EASL Podcasts
The EASL Podcast collection brings together Talk Liver to Me, EASL’s exclusive original podcast, alongside educational audio content adapted from EASL Studio, DeepDive webinars, and Policy Dialogues. Stay informed with expert insights, practical discussions, and the latest knowledge in hepatology — anytime, anywhere.
Talk Liver To Me - Cholangiocarcinoma surveillance in PSC: What should we do now and what’s coming next?
Discover how clinicians are approaching screening and surveillance in PSC today. From imaging and endoscopy to the promise of new biomarkers, this episode highlights key tools, ongoing challenges, and future directions in improving early detection of cholangiocarcinoma.
Host: Debbie Shawcross (King's College London)
Guests: Jesús Bañales (Donostia University Hospital), Gideon Hirschfield (The Autoimmune and Rare Liver Disease Programme)
This episode is also available on EASL Campus: https://easlcampus.eu/tltm/episode-21
Thank you to our healthcare industry partners for their support. For more i...
EASL DeepDive: AI-Enabled Clinical Trials: Opportunities, Evidence and Oversight
Artificial intelligence (AI) is opening new opportunities to improve the design, efficiency, and evidence generation of clinical trials. This EASL DeepDive examines its applications in patient selection, stratification, and trial workflows, as well as the emerging role of digital twins in simulating treatment responses. Particular attention is given to the use of AI-enabled real-world data to strengthen clinical evidence, while addressing questions of scientific validity, bias, and practical limitations.
Talk Liver To Me - Hepatocellular Carcinoma: Who to screen, when, and how?
Hepatocellular carcinoma (HCC) surveillance is a cornerstone of liver disease management, yet uncertainty persists around who to screen, when to initiate surveillance, and which modalities to use. Evolving risk profiles and variation across guidelines have added complexity to clinical decision-making. In this podcast, we revisit the fundamentals of HCC screening, focusing on practical, evidence-based approaches to patient selection, timing, and surveillance strategies.
Host: Mattias Mandorfer (Medical University of Vienna)
Guests: Peter Jepsen (Aarhus University), Amit Singal (UT Southwestern Medical Center)
This episode is also available on EASL Campus: https://easlcampus...
Talk Liver To Me - Psychohepatology: Are we overlooking mental health in liver disease care?
This episode explores psychohepatology, examining the gut–liver–brain axis and the bidirectional links between liver disease and mental health. Discussion covers addiction biology, the impact of trauma and post-traumatic stress disorder (PTSD) on alcohol use, and the high prevalence of depression and anxiety in cirrhosis, highlighting integrated approaches to liver and mental health care.
Host: Mads Israelsen (Odense University Hospital)
Guests: Nicola Kalk (South London and Maudsley NHS Foundation Trust), Victoria Kronsten (King's College London)
This episode is also available on EASL Campus: https://easlcampus.eu/tltm/episode-19
EASL DeepDive: Key Updates in the EASL Clinical Practice Guidelines on the management of hepatocellular carcinoma
This EASL Deep Dive explores key updates from the EASL Clinical Practice Guidelines on hepatocellular carcinoma (HCC), with a practical focus on diagnosis and treatment selection. Experts will discuss evolving imaging and diagnostic criteria, patient selection for surgery and locoregional therapies, and how to adapt management according to response to systemic treatment. The session will also highlight the growing importance of multidisciplinary, individualised care across the HCC treatment pathway.
Talk Liver To Me - Resmetirom and Semaglutide in MASH: Who, when and how to monitor?
This episode of Talk Liver to Me explores the practical use of resmetirom and semaglutide in MASH, based on the 2026 EASL–EASD–EASO Guidance. Experts discuss who may benefit from treatment, when to initiate therapy, and how to monitor response and efficacy in clinical practice.
Host: Debbie Shawcross (EASL)
Guests: Andreea Ciudin (EASO), Amalia Gastaldelli (EASD), Frank Tacke (EASL)
This episode is also available on EASL Campus: https://easlcampus.eu/tltm/episode-18
Thank you to our healthcare industry partners for their support. For more informat...
Talk Liver To Me - Africa’s Liver Crisis: Why Is No One Talking About It?
