Clinical Chemistry Podcast

40 Episodes
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By: Association for Diagnostics and Laboratory Medicine

This free monthly podcast is offered by Clinical Chemistry. Clinical Chemistry is the leading forum for peer-reviewed, original research on innovative practices in today's clinical laboratory.

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From Pooled Cohorts to PREVENT: A Perspective for Clinical Laboratorians
Yesterday at 6:53 PM

Ryan Pearce, Leslie J Donato, Vlad C Vasile, Allan S Jaffe, Jeffrey W Meeusen. From Pooled Cohorts to PREVENT: A Perspective for Clinical Laboratorians. Clinical Chemistry, Volume 72, Issue 7, July 2026, Pages 814–816. https://doi.org/10.1093/clinchem/hvag044


Disseminated Coccidioidomycosis in Immunocompetent Hosts: Opportunities for Increased Recognition and Timely Diagnosis
Last Wednesday at 6:00 PM

Anna C H Hoge, Thomas E Grys, Erin H Graf. Disseminated Coccidioidomycosis in Immunocompetent Hosts: Opportunities for Increased Recognition and Timely Diagnosis. Clinical Chemistry, Volume 72, Issue 5, May 2026, Pages 575–582. https://doi.org/10.1093/clinchem/hvaf187


Audio Summary July 2026
06/23/2026


DPYD Sequencing Identifies More Clinically Relevant Variants as Compared to Targeted Genotyping
06/22/2026

Ann M Moyer, Emma Lundquist, Emily K Thoreson, Michelle L Kluge, Katrina E Kotzer, Elyse M Love, Heather L Glessner, Sarah K Arneson, Loralie J Langman, Linnea M Baudhuin, John Logan Black. DPYD Sequencing Identifies More Clinically Relevant Variants as Compared to Targeted Genotyping. Clinical Chemistry, Volume 72, Issue 6, June 2026, Pages 662–669. https://doi.org/10.1093/clinchem/hvag007.


Universal Presence of Gene/Variant Nomenclature Errors in Journal Manuscript Submissions
06/05/2026

Lisa A Lansdon, Binu Porath, Mari Mori, David T Miller, Diane Dunham Drexler, Catherine Wattenberg, Morgan Richardson, Robert D Steiner, Peter J Freeman. Universal Presence of Gene/Variant Nomenclature Errors in Journal Manuscript Submissions. Clinical Chemistry, Volume 72, Issue 6, June 2026, Pages 652–661. https://doi.org/10.1093/clinchem/hvag010


Frameworks of Health Outcomes for Performance Specifications in Laboratory Medicine
06/04/2026

Patrick M Bossuyt, Tze Ping Loh, Katy Bell, Sally Lord, Andrea R Horvath. Frameworks of Health Outcomes for Performance Specifications in Laboratory Medicine. Clinical Chemistry, Volume 72, Issue 5, May 2026, Pages 546–553. 

https://doi.org/10.1093/clinchem/hvag014


Fecal Microbiota Therapy: Clinical Laboratory Testing and Metabolomic Approaches for Donor Screening, Product Assessment, and Patient Monitoring
05/28/2026

Grace Drew, Colleen S Kraft, Nirja Mehta. Fecal Microbiota Therapy: Clinical Laboratory Testing and Metabolomic Approaches for Donor Screening, Product Assessment, and Patient Monitoring. Clinical Chemistry, Volume 72, Issue 5, May 2026, Pages 554–563.  

https://doi.org/10.1093/clinchem/hvaf156


Audio Summary June 2026
05/22/2026


Diagnostic Value of Serum p-tau217 in Alzheimer Disease: Equal to Plasma in Levels and Clinical Utility?
05/18/2026

Andrea L Benedet, Burak Arslan, Kubra Tan, Hanna Huber, Ilaria Pola, Guglielmo Di Molfetta, Hlin Kvartsberg, Anna Orduña Dolado, Shorena Janelidze, Kaj Blennow, Henrik Zetterberg, Oskar Hansson, Pedro Rosa-Neto, Nicholas J Ashton. Diagnostic Value of Serum p-tau217 in Alzheimer Disease: Equal to Plasma in Levels and Clinical Utility? Clinical Chemistry, Volume 72, Issue 2, February 2026, Pages 303–315, https://doi.org/10.1093/clinchem/hvaf162


Methods to Improve Confidence in the Accuracy of Molecular Testing for Multidrug-Resistant Tuberculosis
05/13/2026

