ICU Ed and Todd-Cast

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Episode 103 LIVE from CHEST in Phoenix. It was a wonderful conference and thanks for everyone who came and joined us! In this episode we talk about lung recruitment during sigh breaths and GLP-1 use and its association with mortality in septic shock! Thanks also to special guest Hayley Gershengorn and congrats to both Todd and Hayley for winning big awards at the CHEST conference!

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Episode 102! In this episode we talk about ECMO anticoagulation strategies with RATE and go back in time to talk about the original landmark trial for ECMO in CESAR

RATE: https://pubmed.ncbi.nlm.nih.gov/42413523/
CESAR: https://pubmed.ncbi.nlm.nih.gov/19762075/

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Episode 101! In this episode we talk about targeted temperature management starting with TTM2 to set the stage and moving towards ICECAP published by Muerer et al in JAMA August 2026!

TTM2: https://pubmed.ncbi.nlm.nih.gov/34133859/
ICECAP: https://pubmed.ncbi.nlm.nih.gov/42554995/

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Episode 100! Can't believe we made it here. 100 episode of trying to fit into Todd's triple booked schedule. This episode we do a little reminiscing about the past 3 years of podcasting but not after talking about a trial published in the form of a research letter about olanzapine versus dexmedetomidine for delirium by Liu et al published in the Blue Journal May 2026

Olanzapine vs Dex: https://pubmed.ncbi.nlm.nih.gov/42118124/

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Episode 99! In this episode we talk about Nutrition and Exercise in Critical Illness published in AJRCCM June 2026 by Needham et al. A shorter episode today as we're dealing with end-of-summer travel schedules so we add a mailbag segment to this one. 

NEXIS: https://pubmed.ncbi.nlm.nih.gov/42438140/

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Episode 98! We talk about polymyxin B filtration of endotoxin for patients with septic shock in EUPHRATES which sets the stage for Tigris. We also butcher Mesopotamian history (sorry!)

EUPHRATES: https://pubmed.ncbi.nlm.nih.gov/30304428/
Tigris:https://pubmed.ncbi.nlm.nih.gov/41887242/

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Episode 97! In this episode we talk about mucolytics for patients with difficult to clear secretions on the ventilator and the effects of a tele ICU rehabilitation intervention! We also have some emails following up on scurvy and the taste of chalk.

Scurvy History:https://pmc.ncbi.nlm.nih.gov/articles/PMC1276007/
Bootcamp: https://www.vumc.org/advanced-practice-critical-care/welcome
MARCH: https://www.nejm.org/doi/pdf/10.1056/NEJMoa2603406
Tele-Rehab: https://jamanetwork.com/journals/jama/article-abstract/2850403

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Episode 96. In this episode we talk about ARISE FLUIDS (early pressors vs early fluids) and VICTORY (high dose Vitamin C in severe burn) both simultaneously presented and published at the CCR26 conference. Then we start digging out form our ever growing mailbag

ARISE-FLUIDS: https://pubmed.ncbi.nlm.nih.gov/42274006/

VICTORY:  https://pubmed.ncbi.nlm.nih.gov/42267875/

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Episode 95! In this episode we talk about "Sodium Bicarbonate for In-Hospital Cardiac Arrest" by Granfeldt et al and "Sodium Bicarbonate for Critically Ill Adults with Metabolic Acidosis and Shock" published by the ANZICS group both presented at the CCR26 conference.

BiHCA: https://pubmed.ncbi.nlm.nih.gov/42273960/
BiHCA: https://jamanetwork.com/journals/jama/article-abstract/2850405
SODa-BIC: https://pubmed.ncbi.nlm.nih.gov/42283370/
SODa-BIC: https://www.nejm.org/doi/10.1056/NEJMoa2600526

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Episode 94! In this episode we give some general reactions to the CCR conference, discuss our impact on the critical care world, and talk briefly about 3 of the presentations from the conference that did NOT have a simultaneous publication (REMAP-CAP oseltamivir, FISSH, and SAVE-ICU)

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Episode 93! In this episode we go over TOWAR or "Prehospital Resuscitation with Type O Whole Blood for Trauma and Hemorrhage" by Sperry et all published in NEJM and "Remote Multicomponent Rehabilitation in Intensive Care Unit Survivors" published by O'Neill et al in JAMA both in May 2026 and presented at the ATS International Conference! Then we talk a little bit about some current events with Hantavirus and sepsis that has hit the news cycles

TOWAR (NEJM): https://www.nejm.org/doi/full/10.1056/NEJMoa2602167<...

