Intelligent Medicine | The Best of High Tech Medicine and Alternative Modalities

“The quick and the dead”: 80+ “Supermovers” show slowed cognitive decline; Dietary polyphenols help overcome vascular effects of prolonged sitting; Pros and cons of ketamine therapy for depression; Time-restricted eating alters microbiome to promote weight loss; Magnesium—what research reveals about better sleep, stress resilience, and whole-body wellness.

CBD may slow Alzheimer’s progression by tamping down brain inflammation; Fifty million dollar settlement in Gardasil Classic action; Urethral stricture as a side effect of ablation for enlarged prostate; Zero-sugar diet may have unanticipated adverse health consequences; Are there drug-free alternatives for atrial fibrillation? Can you reverse lactose intolerance with a skin patch?

Vitamin K2 (MK-7) and Coronary Artery Calcification: Insights from a 2-Year Trial: Nutritionist Leyla Muedin discusses a two-year randomized clinical trial in JAMA Cardiology from Maastricht University Medical Center reporting that daily vitamin K2 (menaquinone-7, MK-7) at 360 mcg slowed progression of coronary artery calcification (CAC) in 180 patients with confirmed atherosclerotic cardiovascular disease and baseline CAC 50–400 Agatston units. Compared with placebo, consistent MK-7 use was associated with 29% lower CAC progression and 42% less arterial calcium mass progression, though CAC still increased in both groups; stenosis increases were numerically lower with MK-7 but not statistically significant. Leyla notes many participants were on st...

World Cup!What did humans eat from the Ice Age to the Bronze Age?What supplements should I avoid while undergoing radiation therapy for prostate cancer?What is the treatment for sarcoidosis of the lung? Both my friend and his wife have it.

I'm 78 and had a hysterectomy.  Is it safe for me to eat tofu or other soy foods?Mitopure joins L'Oreal to create a face cream with Urolithin A.Does taking hyaluronic acid orally cause water retention?Can you discuss ETA contained in New Zealand green mussels?What are your thoughts on using vibration devices to help osteoporosis?

Nathan Jones, founder and CEO of Xlear, Inc., reveals xylitol’s role in supporting oral and nasal “gateway” microbiomes by selectively starving acid-producing Strep mutans rather than indiscriminately killing bacteria, and warns that harsh mouthwashes can disrupt beneficial oral bacteria linked to nitric oxide production and possibly blood pressure. Jones outlines Spry and Xlear products (gum, mints, toothpaste, mouthwash, dry-mouth “Rain,” and upcoming gummy candies, a new dental probiotic with added nutrients, and a direct-to-consumer oral bacteria test kit with pre/post tracking). He discusses diet, emphasizing sugar as a key driver of cavities and criticizing limited focus on sugar in a...

Dr. Hoffman continues his conversation with Nathan Jones, founder and CEO of Xlear, Inc.

Nitric Oxide Explained: Vascular Health, Exercise Performance, and N1o1 with Dr. Nathan Bryan, international Leader in Molecular Medicine, the first to describe nitrite and nitrate as indispensable nutrients required for optimal cardiovascular health. He details NO as a ubiquitous messenger affecting blood flow, erectile function, cognition, exercise performance, endothelial dysfunction, and aging-related declines in NO production. Bryan explains why PDE5 inhibitors like Viagra prolong cyclic GMP signaling but don’t fix NO deficiency, and why beet products often fail due to variable nitrate content and inadequate dosing. He outlines his NO lozenge approach that generates NO gas from so...

Dr. Hoffman continues his conversation with Dr. Nathan Bryan, international Leader in Molecular Medicine, the first to describe nitrite and nitrate as indispensable nutrients required for optimal cardiovascular health. 

Should you stop taking glucosamine based on a new study linking it to Alzheimer’s? What’s behind the spate of “Tai Chi Walking” social media posts? Undereye “festoons”—what to do about them? Are antibiotics the only treatment for SIBO? Vaping after smoking hikes risk for lung cancer.