Denise M O'Sullivan, Gerwyn M Jones, Manca Zolnir-Dovc, Richard Phillips, Rejoice Arthur, Bariki Mtafya, Daniel Adon Mapamba, Daniela Maria Cirillo, Ewa Augustynowicz-Kopeć, Mei Mei Ho, Belinda Dagg, Sven O Friedrich, Francesca Colavita, Antonella Vulcano, Prince Asare, Dorothy Yeboah-Manu, Timothy D McHugh, Jim F Huggett. Methods to Improve Confidence in the Accuracy of Molecular Testing for Multidrug-Resistant Tuberculosis. Clinical Chemistry, Volume 72, Issue 3, March 2026, Pages 390–397. https://doi.org/10.1093/clinchem/hvaf178


Audio Summary May 2026
04/23/2026


Quantum Machine Learning and Data Re-Uploading: Evaluation on Benchmark and Laboratory Medicine Data Sets
04/21/2026

Thomas J S Durant, Seung Joo Lee, Sarah N Dudgeon, Elizabeth Knight, Brent Nelson, H Patrick Young, Lucila Ohno-Machado, Wade L Schulz. Quantum Machine Learning and Data Re-Uploading: Evaluation on Benchmark and Laboratory Medicine Data Sets. Clinical Chemistry, Volume 72, Issue 4, April 2026, Pages 451–460. https://doi.org/10.1093/clinchem/hvaf192


Scientific Fraud at Scale: Challenges for Trust in Published Data
04/21/2026

Preejith P Vachali, Adam J McShane. Scientific Fraud at Scale: Challenges for Trust in Published Data. Clinical Chemistry, Volume 72, Issue 4, April 2026, Pages 518–519.  

https://doi.org/10.1093/clinchem/hvag002


Pre-Exposure Prophylaxis (PrEP)-Associated HIV Monitoring and Self-Testing
04/14/2026

Yusheng Zhu, Jarrett Sell. Pre-Exposure Prophylaxis (PrEP)-Associated HIV Monitoring and Self-Testing. Clinical Chemistry, Volume 72, Issue 4, April 2026, Pages 439–450. https://doi.org/10.1093/clinchem/hvaf155


Endogenous Lithium Levels and Alzheimer Disease
04/13/2026

Raymond T Suhandynata, Elizabeth A Bevins, Imir G Metushi. Endogenous Lithium Levels and Alzheimer Disease. Clinical Chemistry, Volume 72, Issue 3, March 2026, Pages 424–425. https://doi.org/10.1093/clinchem/hvaf174


Audio Summary April 2026
03/28/2026


PREEMPT'ing Overreliance on Peripheral Blood-Based ColoRectal Cancer Screening
03/10/2026

David H Wang. PREEMPT'ing Overreliance on Peripheral Blood-Based ColoRectal Cancer Screening. Clinical Chemistry, Volume 72, Issue 3, March 2026, Pages 328–330. https://doi.org/10.1093/clinchem/hvaf137


A Turning Point for Lipoprotein(a) Treatment: Are Clinical Laboratories Ready?
02/23/2026

Leslie J Donato. A Turning Point for Lipoprotein(a) Treatment: Are Clinical Laboratories Ready? Clinical Chemistry, Volume 72, Issue 2, February 2026, Pages 222–224. https://doi.org/10.1093/clinchem/hvaf101


Audio Summary March 2026
02/23/2026


Global IVD: Barriers, Trends, and Future
02/09/2026

Min Yu, Zhen Zhao, Dennis J Dietzen, Damien Gruson, Jinjie Hu, Anthony A Killeen, Davide Manissero, Tahir S Pillay. Global IVD: Barriers, Trends, and Future. Clinical Chemistry, Volume 72, Issue 2, February 2026, Pages 225–231.  https://doi.org/10.1093/clinchem/hvaf184


Uterus Transplantation—Current Evaluation, Monitoring, and Emerging Diagnostics
01/27/2026

Andrew Jacques, Giuliano Testa, Massimo Mangiola, Liza Johannesson. Uterus Transplantation—Current Evaluation, Monitoring, and Emerging Diagnostics. Clinical Chemistry, Volume 72, Issue 1, January 2026, Pages 18–26. https://doi.org/10.1093/clinchem/hvaf143


Audio Summary February 2026
01/26/2026


Unmet Clinical Needs and Remaining Challenges of Pregnancy Reference Intervals
01/21/2026

Vilte E Barakauskas, Samantha Pawer, Wee-Shian Chan, Benjamin P Jung. Unmet Clinical Needs and Remaining Challenges of Pregnancy Reference Intervals. Clinical Chemistry, Volume 72, Issue 1, January 2026, Pages 47–60. https://doi.org/10.1093/clinchem/hvaf150