Liver disease represents a major and under-recognised public health challenge across Africa, driven by a complex interplay of viral hepatitis, rising metabolic dysfunction-associated steatotic liver disease, and a high burden of hepatocellular carcinoma (HCC). Despite this, awareness, surveillance, and access to care remain limited. In this podcast, we explore the evolving epidemiology of liver disease across the continent, highlighting key drivers, regional variations, and gaps in diagnosis and treatment. Why does the burden remain so under-recognised, and what are the priorities for prevention, early detection, and equitable care in Africa?
Host: Debbie Shawcross (King's College...
EASL DeepDive: Utility and challenges of genetic testing in PFIC
This webinar explores the role of genetic testing in diagnosing Progressive Familial Intrahepatic Cholestasis (PFIC). Attendees will review key test types, understand the principles behind modern genomic technologies, and learn how to position these tests in the diagnostic approach of a person with a suspicion of PFIC and how to navigate common challenges in interpreting genetic results. The session will also highlight emerging trends shaping the future of genetic diagnostics in hepatology.
Learning objectives
Understand the genetic drivers of PFIC and the utility of their testing. Describe basic principles behind modern diagnostic genetic testing rel...Talk Liver To Me - What are the Dos and Don'ts in Acute Liver Failure?
Acute liver failure (ALF) is a rare but life-threatening condition requiring rapid recognition and decisive management. Early decisions around investigation, escalation, and referral can significantly impact outcomes. Despite advances in care, variation in practice and avoidable pitfalls remain common. In this podcast, we take a practical, case-based approach to the key “dos and don’ts” in ALF management, focusing on early diagnosis, initial stabilisation, appropriate investigations, and timely referral to specialist centres. What should clinicians prioritise, what should be avoided, and how can we optimise care in the critical early stages of acute liver failure?
Host: Mat...
Talk Liver To Me - Endohepatology: Added value or added complexity?
Endohepatology is emerging as a novel approach to liver disease assessment, with the potential to combine EUS-guided liver biopsy, portal pressure measurement, and variceal evaluation within a single session. This “one-stop shop” model could streamline diagnostic pathways and enable integrated, real-time clinical decision-making. However, this innovation comes at a time when hepatology is moving increasingly towards non-invasive testing strategies. Questions therefore remain around its appropriateness, clinical utility, and feasibility in routine practice. In this podcast, we explore whether this approach represents meaningful progress or premature adoption, examining current evidence, potential benefits, and practical challenges.
This episode is produ...
Talk Liver To Me - What nobody tells you about starting a research group
Early-career researchers and clinician-scientists play a central role in advancing hepatology research and innovation, yet the transition to independence often comes with challenges that extend beyond scientific expertise. Building a research programme, leading teams, securing funding, and developing a sustainable academic career require skills that are rarely addressed during formal training. In this podcast, we explore the realities of early academic leadership, focusing on the practical and professional challenges faced during the first years of research independence.
Host: Carolin Schneider (RWTH Aachen University)
Guests: Pierre-Emmanuel Rautou (Hôpital Beaujon, APHP & Université Paris Cit...
Talk Liver To Me - Global Updates on Hepatitis E: How Should We Manage Acute and Chronic Infection?
Hepatitis E is a globally prevalent infection with diverse clinical manifestations, ranging from self-limiting acute hepatitis to chronic infection in immunosuppressed patients. Its presentation and epidemiology vary significantly between regions, influencing diagnostic and management strategies. Despite increasing recognition, uncertainty remains around who to test, when to treat, and how to manage chronic disease effectively. In this podcast, we bring together perspectives from Europe and Asia to explore key differences in clinical practice, emerging evidence, and practical approaches to care.
Host: Thomas Marjot (Kings College London)
Guests: Tobias Böttler (Un...
Talk Liver To Me - MASLD and HFpEF: Do We Need a Shared Treatment Strategy?
Metabolic dysfunction-associated steatotic liver disease (MASLD) and heart failure with preserved ejection fraction (HFpEF) are increasingly recognised as manifestations of a shared cardiometabolic disorder. Driven by overlapping risk factors such as obesity and insulin resistance, these conditions frequently coexist and may interact through liver–heart crosstalk. Despite this, they are typically managed separately, with limited disease-specific therapies and suboptimal outcomes. In this podcast, we explore whether a more integrated approach could improve diagnosis, risk stratification, and treatment.
Host: Cyrielle Caussy (Lyon 1 University and Hospices Civils de Lyon)
Guests: Zannad Faiez (University of...
