Serious Inquiries Only

I cannot stop thinking about Cody from Some More News's video in which he could not stop thinking about Spider-Man: Brand New Day. Cody is INCREDIBLY sure that you're an idiot incapable of watching movies or consuming art if you don't agree with his conception of what the ending of Brand New Day meant. The problem is... Cody gets about a billion things wrong and his arguments are terrible.

This was going to be just a Patreon bonus of Serious Inquiries Only but I wanted to put it up on YouTube so it's going out...

... and other autism/ADHD research! So pleased to have Dr. Jenessa Seymour back - this time with a variety of studies in the Autism and ADHD realms.

Jurek, L., Duchier, A., Gauld, C., Henault, L., Giroudon, C., Fourneret, P., … Nourredine, M. (2025). Sensory processing in individuals with Attention-Deficit/Hyperactivity Disorder compared with control populations: A systematic review and meta-analysis. Journal of the American Academy of Child & Adolescent Psychiatry, 64, 1132-1147.

Le Cunff, A., Russell, C. & Dommett, E.J. (2026). Hyperactive–impulsive ADHD traits predict

Part 2! Dr. Eric Jaffe returns to actually treat the cancer this time: why radiation is basically catching your kid smoking and making him finish the carton, how CRISPR turns your own T cells into an assassin squad, and why oncolytic viruses are just Jurassic World Dominion for tumors.

Haven't heard Part 1 yet? Start there or you'll be lost.

Mentioned:

CAR-T therapy

RAS inhibitor drugs

Oncolytic viruses

mRNA cancer vaccines

Red Queen hypothesis

Cancer-sniffing dogs

Are you an expert in something and...

Part 1! Dr. Eric Jaffe, the biology teacher who keeps naming proteins after cartoon characters, returns for a two-part cancer deep dive. Today: what cancer actually is at the cellular level, why elephants barely get it, why whales get it even less, and why the "they're hiding the cure" conspiracy falls apart the second you learn who actually funds the research.

Mentioned:

Peto's paradox

HeLa cells

The Immortal Life of Henrietta Lacks

XKCD cancer comic

Part 2, the cure, is already up for Patreon supporters!

Are you...

Part 2! Thomas is joined again by David O'Brien, a higher education policy scholar with the California Community Colleges system, to finish dismantling The Daily's take on Trump's student loan crackdown. Reagan, Pell Grants, and decades of quiet state defunding all get their due, plus a theory on why tuition keeps climbing that has nothing to do with cosmetology degrees.

Mentioned:

The Daily college episode

Gainful employment rules

Are you an expert in something and want to be on the show? Apply here!

Please support the show on Patreon! You...

Thomas is joined by David O'Brien, a higher education policy scholar who works for the California Community Colleges system, to pick apart Trump's new rules threatening to cut off student loans and Pell grants from "low-earning" degree programs, and to fact-check The Daily's recent take on the same story. The real history runs through Reagan, Prop 13, and decades of quiet austerity nobody on that podcast wants to mention.

Mentioned:

The Daily college episode

Reagan 1966 campaign clip

Prop 13

CUNY tuition history

California Master Plan for Higher Education

Thanks so much to the folks at SkeptiCal for inviting me! Though the talk does deal with the Butler shooting, I thought some way different stuff for this including a ridiculously overwrought hypothetical, my favorite kind! And, I found a Young Turks video where they are apparently Joe Rogan now!

The "nice guy" is the villain. We watched Obsession and cannot stop thinking about it. It has so much to say about gender, consent, "nice guys" and more. And it scarred Lydia for life.

WARNING: CONTAINS SPOILERS.

Are you an expert in something and want to be on the show? Apply here!

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Thomas is joined by Dr. Eric Jaffe, biologist, dinosaur enthusiast, and high school biology teacher, for a conversation that starts with a deceptively simple question: what are biological definitions actually doing?

