events in primary prevention trials. Together, they break down the findings, clinical implications, and why early LDL-C lowering remains central to preventing first cardiovascular events.

Read the meta-analysis: https://www.lipidjournal.com/a...

In this episode of Lipid Insights, host Dr. Peter Jones is joined by renowned experts Robert H. Eckel, MD, FNLA and Samuel M. Kim, MD for a thoughtful discussion on the complex relationship between obesity, weight loss, and cardiometabolic health. 

The National Lipid Association Lipid Insights podcast series brings you engaging discussions on the most relevant, timely, and groundbreaking topics in lipidology. Hosted by Dr. Alan Brown and Dr. Peter Jones, this series explores the latest research, emerging treatments, and key developments in the field. Whether it’s expert analysis on hot...

Hosted by Dave Dixon, PharmD, CLS, FNLA, this episode features an in-depth discussion with three key authors of the NLA’s new statement providing updated guidance on diagnosis, management, and treatment of FH. Together, they review the most important updates in the new guidance, including recommendations for earlier identification, the role of genetic testing and cascade screening, updated LDL-cholesterol treatment targets, and the integration of newer lipid-lowering therapies. The conversation also addresses practical considerations for managing FH across the lifespan, from pediatric care to special populations, with a focus on translating evidence-based recommendations into real-world clinical practice.

Yo...

Dr. Peter Jones welcomes Dr. Nihar Desai for a forward-looking discussion on the future of cardiovascular prevention. From implementation science to performance measurement, this episode challenges traditional approaches and explores how innovation, systems thinking, and accountability can reshape how we achieve lasting cardiovascular health.

Guest:

Nihar R. Desai, MD, MPH

Associate Professor of Medicine

Yale School of Medicine

Vice Chief, Section of Cardiovascular Medicine

Yale New Haven Health System

New Haven, CT

Watch the Video

The National Lipid...

In this episode of Lipid Insights, host Dr. Peter Jones is joined by Dr. Harold Bays for a practical, clinician-focused discussion of the ATTAIN Study and what it means for everyday lipid management. Together, they walk through the key questions clinicians ask when new evidence emerges: what the study set out to evaluate, how to interpret the findings in context, and where the results may (or may not) shift decision-making at the point of care.

Dr. Bays brings a real-world lens to the conversation—highlighting how st...

Join host Peter Jones, MD, MNLA for a conversation on the evolving landscape of metabolic health in youth. In this episode, Dr. Jones is joined by two leading pediatric experts—Don Wilson, MD, FNLA and Amy Shah, MD, FNLA—to explore practical strategies and emerging research on managing lipids and metabolic syndrome in younger populations.

The discussion highlights key findings from their recently published special issue in the Journal of Clinical Lipidology, offering listeners evidence-based insights and clinical pearls to improve outcomes in pediatric and adolescent care. Whet...

Youth-onset type 2 diabetes: Advances, treatments, and challenges in prevention

Rewriting the Risk Equation: The Expanding Role of Lp(a) in Atherosclerotic Disease

Hosted by Dr. Underberg, the Rewriting the Risk Equation: The Expanding Role of Lp(a) in Atherosclerotic Disease podcast is designed to equip clinicians with the latest evidence on Lp(a) biology, screening strategies, and current and emerging therapeutic options. Along with Drs. Soffer, Kulkarni and Wilkinson, they will explore the integration of Lp(a) assessment into routine practice, implications for high-risk populations including those with familial hypercholesterolemia (FH), and strategies to mitigate cardiovascular risk until targeted therapies become available. 

You can w...

Can genetic scores unlock better outcomes for patients with FH? This special Snippet from our Lipid Insights podcast series dives into the award-winning abstract from #NLASessions 2025, exploring how polygenic risk scores for coronary artery disease may transform ASCVD prediction and management. Tune in and see what’s next in lipid science.

Guest Host
Daniel E. Soffer, MD, MNLA
University of Pennsylvania Health System
Internal Medicine/Clinical Lipidology
Perelman Center for Advanced Medicine
Philadelphia, PA

Guest
Alexis Baass, MD, MSc, FNLA Alexis Baass, MD, MSc, FNLA

In this episode of Lipid Insights, Dr. Peter Jones and guest Dr. Kevin Maki explore whether beef deserves its long-standing reputation as a driver of cardiovascular disease. Drawing on a recent systematic review and meta-analysis, they examine beef’s impact on cholesterol, blood pressure, and other key CVD risk factors—providing fresh perspective for clinicians navigating dietary guidance.

 Please note: CME/CE credit for this episode is no longer available. This episode remains available for educational purposes. 

The National Lipid Association Lipid Insights podcast series brings you engaging discussions on the most r...

In this short episode, guest host Dr. Dan Soffer chats with Dr. Joshua Hyman, the Young Investigator Award winner at #NLASessions 2025. Dr. Hyman gives a quick overview of his award-winning abstract and shares insights from his work in advancing lipid research.

The National Lipid Association Lipid Insights podcast series brings you engaging discussions on the most relevant, timely, and groundbreaking topics in lipidology. Hosted by Dr. Alan Brown and Dr. Peter Jones, this series explores the latest research, emerging treatments, and key developments in the field. Whether it’s expert analysis on...

Hosted by Dr. Dan Soffer, this conversation brings NLA President Dr. Willard and Beth Jackson together to unpack the Association’s guidance, “LDL Cholesterol Management Simplified in Adults – Lower for Longer is Better.” The trio turns a big message into practical moves: why lifetime LDL exposure matters, who needs more aggressive targets, and how to streamline therapy choices from high-intensity statins to add-ons (ezetimibe, PCSK9-directed options) when goals aren’t met. They share real-world tactics on adherence, stepwise intensification, shared decision-making, and navigating special populations—all in a clear, clinic-ready format.

Read the featured article H...