Arjun Khemani Podcast

40 Episodes
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By: Arjun Khemani

A podcast about progress, philosophy, science, education, and the unconstrained human condition. www.arjunkhemani.com

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Karl Pfleger: The Road to Solving Aging
Karl Pfleger: The Road to Solving Aging episode artwork
Yesterday at 6:11 PM

Karl Pfleger is the founder of agingbiotech.info and an investor in several rejuvenation startups.

Topics we discuss are well captured by the timestamps below.

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Timestamps

0:00 - Why lifespan is the wrong metric for aging progress

7:28 - Is the hallmarks of aging expanding a problem?

11:36 - Structures vs. processes: the key distinction in aging targets

16:14 - Why Karl favors divide-and-conquer rejuvenation...


David D. Friedman: Death, Taxes, and Other Solvable Problems
David D. Friedman: Death, Taxes, and Other Solvable Problems episode artwork
07/01/2026

David D. Friedman is an anarcho-capitalist economist. He is the author of The Machinery of Freedom, Future Imperfect, and several other books.

Topics we discuss are well captured by the timestamps below.

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Timestamps

0:00 – The economics of longevity

8:05 – Epigenetic reprogramming

12:37 – Overpopulation and the “ultimate resource”

16:33 – Fluid vs. crystallized intelligence, aging and political power

20:46 – Cryonics

24:35 – AI, open source, and the surveillance...


Sean Bowe and Dev Ojha: Architecture of Freedom
Sean Bowe and Dev Ojha: Architecture of Freedom episode artwork
04/04/2026

Sean Bowe is a core cryptographer and engineer who played a major role in building Zcash’s technology.

Dev Ojha, also a cryptographer, is the founder of Osmosis. He is now working on helping Zcash scale and go post quantum.

Topics we discuss are well captured by the timestamps below.

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Timestamps

0:00 - Why Dev’s working on Zcash

12:24 - AI is surveillance’s ultima...


Sean Bowe and Jack Grigg: Encrypted Money at Planetary Scale
Sean Bowe and Jack Grigg: Encrypted Money at Planetary Scale episode artwork
10/11/2025

Sean Bowe and Jack Grigg aka str4d are both cryptographic engineers working on the Zcash protocol. Sean’s latest project is Tachyon, intended to bring encrypted money into the hands of 8 billion people.

Topics we discuss are well captured by the timestamps below.

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Timestamps

0:00 - Project Tachyon

10:20 - Privacy can’t be an afterthought for a protocol

15:24 - Encrypted Bitcoin

22:11 - So...


Samo Burja: Building an Immortal Society
Samo Burja: Building an Immortal Society episode artwork
07/11/2025

My conversation with Samo Burja, founder of Bismarck Analysis. He chairs the editorial board of Palladium Magazine.

Topics we discuss are well captured by the timestamps below.

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Timestamps

0:00 - Intro

1:18 - Live players

5:41 - Great Founder Theory

11:20 - Our material technology rests on our social interactions

14:23 - Optimism, pessimism, and human...


Zooko Wilcox and Josh Swihart: Unstoppable Private Money
Zooko Wilcox and Josh Swihart: Unstoppable Private Money episode artwork
06/03/2025

My conversation with Zooko Wilcox and Josh Swihart on unstoppable private money.

Zooko Wilcox is a legendary cypherpunk and one of the founders of Zcash—private, digital money.

Josh Swihart is the CEO of Electric Coin Company, the team behind the Zcash protocol and the Zashi wallet app.

Topics we discuss are well captured by the timestamps below.

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Timestamps

0:00 - Maya Protocol integrates wi...


Ethan Thornton: The Future of Warfare
Ethan Thornton: The Future of Warfare episode artwork
03/15/2025

My conversation with Ethan Thornton, founder of Mach Industries.

Topics we discuss are well captured by the timestamps below.

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Timestamps

0:00 - Intro

1:07 - Why Mach needs to exist

3:16 - Early experiments

5:07 - Dropping out of MIT

8:36 - Raising $85 million at 19 years old

11:20 - Decentralized vertical supply chains

13:54...


Peter Boghossian: Moral Relativism and The Future of The West
Peter Boghossian: Moral Relativism and The Future of The West episode artwork
02/26/2025

My conversation with philosopher and author Peter Boghossian.