It turns out that biology is far more like history than math, and that difference has enormous consequences for anyone trying to weaponize phrases like "the biological definition of sex." Dr. Jaffe walks through why definitions in inductive sciences are descriptive, not prescriptive, and what that means for species, chromosomes, fungi, LeBron James, and trans people.

"Exceptions aren't the exceptions in biology. They are...

Thomas is joined by Dr. Jenessa Seymour to dig into the brain science behind a surprisingly strange phenomenon: why do astronauts who spent just nine days in space need weeks of physical therapy to walk normally again?

The answer turns out to involve ancient calcium carbonate ear stones, the same material crabs use for shells, a multi-layered sensory system your brain is constantly running without your knowledge, and a wild evolutionary theory about why motion sickness exists at all. Also: why pilots fly perfectly good planes directly into the ground, and what deaf NASA research participants revealed ab...

The history of disability rights is often treated as a modern story, but what if that framing misses centuries of earlier, more complicated history? This week, Thomas is joined by Professor Sari Altschuler, Associate Professor of English at Northeastern University, to explore her new book Before Disability: A History of American Citizenship.

In the book, Professor Altschuler traces how disability and citizenship have been intertwined since the founding of the United States, and what that reveals about who America decided belonged and who didn't. In the early Republic, many physical and mental differences were accommodated within the...

Continuing the discussion of the CNN Rape Academy article. It gets even worse. And also, how our information environment is ruined and getting ruineder.

You might have seen the CNN article from a while back entitled Exposing a global ‘rape academy’. While most of the article is technically true, the broad takeaway that virtually everyone had (including me) was wildly, irresponsibly false.

Even if you came across debunks of this, there's a good chance that I'm debunking this even more than you've seen. I don't think people have fully grasped how misleading it was.

We continue the pruning of idiotic Butler Shooting conspiracy theories. Once we establish the facts using actual sources, what room is there left for a conspiracy or staging theory?

It wasn't staged. None of them were staged. Yes Trump was shot in the ear. I thought you all were doing a bit, but apparently you weren't. This isn't good and you should stop doing it, please. In discussing this current shooting, I found that way too many of you think that it was a hoax and even more think that Trump wasn't shot in the ear. So, let's go through the Butler shooting and see why YES HE F-CKING WAS.

Well, what do you know - it's a day that ends in y so the internet has a woman to hate. You might have seen some of the chatter about child-hating Chappell Roan lately, and it's just so depressing every single time one of these hate campaigns rears its ugly head. Lydia joins the show as resident Chappell Roan fan to discuss what actually happened, and why society so quickly jumps on these opportunities to hate women.

The Chappell Roan Harassment Campaign Is Plain Old Misogyny (Alex Nguyen - Mother Jones, 4/14/2026)

X profits from turning...

Popular media will tell you that placebos, inert inactive substances taken as if they’re medication, can work miracles. …Placebos don’t “work”. But what does that even mean? And if that’s true, why would we include a placebo group in a study? Is there anything remotely like a “true”’placebo effect, where belief in a medication could influence the body? Jenessa walks us through scientific study design, statistical artifacts, and one study that shows maybe just maybe there’s a little something like an actual placebo “effect”… but it’s still not magic! Tune in to hear how on earth that cou...

Everyone's favorite biologist and dinosaur enthusiast Dr. Eric Jaffe is back! Project Hail Mary is a very fun, and quite good, sciency movie that is cleaning up at the box office right now. You should see it! Eric is going to take us through the biology of the movie (and book) and what it gets right, and what it gets quite wrong.

“Yes we can” vote and protest our way out of authoritarianism.

It’s a classic case of academic literature never making it to mainstream consumption. Hang around social media long enough and you’ll hear that we’re basically screwed. A complete fascist take over is either extremely likely, inevitable, or it’s already here. And there’s not much we can do about it. Unless some other country invades us, we’ll be waiting for a civil war or a bloody military coup to hopefully maybe turn things around. That’s what history teaches us, right?

Literally th...