From Diagnosis to Delivery: A Look at the Continuing Gap in Maternal Testing
01/05/2026

Callie Torres, Jeannie Kelly, Ann M Gronowski.
From Diagnosis to Delivery: A Look at the Continuing Gap in Maternal Testing.
Clinical Chemistry, Volume 72, Issue 1, January 2026, Pages 27–34, 
https://doi.org/10.1093/clinchem/hvaf109


Audio Summary January 2026
12/22/2025


Per se driving under the influence of cannabis statutes and blood delta-9-tetrahydrocannabinol concentrations following short-term cannabis abstinence
12/22/2025

Robert L Fitzgerald, Anya Umlauf, Raymond T Suhandynata, David J Grelotti, Marilyn A Huestis, Kyle F Mastropietro, Igor Grant, Thomas D Marcotte. Per Se Driving Under the Influence of Cannabis Statutes and Blood Delta-9-Tetrahydrocannabinol Concentrations following Short-Term Cannabis Abstinence. Clinical Chemistry, Volume 71, Issue 12, December 2025, Pages 1225–1233. https://doi.org/10.1093/clinchem/hvaf121


Regulatory Fragmentation in Europe and Its Risks for Patient Access and Safety: Subcontracting Work Flow Steps of In-House Diagnostic Procedures
12/12/2025

Raymond Nistor-Gallo, Kurt Zatloukal, Karin Schwenoha. Regulatory Fragmentation in Europe and Its Risks for Patient Access and Safety: Subcontracting Work Flow Steps of In-House Diagnostic Procedures. Clinical Chemistry, Volume 71, Issue 12, December 2025, Pages 1202–1211. https://doi.org/10.1093/clinchem/hvaf123


Transdermal GFR Signals a New Horizon in Renal Diagnostics
12/08/2025

Vrajesh Pandya. Transdermal GFR Signals a New Horizon in Renal Diagnostics. Clinical Chemistry, Volume 71, Issue 12, December 2025, Pages 1281–1282. https://doi.org/10.1093/clinchem/hvaf106


Modern Low-Density Lipoprotein Cholesterol Formulas Outperform Direct Methods in Patients with Hypertriglyceridemia and Low Levels of Low-Density Lipoprotein Cholesterol
11/20/2025

Jeffrey W Meeusen, Xin Yi, Steven W Cotten, Jacob B Nielsen, Leslie J Donato, Patricia M Jones, Alagar R Muthukumar, Rafael Zubirán, Alan T Remaley, Jing Cao, Modern Low-Density Lipoprotein Cholesterol Formulas Outperform Direct Methods in Patients with Hypertriglyceridemia and Low Levels of Low-Density Lipoprotein Cholesterol, Clinical Chemistry, Volume 71, Issue 11, November 2025, Pages 1138–1146, https://doi.org/10.1093/clinchem/hvaf099


Audio Summary December 2025
11/17/2025


Post-Translationally Modified Proteoforms as Biomarkers: From Discovery to Clinical Use
11/05/2025

Ruben Y Luo, Priscilla S W Yeung, Morgan W Mann, Lichao Zhang, Yifei K Yang, Andrew N Hoofnagle, Post-Translationally Modified Proteoforms as Biomarkers: From Discovery to Clinical Use, Clinical Chemistry, Volume 71, Issue 11, November 2025, Pages 1111–1124, https://doi.org/10.1093/clinchem/hvaf094


Embracing Generative Artificial Intelligence as a Support Tool for Clinical Decision-Making
11/05/2025

Nicholas C Spies, Embracing Generative Artificial Intelligence as a Support Tool for Clinical Decision-Making, Clinical Chemistry, Volume 71, Issue 11, November 2025, Pages 1178–1179, https://doi.org/10.1093/clinchem/hvaf084


Diagnostic Value of Digital Estimates of Trophoblastic Mosaicism in Genome-Wide Cell-Free Fetal DNA Screening
10/21/2025


Risk vs Prevalence: Weighing Routine DPYD Variant Testing Prior to Fluoropyrimidine-Based Chemotherapy
10/21/2025


Audio Summary November 2025
10/20/2025


Optimizing Estimation: Perspective on Drug Dosing Using New CKD-EPI Equations
10/17/2025


Audio Summary October 2025
09/22/2025


Utilizing the Stability of Individual Homeostatic Setpoints over Time - A Step Forward on the Path to Personalized Laboratory Medicine
09/11/2025


Advances in Syphilis Diagnostics to Address the 21st-Century Epidemic
09/10/2025


Machine Learning for Detecting Iron Deficiency through Comprehensive Blood Analysis
09/04/2025