Topics we discuss are well captured by the timestamps below.

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Timestamps

0:00 - The enlightenment

5:51 - The dangers of moral relativism

21:28 - Modern education is failing us

31:14 - What’s worth preserving in the West

37:00 - Is wokeism filling the void left by atheism?

...


Zooko, Nate Wilcox, and Sean Bowe: Zcash
Zooko, Nate Wilcox, and Sean Bowe: Zcash episode artwork
01/22/2025

My conversation with Zooko, Nate Wilcox, and Sean Bowe about the Zcash protocol.

Zooko is a cypherpunk who co-founded Zcash along with his brother, Nate Wilcox, and others. Sean Bowe is a cryptographer and engineer who has played a crucial role in the development of Zcash and has made significant contributions to advancements in zero-knowledge proofs, particularly zk-SNARKs, which underpin Zcash’s privacy features.

Topics we discuss are well captured by the timestamps below.

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Naval Ravikant: The Beginning of Infinity
Naval Ravikant: The Beginning of Infinity episode artwork
12/18/2024

My conversation with Naval Ravikant. Enjoy!

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Timestamps

0:00 - The Theory of Everything

4:48 - How do you know what’s true?

7:51 - Groups search for consensus, individuals search for truth

13:07 - We have never run out of a single resource

15:25 - Are we destroying the Earth?

17:48 - Marxism denies wealth creation

21:28 - Regulation kills innovation

27:05 - Degrowth and the fall of We...


David Deutsch: The Era of Man, Popper, and Western Civilization
David Deutsch: The Era of Man, Popper, and Western Civilization episode artwork
11/11/2024

I had the pleasure of sitting down with David Deutsch in his lovely garden in Oxford a few months ago. Here’s our conversation.

Topics we discuss are well captured by the timestamps below.

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Timestamps

1:01 - A tragic view of human history

7:04 - Why did it take so long for civilization to arise?

13:31 - Fallibilism

...


#35 – Julian Barbour and Samuel Kuypers: The Nature of Time
#35 – Julian Barbour and Samuel Kuypers: The Nature of Time episode artwork
09/15/2024

Julian Barbour is a renowned physicist known for his groundbreaking work on the nature of time. In his influential books, The End of Time and The Janus Point he explores the concept of a timeless universe, challenging traditional views.

Samuel Kuypers is a theoretical physicist, currently located in MontrĂŠal, who is interested in the foundations of quantum theory and time.

Topics we discuss are well captured by the timestamps below.

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#34 – Nat Eliason: Crypto Confidential, Writing, and The Future of Work
#34 – Nat Eliason: Crypto Confidential, Writing, and The Future of Work episode artwork
07/26/2024

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Nat Eliason is a writer and crypto insider with a wildly popular newsletter and podcast. He is the author of the book Crypto Confidential: Winning and Losing Millions in the New Frontier of Finance.

Topics we discuss are well captured by the timestamps below.

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Timestamps

0:49 - Ayn Rand

6:40 - T...


#33 – Johan Norberg: Capitalism, Degrowth, and Elon Musk
#33 – Johan Norberg: Capitalism, Degrowth, and Elon Musk episode artwork
07/16/2024

Johan Norberg is a senior fellow at the Cato Institute and a writer who focuses on globalization, human progress and intellectual history. He is the author of In Defense of Global Capitalism, Progress: Ten Reasons to Look Forward to the Future, and The Capitalist Manifesto: Why the Global Free Market Will Save the World.

Topics we discuss are well captured by the timestamps below. I hope you enjoy this episode as much as I enjoyed recording it!

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#32 – Riva Tez: Anarchy, Beauty, and Longevity
#32 – Riva Tez: Anarchy, Beauty, and Longevity episode artwork
07/04/2024

Riva Tez is a philosopher, writer, and venture capitalist. She’s the author of the blog Hard to Write.

Topics we discuss are well captured by the timestamps below. I hope you enjoy this episode as much as I enjoyed recording it!

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Timestamps

0:52 - Does crypto make anarcho-capitalism pragmatic?

11:56 - Crypto is both technologically and morally superior

...


#31 – Nicole Behnam: Leveraging Social Media, Building Cults, and Parenting
#31 – Nicole Behnam: Leveraging Social Media, Building Cults, and Parenting episode artwork
06/25/2024

Nicole Behnam is a founder and journalist. She is the creator of Beyond The Interview where she’s interviewed people like Chris Voss, Konstantin Kisin, and Robert Greene.

