Healthy Dialogue
Go beyond the latest discoveries with nuanced, in-depth conversations in Healthy Dialogue, a podcast from the JAMA Network. Host and JAMA Senior Editor, Derek C. Angus, MD, MPH, sits down with the world's leading experts to explore the most pressing issues in health and health care.
Menopause Part 2: Why Are So Many Physicians Unprepared to Treat This Natural Transition?
In episode 2 of our Healthy Dialogue on Menopause, Rebecca Thurston, PhD, discusses the lack of clinician training and research investment in menopause, as well as new treatment options.
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Menopause Part 1: Beyond Hormones and Hot Flashes
Menopause affects half the population yet is critically understudied and often overlooked or misunderstood by much of the medical profession. In episode 1 of our Healthy Dialogue on Menopause, Rebecca Thurston, PhD, explains the physiology, symptoms, and health risks associated with menopause.
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Breast Cancer Part 2: The Reality of Breast Cancer Screening and Care Today
In part 2 of this Healthy Dialogue on breast cancer, Nancy E. Davidson, MD, discusses changes in screening, the patient journey, and what may lie ahead with advances in AI, cancer vaccines, and preventive medicine.
Correction: a previous version of this podcast incorrectly identified Fran Visco as the founder of NABCO. Visco is the president of the National Breast Cancer Coalition (NBCC).
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Breast Cancer Part 1: From Deadly to Manageable Disease
Breast cancer has undergone a dramatic transformation over the past several decades. Five-year survival rates are now 92% compared with 76% in 1975. In this special 2-part episode of Healthy Dialogue, Nancy E. Davidson, MD, oncologist and chief academic officer and executive vice president of Fred Hutchinson Cancer Center, discusses the advancements that led to these improvements.
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Providing Rural Health Care Is Really Hard; 60 Million Americans Rely on It
Approximately 1 in 5 Americans live in rural areas, and in the coming years they will see dramatic shifts in their health care options due to the One Big Beautiful Bill Act. In this episode of Healthy Dialogue Mark Holmes, PhD, joins host Derek C. Angus, MD, MPH, to explore the impact of upcoming cuts to Medicaid and the $50 billion Rural Health Transformation Program.
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Long COVID: the problem society wants to forget
Long COVID is a debilitating condition impacting millions of people around the world, but is still poorly understood, poorly defined, and poorly treated. In this episode of Healthy Dialogue, host Derek C. Angus, MD, MPH, discusses long COVID with Wes Ely, MD, MPH, professor of medicine at Vanderbilt University, and co-author of the NASEM report on Long COVID.
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Everyone Will Feel the $1 Trillion Cut in Medicaid
Medicaid provides health insurance for 1 in 5 Americans and plays a crucial role in US health care infrastructure. The One Big Beautiful Bill Act (OBBBA) is estimated to cut Medicaid spending by nearly $1 trillion by 2034 and cause millions of enrollees to lose coverage. In this episode of Healthy Dialogue, Julie Donohue, PhD, professor and chair of health policy and management at the University of Pittsburgh, breaks down what Medicaid is, who it covers, and how proposed cuts in the OBBBA could have far-reaching effects on patients, clinicians, hospitals and communities.
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Should Everyone be on GLP-1s?
GLP-1 receptor agonists are one of the most revolutionary new classes of drugs in decades. In this episode of Healthy Dialogue, host Derek C. Angus, MD, MPH, sat down with Jens Juul Holst, MD, DMSc, and Lotte Bjerre Knudsen, DMSc, 2 pioneering scientists behind the discovery and development of GLP-1 RAs. Together, they traced the fascinating origin story of GLP-1 RAs and offered their thoughts on what comes next.
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Food Politics, Obesity, and the "Wicked Mess" We're In
The United States has witnessed a staggering rise in obesity beginning in the early 1980s, leading to a wide array of important health consequences including heart disease, diabetes, and premature death. In this episode of Healthy Dialogue, Host Derek C. Angus, MD, MPH, talks with Marion Nestle, PhD, MPH, Paulette Goddard Professor Emerita at New York University and influential author on food politics, for a candid conversation about how society became ensnared in the current obesity epidemic and what might untangle it.
