In this episode, I’m joined by Dr. Abbie Smith-Ryan—one of the leading researchers in exercise physiology and women’s metabolism—to unpack the science of how women should be training through perimenopause, postmenopause, and beyond. We dive into the physiological changes that impact body composition, performance, and recovery—and how to adjust training and nutrition to match.

We discuss:

This week in the studio, I'm joined by Dr. Nick Barringer—Army Ranger, performance nutrition expert, and one of the sharpest minds in military and metabolic health. Together, we cut through the noise around today's most controversial nutrition topics. If you’ve ever felt whiplash trying to make sense of conflicting headlines, this episode is your science-based compass.

What’s really going on with artificial sweeteners like sucralose and aspartame? Are seed oils toxic—or just misunderstood? And what’s the actual science behind popular supplements like creatine, testosterone boosters and fat burners?

Dr. Barringer brings two...

In this episode, I’m joined by Shaun Noorian—engineer, entrepreneur, and CEO of Empower Pharmacy, the largest compounding pharmacy in the world. With compounded GLP-1s making headlines and lawsuits from Big Pharma intensifying, Shaun joins me to pull back the curtain on the regulatory, financial, and ethical storm brewing behind the scenes.

Are compounded GLP-1s legal? Safe? Who controls drug pricing in the U.S., and why are Americans paying 10x more than Europeans for the same medication? And most importantly—what does all this mean for access, affordability, and patient care?

This e...

In this episode, I’m joined by Dr. Melanie Cree—physician-scientist, pediatric endocrinologist, and one of the leading researchers redefining how we understand and treat Polycystic Ovary Syndrome (PCOS). PCOS affects millions of women, yet it's still underdiagnosed, misunderstood, and often mistreated. Dr. Cree cuts through the confusion, offering a deeply scientific yet compassionate look at what’s really driving this complex condition—from insulin resistance and mitochondrial dysfunction to skeletal muscle quality and fertility trajectories across a woman’s lifespan.

We cover:

In this episode, I’m joined by Dr. Jocelyn Wittstein—orthopedic surgeon, sports medicine expert, and Associate Professor at Duke University—for a powerful and practical conversation about  bone and joint health across the lifespan. From the challenges of frozen shoulder and arthritis to the truth about running and menopause hormone therapy, this episode is your definitive guide to staying strong, mobile, and pain-free well into your 40s, 50s, and beyond.

We cover:

In this episode, I’m joined by Dr. Shane Kronstedt—former Navy SEAL, physician, surgical resident, and most importantly, my husband—for a powerful conversation about discipline, resilience, and the real-life moments that define us. From his early years of martial arts and mixed martial arts to surviving Hell Week and life-or-death missions in Afghanistan and Uganda, Shane shares how pressure creates clarity, why mindset matters most, and what it truly means to lead by example. This deeply personal episode gives you a rare glimpse into the man behind the mission.

We cover:

Jeff Krasno’s personal health transformation—reversing diabetes, shedding 60 pounds, and reclaiming his health at age 50—is a masterclass in what he calls “good stress.” In this episode, we dive into the simple but powerful idea that discomfort might just be the medicine we all need. Jeff, the founder of Commune and host of the Commune podcast, shares how fasting, cold exposure, resistance training, and attention to modern habits helped him regain his energy, build muscle, and thrive.

Together, we discuss how metabolic dysfunction has become the norm, how adaptive stress responses can be harnessed to reverse chronic il...

Nelson Vergel’s story is one of resilience, perseverance, and an unrelenting drive to defy the odds. In the mid-1980s, he was handed what many would have considered a death sentence—an HIV diagnosis at a time when there were no effective treatments, no clear answers, and little hope. Today, he is a beacon of knowledge and empowerment for those seeking to take control of their health, whether they are dealing with wasting conditions, hormone deficiencies, or simply aiming for peak performance. Nelson has spent decades researching and advocating for hormone health, muscle preservation, and medical autonomy, particularly for...