Why aren’t there more medical insurance plans that cover alternative medicine? Solutions for Long Covid; MK7 vitamin K slows arterial calcification; Keto diet shows promise for treatment of anorexia; It’s not so much salt restriction—it’s the dietary sodium/potassium ratio in hypertension; Study finds multivitamins don’t keep you from getting Covid—but when you get it, it’s milder; Incidence of social anxiety disorder is soaring among young people.

Sleep, Glymphatic Detox, and the Hidden Heart Risks of Sleep Apnea: Nutritionist Leyla Muedin explains how sleep supports brain “housekeeping” via the glymphatic system, a glial-lymphatic waste-clearance network most active during sleep that moves cerebrospinal fluid through brain spaces to remove metabolites and toxic proteins such as amyloid beta, with sleep deprivation linked to amyloid accumulation. She notes other clearance pathways, including meningeal lymphatic vessels, whose impaired function is associated with neurodegenerative disease and brain injury. Reviews of human studies suggest sleep influences glymphatic outcomes, though results are inconsistent and methods vary. She emphasizes that poor sleep is associated with...

Is there any truth to some of the latest news that claims glucosamine supplements accelerate dementia and Alzheimer's?Some key points on methodology - what were they actually measuring?What does glucosamine have to do with hyperglycosylation?

What may be the real driver of persistent musculoskeletal pain in menopause?What are your thoughts on hyperbaric oxygen for treating hard-to-heal wounds?Kudos to holistic veterinarians!My prostate is Swiss cheese now after so many biopsiesWhat's the latest on melatonin?

In this episode of the Intelligent Medicine podcast, Dr. Ronald Hoffman interviews Professor Kieran Murphy, an interventional neuro radiologist and prolific inventor from Toronto Western Hospital. Dr. Murphy has developed numerous innovative medical devices and filed 60 patents. He shares insights from his book, “The Essence of Invention: Medicine and the Joy of Creativity,” discussing his work on medical innovation, his unique background, and personal experiences that have driven his creative solutions. The conversation covers various topics, including the importance of creativity, the impact of bureaucracy on modern medicine, and groundbreaking innovations like ozone therapy for herniated discs and a radi...

Dr. Hoffman continues his conversation with Dr. Kieran Murphy, author of “The Essence of Invention: Medicine and the Joy of Creativity,”

Pandemic Policies, Vaccines, and Harms to Children: pediatrician and author Dr. Elizabeth Mumper discusses her book “Kids and COVID: Costly Mistakes That Must Never Happen Again.” Mumper argues parents should question authorities, citing early pandemic decisions such as lockdowns, masking, and a “one size fits all” vaccine strategy despite children’s low risk from COVID. She supports the Great Barrington Declaration’s focus on protecting high-risk groups and criticizes suppression of repurposed treatments like hydroxychloroquine and ivermectin. The discussion raises concerns about mRNA vaccine safety, biodistribution of lipid nanoparticles, underreporting to VAERS, loss of long-term control groups, myocarditis risk in young mal...

Dr. Hoffman continues his conversation with pediatrician and author Dr. Elizabeth Mumper.

Want a suitcase of antibiotics? Online “wellness” companies will oblige, but the disruption to your microbiome may last up to 8 years; What’s the best form of curcumin? New push to promote nutrition instruction for doctors—is it enough? “Borderline anemia”—what could be the cause?

More than just a game—Knicks overcoming odds in game 4 comeback is a parable of resilience; A one and done lifetime cholesterol fix via gene modification; Will cataract surgery interfere with benefits of light exposure? Do amounts of vitamin A in various supplements taken together court the risk of toxicity? Smartphones and social media create real harm for adolescents; Experts determine the exact right amount of sleep down to the minute—but is it overreach? 