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Why and How Should the Government Fund Biomedical Research?
This episode of Healthy Dialogue explores the history and future of science funding in the US in light of recent changes, and proposed changes, from the federal government. Host Derek Angus, MD, MPH, speaks with former editor in chief of Science and a former director of the National Institute of General Medical Sciences at the NIH, Jeremy Berg, PhD.
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Social Media Use by Children – wonderful, hazardous, or something in-between?
In this episode of Healthy Dialogue, host Derek Angus, MD, MPH sits down with Dimitri Christakis, MD, MPH, to discuss whether social media use disorder is a real phenomenon, the mechanisms behind it, and its consequences for young people.
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Unpacking the Increase in Early-Onset Cancer
A growing number of young adults are being diagnosed with cancer, particularly colorectal cancer, but the underlying cause remains unclear. In this episode of Healthy Dialogue, Kimmie Ng, MD, MPH, and Ilana Richman, MD, MHS, discuss the increase in cases, potential causes, diagnostics, treatment, and more.
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Private Equity's Growing Presence in Health Care: Promise or Peril?
Private equity investment continues to expand across US health care. Current estimates put private equity ownership at almost 10% of hospitals and more than one-fifth of for-profit hospitals nationwide. In this episode of Healthy Dialogue, Sneha Kannan, MD, MS, assistant professor of critical care medicine at the University of Pittsburgh, joins host Derek C. Angus, MD, MPH, to discuss the complex role of private equity in health care and what it means for clinicians and patients.
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A New Era in Dementia: Advances in Diagnostic Blood Tests, Novel Drugs, and the Power of Lifestyle Changes
Dementia affects millions of people globally, causing profound memory loss and cognitive impairment and compromising the ability to function independently in day-to-day life. In this episode of Healthy Dialogue, host Derek C. Angus, MD, MPH, sat down with Gil Rabinovici, MD, a neurologist and director of the UCSF Alzheimer's Disease Research Center, to discuss the latest developments in dementia and Alzheimer disease research.
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AI Scribes Are Here, but Is Health Care Ready?
The rise in use and function of ambient AI scribes is arguably one of the fastest technologic changes ever seen in health care. In this episode of Healthy Dialogue, host Derek Angus, MD, MPH, is joined by Vincent Liu, MD, MS, Chief Data Officer of The Permanente Medical Group in Kaiser Permanente, to discuss the rapidly changing world of ambient AI.
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Rethinking the Autism "Epidemic": What's Driving the Rise in Diagnosis
What is behind the rise in autism diagnoses? Join Jeremy Veenstra-VanderWeele, MD, professor of developmental neuropsychiatry at Columbia University, and JAMA Psychiatry Editor Dost Ă–ngĂĽr, MD, PhD, as they discuss the history of autism spectrum disorder, the role that genetics and environmental factors play, the importance of early intervention in treatment, and more with JAMA Senior Editor Derek Angus, MD, MPH.
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Introducing Healthy Dialogue
Go beyond the latest discoveries with nuanced, in-depth conversations in Healthy Dialogue, a podcast from the JAMA Network. Host and JAMA Senior Editor, Derek C. Angus, MD, MPH, sits down with the world's leading experts to explore the most pressing issues in health and health care.
From the JAMA Network: JAMA Research of the Year With Editor in Chief Kirsten Bibbins-Domingo
In this episode, JAMA Editor in Chief Kirsten Bibbins-Domingo, PhD, MD, MAS, and Medical News Director Jennifer Abbasi discuss the journal's inaugural Research of the Year roundup.
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The Sequential Organ Failure Assessment (SOFA)-2 Score
SOFA-2, validated in more than 3 million intensive care unit (ICU) patients, incorporates contemporary organ support treatments, showing strong predictive validity for ICU mortality in diverse international settings. Coauthor Mervyn Singer, MD, joins JAMA Associate Editor Christopher W. Seymour, MD, MSc, to discuss.
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From the JAMA Network: Acetaminophen Use in Pregnancy and Risk of Autism
Epidemiologist Brian Lee, PhD, discusses his study on acetaminophen use during pregnancy and children's risk of autism and other neurodevelopmental disorders in this interview with JAMA Deputy Editor Linda Brubaker, MD.
