Intelligent Medicine

Nutritionist Leyla Muedin discusses the important relationship between gut health and bone health. Leyla delves into the ways gastrointestinal disorders like Crohn's disease, ulcerative colitis, and irritable bowel syndrome can lead to osteoporosis and increased fracture risks. She explains how chronic inflammation, malabsorption, and dysbiosis are common underlying causes of bone loss. Leyla also reviews scientific studies on the link between the gut microbiome and bone mass, highlighting the potential of fecal microbiome transplants as future treatments for osteoporosis.

"Wintering" - how to optimize your winter experienceWhat we're eating for dinnerAn overview of the Dietary Guidelines for AmericansWhat can I do to rectify any scar tissue in my throat from previous thyroid surgery?What can my son do or take to minimize scarring above his right cheek from a basketball game tussle?

I have neuropathy in both my feet and lower legs.  Are there any natural supplements I can take for it?I purchased two containers of Flavamix. What is the ingredient Lucuma and why is it in their cocoa powder?What are your thoughts on the PSMA PET scan for detecting prostate cancer?What supplements do you recommend for prostate health?What are your thoughts on taking famotidine 2 to 3 times a day for GERD?  Can you discuss the different creatine products?

Exploring the Future of Aging with Journalist William J. Cole, author of “The Big 100: Uncovering the Keys to Longevity." The discussion delves into the challenges and societal implications of increased lifespans, especially among baby boomers. They explore the interplay of genetics and lifestyle in achieving longevity, the role of positivity, and the looming financial and caregiving challenges due to an aging population. Cole emphasizes the importance of adapting society to accommodate this demographic shift and highlights the importance of sustainable and healthy aging practices.

Dr. Hoffman continues his conversation with Journalist William J. Cole, author of “The Big 100: Uncovering the Keys to Longevity."

Embracing a Holistic, Pain-Free Approach to Exercise with Dr. John Rusin, world-renowned strength coach, physical therapist, and injury prevention expert. He's author of "Pain-Free Performance: Move Better, Train Smarter, and Build an Unbreakable Body." John is the founder of the Pain-Free Performance Specialist Certification (PPSC), which has certified over 20,000 fitness and rehab professionals worldwide. He discusses the importance of a comprehensive approach to fitness, focusing on diet, sleep, mood, attitude, supplements, and, importantly, exercise. He emphasizes sustainable, pain-free strength training suitable for all ages and fitness levels. The conversation challenges the outdated 'no pain, no gain' philosophy and highlights...

Dr. Hoffman continues his conversation with Dr. John Rusin, world-renowned strength coach, physical therapist, and injury prevention expert. He's author of "Pain-Free Performance: Move Better, Train Smarter, and Build an Unbreakable Body."

Oprah’s new book encourages followers to “free themselves” from “shame and blame” by accessing weight loss meds; Her claim “it’s the obesity gene” is put to the test by twin studies; Study shows brain stimulation with external electronic headset produces weight loss rivaling shots, pills; Ultra-processed food ups daily calorie intake by 500; Breast-feeding moms gain less post-pregnancy weight; Solutions for  Myelodysplastic Syndrome; Scientists find hidden weight gain trigger in soybean oil.

Calculators that assess your risk for heart disease miss the boat—half of actual heart attack victims were said to be at low-risk; Why an app could erroneously tell you that you should be taking a statin; New ways to fix a calcified aortic valve; Common amino acid may bust Alzheimer’s plaque, Adequate sleep may trump healthy diet, exercise for longevity; Chinese vegetarians less likely than omnivores to surpass 100; Easily-gobbled “fast food” stokes total daily calorie intake; Common chemicals hike MS risk two-fold; Low-glutamate diet relieves migraines; Fish oil confers substantial stroke, heart attack protection to dialysis patients.

Challenges of GLP-1 Drugs and New Dietary Guidelines for Americans. Nutritionist Leyla Muedin discusses the recent findings on weight regain after stopping GLP-1 receptor agonists like OZEMPIC and Wegovy, based on a recent British Medical Journal editorial. The episode also highlights the Dietary Guidelines for Americans (2025-2030), which recommend focusing on real, nutrient-dense foods, prioritizing protein, and reducing highly processed foods. Leyla addresses the importance of maintaining healthy eating habits during and after using GLP-1 drugs to achieve long-term weight management and overall health.

A spoof on suggested nutrition guidelinesDoes nicotine destroy the spine?  I can't seem to find Alpha Base with or without iron anymore. What do you recommend?

I'm an 88-year-old man with an irregular heart rate.  Any suggestions to treat this?My PSA is on an upward trend since my last test. Should I stop taking testosterone?What can I take for essential tremors?  I wake often during the night.  What can I take to help me stay asleep?What are your thoughts on grounding mats, mattress covers, and sheets? Are they the real deal?