Dr. James Hill—a expert on obesity, metabolism, and long-term weight management—joins me this week to unpack the biggest challenges in sustainable fat loss. Dr. Hill has spent decades researching weight control and the factors that determine whether people can keep weight off long-term. We discuss the science behind energy balance, metabolic flexibility, and why long-term weight loss is about more than just diet and exercise. He shares insights from his groundbreaking work with the National Weight Control Registry, the role of GLP-1 medications, and why physical activity is the key to preventing weight regain.

We cove...

In this episode, Dr. Abraham Morgentaler—an expert in urology and hormone health—helps unpack the biggest myths and misconceptions surrounding testosterone therapy for both men and women. He shares his pioneering research on testosterone replacement therapy, challenging outdated fears about its link to prostate cancer and highlighting the latest findings on how hormone therapy can impact overall health, libido, and longevity. The conversation explores the controversial history of testosterone in medicine, the common mismanagement of hormone deficiencies, and why free testosterone may be one of the most important markers for health.

We cover:

Misinformation in nutrition is rampant. From demonizing red meat to hyping plant-based diets, conflicting advice has left many people confused about what’s truly evidence-based. In this episode, I am joined by Dr. Bradley Johnston, an expert in evidence-based nutrition and public health policies, to separate fact from fiction. With nearly 200 peer-reviewed publications, Dr. Johnston has challenged conventional wisdom—including recommendations from major organizations like the World Health Organization. He shares how evidence-based practices should guide our dietary choices, the importance of systematic reviews and meta-analyses, and how cognitive biases influence the research we trust.

Key Points:

In this episode, I sit down with Dr. Kristy Hamilton, a board-certified plastic surgeon, to explore the latest advancements in aesthetic medicine, the impact of social media on beauty standards, and the reality of breast implant illness. Dr. Hamilton shares her expert insights on facial rejuvenation, fat transfer, the safety of fillers, and new biostimulators while debunking common myths around plastic surgery. We also dive deep into the controversial rise of explant surgeries, the latest data on BII, and how surgical and non-surgical options can help individuals feel more confident in their skin. From the influence of celebrity procedures...

Today, I welcome Dr. Donald Layman back to The Dr. Gabrielle Lyon Show for a deep dive into his decades of protein research, the flaws in dietary guidelines, and the evolving landscape of nutrition. Together, we explore the real reasons behind the obesity epidemic, why decades of dietary advice have led us astray, and how we can reclaim metabolic health through high-quality protein intake. Dr. Layman shares compelling research on protein requirements, nutrient density, and how misleading narratives around fat and cholesterol have shaped our food choices. This conversation will challenge what you think you know about nutrition and...

Today, I welcome ultra-endurance athlete and world record holder Zach Bitter to The Dr. Gabrielle Lyon Show for an insightful conversation on the extreme physical and mental demands of ultra-marathons. Zach shares his mindset strategies for overcoming the inevitable dark moments in long-distance races, including visualization techniques and the importance of mental resilience in performance.

We also dive into personalized nutrition and training adaptations, as Zach details his transition from a high-carb to a low-carb diet and how it has influenced his endurance, recovery, and overall performance. Our discussion highlights the importance of metabolic flexibility, optimizing fuel...

Today, I welcome Dr. Heather Leidy to The Dr. Gabrielle Lyon Show for an in-depth conversation about the evolving landscape of nutrition science. Together, they tackle pressing topics like the future of the U.S. Dietary Guidelines, the impact of protein timing, and the importance of protein quality in supporting health and mitigating frailty. Dr. Leidy highlights recent research that explores behavioral strategies for sustainable weight management, the role of animal-sourced foods in nutrient adequacy, and the effects of GLP-1 medications on diet and health outcomes.

Key Discussion Points:

Dr. Stephan Van Vliet joins us for an enlightening exploration of nutrition, agriculture, and human health. Our discussion navigates the often-overlooked complexities of food production, examining the nutritional differences between pasture-finished and grain-finished beef. We also uncover how maternal nutrition might set the stage for children's future dietary preferences. Dr. Van Vliet introduces the intriguing concept of the food matrix, emphasizing the profound impact of bioactive compounds in whole foods that go far beyond mere macronutrient content.