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From the JAMA Network: AI-Based Analysis for Parkinsonism
Delaying diagnosis of parkinsonism can mean delaying care. In a study recently published in JAMA Neurology, David Vaillancourt, PhD, and colleagues tested the ability of an AI model to differentiate between Parkinson disease and other neurodegenerative disorders when paired with MRI. He joins JAMA and JAMA+ AI Associate Editor Yulin Hswen, ScD, MPH to discuss.
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Treatment of Complicated Staphylococcus aureus Bacteremia
Dalbavancin, a long-acting IV lipoglycopeptide, may be an option for the treatment of complicated Staphylococcus aureus bacteremia without requiring long-term IV access. Author Thomas L. Holland, MD, MSc, from Duke University School of Medicine discusses key points of the DOTS randomized clinical trial and more with JAMA Deputy Editor Preeti Malani, MD, MSJ.
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From the JAMA Network: Incidence and Nature of Antidepressant Discontinuation Symptoms
Interview with Sameer Jauhar, PhD, author of Incidence and Nature of Antidepressant Discontinuation Symptoms: A Systematic Review and Meta-Analysis. Hosted by John Torous, MD.
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From the JAMA Network: GLP-1 Receptor Agonists in Idiopathic Intracranial Hypertension
Interview with Dennis J. Rivet II, MD, author of GLP-1 Receptor Agonists in Idiopathic Intracranial Hypertension. Hosted by Cynthia E. Armand, MD.
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Life Support and Outcomes in Patients Admitted to Intensive Care Units
Nationwide data are unavailable regarding changes in intensive care unit (ICU) outcomes over the past 10 years, limiting understanding of practice changes. Authors Emily Moin, MD, MBE, and Scott D. Halpern, MD, PhD, MBE, of the University of Pennsylvania join JAMA Associate Editor Christopher W. Seymour, MD, MSc, to discuss how ICU care and outcomes have changed in the US over the past decade.
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Increases in Invasive Group A Streptococcal Infections
The incidence of invasive group A streptococcal infections has risen in the US. Similar observations have been reported in other parts of the world. Authors Joshua Osowicki, MBBS, PhD, of Murdoch Children's Research Institute and Theresa L. Lamagni, MSc, PhD, of the United Kingdom Health Security Agency join JAMA Deputy Editor Preeti Malani, MD, MSJ, to discuss the public health challenge posed by group A strep.
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Preventive Health Care Among Adults Eligible for Lung Cancer Screening
Less than 20% of patients eligible for lung cancer screening get screened in the US. A recent study examined whether adults eligible for lung cancer screening engage in screening for other types of cancer. Coauthor Chi-Fu Jeffrey Yang, MD, of Harvard Medical School joins JAMA Deputy Editor Tracy Lieu, MD, to discuss.
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Cardiac Arrests During Long-Distance Running: What's Changed?
Despite increased participation in US long-distance running races, cardiac arrest incidence remains stable. Authors Jonathan Kim, MD, MSc, of Emory University, and Aaron Baggish, MD, of the University of Lausanne Switzerland, discuss the RACER 2 study and compare results with initial findings published in the RACER 1 study from 13 years ago, with JAMA Associate Editor Gregory Marcus, MD, MAS.
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Inhaled Sedation With Sevoflurane for Acute Respiratory Distress Syndrome (ARDS)
ARDS, which is characterized by hypoxemic respiratory failure and inflammatory injury to the lungs, has a mortality rate of 30% to 40%. Balasubramanian Venkatesh, MD, of the George Institute for Global Health joins JAMA Deputy Editor Kristin Walter, MD, MS, to discuss the effects of inhaled sedation with sevoflurane for patients with moderate to severe ARDS.
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New FDA Pulse Oximetry Guidance: Strengths and Weaknesses
The US Food and Drug Administration (FDA) issued new draft regulatory guidance for pulse oximeters related to skin pigment. The guidance is a step forward but it may have unintended consequences. Authors Michael Lipnick, MD, and Philip Bicker, MD, PhD, professors of anesthesia at University of California, San Francisco, discuss this and more with JAMA Executive Editor Gregory Curfman, MD.
