Intelligent Medicine

40 Episodes
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By: Dr. Ronald Hoffman

Pioneering complementary medicine practitioner Dr. Ronald Hoffman takes a cutting-edge approach to health, wellness, and aging. He covers both conventional and alternative modalities, as well as nutrition, exercise, and supplements.

Leyla Weighs In: Rethinking Alzheimer's
Today at 7:00 AM

Nutritionist Leyla Muedin focuses on a new perspective in Alzheimer's research, particularly the role of microglial cells. She reveals insights from integrative neurologist Dr. David Perlmutter's presentation at the Integrative Healthcare Symposium, emphasizing the significance of microglial cells in Alzheimer's disease. The discussion highlights the traditional focus on beta amyloid plaques and introduces the importance of shifting from the M1 pro-inflammatory phenotype to the M2 anti-inflammatory phenotype of microglial cells. Dr. Perlmutter advocates for addressing systemic metabolic and inflammatory issues, pointing out factors like poor diet, lack of sleep, and high blood sugar, which are crucial in preventing Alzheimer's...


Q&A with Leyla, Part 1: Soup in Cold Weather
Yesterday at 7:02 AM

Soup in cold weatherStudy: No benefit from beta-blockers post heart attack, but vitamin D cuts risk of 2nd heart attack in half!New study links oxalic acid to gadolinium side effects and toxicityMore on the assault on young people's brains


Q&A With Leyla, Part 2: Water Filters
Yesterday at 7:00 AM

What can I do about a hip labrum tear?Are there any specific water filters that you recommend?What say you about lead levels in dark chocolate?



Aged Garlic Extract's Impact on Periodontal and Cardiovascular Health, Part 1
Last Wednesday at 7:02 AM

Clinical Pharmacist, Author, Board-Certified Clinical Nutritionist, and Health Expert Jim LaValle details the many health benefits of aged garlic extract, particularly its impact on periodontal disease. He reveals exciting new research findings that show Kyolic Aged Garlic Extract supplements can significantly reduce periodontal pocket depth -- a key indicator of gingivitis and periodontal disease progression. He also highlights the role of aged garlic extract in reducing inflammation and improving gum health, which in turn has significant implications for cardiovascular and cognitive health. The conversation also touches on various formulations of aged garlic extract available from Kyolic, the importance of...


Aged Garlic Extract's Impact on Periodontal and Cardiovascular Health, Part 2
Last Wednesday at 7:00 AM

Dr. Hoffman continues his conversation with clinical pharmacist, author, board-certified clinical nutritionist, and health expert Jim LaValle on the many health benefits of aged garlic extract.


Nasal Hygiene and Tooth Decay: The Science of Xylitol, Part 1
Last Tuesday at 7:02 AM

Nathan Jones, CEO of Xlear, Inc., details the benefits of xylitol in dental and respiratory health products such as nasal sprays and chewing gums under the Spry brand. Nathan advocates for the FDA to allow anti-cavity claims for xylitol and other compounds despite the current monopoly of fluoride in such claims. They question the efficacy and potential downsides of fluoride, and explore alternative dental health interventions. The episode also covers xylitol’s role in preventing tooth decay, respiratory health benefits during the COVID-19 pandemic, and ongoing legal challenges with the FTC. Discussions highlight the potential implications of oral health on...


Nasal Hygiene and Tooth Decay: The Science of Xylitol, Part 2
Last Tuesday at 7:00 AM

Dr. Hoffman continues his conversation with Nathan Jones, CEO of Xlear, Inc.


Intelligent Medicine Radio for November 15, Part 1: Benefits of Cocoa Flavanols
Last Monday at 7:02 AM

“Study” that’s not even a study spreads panic about dubious melatonin-heart failure link; Should you ignore dr’s advice to take powerful acid-blocking drugs? Novel implantable electrical pacemakers may bring relief to sufferers of severe constipation; Benefits of cocoa flavanols for heart, brain, athletic performance.