Topics we discuss are well captured by the timestamps below.

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Timestamps

0:00 - Nicole’s relationship with her parents and books

4:45 - On being a red carpet host

9:57 - Clubh...


#30 – Niklas Anzinger: Longevity, Crypto, and Network States
#30 – Niklas Anzinger: Longevity, Crypto, and Network States episode artwork
06/05/2024

Niklas Anzinger is the founder of Infinita VC and Vitalia. He is also the host of the Stranded Technologies Podcast.

Topics we discuss are well captured by the timestamps below.

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Timestamps

0:32 - Building Vitalia and Infinita VC

6:05 - The parallels between longevity and crypto

17:35 - How to convince people that living longer is a worthy goa...


#29 – Ashley St. Clair: Immigration Crisis, Free Speech, and Birth Control
#29 – Ashley St. Clair: Immigration Crisis, Free Speech, and Birth Control episode artwork
05/14/2024

Ashley St. Clair is the Operations Manager at Babylon Bee and author of the children’s book Elephants Are Not Birds. This interview was recorded on Airchat.

Topics we discuss are well captured by the timestamps below.

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Timestamps

0:19 - The immigration crisis in the US

11:08 - DEI and Mark Cuban

14:29 - Anti-humanism and Gen Z

...


#28 – Matthew Lysiak: Fiat Food, Bitcoin, and Fake Science
#28 – Matthew Lysiak: Fiat Food, Bitcoin, and Fake Science episode artwork
05/06/2024

Matthew Lysiak is an investigative journalist and author of Fiat Food: Why Inflation Destroyed Our Health and How Bitcoin Fixes It.

Topics we discuss are well captured by the timestamps below.

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Timestamps

0:49 - Why Matthew wrote Fiat Food

5:29 - Restructuring the American diet after the gold standard

11:25 - The Seventh-day Adventist Church

16:09 - The...


#27 – Farbood Nivi: Follistatin Gene Therapy, E/Acc, and Following Your Heart
#27 – Farbood Nivi: Follistatin Gene Therapy, E/Acc, and Following Your Heart episode artwork
03/23/2024

Farbood Nivi is the founder of Grockit (acquired by Kaplan in 2013). He has been biohacking for 25 years. Recently, he became one of the first 200 people in the world to receive Follistatin gene therapy.

Topics we discuss are well captured by the timestamps below.

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Timestamps

0:39 - Biohacking for 25 years

7:23 - Follistatin gene therapy

11:15 - Farbood’s proto...


#26 – Jeremy Shearmur: Epistemology, Austrian economics, and The Life of Karl Popper
#26 – Jeremy Shearmur: Epistemology, Austrian economics, and The Life of Karl Popper episode artwork
02/14/2024

Jeremy Shearmur is a fellow emeritus in philosophy at the Australian National University. He is the author of Hayek and After and The Political Thought of Karl Popper. He also worked as assistant to Karl Popper for eight years.

Topics we discuss are well captured by the timestamps below.

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Timestamps

0:00 - The commonalities (and...


#25 – David Deutsch: Free-Will, Taking Children Seriously, and Anarcho-Capitalism
#25 – David Deutsch: Free-Will, Taking Children Seriously, and Anarcho-Capitalism episode artwork
01/01/2024

David Deutsch is the author of The Fabric of Reality and The Beginning of Infinity. He works on fundamental issues in physics, particularly the quantum theory of computation and information, and constructor theory. He is known as the father of quantum computing for his contributions to the field. He is an advocate of Taking Children Seriously, a new, non-paternalistic view of children.

Topics we discuss are well captured by the timestamps below.

Watch on YouTube or X. Listen on Apple Podcasts, Spotify, or any other podcast platform. Read the full transcript below. Follow me on X fo...


#24 – Max More: Cryonics, Transhumanism, and The Morality of Progress
#24 – Max More: Cryonics, Transhumanism, and The Morality of Progress episode artwork
11/05/2023

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Max More is a philosopher, futurist, and former CEO of Alcor Life Extension Foundation. He is currently Director of Communications at Biostasis Technologies. Max wrote the first definition of “Transhumanism” in its modern sense.