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Episode 92! In this episode we talk about "Restrictive vs Liberal Physical Restraint Strategies in Critically Ill Patients" published in JAMA by Sonneville et al April 2026!

R2D2 (pubmed): https://pubmed.ncbi.nlm.nih.gov/41841304/

R2D2 (JAMA): https://jamanetwork.com/journals/jama/article-abstract/2846726

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Episode 91! In this episode we talk about "Dexmedetomidine for treatment of hyperactive delirium in non-intubated ICU patients" published by Godet et al in Intensive Care Medicine October of 2025! We are going to be on a one article per episode kick for a while but hope to get back to normal programming soon!

4D: https://pubmed.ncbi.nlm.nih.gov/41160116/

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Episode 90! In this episode we talk about the 2026 Surviving Sepsis Campaign Guidelines lead by Prescott et all and published in Critical Care Medicine in March of 2026! We review all that's new and all that's changed

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Episode 89! In this episode we talk about HI-PEITHO or catheter directed thrombolysis versus conventional anticoagulation for intermediate risk pulmonary embolism. This was published in the New England Journal of Medicine by Rosenfield et al.

HI-PEITHO: http://nejm.org/doi/full/10.1056/NEJMoa2516567

HI-PEITHO (pubmed): https://pubmed.ncbi.nlm.nih.gov/41910345/

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Episodes 88! In this episode we talk about guidelines recently released for the management of pulmonary embolism and cardiac arrest! A little hap hazard of an episode as we jump around from topic to topic but good to highlight things that are new and things that are changing!

PE: https://pubmed.ncbi.nlm.nih.gov/41712898/

CPR: https://pubmed.ncbi.nlm.nih.gov/41122893/

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Episode 87! In this episode we talk about Albumin with two related studies, ALBIOS ("Albumin replacement in patients with severe sepsis or septic shock" by Caironi et al) and ARISS ("Albumin Replacement Therapy in Septic Shock" by Sakr et al)

ALBIOS: https://pubmed.ncbi.nlm.nih.gov/24635772/

ARISS: https://pubmed.ncbi.nlm.nih.gov/41712212/

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Episode 86! In this episode we talk about endotracheal tubes or "Hospital and long-term outcomes for subglottic suction and polyurethane cuff versus standard endotracheal tubes in emergency intubation" published in Lancet Respiratory Medicine February 2026 by Treggiari et al.

Pubmed: https://pubmed.ncbi.nlm.nih.gov/41319662/

LRM: https://www.thelancet.com/journals/lanres/article/PIIS2213-2600(25)00294-2/abstract

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Episode 85! In this episode we go over LIBERATE-D or "A Conservative Dialysis Strategy and Kidney Function Recovery in Dialysis-Requiring Acute Kidney Injury" by Liu et al in JAMA 2026. We have the second author, Eddie Siew, on with us to discuss!

LIBERATE-D (pubmed): https://pubmed.ncbi.nlm.nih.gov/41201895/

LIBERATE-D (JAMA): https://jamanetwork.com/journals/jama/article-abstract/2841171

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Episode 84! In this episode we finish up our discussion of the articles presented with the CCR Down Under Conference with ACTiVE (close loop ventilation) and CLIP2 (cryopreserved platelets for surgical bleeding). Both are neutral trials at best, so we took them both pretty short.

ACTiVE: https://pubmed.ncbi.nlm.nih.gov/41361939/

ACTiVE (JAMA): https://jamanetwork.com/journals/jama/article-abstract/2842610

CLIP2: https://pubmed.ncbi.nlm.nih.gov/41360717/

CLIP2 (JAMA): https://jamanetwork.com/journals/jama/article-abstract/2842479

...

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Episode 83! Only one article this episode since Todd is feeling a little under the weather, but still a good discussion!

ImmunoSep (JAMA): https://jamanetwork.com/journals/jama/article-abstract/2842634

ImmunoSep (pubmed): https://pubmed.ncbi.nlm.nih.gov/41359996/

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Back by popular demand, year in review! Or probably better titled "Our Favorite Articles of the Year" but I kept the title from last year. A smattering of papers and topics in this one ranging from avalanche survival, to intubation, to cardiac resuscitation and more. 

Happy New Year everyone! We will see you in 2026, thanks for listening and spending sometime with us.