A joint EASL-ERN RARE-LIVER DeepDive – Wilson’s disease: a 2026 update
The following objectives will be addressed in this EASL Deep Dive episode:
Have a profound knowledge of the pitfalls, limitations and difficulty of interpretation of the different tests of copper metabolism and liver copper assessmentsBe able to establish a diagnostic approach to Wilson’s disease, integrating clinical, laboratory, genetic and imaging toolsHave a good understanding of the different treatment modalities, how to position them in the disease course, how to monitor treatment and what to expect as a result/outcome?This EASL DeepDive webinar is supported by Orphalan and Univar Solutions. Orphalan and Univar So...
Talk Liver To Me - Chasing the perfect SLD preclinical model
Steatotic liver disease (SLD) research relies heavily on preclinical models, yet no single model can fully capture the complexity of human disease. In this episode, we explore the new EASL position paper on preclinical SLD models. From MASLD and MetALD to organoids and precision-cut liver slices, we discuss the strengths, limitations, and translational relevance of today's most widely used models. How do we choose the right model, and are we any closer to finding the perfect one?
Based on EASL position paper on preclinical models of steatotic liver disease
Host: Rui Castro (University...
Talk Liver To Me - Haemochromatosis in 2026: Who Needs Testing and Who Needs Treatment?
Haemochromatosis remains one of the most common inherited metabolic disorders, yet it is frequently underdiagnosed and inconsistently managed in clinical practice. With widespread use of iron studies and genetic testing, clinicians are increasingly faced with questions around interpretation, penetrance, and clinical significance. In this podcast, we explore current challenges in diagnosis and management, focusing on who should be tested, how to interpret results, and which patients benefit from intervention in modern hepatology practice.
Host: Thomas Marjot (King's College, London)
Speakers: John Ryan (Beaumont Hospital, Dublin) and Heinz Zoller (Medical University of Innsbruck)
Talk Liver To Me - Liver Transplantation: Rise of the machines
In this episode, we discuss the first pig-to-human liver xenotransplantation and the breakthroughs behind the revival of xenotransplantation, examining its potential and remaining challenges. We also explore the accelerating field of machine perfusion, clarifying different approaches and reviewing the evidence supporting their role in organ assessment, optimisation, and DCD utilisation.
Host: Sarwa Darwish Murad (Erasmus University Rotterdam)
Speakers: Jeroen de Jonge (Erasmus University Rotterdam) and Matthew Armstrong (University Hospital Birmingham)
This episode is also available on EASL Campus: https://easlcampus.eu/tltm/episode-09
Talk Liver To Me - Spontaneous Bacterial Peritonitis: Time to Rethink the Rules?
Spontaneous bacterial peritonitis (SBP) remains a major complication of cirrhosis - but rising antimicrobial resistance and emerging data are challenging long-standing practices.
In this episode, we review current evidence on primary and secondary prophylaxis, resistance patterns, albumin use, and treatment strategies. How should clinicians balance prevention with antimicrobial stewardship? And where might practice need to evolve in 2026?
Host: Thomas Marjot (King's College London)
Speakers: Bogdan Procopet (Institute of Gastroenterology and Hepatology, Cluj-Napoca) and Alastair O'Brien (Royal Free Hospital, London)
This episode is also available on EASL Campus: https://ea...
EASL DeepDive: Key Updates in the EASL Clinical Practice Guidelines on extrahepatic Cholangiocarcinoma (eCCA)
In this EASL DeepDive webinar, the expert panel presents and explains the key studies behind the latest recommendations included in the EASL Clinical Practice Guidelines on the management of extrahepatic cholangiocarcinoma.
Learning Objectives
To identify patients at risk for eCCA, and review the current tools and strategies for its surveillance, diagnosis, staging, and classificationTo define the optimal candidates for resection and liver transplantation, and discuss challenges in the surgical management of eCCATo discuss the role of systemic therapy in the management of eCCA across all disease stages (including neoadjuvant, adjuvant, and palliative settings)<...
Talk Liver To Me - World Liver Day: Making Lifestyle Change Possible
This episode explores the role of lifestyle in preventing and managing liver disease, including MASLD/MASH. Our experts discuss the impact of diet and physical activity, why lifestyle change can be difficult to start and sustain, and why small, achievable steps can still make a meaningful difference.
Host: Cyrielle Caussy
Speakers: Kate Hallsworth and Manuel Romero-Gómez
This episode is also available on EASL Campus: https://easlcampus.eu/tltm/episode-07
EASL DeepDive: Key Changes in the New EASL HBV Guidelines
In this EASL DeepDive, experts will discuss the latest advances in the EASL Clinical Practice Guidelines on the management of hepatitis B virus infection, published in the "Journal of Hepatology" in 2025.