Give the gift of healthy chocolate! Go to FlavaNaturals.com and use coupon code HOFFMAN20 for 20% off site-wide. Plus get free shipping on all orders over $30. 


Intelligent Medicine Radio for November 15, Part 2: Coffee and Atrial Fibrillation
Last Monday at 7:00 AM

The FDA belatedly liberates women’s hormone replacement; Beta-blockers now deemed passé for routine heart attack aftercare; After most breast cancer surgery, adjuvant radiation brings no survival benefits; Can you drink caffeinated coffee if you have atrial fibrillation? Ignore frequent falls without attention to balance and stability training at your peril; Is it reasonable to contemplate a knee replacement surgery at 88? 


Leyla Weighs In: Exploring Antinutrients--The Double-Edged Sword in Your Diet
11/14/2025

Navigating the Complexities of Antinutrients in Your Diet: Leyla Muedin, a registered dietitian nutritionist, delves into the controversial topic of antinutrients. Responding to a question from a listener named Deanna, Leyla explains the different types of antinutrients—such as phytates, oxalates, tannins, lectins, goitrogens, and phytoestrogens—and their potential impacts on nutrient absorption. She discusses the dual nature of these compounds, highlighting their possible negative effects along with their roles in health benefits like gut microbiota support and anti-cancer properties. Leyla also shares practical food preparation tips for mitigating the adverse effects of antinutrients and emphasizes the importance of diet...


Q&A with Leyla, Part 1: Are children's IQs going down?
11/13/2025

Are children's IQs going down?An overview of medical reversalsCan you comment on the melatonin and heart failure study?Result of a prostate artery embolization


Q&A with Leyla, Part 2: The State of our Healthcare System
11/13/2025

I have hypothyroidism.  Do I need to be concerned about low ferritin levels?What are the benefits of lower-dose fish oil?Is there a connection between melatonin supplementation and depression?Can I take melatonin while on warfarin?What to do about the state of our healthcare system?


Holistic and High-Tech Approaches to Fertility with Gabriela Rosa, Part 1
11/12/2025

Fertility specialist Gabriela Rosa, the CEO and founder of the Rosa Institute, discusses the decline in fertility rates, the experiences of couples struggling to conceive, and the multifaceted methods used to address this issue. Gabriela shares her journey of merging conventional and holistic fertility sciences, citing real-life cases of couples who succeeded in conceiving after addressing underlying health issues. They delve into the importance of lifestyle factors, such as diet, exercise, and mental health, and discuss specific interventions like hormone management and supplements. The conversation also covers environmental influences, the role of metabolic health, and the critical importance of...


Holistic and High-Tech Approaches to Fertility with Gabriela Rosa, Part 2
11/12/2025

Dr. Hoffman continues his conversation with fertility specialist Gabriela Rosa, the CEO and founder of the Rosa Institute.


Women's Health Essentials, Part 1
11/11/2025

Neil Levin, Senior Nutrition Education Manager and product formulator for Now Foods and Protocol for Life Balance, discusses the importance of targeted nutrients for women's health. They delve into various supplements such as magnesium, myo-inositol, progesterone cream, D-Mannose, and biotin, explaining their benefits for conditions like PCOS, blood sugar regulation, menstrual migraines, urinary tract infections, and overall skin, hair, and nail health. The conversation also touches on the importance of tailoring nutrients to individual needs and the role of personalized nutrition in supporting women's health amidst modern stresses.


Women's Health Essentials, Part 2
11/11/2025

Dr. Hoffman continues his conversation with Neil Levin, Senior Nutrition Education Manager and product formulator for Now Foods and Protocol for Life Balance.