As we venture into the emerging field of food metabolomics, Dr. Van Vliet reveals how metabolites in plants and animals...

In this episode of The Dr. Gabrielle Lyon Show, I sit down with my friend, Dr. Allison Brager, a neurobiologist, researcher, and active-duty U.S. Army neuroscientist whose work redefines what we know about sleep and human performance. Allison’s expertise goes beyond the usual advice about getting eight hours of sleep. Instead, we explore how to optimize performance and resilience when life doesn’t allow for a perfect sleep routine—something we can all relate to.

Allison shares fascinating insights from her work with military special operations, studying how sleep deprivation impacts cognitive and physical performance in hig...

In this episode of The Dr. Gabrielle Lyon Show, Dr. Gabrielle Lyon sits down with Dr. Susanna Søberg, a leading expert in cold exposure and metabolism. They dive deep into the science behind cold plunging, the benefits of brown adipose tissue (BAT), and how minimal doses of cold can dramatically improve metabolic health, mental resilience, and overall well-being.

Dr. Søberg shares her personal journey from working as a nurse to becoming a PhD researcher in metabolism, uncovering the surprising role that brown fat plays in regulating blood sugar, burning fat, and improving cardiovascular health. The co...

In this episode of The Dr. Gabrielle Lyon Show, I sit down with Dr. Faidon Magkos, a leading expert in obesity and metabolism at the University of Copenhagen, to tackle one of the most debated topics in nutrition science – the root causes of obesity. We dive into the contrasting theories of energy balance and the carbohydrate-insulin model, shedding light on what the latest research reveals – and what remains unknown. Dr. Magkos also discusses how environmental factors, genetics, and muscle health shape metabolic outcomes.

Together, we discuss:

Dr. Kevin Maki, renowned scientist and co-founder of multiple biomedical research centers, joins us to demystify the world of nutrition science. With a career spanning decades in epidemiology and clinical trials, Dr. Maki dives into the evidence behind red meat, cholesterol, saturated fats, and the impact of dietary habits on heart health. Discover the truth behind common misconceptions and gain clarity on making informed dietary choices.

In This Episode:

• What does the science really say about red meat and cholesterol?

• Understanding the role of saturated fats in heart health

• How observational studie...

In this episode of The Dr. Gabrielle Lyon Show, I sit down with Dr. Mike Israetel, an exercise physiologist and co-founder of Renaissance Periodization, to break down the science of sustainable fat loss and muscle gain. We explore the essential strategies for transforming your physique without falling for quick fixes or fad diets. From macronutrient distribution to the critical role of resistance training, Dr. Israetel offers practical, science-backed guidance for anyone looking to optimize their health and fitness. From macronutrients to supplements, we cover it all! 

We dive into: 

In this episode of The Dr. Gabrielle Lyon Show, Dr. Lyon is joined by Dr. Russell Surasky, a board-certified neurologist and addiction specialist, to discuss one of the most pressing issues of our time: addiction. With a deeply personal connection to the topic, Dr. Surasky sheds light on the reality of addiction as a chronic brain disease and dispels the myths that have fueled stigma for decades.

Dr. Surasky explains how addiction fundamentally alters brain function, the role of genetic susceptibility, and why opioids—particularly fentanyl—pose an unprecedented threat. He shares actionable insights into treatment options, inclu...

Join Dr. Gabrielle Lyon and Dr Christie Ballantyne, one of the world’s leading cardiologists, for an insightful conversation on the science behind cardiovascular health, metabolic wellness, and disease prevention. In this episode, Dr. Ballantyne shares groundbreaking research, the role of genetics, and practical steps you can take to optimize heart health. Whether it’s through diet, exercise, or understanding your unique health profile, this discussion is packed with actionable strategies to help you live a longer, healthier life.

💡 Key Topics Covered:

Dive into an extraordinary conversation with Dr. Gabrielle Lyon and Dr. Jamie Baum, Associate Professor and Director of the Center for Human Nutrition at the University of Arkansas. In this episode, we explore revolutionary topics:

The role of skeletal muscle in appetite regulation.

Cutting-edge research on perimenopause and postmenopause nutrition.