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Episode 81! In this episode we talk to Yonathan Fruend the senior author on the MODS study looking at a single questions approach to ruling out pulmonary embolism in the emergency department. This is not our typical patient population but this is a good episode, don't miss this one!

MODS: https://pubmed.ncbi.nlm.nih.gov/41135553/

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We start our Critical Care Reviews Down Under coverage with RSI talking with the first author of the "Ketamine versus Etomidate for Adults Receiving Emergency Endotrachael Intubation", Jonathan Casey! We will pick up the rest of our CCR Down Under Coverage after the holiday break!

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Episode 79! We talk all about perfusion with arterial lines in EVERDAC and personalized resuscitation with ANDROMEDA SHOCK 2! 

EVERDAC: https://pubmed.ncbi.nlm.nih.gov/41159885/

EVERDAC (NEJM): https://www.nejm.org/doi/10.1056/NEJMoa2502136

ANDROMEDA SHOCK 2: https://pubmed.ncbi.nlm.nih.gov/41159835/

ANDROMEDA SHOCK 2(JAMA): https://jamanetwork.com/journals/jama/fullarticle/2840823

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Episode 78! We start our discussion of the trials that drop with ESICM with the much anticipated BICAR-ICU 2! Then we talk briefly about some changes to the SOFA score with the new SOFA-2 score. 

BICAR-ICU2: https://pubmed.ncbi.nlm.nih.gov/41159812/

BICAR-ICU 2 (JAMA): https://jamanetwork.com/journals/jama/fullarticle/2840824

SOFA-2: https://pubmed.ncbi.nlm.nih.gov/41159833/

SOFA-2 (JAMA): https://jamanetwork.com/journals/jama/fullarticle/2840822

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Episode 77! We will start on ESICM coverage next episode. In this episode we talk about WFIT or "A Randomized Controlled Trial of a Post-ICU Telehealth Care Model" by Bakhru et al published in the blue journal September 2025! A long discussion but a good one!

WFIT: https://pubmed.ncbi.nlm.nih.gov/40532205/

Editorial: https://pubmed.ncbi.nlm.nih.gov/40700738/

ICU Recovery Pilot: https://pubmed.ncbi.nlm.nih.gov/31385881/

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We were LIVE from the CHEST Annual Meeting 2025! Thanks to everyone who came out and stuck around to chat afterwards. We cover a lot of ground including some conference and Chicago related banter (~8 minutes if you wanted to skip to the learning!)

High frequency oscillation: https://pubmed.ncbi.nlm.nih.gov/40983167/

MELLOW: https://pubmed.ncbi.nlm.nih.gov/39800236/

Continuous glucose monitoring: https://pubmed.ncbi.nlm.nih.gov/39956190/

SAFE-ECMO: https://pubmed.ncbi.nlm.nih.gov/40081660/

...

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Episode 75! We talk about melatonin! We highlight MELLOW because it has the best acronym (by Burry et al in CHEST 2025). Then we dive into our mailbag!

MELLOW: https://pubmed.ncbi.nlm.nih.gov/39800236/

DEMEL: https://pubmed.ncbi.nlm.nih.gov/40608082/

Meta-analysis: https://pubmed.ncbi.nlm.nih.gov/40662882/

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Episode 74! We talk about the history and current practice of SBTs with "Providers Consistently Delay Extubation After Successful Spontaneous Breathing Trials" by Barker et al in Annals of the ATS and the original 1996 SBT article by Ely et al in NEJM.

SBT: https://pubmed.ncbi.nlm.nih.gov/8948561/

SBT (NEJM): https://www.nejm.org/doi/10.1056/NEJM199612193352502

SBT Timing: https://pubmed.ncbi.nlm.nih.gov/40393063/

SBT Timing (Annals ATS): https://www.atsjournals.org/doi/10.1513/AnnalsATS.202502-188OC<...

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We are (were) LIVE at ACNP Critical Care Bootcamp 2025! Thank you to the organizers of the conference for inviting us do a live show and thank you to everyone who came out to listen! We talk about the PIC trial or "Adjunctive corticosteroids in non-AIDS patients with severe Pneumocystis jirovecii pneumonia" by Lemiale et al published in the Lancet Respiratory Medicine September 2025

PIC (pubmed): https://pubmed.ncbi.nlm.nih.gov/40652952/
PIC (LRM): https://www.thelancet.com/journals/lanres/article/PIIS2213-2600(25)00125...