It's part 2 of the Minnesota fraud stuff. We get a little more Nick Shirley, dumbest person ever to testify in congress. And then I debunk the main claims against Gov. Walz and AG Ellison. Did Walz un-stop the payments to Feed Our Future? Did Ellison meet with, and then get campaign donations from the fraudsters?

So now that we've covered a real hearing with brave whistleblowers that got NO attention, it's time to look at what happens over on the other side of the aisle.

Last month, there was a devastating hearing featuring a victim of ICE, an ICE whistleblower, and a previous DHS attorney. It revealed what, in any other time, would have been a massive scandal likely resulting in multiple firings. But we live in the bad times, which means this hearing took place in a maintenance shed barely on Congressional property during lunchtime put on by a ragtag team of the few remaining people who give a shit about constitutional rights. I take you through the hearing, and then next episode we're going to compare this to the Minnesota fraud hearings...

Part 2! Even more fun Quibbies.

Allergies

Bansal, A.S., Chee, R., Nagendran, V., Warner, A., & Hayman, G. (2007). Dangerous liaison: Sexually transmitted allergic reaction to Brazil nuts. Journal of Investigational Allergology and Clinical Immunology, 17, 189-191.

Testosterone

University of Zurich (2009, December 9). Testosterone does not induce aggression, study shows. ScienceDaily.

Eisenegger, C., Naef, M., Snozzi, R., Heinrichs, M., & Fehr, E. (2010). Prejudice and truth about the effect of testosterone on human bargaining behavior. Nature, 463, 356-359.

ADHD and TikTok

Verma, S. & Sinha, S.K. (2024). How evidence-based is the “hashtag ADHD te...

It's Quibi Time (tm) with Jenessa! (Don't worry, I'll explain...) It's 2 debunks for the price of 1, or actually 5 debunks for the price of 2, because this is a two-parter! Here are the first two:

AI girlfriend

Caramela, S. (2025, January 31). Most Men Would Marry Their AI Girlfriend if it were Legal. Vice.

Fiorillo, C. & Bartlett, S. (2025, January 28). AI girlfriends could be a thing of the future as men admit they would marry robot lovers. The Mirror.

Koetsier, J. (2025, April 29). 80% Of Gen Zers Would Marry An AI: Study. Forbes.

Mashable. (2025, May 22). Majority...

I had a lot I needed to say about the ICE murders of Rene Good and Alex Pretti. And about the fascists who lie to our faces and know we can't do anything about it. And the concentration camps we already have. I did video because there was so much visual element to this, so watching would be best.

Subject of much sci-fi media and philosophy discussions, the "hive mind" is also a key element of Vince Gilligan's (Breaking Bad, Better Call Saul) new show, Pluribus. Dr. Jenessa Seymour joins the pod to walk us through examples that we have studied of hive mind behavior (in the insect world), and why we can reasonably assert that you could not maintain your individuality if our brains directly communicated with each other (in the human world).

Wolman, D. (2012). A tale of two halves. Nature, 483, 260-263.

Split brain patient video demonstration

Wittlinger, M., Wehner, R...

Brain pics, or they didn't happen? There's a recent study that demonstrates that some brain region activity might interact differently with oxygen than previously assumed. This could upend significant neuroscience research spanning decades. Thankfully SIO has Dr. Jenessa Seymour to come in and break it all down for us!

We start with a primer on the science of neuroimaging tools and the images they produce. How in the WORLD can we get a picture of a brain while a person is still alive? What are the things we need to know when evaluating scholarly articles or popular m...

In late September, shortly after declaring antifa a "domestic terrorist", Trump issued a memorandum directing the IRS to investigate tax-exempt organizations that could be "directly or indirectly financing political violence or domestic terrorism" and nonprofit organizations reasonably felt concerned of being targeted. A couple of weeks later, Lydia and Thomas ran into Nick Fish, President of the American Atheists, at California Freethought Day and asked how he and the organization were holding up in light of everything.

We're pleased to have Nick on to discuss what nonprofit organizations can do to protect themselves, as well as the...