TIMESTAMPS

0:45 - Why Max changed his last name to “More”

2:45 - Max’s early life and interest in cryonics and life extension

8:00 - Extropian philosophy and Transhumanism

9:15 - Cryonics explained

26:06 - Hardest challenges in achieving indefinite lifespan

33:16 - Humans don’t like...


#23 – Tom Hyde: Population, Immortality, Anarchism, and Gender
#23 – Tom Hyde: Population, Immortality, Anarchism, and Gender episode artwork
09/24/2023

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Bitcoin donations at: bc1q3vajy7e79080uzg5j7watdtl2h7ktqx9l7x8w8

Tom Hyde is a geologist with degrees in geoscience and natural hazards. In addition to his academic background, Tom has a keen interest in the scientific and philosophical works of Karl Popper and David Deutsch, as well as in libertarianism, climate and risk, gender theory, aesthetics, anti-aging, and pro-natalism, among other topics.

TIMESTAMPS

0:39 - Why a larger population is good for the world

11:18...


#22 – Per Bylund: Economic Illiteracy, Entrepreneurship, and The Primacy of Theory
#22 – Per Bylund: Economic Illiteracy, Entrepreneurship, and The Primacy of Theory episode artwork
09/20/2023

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Per Bylund is an Associate Professor of Entrepreneurship at Oklahoma State University and a Senior Fellow at the Mises Institute. His latest book, How to Think about the Economy: A Primer, serves as an introduction to economic reasoning and aims to improve economic literacy.

TIMESTAMPS

0:04 - Why economic illiteracy is so prevalent

5:25 - Individualists trying to spread their ideas in a collectivist manner

<...


#21 – David D. Friedman: The Machinery of Freedom, Education, and India
#21 – David D. Friedman: The Machinery of Freedom, Education, and India episode artwork
09/01/2023

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David D. Friedman is an anarcho-capitalist economist, author of ‘The Machinery of Freedom’, and son of Milton Friedman.

TIMESTAMPS

0:44 - 50 years of The Machinery of Freedom

3:35 - What is a government?

9:22 - How law could be produced and enforced in an anarcho-capitalist society

12:00 - Laws produced by the market will be biased toward freedom

14:27 - Is David an anarchist for pragmatic or ethical reasons?

15:41 - Strategy

18:19 - Governments evolving into private firms and science-fiction

25...


#20 – Jim O'Shaughnessy: AI, Education, Media, and Living Forever
#20 – Jim O'Shaughnessy: AI, Education, Media, and Living Forever episode artwork
08/15/2023

Support this podcast at: https://www.buymeacoffee.com/arjunkhemani

Jim O’Shaughnessy is the founder and CEO of O’Shaughnessy Ventures LLC. He also serves as the executive chair of the board of directors at Stability AI and is the host of the Infinite Loops podcast.

TIMESTAMPS

0:27 - The future of AI and Jim’s investment in Stability AI

4:51 - The Beginning of Infinity and the ideas of David Deutsch

12:32 - The perils of labeling things and the illusion of certainty

17:35 - Thinking probabilistically vs. deterministically

23:1...


#19 – Logan Chipkin: Understanding Economics
#19 – Logan Chipkin: Understanding Economics episode artwork
07/28/2023

This episode was recorded on Airchat. Learn more at getairchat.com.

Logan Chipkin is a writer. You can purchase his recently published fantasy novel, Windfall here.

Follow Logan on Twitter @ChipkinLogan and on Airchat @logan.

TIMESTAMPS

0:33 - A brief history of Austrian economics

9:15 - Is economics a science?

14:12 - How to think about the state

21:05 - The problem with welfare statism

30:05 - Constructor Theory and Austrian economics

33:12 - Economic creationism

41:20 - Consumerism: does capitalism rob us of meaning from...


#18 – Yaron Brook: Humans, Inequality and AI
#18 – Yaron Brook: Humans, Inequality and AI episode artwork
05/29/2023

Yaron Brook is an objectivist philosopher, podcaster, and author. He’s also the chairman of the Ayn Rand Institute.

Support the podcast at: https://www.buymeacoffee.com/arjunkhemani

TIMESTAMPS

0:30 - What makes humans different

3:50 - Christian atheists

8:05 - Inequality good?