Intelligent Medicine Radio for November 8, Part 1: 4 Simple Lifestyle Measures Deliver 9 Additional Years of Disease-Free Healthspan
11/10/2025

Just 4 simple lifestyle measures deliver 9 additional years of disease-free healthspan; Study underscores protein’s role in staving off cancer, heart disease, and death; CoQ10 scores vs. neurodegeneration; Urolithin A (Mitopure®️) found to support athletic performance, immune function; Why you should ignore some influencers’ advice to avoid fish oil. 


Intelligent Medicine Radio for November 8, Part 2: New Non-Invasive Option for Men’s Age-Related Urinary Problems
11/10/2025

As little as 3000 steps per day can slow progression to Alzheimer’s Disease; Self-reports of memory impairment soaring among young people; New study vindicates unprocessed red meat—and even often-vilified processed red meat—for cancer and overall health. Prostate artery embolization (PAE) offers new non-invasive option for men’s age-related urinary problems; Targeting the mitochondria and the microbiome for Parkinson’s Disease; Popular prostate and hair loss prevention drugs linked to depression and suicide—while Cialis for urinary symptoms may stave off cardiovascular disease; Discovery that a safe, cheap medication may increase survival after breast cancer surgery. 


Leyla Weighs In: Part Two of The Gluten and Fructan Intolerance Dilemma
11/07/2025

Nutritionist Leyla Muedin discusses the differences between gluten intolerance and fructan intolerance, highlighting how many people mistakenly attribute their symptoms to gluten. She explains the role of FODMAPs in diet, their impact on gut health, and the importance of a personalized approach to managing intolerances. Additionally, Leyla reviews a recent study showing that vegans have significantly lower levels of Omega-3 fatty acids compared to other dietary groups, emphasizing the need for careful planning and necessary supplementation to maintain optimal health for those on plant-based diets.


Q&A with Leyla, Part 1: Melatonin for Bone Mineral Density?
11/06/2025

More on gadolinium effects and detoxI was found to have a small pericardial effusion. What advice can you give me?Is melatonin beneficial for bone mineral density? If so, how much should I take?


Q&A with Leyla, Part 2: Coffee Enemas for Liver Detox?
11/06/2025

Study: Mitopure's impact on immune parametersWhat important blood tests should one get, and what are the ideal levels to look for?I do coffee enemas for liver detox. How many can I do per week?  I've been on Metformin and lost some weight. Should I increase my dose to lose more?Could a recent dental implant be causing clogged ears and a hissing noise?


Tracking Cortisol: How Instant Monitoring Can Transform Your Health, Part 1
11/05/2025

Marina Pavlovic Rivas, co-founder and CEO of Eli Health, reveals a revolution in personal health monitoring through advanced wearable devices. They discuss the journey from primitive step counters to sophisticated devices, such as continuous glucose monitors (CGMs) and the world's first instant hormone monitoring system by Eli Health. The conversation delves into the new cortisol testing kit from Eli Health, exploring its implications for understanding stress, sleep, metabolism, and overall health. Rivas explains the process of using the device, its integration with a smartphone, and how AI helps interpret the hormone data for actionable insights. Future plans for Eli...


Tracking Cortisol: How Instant Monitoring Can Transform Your Health, Part 2
11/05/2025

Dr. Hoffman continues his conversation with Marina Pavlovic Rivas, co-founder and CEO of Eli Health.


Stress, Exercise, and the Heart: The Six Domains of Holistic Health, Part 1
11/04/2025

Dr. Alan Rozanski, a distinguished Professor of Medicine at the Icahn School of Medicine at Mount Sinai and Director of Nuclear Cardiology at Mount Sinai St. Luke's in New York City, details the holistic aspects of medicine, emphasizing the integrative approach involving lifestyle, mental health, exercise, and the psychological dimensions of heart health. Dr. Rozanski reveals the six domains of optimal health and vitality, sharing insights from his pioneering work in integrating such approaches into cardiology, the significant impact of stress, and the importance of maintaining a sense of life purpose and social connections. He also delves into modern...