Learning objectives
Understand the updated EASL recommendations for initiating and discontinuing antiviral therapy in chronic hepatitis B, including key differences with other HBV guidelines. Participants will be able to identify treatment indications and make informed decisions about when and how to stop antiviral therapy.Learn how to monitor patients with hepatitis B across different clinical scenarios, including those not on treatment, those receiving...EASL DeepDive: EASL Clinical Practice Guidelines on the management of autoimmune hepatitis
In this EASL DeepDive, experts will discuss the latest advances in the EASL Clinical Practice Guidelines on the management of autoimmune hepatitis, published in the "Journal of Hepatology" in 2025.
Learning objectives
Select induction and maintenance treatment strategies aimed at achieving complete biochemical responseRecognise and manage disease flares, treatment intolerance, and suboptimal response in autoimmune hepatitisUnderstand tailored approaches to autoimmune hepatitis management in specific patient groupsFaculty
Mária Papp - ModeratorMichael Heneghan - SpeakerGeorge Dalekos - SpeakerMaria Carlota Londoño - SpeakerEASL DeepDive: The Pursuit of a Cure: HCC Management Strategies
Hepatocellular carcinoma (HCC) is responsible for 75% of all primary liver cancers and is the third most prevalent cause of cancer death worldwide, with 900,000 new cases diagnosed each year. Many patients are diagnosed at an advanced stage, making curative treatment difficult.
In this DeepDive Webinar, you’ll be guided through the latest advances in hepatocellular carcinoma management, from the rising impact of immunotherapy combinations to evolving approaches in intermediate-stage disease.
This EASL DeepDive webinar is supported by Bayer AG. Bayer AG has had no input into the content of this EASL DeepDive.
Learning Obj...
Talk Liver To Me - Baveno VIII: The takeaways you shouldn’t miss
In this episode our speakers share their immediate impressions and break down the key highlights shaping the management of portal hypertension and advanced liver disease. What has truly changed in practice? Where was consensus reached and where do controversies remain?
Tune in for a clear, practical overview of what you need to know from Baveno VIII.
Host: Thomas Marjot
Speakers: Mattias Mandorfer and Cristina Ripoll
This episode is also available on EASL Campus: https://easlcampus.eu/tltm/episode-06
Talk Liver To Me - Updated BCLC Guidelines for HCC: Protocolised or Patient-Centred Care?
This episode unpacks the updated BCLC guidelines for hepatocellular carcinoma management. Experts discuss the strengths and limitations of the BCLC model in an era of rapidly evolving systemic therapies and personalised care, sharing real-world examples of when the algorithm helps and when clinical practice diverges.
Host: Mattias Mandorfer
Speakers: Marco Sanduzzi, Lorenza Rimassa
This episode is also available on EASL Campus: https://easlcampus.eu/tltm/episode-05
Talk Liver To Me - When Cure isn’t the only goal: Palliative Care in Advanced Liver Disease
As deaths from advanced chronic liver disease rise, many patients never receive timely palliative care.
In this episode, we explore why early, holistic support is essential in advanced liver disease and HCC, and unpack key recommendations from the new EASL Position Paper to help reduce suffering and improve quality of life.
Host: Debbie Shawcross
Speakers: Patrizia-Künzler-Heule, Sumita Verma
This episode is also available on EASL Campus: https://easlcampus.eu/tltm/episode-04
Talk Liver To Me - MetALD in Practice: Does it Change How We Treat Patients?
This episode explores whether MetALD is a meaningful clinical entity or an unnecessary complication. Experts discuss the overlap between metabolic dysfunction and alcohol use, the challenges of applying the MetALD definition in practice, and its impact on classification, guidelines, drug development, and patient care.
Host: Thomas Marjot
Speakers: Mary Rinella , Aleksander Krag
This episode is also available on EASL Campus: https://easlcampus.eu/tltm/episode-03
Talk Liver To Me - From imposter syndrome to influence: Women shaping hepatology
EASL’s Secretary General and Vice Secretary General share an open conversation on the challenges and opportunities for women in hepatology. The episode explores the role of mentorship across career stages and reflects on the journey toward EASL’s first female Secretary General, offering insights on leadership and change in the field.