12:25 - AGI Doomerism

21:46 - Aliens

23:37 - Bad philosophy in popular movies

26:29 - The education system

28:37 - Epistemology and The Beginning of Infinity

40:58 - Advice for young people

YARON'S LINKS

* Twitter: https://twitter.com/ya...


#17 – Lulie Tanett: Epistemology in the Social Sciences, Mindfulness and Taking Children Seriously
#17 – Lulie Tanett: Epistemology in the Social Sciences, Mindfulness and Taking Children Seriously episode artwork
04/12/2023

Lulie Tanett is a writer and expositor of ideas of applied critical rationalism.

If you enjoy this podcast, please consider supporting it at: https://buymeacoffee.com/arjunkhemani

We talk about:

* Lulie’s untypical childhood and the parenting philosophy she was raised under

* What psychology and the social sciences can learn from epistemology

* Mindfulness tied to Critical Rationalism

* The constraints of creativity

* And much more!

TIMESTAMPS

0:00 - Lulie’s childhood and Taking Children Seriously

9:30 - Why social science isn’t scienc...


#16 – Nat and Martha Sharpe: Alternative-Education, Making Movies and Doing Stuff
#16 – Nat and Martha Sharpe: Alternative-Education, Making Movies and Doing Stuff episode artwork
04/04/2023

Nat and Martha are filmmakers. In February 2023, they won a fellowship through O’Shaughnessy Ventures to explore alternative education. 

Support this podcast: https://www.buymeacoffee.com/arjunkhemani

TIMESTAMPS0:00 - Preview and intro1:16 - Nat and Martha’s background (making movies)6:20 - Living on the road in an RV for a whole year11:47 - “you can just do stuff”15:30 - Winning $100,000 fellowship through O'Shaughnessey Ventures22:36 - Education, homeschooling/unschooling, “follow the fear”, gaps in knowledge, socialization, authority, Taking Children Seriously57:11 - Winning the social media game

NAT & MARTHA'S LINKS Website: https://natandmartha.comYouTube: https://www.youtube.c...


#15 – Naval Ravikant and Brett Hall: Knowledge, Constraints, and Truth-Seeking Mechanisms
#15 – Naval Ravikant and Brett Hall: Knowledge, Constraints, and Truth-Seeking Mechanisms episode artwork
03/25/2023

Airchat: https://www.getairchat.com

TIMESTAMPS0:24 - The nature of knowledge1:01- Constraints of progress6:31 - The finite speed of light is not a problem13:36 - “Any system that doesn’t get its feedback from free markets or nature eventually gets corrupted.” — Naval19:54 - Knowledge creation leads to wealth creation25:44 - Free will

RELEVANT LINKSNaval on Airchat: https://www.getairchat.com/navalBrett on Airchat: https://www.getairchat.com/bretthallKeith on Airchat: https://www.getairchat.com/welivetoserveArjun on Airchat: https://www.getairchat.com/arjunKnowledge | Airchat: https://www.getairchat.com/arjun/knowledge

Arjun’s Twitter: https://tw...


#15 – Naval Ravikant and Brett Hall: Knowledge, Constraints, and Truth-Seeking Mechanisms
#15 – Naval Ravikant and Brett Hall: Knowledge, Constraints, and Truth-Seeking Mechanisms episode artwork
03/25/2023

Airchat: https://www.getairchat.com

Naval on Airchat: https://www.getairchat.com/naval

Brett on Airchat: https://www.getairchat.com/bretthall

Keith on Airchat: https://www.getairchat.com/welivetoserve

Arjun on Airchat: https://www.getairchat.com/arjun

Twitter: https://twitter.com/arjunkhemani



This is a public episode. If you would like to discuss this with other subscribers or get access to bonus episodes, visit arjunkhemani.substack.com


14 – Don Watkins: Virtue of Selfishness, Ayn Rand, Epistemology and Wealth
14 – Don Watkins: Virtue of Selfishness, Ayn Rand, Epistemology and Wealth episode artwork
02/16/2023

Don Watkins is a fellow at the Ayn Rand Institute. He is the coauthor, along with Yaron Brook, of Free Market Revolution: How Ayn Rand's Ideas Can End Big Government and Equal is Unfair: America's Misguided Fight Against Income Inequality.

Support this podcast: https://buymeacoffee.com/arjunkhemani

TIMESTAMPS

0:39 - On a quest for the best life that you can achieve

4:02 - Happiness without morality or morality without happiness

5:27 - The interests of humans are at harmony

7:58 - Sacrifice is not good for you and the world

<...