Embracing Winter: Strategies for Wellbeing with Dr. Kari Leibowitz, health psychologist and author of "How to Winter: Harness Your Mindset to Thrive on Cold, Dark, or Difficult Days." She explores how to push back against the notion of winter gloom and discusses the importance of mindset, cultural practices, and cognitive behavioral therapy in improving mental well-being during the winter months. Dr. Leibowitz shares insights from her experiences in Nordic countries and practical tips for maintaining a positive outlook, staying active, and embracing seasonal activities. She also covers the physiological and mental health benefits of practices such as cold water...

Dr. Hoffman continues his conversation with Dr. Kari Leibowitz, health psychologist and author of "How to Winter: Harness Your Mindset to Thrive on Cold, Dark, or Difficult Days," about winter survival strategies.

Unlocking Mitochondrial Health: Exploring Urolithin A and Mitochondria-Boosting Supplements with Dr. Brad Currier, a senior scientist and manager of clinical trials at Timeline, a Swiss biotech company known for their product MitoPure. The conversation delves into a unique compound, Urolithin A, which is derived from pomegranates and identified as a key activator of mitophagy—the cellular process of recycling and rejuvenating damaged mitochondria. Dr. Currier elaborates on the significant health benefits of Urolithin A, including improved muscle strength, enhanced immune function, and its potential cognitive and anti-aging effects. The episode also covers topics such as the role of exercise an...

Dr. Hoffman continues his conversation with Dr. Brad Currier, a senior scientist and manager of clinical trials at Timeline, a Swiss biotech company known for their product MitoPure.

Applauding a long-overdue change to the broken Food Pyramid; Vitamin C enhances skin health, protects against environmental pollutants; FDA green lights testosterone replacement; Does CoQ10 protect against statin muscle damage? The story of America’s first vitamin pioneer; Millions of America’s seniors take 8 or more prescription drugs simultaneously. 

MAHA derailed by federal policies that allow harmful chemicals to proliferate; 25 years later, a study that exonerated glyphosate has been retracted due to undue influence from Monsanto; Judge blocks W. Virginia artificial food dye and additive ban; New refined criteria would raise US obesity rate to nearly 70%; FDA approves electrical stimulation headset as safe and effective for home-use to treat depression; Accidental toxic fume releases on planes cause long-term disability, deaths, in passengers and crew. “Digital pacifier” screen time for toddlers found to hike risk for adolescent focus problems, anxiety; Is just a little red wine every day bad for...

Nutritionist Leyla Muedin discusses the crucial importance of Omega-3 fats, particularly emphasizing their role in mental and heart health. She highlights a recent UK Biobank study demonstrating that higher Omega-3 levels are linked to a significantly lower risk of self-harm and suicidal ideation. Additionally, another study in the Journal of the American Heart Association reveals that elevated Omega-3 levels correlate with a reduced risk of atrial fibrillation (AFib). Leyla underscores the necessity of a balanced diet rich in Omega-3 sources like fatty fish and grass-fed meats, arguing that these nutrients are crucial for optimal mental and heart health.

Top stories of 2025Does the use of statins lead to muscle loss?I have mitral valve prolapse with regurgitation. Should I increase my supplement dosages?

Could you discuss GABA for insomnia and sleep support?  Are there long-term health benefits?What impact does a cocktail of pharmaceutical drugs have on the microbiome?Can I take more than 2 daily doses of Dr. Ohira's probiotics?Which is the correct estrogen to take in HRT?  Estriol or estradiol?In light of the recent EPA proposal to double permissible formaldehyde emissions, how does this jibe with MAHA?

Innovative Approaches to Parkinson's Disease with Dr. Heather Zwickey, Vice President of Research and Academic Excellence, Provost, and Professor of Immunology at the National University of Natural Medicine (NUNM), and author of "Eating Better for Parkinson’s: A Nutritional Starter Guide." She delves into innovative treatments for Parkinson's disease, including the role of diet, particularly a ketogenic diet, and the impact of the gut microbiome. Dr. Zwickey shares her inspiration from NBA player Brian Grant's experience with Parkinson's and discusses her small study on the feasibility of a ketogenic diet, showing promising results. She also details other potential treatments li...

Dr. Hoffman continues his conversation with Dr. Heather Zwickey, Vice President of Research and Academic Excellence, Provost, and Professor of Immunology at the National University of Natural Medicine (NUNM).

Understanding and Treating Complex Illnesses with Dr. Neil Nathan, author of “Toxic 2nd Edition: Heal Your Body from Mold Toxicity, Lyme Disease, Multiple Chemical Sensitivities, and Chronic Environmental Illness.” Dr. Nathan shares his expertise on the multifaceted nature of chronic illnesses, which often defy simple categorization and may be misdiagnosed as psychiatric issues. The discussion covers the impact of environmental toxins, electromagnetic fields, and infections like Lyme disease and long COVID. Dr. Nathan also highlights the importance of understanding inflammation's complex pathways and offers suggestions for both elimination of root causes and restoration of immune system functionality. The episode prov...

Dr. Hoffman continues his conversation with Dr. Neil Nathan, author of “Toxic 2nd Edition: Heal Your Body from Mold Toxicity, Lyme Disease, Multiple Chemical Sensitivities, and Chronic Environmental Illness.”