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Episode 72! We continue talking about the articles from the CCR25 conference with UK-ROX or "Conservative Oxygen Therapy in Mechanically Ventilated Critically Ill Adult Patients" published in JAMA 2025 by Martin et al and TARGET-Protein or "Sodium bicarbonate therapy for patients with severe metabolic acidaemia in the intensive care unit" by Jaber et al in Lancet 2018.

UK-ROX: https://pubmed.ncbi.nlm.nih.gov/40501321/

UK-ROX (JAMA): https://jamanetwork.com/journals/jama/article-abstract/2835384

TARGET-Protein: https://pubmed.ncbi.nlm.nih.gov/40495743/

...

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Episode 71! We continue talking about the articles from the CCR25 conference with FLUID or "A Crossover Trial of Hospital-Wide Lactated Ringer's Solution versus Normal Saline" published in NEJM 2025 by McIntyre et al and our old article is BICAR-ICU or "Sodium bicarbonate therapy for patients with severe metabolic acidaemia in the intensive care unit" by Jaber et al in Lancet 2018.

FLUID: https://pubmed.ncbi.nlm.nih.gov/40503714/

FLUID (NEJM): https://www.nejm.org/doi/10.1056/NEJMoa2416761

BICAR-ICU: https://pubmed.ncbi...

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Episode 70! In this episode we have a special guest, Wes Ely, join us to talk about A2B or "Dexmedetomidine- or Clonidine-Based Sedation Compared With Propofol in Critically Ill Patients" by Walsh et al published in JAMA May of 2025. A long discussion but a good one, don't miss this one!

Pubmed: https://pubmed.ncbi.nlm.nih.gov/40388916/

JAMA: https://jamanetwork.com/journals/jama/article-abstract/2834276

Editorial: https://jamanetwork.com/journals/jama/article-abstract/2834277

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Episode 69! We start talking about the articles from the CCR25 conference with RESCUE-3 or "Temporary Transvenous Diaphragm Neurostimulation for Weaning from Mechanical Ventilation" published in AJRCCM by Dres et al and PROMIZING or "Proportional-Assist Ventilation for Minimizing the Duration of Mechanical Ventilation" by Bosma et al in NEJM.

RESCUE-3 (pubmed): https://pubmed.ncbi.nlm.nih.gov/40498082/

PROMIZING (pubmed): https://pubmed.ncbi.nlm.nih.gov/40513024/

PROMIZING (NEJM): https://www.nejm.org/doi/10.1056/NEJMoa2505708

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Episode 68! Today we talk about modes of mechanical ventilation with the first author Dr. Kevin Seitz. This was published in CHEST April of 2025 as "Effect of Ventilator Mode on Ventilator-Free Days in Critically Ill Adults: A Randomized Clinical Trial".

Disclaimer, this is stated in the episode but Todd and I are authors on this paper. Please keep that in mind as you enjoy the episode!

Pubmed: https://pubmed.ncbi.nlm.nih.gov/40189043/

CHEST: https://journal...

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Episode 67! Today we do a quick overview of the presentations from the Critical Care Reviews 2025 (CCR25) Conference!

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Episode 66! Today we talk about Acute Chest Syndrome in Sickle Cell Disease with one of our favorite hematologists, Benjamin Tillman! We base our discussion around the TASC trial or "Comparison of Prophylactic and Therapeutic Doses of Anticoagulation for Acute Chest Syndrome in Sickle Cell Disease" published by Dessap et al in AJRCCM April of 2025.

Pubmed: https://pubmed.ncbi.nlm.nih.gov/40209087/

AJRCCM: https://www.atsjournals.org/doi/10.1164/rccm.202409-1727OC

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Episode 65! Though this is during ATS, this episode was pre-recorded so you will get some reactions to the conference in the coming episodes. Instead we have a short episode where we talk about risk factors for stress ulcers and transfusion threshold in upper GI bleeding!

Risk factors: https://pubmed.ncbi.nlm.nih.gov/40315134/
Transfusion threshold: https://pubmed.ncbi.nlm.nih.gov/23281973/
Transfusion threshold (NEJM): https://www.nejm.org/doi/10.1056/NEJMoa1211801

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Episode 64! We talk more about steroids in severe community acquired pneumonia with "Effect of hydrocortisone on mortality in patients with severe community-acquired pneumonia : The REMAP-CAP Corticosteroid Domain Randomized Clinical Trial" published in Intensive Care Medicine April of 2025.

Pubmed: https://pubmed.ncbi.nlm.nih.gov/40261382/

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