#13 – Danny Miranda: Creating Podcasts and The Future
#13 – Danny Miranda: Creating Podcasts and The Future episode artwork
02/06/2023

Danny Miranda is the host of The Danny Miranda Podcast where he’s interviewed people like Bryan Johnson, Morgan Housel, Gary Vaynerchuck, David Perell, Jim O’Shaughnessy, Sam Parr, Anthony Pompliano, Derek Sivers, among many others.

If you enjoy the podcast, the best way to support it is by sharing it. And if you have the means, please consider buying me a coffee.

TIMESTAMPS

0:00 - 7-year-old Danny taking over the New York Times

2:17 - Thoughts on creating content

5:09 - The desire to be normal

8:22 - Danny’s entire...


#12 – James Pierce: Perspective, Prescriptions, and Sincerity
#12 – James Pierce: Perspective, Prescriptions, and Sincerity episode artwork
01/15/2023

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James Pierce is a writer, executive coach and a philosopher.

TIMESTAMPS

0:50 - How modern psychology weakens the mind and how to conquer anxiety

4:15 - Perspective and “direct observation”

8:25 - Shoulds, prescriptions, and inexplicit knowledge

15:58 - Sincere questions

17:59 - Why James doesn’t meditate, the sense of sense, and enlightenment

21:05 - The ultimate cause for all relationship problems

26:20 - Peace

33:30 - Insincere questions

36:40 - Freedom

JAMES’ LINKS

Web...


#11 – David Perell: Writing and Education
#11 – David Perell: Writing and Education episode artwork
12/17/2022

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David Perell is a writer, podcaster and founder of the course Write of Passage.

We talk about David’s new writing course for high schoolers, why he thinks the Internet is the best thing that happened to education, writing online and effective ways to do so, how to tackle long term goals, ChatGPT and more!

TIMESTAMPS

0:30 - The problem David is trying to solve with his new writing course for high schoolers

6:10 - What David would do and how he w...


#10 – Andrew Kirby: Hitting Financial Freedom At Age 22, Solving Problems and Happiness
#10 – Andrew Kirby: Hitting Financial Freedom At Age 22, Solving Problems and Happiness episode artwork
12/02/2022

Andrew Kirby is a YouTuber with over 600,000 subscribers who became financially free at age 22 by synthesizing content on the Internet.

We talk about the path Andrew takes to attain financial freedom at age 22, how to write good cold DMs, entrepreneurship, misconceptions around money, The Beginning of Infinity and Andrew’s most influential books, the pursuit of creation, happiness and much more!

Listen on Apple Podcasts or Spotify

TIMESTAMPS

0:00 - Andrew’s backstory // his entrepreneurial childhood

4:50 - How Andrew became financially free at 22 // being a permission-less apprentice

9:15 - The...


#9 – Chiara Marletto: Knowledge, Constraints and Good Explanations
#9 – Chiara Marletto: Knowledge, Constraints and Good Explanations episode artwork
11/22/2022

Chiara is a quantum physicist and research fellow at Wolfson College, University of Oxford. Her research interests are at the foundations of physics. Together with David Deutsch she is the pioneer of constructor theory, a new mode of scientific explanation which expresses physical laws in terms of counterfactuals, i.e. what can and cannot happen.

She is the author of The Science of Can and Can’t subtitled “A Physicist’s Journey Through the Land of Counterfactuals” which is all about constructor theory and its implications.

We talk about Chiara’s lovely childhood that led to her dev...


#8 – Charlie Jungheim: From Meditation to Mars
#8 – Charlie Jungheim: From Meditation to Mars episode artwork
11/12/2022

Charlie Jungheim (aka Hermes of Reason) makes really cool videos about Critical Rationalism following the works of Karl Popper and David Deutsch. He’s a musician and comedian.

In a fun and wide-ranging conversation, we talk about mixing comedy with intellectual stuff, our lives being transformed by the works of David Deutsch, how meditation links to epistemology, then Mars and more!

TIMESTAMPS

0:45 - Charlie’s INCREDIBLE content around critical rationalism (comedy mixed with intellectual stuff)

6:17 - Most intellectual heroes are dead. Ours isn’t.

11:55 - Deep ideas can take a whil...