Dr. Jenessa Seymour is on to teach us more about the brain! What do hallucinations, ear-worms, and phantom limbs have in common? And is "hallucinating" really a good term for what AI does when it makes something up?

Part 2 of Asra Nomani's insanely terrible Fox News article. Make sure you listened to part 1!

This is big, folks. Think Watergate combined with Deflate-gate combined with Christina Applegate combined with the Bowling Green Massacre. THAT's how big of a scandal this is.

You thought Zohran Mamdani was just an innocent 34 year old assemblyman who rose to stardom by being an incredibly good candidate and relentless campaigning an economic message in a positive way. But you were an idiot. Dummy.

Asra Nomani broke it here, but let Jenessa and I explain it to you b...

Part 1. This is big, folks. Think Watergate combined with Deflate-gate combined with Christina Applegate combined with the Bowling Green Massacre. THAT's how big of a scandal this is.

You thought Zohran Mamdani was just an innocent 34 year old assemblyman who rose to stardom by being an incredibly good candidate and relentless campaigning an economic message in a positive way. But you were an idiot. Dummy.

Asra Nomani broke it here, but let Jenessa and I explain it to you because clearly your feeble, gullible brain can't process. information properly.

Stormy Decisis AKA Dr. Alan Smerbeck is back! With multiple stories in the news of AI Chatbots potentially driving people to delusion or psychosis, Stormy wanted to explain to us what's going on and what the actual differences are between psychosis, delusions, schizophrenia, and more.

Visit Stormy's amazing project, sharebannedbooks.com!

***This is a two-parter. Listen to part 1!

Previously, the leading theory was that kids with autism and/or ADHD had mental health struggles due to emotional regulation issues or other direct elements of their neurodivergence. But what if it's actually that they have to deal with more stressors than the other kids? Dr. Jenessa Seymour, fellow haver of ADHD, is here to break it down for us!

Previously, the leading theory was that kids with autism and/or ADHD had mental health struggles due to emotional regulation issues or other direct elements of their neurodivergence. But what if it's actually that they have to deal with more stressors than the other kids? Dr. Jenessa Seymour, fellow haver of ADHD, is here to break it down for us!

This is a 2-parter! Get part 2 on patreon.com/seriouspod, or just wait a little!

Part 2 of my thoughts and observations based on all the info I could gather on Tyler Robinson. I think there's an aspect to him that isn't being emphasized enough that might help explain why he did what he did.

The public has gone through several phases of evolution on what the shooter's motive was. At first, it was assumed he was a leftwing terrorist. Then it seemed clear he was on the right. Or maybe nihilist. Then, the charging documents were released. These contained some selected texts with Robinson's transgender roommate who he seems to have been in a romantic relationship with. They are... weird. But what is going on here? What can we actually reasonably conclude at this time?

Dr. Bryan Gillis is back after far too long! But instead of space, he's here to talk about the problems in academia that lead to women and minority groups being underrepresented at astonishing and depressing levels.

Dr. Jenessa Seymour joins to discuss why TikTok's move here is aligned with what we know about eating disorders from the literature, and what happens when the internet doesn't draw a line like this.

Are you an expert in something and want to be on the show? Apply here!

Please support the show on patreon! You get ad free episodes, early episodes, and other bonus content!

Lydia and I invite one of our good friends, Holly, to share her recent viral story of harassment at a public park in Glendale, California. We discuss what happened that day, the spread and impact of the video, as well as the broader issue at hand and how it has shifted with a new Trump administration coming into office.

After the main show, Holly sticks around for a special discussion for patrons only because Lydia has A LOT to talk about after recently seeing Thunder From Down Under in Las Vegas (with Holly)! How exactly did a...

We had like, a mini war over Iran's nuclear situation and it is barely even a memory in today's news cycle. But what happened there? Did Iran have nuclear weapons? What does it take for them to make some? Was Obama's Iran Nuclear Deal good? And what happened after it was no longer in place? What might happen now?

Joining is Evan McDonell, a former nuclear engineer with the US Naval nuclear program to give us the breakdown!