How dietary protein impacts health and weight management.

Surprising findings on protein supplementation and sleep quality.

The science behind muscle-brain crosstalk and its effects on aging.

Dr. Baum shares her journey into research focused on women's health...

The Dietary Guidelines Are Failing Us

In this episode of The Dr. Gabrielle Lyon Show, Dr. Lyon is joined by Dr. Donald Layman, a world-renowned expert in protein metabolism and a pioneer in the field of nutritional science. With over 20 years of mentorship between them, Dr. Layman and Dr. Lyon dive deep into the flaws, myths, and future of U.S. Dietary Guidelines, offering a clear path to better health through smarter dietary decisions.

Dr. Layman shares his revolutionary perspective on why protein intake should focus on essential amino acids, how carbohydrates—not fats—are driv...

Testosterone Matters for Everyone

In this episode of The Dr. Gabrielle Lyon Show, Dr. Lyon sits down with Shalin Shah, CEO of Marius Pharmaceuticals, to explore the science, benefits, and future of testosterone therapy. Shalin has been a driving force behind bringing Kyzatrex, an FDA-approved oral testosterone, to market—making testosterone therapy more accessible and effective for both men and women. From breaking down misconceptions to advocating for better access to hormone therapy, this conversation sheds light on how testosterone plays a crucial role in overall health and wellness.

Shalin shares his journey, discussing how hi...

Designing Confidence

In this episode of The Dr. Gabrielle Lyon Show, Dr. Lyon sits down with Heidi Somers, the founder of Buffbunny Collection, a dynamic and empowering fitness and lifestyle brand that has taken the industry by storm. From growing up in a small town in Alaska to becoming a successful entrepreneur, Heidi’s journey is a testament to the power of resilience, self-belief, and authenticity.

Heidi opens up about her humble beginnings, including her early struggles with weight and body image, and shares how these experiences fueled her passion to help other women feel st...

Raising Healthy Athletes

In this enlightening episode of the Dr. Gabrielle Lyon Show, we dive deep into the world of youth training and the crucial role it plays in long-term health and athletic development. Joined by Judd Leinhard, former Army Ranger, collegiate lineman, and expert in speed training, we explore how training children differs from adults, debunk common myths, and reveal the surprising truth about building strength and resilience in kids.

We dive into:

In this episode of The Dr. Gabrielle Lyon Show, I sit down with Dr. Layne Norton, a scientist and nutrition expert, to unpack the complex truths behind obesity, weight management, and diet myths. Together, we discuss what truly drives weight gain beyond the “calories in vs. calories out” model, exploring the impacts of hormones, metabolic rates, and lifestyle choices.

We dive into:

- How the body processes carbs, fats, and proteins

- Challenging the carb-insulin model of obesity

- Practical tips on meal structuring and muscle maintenance

- The sign...

Defying Aging

In this episode of the Dr. Gabrielle Lyon Show, I sit down with Dr. Vonda Wright, a pioneering orthopedic surgeon and women’s health advocate, to explore the powerful intersection of mobility, aging, and resilience. Dr. Wright shares her inspiring journey from growing up on a Kansas farm to becoming a leader in orthopedics, and how her non-traditional path shaped her approach to health and wellness.

We explore:

Whether you're curious about aging well, staying strong, or redefining your heal...

Resetting the Nervous System

In this episode of the Dr. Gabrielle Lyon Show, we dive deep into groundbreaking approaches for treating PTSD, anxiety, and depression with Dr. John How, an emergency physician turned mental health advocate. Dr. How introduces us to the Stellate Ganglion Block, a powerful and non-invasive procedure that's transforming how we manage trauma and mental health without relying solely on medications.

We explore:

Breaking the Cycle

In this episode of the Dr. Gabrielle Lyon Show, I sit down with the incredible Thais Gibson, an expert in attachment theory and personal development. Together, we dive deep into the fascinating world of attachment styles and explore how early childhood experiences shape our emotional patterns, relationships, and even our overall health.

We cover:

Can you Build Muscle without Heavy Lifting?