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Combining CAC Score With Treatment on Plaque Progression in Familial Coronary Artery Disease
The CAUGHT-CAD randomized clinical trial sought to determine whether a CAC score-informed strategy could slow the progression of coronary plaque volume. Author Thomas H. Marwick of the Baker Heart & Diabetes Institute joins JAMA Associate Editor Pradeep Natarajan to discuss "Effects of Combining Coronary Calcium Score With Treatment on Plaque Progression in Familial Coronary Artery Disease."
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Evaluating Treatments for Amyotrophic Lateral Sclerosis
The HEALEY ALS platform is an innovative first attempt at platform trials in ALS, looking to slow ALS disease progression. Author Sabrina Paganoni, MD, PhD, of Massachusetts General Hospital and Harvard Medical School, discusses results of the first 4 drug regimens from this platform trial and how this study design makes efficient use of resources, with JAMA Deputy Editor Christopher Muth, MD.
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US Health Care Spending by Health Condition and County—What Drives Variation?
Understanding health conditions with the most spending and variation across locations and over time is important for identifying trends, inequalities, and strategies for lowering health spending. Joseph Dieleman, PhD, of the University of Washington speaks with JAMA Associate Editor Karen Joynt Maddox, MD, MPH, about county-level variation in health care spending across the US.
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Supporting Children and Families in an Era With Abortion Restrictions
Two recent studies published in JAMA provide evidence about the effects of state-level abortion restrictions on birth rates and infant mortality. Author Alyssa Bilinski, PhD, MSc, of Brown University School of Public Health joins JAMA Deputy Editor Tracy Lieu, MD, to discuss her related Editorial "Abortion May Be Controversial—Supporting Children and Families Need Not Be."
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Evaluating Comprehensive Models–Challenges and Innovations in Dementia Care
Contemporary models of dementia care are multidisciplinary and aim to bridge medical and social services. Julie P. W. Bynum, MD, MPH, of the University of Michigan speaks with JAMA Deputy Editor Christopher C. Muth, MD, about 2 trials—the D-CARE and IN-PEACE trials—that evaluated care models to support people diagnosed with dementia and their caregivers.
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Intra-Arterial Thrombolytics Following Thrombectomy for Ischemic Stroke
Two new trials published in JAMA evaluate the efficacy of periprocedural intra-arterial thrombolytics after successful endovascular thrombectomy for patients with acute ischemic stroke. Diederik Dippel, MD, PhD, of Erasmus University Medical Center discusses this and more with JAMA Deputy Editor Christopher C. Muth, MD.
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Impact of Private Equity Acquisition on Patient Care Experience in US Hospitals
Private equity acquisitions of health care facilities have rapidly increased over the past decade. However, little is known about the effects of these acquisitions on patient experience. Author Rishi K. Wadhera, MD, MPP, MPhil, of Harvard Medical School discusses this topic with JAMA Associate Editor Karen Joynt Maddox, MD, MPH.
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Asthma Endotypes Based on Nasal Epithelial Biopsies in School-Aged Youth
Certain CD4+ T-cell subtypes play a role in asthma. Characterizing asthma endotypes in diverse groups is important to help develop effective therapies for youth with asthma. Author Juan C. Celedon, MD, DrPH, University of Pittsburgh, Department of Pediatrics, discusses this and more with JAMA Deputy Editor Kristin L. Walter, MD, MS.
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Dental Benefits and Medicare Advantage Plans
Most Medicare Advantage (MA) plans offer dental care coverage as a supplemental benefit. However,few beneficiaries are enrolled in an MA plan that provides comprehensive dental benefits. Lisa Simon, MD, DMD, discusses this and more with JAMA Deputy Editor Kristin L. Walter, MD, MS.
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2024 Update on Long COVID Classification and Symptom List
Long COVID is now defined as a heterogeneous, infection-associated chronic condition present for at least 3 months after SARS-CoV-2 infection. Author Leora Horwitz, MD, MHS, of NYU Grossman School of Medicine joins JAMA Executive Editor Gregory Curfman, MD, to discuss the JAMA article "2024 Update of the RECOVER-Adult Long COVID Research Index."
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