Perimenopause, Insulin Resistance, and Persistent Muscle & Joint Pain: A Functional Medicine Framework: Nutritionist Leyla Muedin discusses perimenopausal musculoskeletal symptoms—new or persistent joint pain, muscle aches, and tendon problems—and highlights a Clinician’s Journal article by physical therapist Tara Moore proposing insulin resistance screening in perimenopausal musculoskeletal care. She explains that declining estradiol during the menopausal transition can worsen insulin signaling, increase visceral fat, and reduce insulin sensitivity, affecting skeletal muscle recovery and potentially contributing to tendinopathies and poor or short-lived responses to localized treatments like PT. The framework emphasizes assessing systemic metabolic contributors (e.g., sedentary behavior, high-c...

Deprescribing thyroid and other meds in older adultsCan I safely take serrapeptase for longer than four weeks?I want to take nattokinase but isn't there a 'clot dislodging' risk?Could you discuss C. difficile and how to treat it?

I do stair climbing indoors in bad weather instead of walking outdoors. Is this worthwhile?The FDA no longer recommends use of radiation shields during X-ray procedures.  What say you?I have a queasy stomach feeling, and my blood sugar is higher than usual.  What are your thoughts?I've been using magnesium taurate to control palpitations and find I need more than usual.A comment about performance-enhancing drugs in professional sports

Comprehensive Insights into Bioidentical Hormone Replacement Therapy with Dr. Erika Schwartz, author of “The New Hormone Solution.” In this episode of the Intelligent Medicine Podcast, Dr. Ronald Hoffman speaks with Dr. Erika Schwartz, an expert in bioidentical hormone replacement therapy. They discuss the evolution and controversies surrounding hormone therapies, including the impact of the Women's Health Initiative study. Dr. Schwartz shares her insights on the importance of a tailored approach to hormone replacement, the benefits of different forms of estrogen and progesterone, and the role of testosterone, DHEA, and lifestyle choices in comprehensive care for menopause and andropause. Additionally, they...

Dr. Hoffman continues his conversation with Dr. Erika Schwartz, author of “The New Hormone Solution.”

Dr. Garth Nicolson, Founder, President, Chief Scientific Officer, and Emeritus Research Professor of Molecular Pathology at the Institute for Molecular Medicine in Huntington Beach, California, and Research Advisor for Nutritional Therapeutics, explains how membrane damage from free radicals and loss of mitochondrial transmembrane potential contribute to declining energy with age, noting studies in older adults showing improved energy output, fatigue, cognition, mood, and activity after NTFactor lipids, a protected phospholipid supplement balanced toward mitochondrial lipid composition. He describes evidence of lipid delivery using fluorescent-tagged lipids in sperm, with improved motility, and discusses applications including wound healing in veterans, removal...

Dr. Hoffman continues his conversation with Dr. Garth Nicolson, Founder, President, Chief Scientific Officer, and Emeritus Research Professor of Molecular Pathology at the Institute for Molecular Medicine in Huntington Beach, California, and Research Advisor for Nutritional Therapeutics.

The “Enhanced Games”, with no-holds-barred performance-enhancing drugs, yields scant advantages over “clean” contests; Does saturated fat increase insulin resistance? Can a heart attack victim avoid statin use with CoQ10? Omega-3 fish oil shows promise vs. type 2 diabetes; Motorized e-scooter use needs to be regulated NOW!

AI founders call for Congress to set guardrails against AI-accelerated bioweapon development; Deprescribing thyroid medication in seniors; Low-arginine/high lysine diets vs. herpes; Researchers test the “5 second rule” for dropped food; Long-term antidepressant use comes under new scrutiny.

Nutritionist Leyla Muedin discusses research showing simple strength tests—grip strength and a five-rep sit-to-stand chair test—predict longevity in older women. In a University at Buffalo study of over 5,000 women ages 63–99 followed for eight years, stronger grip and faster chair-stand times were linked to lower mortality; every additional 7 kg of grip strength corresponded to a 12% reduction in death risk, and faster chair-stands were also associated with improved survival, even after adjusting for activity, cardiovascular fitness, and inflammation. She emphasizes prioritizing muscle-strengthening alongside aerobic exercise and suggests accessible resistance options (weights, bodyweight moves, or household items) with professional guidance as nee...