The advent of artificial light is obliterating women’s moon-driven menstrual cycle rhythms; When the triple whammy of cataracts, glaucoma, and macular degeneration strikes; Why can systolic blood pressure spike erratically? Are wrist and finger wearables for blood pressure ready for prime time? Nearly half of drivers killed in crashes have THC in their blood; Drinking bottled water causes surge in plastic micro-particle intake; The common supplement that can supercharge cancer immunotherapy.

Examining the claim that cabbage family vegetables are bad for the thyroid; Walmart announces sweeping move to reformulate its products without synthetic dyes, sketchy additives; Under Congressional questioning, Google admits to censoring contrary narratives on YouTube during Covid; Children garner psychological benefits from grandparent time; J&J fined nearly $1 billion in landmark talc baby powder lawsuit; Humans are among the few animals who can’t make their own vitamin C—why that may be a good thing.

Nutritionist Leyla Muedin discusses the renaming of fatty liver disease to metabolic dysfunction-associated steatotic liver disease (M-A-S-L-D) to reduce stigma and improve diagnosis. Dr. Mary Ella's efforts at the University of Chicago Medicine highlight how this change aids in better patient identification and treatment. Leyla emphasizes lifestyle changes like a low-carb diet to manage and reverse the disease. The episode also covers the prevalence of fake extra virgin olive oil (EVOO) on the market, ways to identify authentic olive oil, and the importance of choosing quality over mass-produced options.

Consequences of weight loss with weight loss drugs...Enter myostatin inhibitor drugsMy latest HgbA1c is 5.9, and I'm doing everything right. What gives?I'm approaching 80. Could you discuss aging?

What are your thoughts on Alpha-ketoglutarate for healthy aging?A treatment for warts?Am I destined to develop diabetes given my strong family history of diabetes and high blood pressure?

Holiday Stress tops tax season stressWhat would Dr. Hoffman say?Is berberine truly efficacious?My doctor recommends I drink alcohol to reduce stress and improve circulation

What do you think of thiamine as a treatment for Parkinson's?Is there a natural thyroid medicine you recommend that is not pork-derived?Please discuss the COVID-19 vaccine and cardiology issuesCan you help my granddaughter with guttate psoriasis?

The Holiday Season in NYCPeanut allergies cause and effectWhich calcium supplements can I take if I'm allergic to cow protein?Can my husband take saw palmetto in lieu of his prostate medications?What do you think of traction to help bulging discs?What is your take on green powder supplements?

What do you think of serrapeptase for reducing coronary plaque?We were told to get a TDAP vaccine or we wouldn't be able to see our new grandchild for 8 weeks!Do I have lupus?Which supplements tend to reduce negative effects of X-rays?

RFK Jr. issues sharpest ultimatum yet to medical schools: “Start teaching nutrition now or face penalties!” Fast-food outlets continue to abound in teaching hospitals; Once serious causes of flank pain are ruled out, patients are often left to fend for themselves; Potatoes don’t increase risk of diabetes—unless you eat French fries; Deep-frying in seed oils can yield harmful byproducts—but so, too, when you substitute with lard; As doctors get more aggressive treating blood pressure, how to minimize medication side effects; New study shows beetroot juice can lower BP by 7 points.

For weight loss, complete avoidance of ultra-processed foods outperforms mere “healthy diet” comprising minimally-processed items; Research fraud undermines anti-dementia drug pipeline; Comprehensive lifestyle modification program scores against cognitive decline; Women’s brains especially vulnerable to Omega-3 deficiencies; Bible says “Lame shall walk again” and 21st century science may soon bring about this miracle; Breakthroughs in rheumatoid arthritis treatment.

Nutritionist Leyla Muedin details key aspects of supplement use and addresses frequently asked questions. Topics include the importance of targeted supplementation, the rationale behind personalized dosages, best practices for starting new supplements, and managing common issues like nausea and bright yellow urine. Leyla also explains why some supplements may cause gastrointestinal discomfort and provides guidance on how to adjust dosages for optimal results. Emphasis is placed on the benefits of pharmaceutical-grade supplements available on Fullscript and the necessity of regular blood tests to fine-tune supplementation.

For dark days, get some sun in your eyesThe misleading vegan diet twin studyA least favorite thing from one of our listeners

What are your thoughts on the efficacy of strontium for bone health?What to you think of HRT for bone health?I have aortic valve stenosis. Is there any alternative to surgery?I have dry eyes after cataract surgeryAre there any benefits to Deer Antler for increasing HGH?

Dr. Jeffrey Bland, founder and president of the Personalized Lifestyle Medicine Institute and Big Bold Health, discusses his significant influence on functional medicine and offers a deep dive into the history and benefits of fish oil, including its impact on cardiovascular health, inflammation, and immune system resilience. Dr. Bland elaborates on the necessity of balanced Omega-3 fatty acids, particularly EPA and DHA, and the unique benefits of cold-processed fish oils that retain natural nutrients. The conversation also touches on Big Bold Health's innovative approach to health through products like Omega-3 Rejuvenate and Himalayan Tartary Buckwheat, highlighting their roles in...