Stress, Exercise, and the Heart: The Six Domains of Holistic Health, Part 2
11/04/2025

Dr. Hoffman continues his conversation with Dr. Alan Rozanski, a distinguished Professor of Medicine at the Icahn School of Medicine at Mount Sinai and Director of Nuclear Cardiology at Mount Sinai St. Luke's in New York City.


Intelligent Medicine Radio for November 1, Part 1: Topical Steroid Withdrawal
11/03/2025

TSW—Topical Steroid Withdrawal—when you’re hooked on steroid creams for a skin condition and can’t get off; Can diet, supplements, or Traditional Chinese Medicine help eczema? Strange bedfellows—when your hospital assigns you a homicidal roommate; Every step you take may reduce your risk of dying; Vitamin D and Omega-3 supplements reduce risk of autoimmune conditions; How long to curtail fish oil before a medical procedure or surgery? Supplements for neuropathy.


Intelligent Medicine Radio for November 1, Part 2: Daylight Savings Time Changeover Health Myths
11/03/2025

Daylight Savings Time changeover health myths busted; A doctor breaks her ankle and is billed $64,000 in uncovered expenses; Vitamin D shields life-prolonging telomeres, may help depression; The vaunted DASH Diet for hypertension faces off against low-carb alternative; The critical first 1000 days after conception—early life sugar avoidance yields major later life health dividends; Do you really need hot water to disinfect your hands?


Leyla Weighs In: The Truth About Gluten-Free Diets; Is Fructan Intolerance the Real Issue?
10/31/2025

Unveiling Fructan Intolerance: The Hidden Culprit Behind GI Issues. Leyla Muedin, a registered dietitian nutritionist, delves into the often misunderstood world of gastrointestinal issues, differentiating between gluten intolerance and fructan intolerance. She explains how emerging research suggests fructans, not gluten, may be the real trigger for many GI symptoms. Leyla discusses the structure, impact, and prevalence of fructans in various foods, and their role as prebiotics. She also highlights diagnostic methods and dietary approaches, particularly the Low FODMAP diet, to manage symptoms and properly identify intolerances. Check out part two of this episode next Friday.


Q&A with Leyla, Part 1: Sore Feet and Toes
10/30/2025

Will Truheight vitamins really make your kids grow?Where can I learn more about complementary medicine and nutrition?The balls of my feet are sore along with my toes. Is this a vitamin deficiency?


Q&A with Leyla, Part 2: Whole-Body Scans
10/30/2025

I recently had an ApoB test and am surprised that it isn't lower than it is.  Can you explain?I have an ascending thoracic aortic aneurysm.  How can I keep it from enlarging?Why are you against whole-body scans? Aren't they helpful?Can I take magnesium L-threonate while also taking magnesium glycinate?


Say Yes to NO: Exploring Nitric Oxide's Role in Health, Part 1
10/29/2025

In this episode of the Intelligent Medicine podcast, Dr. Ronald Hoffman discusses the vital role of nitric oxide in human health with expert Dr. Nathan Bryan, a pioneering scientist, health innovator, and biotech entrepreneur who's reshaping the conversation around longevity, human performance, and the truth behind modern health. He’s author of "The Secret of Nitric Oxide: Bringing the Science to Life." They explore the science behind nitric oxide, its numerous benefits, including its impact on cardiovascular health and erectile function, and the misconceptions surrounding common supplementation methods. Dr. Bryan explains how his research led to the development of ef...


Say Yes to NO: Exploring Nitric Oxide's Role in Health, Part 2
10/29/2025

Dr. Hoffman continues his conversation with  Dr. Nathan Bryan, a pioneering scientist, health innovator, biotech entrepreneur, and author of "The Secret of Nitric Oxide: Bringing the Science to Life." 