Can topical B12 help relieve itching?The types of doctors to avoidGetting back to basicsA case study of lavender oil helping to relieve itchingYou say you're dairy sensitive but you use whey protein. Please explain.What are your thoughts on a lactose relief patch that is on offer?

Is high blood pressure genetic? Are we stuck having to take blood pressure meds?Could you please critique the study asserting fish oil supplements elevate the risk of atrial fibrillation?I've had strep throat three times in two months! What gives?I've had queasy reactions to protein added foods

A Brand New Tool for Gut, Inflammation, and Brain Support: Holistic Practitioner Jane Jansen details Essential Formulas’ Dr. Ohhira’s Postbiotic Fermented Food Concentrate, a non-GMO, gluten-free, dairy-free, capsule-free fermented paste in travel-friendly, non-refrigerated sachet packets. She explains the difference between probiotics and postbiotics, emphasizing that this concentrate delivers postbiotic metabolites (including short-chain fatty acids like butyrate, plus enzymes, amino acids, vitamins, peptides, and growth/repair factors) created via a five-year fermentation of fruits, vegetables, mushrooms, and seaweeds. 

Dr. Hoffman continues his conversation with holistic practitioner Jane Jansen.

Naturally Healthy Pets: Whole-Food Diets, Microbiome Repair, and Integrative Therapies with integrative veterinarian Dr. Judy Morgan, DVM, CVA, CVCP, CVFT. She argues that pet ownership benefits human wellbeing and that pets concentrate household toxins, warning against routine pesticide-based flea/tick and other veterinary drugs due to environmental contamination and adverse events. She recommends species-appropriate whole-food diets (cats as obligate carnivores; dogs mostly meat) and criticizes ultra-processed pet foods, synthetic nutrient premixes, grains/legumes in kibble, and high-carb diets that fuel yeast and inflammation; she discusses safe calcium, zinc, and vitamin D sources. In part two, she describes veterinary acupuncture...

Dr. Hoffman continues his conversation with integrative veterinarian Dr. Judy Morgan, DVM, CVA, CVCP, CVFT. 

A tale of 2 pneumonias—NASCAR racer Kyle Busch dead at 41 while Rudy Giuliani, age 81, survives critical care; Newly discovered evidence that Neanderthals were practicing dentistry—59,000 years ago! “Fatty 15”—does it measure up to the hype? Stem Wave—A shocking way to obtain pain relief; When to give antibiotics for a tick bite; Proposed ban on tobacco products for future generations of Brits aims to eradicate smoking.

Soon-to-arrive drugs promise to address elevated Lp(a); Best natural alternatives to repel mosquitoes and ticks; When cancer treatments cause osteoporosis; Organoids and computer simulations promise to reduce the toll of live animal experimentation; Land snails and pythons yield clues for new drug development; Shortfall in doctors accelerated by early retirement as physicians cite “hassle factor.”

Registered dietitian nutritionist Leyla Muedin discusses the growing interest in biological age versus chronological age and explains that biological aging is modifiable through consistent lifestyle choices. She outlines common measurement tools and biomarkers, including epigenetic clocks (DNA methylation), telomere length, VO2 max, inflammatory markers, grip strength, and muscle mass, noting that genetics account for only about 25–40% of biological aging variation. Key interventions include regular aerobic and resistance exercise, protein-adequate nutrition to preserve muscle and prevent sarcopenia (with whey protein and leucine-rich foods noted), improved sleep, stress management, reducing processed foods and visceral fat, and lowering chronic inflammation (CRP, IL-6). Sh...

An overview of itchingWould tofu be a good addition to my diet?Is TMAO a risk factor for heart disease when eating meat?How about interviewing an expert on vegetarianism?