Join Dr. Gabrielle Lyon as she sits down with Dr. Jeremy Loenneke, an associate professor of exercise science at the University of Mississippi and one of the world’s leading experts in blood flow restriction (BFR) training. They discuss the science behind skeletal muscle adaptation, how BFR can help you get stronger without heavy weights, and why muscle growth and strength aren’t always the same thing.

Dr. Loenneke shares insights on how BFR works—using low loads to trigger muscle adaptation and growth—and the potential benefits for reco...

Innovating Women’s Health

In this episode of The Dr. Gabrielle Lyon Show, I sit down with the incredible Cindy Eckert—serial entrepreneur, founder of Sprout Pharmaceuticals, and the driving force behind Addyi (commonly known as “the female Viagra”). Cindy shares her groundbreaking journey in advocating for women’s sexual health, challenging the medical system, and fighting for equal treatment in medicine.

Cindy reveals the startling double standards between male and female sexual health, recounting her experiences bringing Addyi to market and navigating the resistance she faced. Together, we dive deep into why women’s pleasure, he...

Building Muscle, Preventing Injury

In this episode we sit down with Dr. Jordan Shallow, chiropractor, strength and conditioning coach, and founder of Prescript. Dr. Shallow works with top athletes from the NFL, NHL, UFC, and more, helping them stay injury-free and perform at their best.

We dive deep into the world of biomechanics and movement, discussing the critical importance of "physical empathy" — understanding how the body interacts with gravity — and why it’s key to both performance and injury prevention. Whether you're an elite athlete or just starting your fitness journey, Dr. Shallow’s principles can help...

In this episode of the Dr. Gabrielle Lyon Show, we welcome back neurophysiologist and human performance expert, Louisa Nicola. Together, we explore the powerful connection between exercise, cognitive function, and the prevention of Alzheimer's disease. With cutting-edge insights from Louisa’s recent research, we dive deep into the impact of resistance training, cardiovascular exercise, and lifestyle interventions on brain health and longevity.

In this episode, you’ll learn:

In this episode of the Dr. Gabrielle Lyon Show, we dive deep into the world of compounding pharmacies and the transformative power of anabolic steroids with special guest Shaun Noorian, founder of Empower Pharmacy, one of the largest compounding pharmacies in the U.S.

Join us as Shaun shares his personal journey from engineering to pharmacy, sparked by a life-changing back injury that led him to discover the benefits of testosterone therapy. We explore the critical role compounding pharmacies play in providing customized medications that can dramatically improve health outcomes, particularly for those dealing with hormonal imbalances...

Breaking Health Myths

In this episode of the Dr. Gabrielle Lyon Show, we sit down with Mari Llewellyn. Mari opens up about her incredible transformation journey, losing over 100 pounds and reclaiming her mental and physical health. From hitting rock bottom to building a thriving wellness empire, Mari shares invaluable insights into the importance of weight training, discipline, and self-reflection.

Tune in as Mari discusses the challenges of navigating health trends, the responsibilities that come with being a public figure, and the evolving landscape of women’s health. Whether you’re struggling with weight loss, mental heal...

Discover the groundbreaking science behind healthy aging in this episode of the Dr. Gabrielle Lyon Show!

Join Dr. Lyon as she sits down with Dr. Anurag Singh, an MD PhD with extensive research in immunology, to explore the incredible benefits of Urolithin A, a compound that's showing promise in protecting muscle health and enhancing mitochondrial function.

Dr. Singh shares his remarkable journey from medical school in India to becoming a leading researcher in the United States, where he’s been at the forefront of studying the impact of Urolithin A on aging. They dive deep in...

From Crisis to Confidence

In this episode of the Dr. Gabrielle Lyon Show, Dr. Lyon engages in an insightful conversation with Greg Scheinman, a successful entrepreneur, coach, and the creator of the Midlife Male movement. Greg's journey is a testament to the fact that midlife doesn't have to be a crisis—it can be a time of transformation, growth, and renewed purpose.

Greg opens up about his personal struggles with burnout, unhealthy habits, and the societal pressures that many men face as they navigate their 40s and 50s. He discusses the pivotal moment that led hi...