Mind, Body, Gut: A Comprehensive Look at Gastroenterology, Part 1
10/28/2025

In this episode of the Intelligent Medicine podcast, Dr. Ronald Hoffman is joined by Dr. Alexandra Shustina, a distinguished integrative gastroenterologist based in New York City and Miami. They delve into Dr. Shustina’s journey from conventional to integrative medicine, the importance of addressing the microbiome, and holistic approaches to treating gastrointestinal ailments like IBS, Crohn's disease, and ulcerative colitis. Dr. Shustina shares her insights on diet, the impact of stress, and the role of supplements and herbal remedies. She discusses the significance of personalized care, visceral manipulation, and mind-body techniques in promoting gut health. The episode also touches on...


Mind, Body, Gut: A Comprehensive Look at Gastroenterology, Part 2
10/28/2025

Dr. Hoffman continues his conversation with Dr. Alexandra Shustina, NYC’s and Miami’s premier Integrative board-certified Gastroenterologist and gut health specialist, an expert in the gut microbiome and its role in health and wellness.


Intelligent Medicine Radio for October 25, Part 1: Why Not All Fish Oils Are Alike
10/27/2025

New study suggests taking thyroid medication WITH food may be just as good as taking it on an empty stomach; Natural support for Parkinson’s Disease; Reviving the lost art of handwriting may be key to kid’s learning; Dr. Jeffrey Bland does a deep dive on why not all fish oils are alike.


Intelligent Medicine Radio for October 25, Part 2: Cancer Incidence is Soaring
10/27/2025

While we’re making progress in TREATING cancer, worldwide cancer INCIDENCE is soaring, especially among young people; New guidelines for colon cancer screening urge earlier start at age 45; Rates of peanut allergy are declining as more parents follow revised advice to introduce nuts earlier to kids; What’s with all the buzz about methylene blue? Legalization and stronger pot are creating an epidemic of ER visits for uncontrolled vomiting, debilitating abdominal pain; New smart toilet gives you a report card on your poop; When Zoloft doesn’t work for anxiety.


Leyla Weighs In on Navigating GLP-1 Medications: Addressing Side Effects and Maintaining Muscle Mass
10/24/2025

Leyla Muedin, a registered dietitian nutritionist, discusses the gastrointestinal (GI) side effects commonly experienced by patients using GLP-1 medications such as Ozempic and Rybelsus. Leyla introduces a nutraceutical called Digexin, created by N-X-T-U-S-A, which has shown promise in mitigating these side effects and improving overall well-being. The episode highlights the need for patients to prioritize animal protein intake and incorporate strength training to maintain muscle mass, especially when taking GLP-1 medications. Leyla emphasizes the importance of developing healthy habits and lifestyle changes to sustain weight loss after discontinuing these drugs.


Q&A with Leyla, Part 1: Hip Pain
10/23/2025

INFINITY Study on the timing of thyroid medication ingestionI have a growth near my eye that is changing in color and becoming crusty. What should I do?I've been suffering from hip pain for the last three years. Any suggestions on what to do?Could toxic exposures like mold cause conditions like low thyroid or autoimmunity?


Q&A with Leyla, Part 2: IBS
10/23/2025

With a calcium score of zero, is there any fat in your diet?  Are there any recommended supplements for IBS?What is the safest and most appropriate dose of vitamin D3 for most seniors?


ENCORE: Rethinking SNAP: Enhancing Nutrition and Access, Part 1
10/22/2025

Reforming SNAP. The Supplemental Nutrition Assistance Program—formerly known as food stamps—is designed to address nutritional gaps for economically disadvantaged Americans. But critics argue that SNAP’s lack of selectivity when it comes to ultra-processed foods stokes the current epidemic of obesity and metabolic disorders. Nutritionist Carolina Schneider, MS, RD, joins us to discuss an opportunity to reform SNAP. She makes the case for emphasizing fresh, minimally processed food as eligible for purchase under SNAP. Also, she urges inclusion of vitamin D under SNAP benefits because of the pervasiveness of vitamin D deficiency, especially among SNAP recipients. Check out a...