Host: Maja Thiele
Speakers: Debbie Shawcross, Ana Lleo
This episode is also available on EASL Campus: https://easlcampus.eu/tltm/episode-02
Talk Liver To Me - Hepatology Ward Rounds: East Meets West
In collaboration with the Indian National Association for the Study of the Liver (INASL), hepatologists from South Asia and North America/Europe take listeners inside their liver wards to explore how regional context shapes acute liver care. From admission patterns to alcohol use, infections, DILI, nutrition, and access to transplant, the episode highlights key differences and opportunities for shared learning across regions.
This episode is also available on EASL Campus: https://easlcampus.eu/tltm/episode-01
EASL Studio Podcast: Collaborating across disciplines to find the best solution for people living with PBC
This EASL Studio episode brings key insights from the 2025 EASL–AASLD Consensus Conference on Primary Biliary Cholangitis (PBC).
Experts explore the use of surrogate endpoints, the challenges in current trial design and regulation, the value of real-world evidence, and how quality-of-life assessment can support future pathways.
Moderator: David Jones
Speakers: Marco Carbone, Bettina Hansen, and Ana Lleo
All EASL Studio Podcasts are available on EASL Campus.
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EASL Studio Podcast: What Can Be Done to Safeguard Young Adults from SLD?
How can we protect young adults from steatotic liver disease (SLD)? This episode explores the burden of MASLD, MetALD, and ALD in Europe, the synergistic effects of alcohol and metabolic risk factors, and why the younger population is especially vulnerable. Experts also examine the disparities in risk factors and the role of clinics and policymakers in prevention.
Moderator: Shira Zelber Sagi
Speakers: Carina Ferreira-Borges (WHO representative) and Zobair Younossi
This EASL Studio is supported by Opella. EASL has received no input from Opella with regards to the content of...
EASL Studio Podcast: Decoding AASLD The Liver Meeting: Trends Shaping Hepatology
What were the key takeaways from this year’s AASLD The Liver Meeting? In this episode, experts unpack the most impactful studies, clinical insights, and emerging trends shaping the future of hepatology. From liver cancer breakthroughs to MASLD, ALD, and beyond.
Moderator: Debbie Shawcross
Speakers: Saul Karpen, Allison Kwong, Mazen Noureddin
All EASL Studio Podcasts are available on EASL Campus.
Click here to see all EASL Video Podcasts on Apple Podcasts.
EASL Studio Podcast: Rifaximin for Hepatic Encephalopathy: Balancacing Benefits and Risks in the Era of Antimicrobial Resistance
For World Antimicrobial Awareness Week 2025 (“Act Now: Protect Our Present, Secure Our Future”), this EASL Studio explores the balance between rifaximin’s benefits in hepatic encephalopathy and the global challenge of antimicrobial resistance.
Moderator: Debbie Shawcross
Speakers: Rajiv Jalan, Vishal Patel, Jonel Trebicka
All EASL Studio Podcasts are available on EASL Campus.
Click here to see all EASL Video Podcasts on Apple Podcasts.
This EASL Studio is supported by Alfasigma and Norgine. EASL has received no input from Alfasigma or Norgine with regard...
EASL Studio Podcast: Behind the Decision: How Can You Maximize Your Chances of Publication in JHEP Reports?
Ever wondered what happens to your manuscript after submission? In this episode, the JHEP Reports editorial team takes you behind the scenes: from first triage to reviewer selection, smart moves vs. red flags, and how final decisions are made. The discussion also explores the potential, limitations, and ethical pitfalls.
Moderator: Mattias Mandorfer
Speakers: Tobias Böttler, Virginia Hernández-Gea, Josep Llovet
All EASL Studio Podcasts are available on EASL Campus.
Click here to see all EASL Video Podcasts on Apple Podcasts.
EASL Studio Podcast: Are we finally entering an era of effective treatment for PSC?
After years of limited progress, recent trials hint at a changing landscape for primary sclerosing cholangitis (PSC). In this episode, experts review emerging data and explore whether we’re approaching a new era of effective treatment. How should clinicians assess these therapies, and could they shift the current management of PSC?
Moderator: Debbie Shawcross
Speakers: Cynthia Levy, Stephen Rossi, Michael Trauner
All EASL Studio Podcasts are available on EASL Campus.
Click here to see all EASL Video Podcasts on Apple Podcasts.
EASL Studio Podcast: Does it really matter whether we call it ACLF or acute decompensation?
This episode questions whether assigning the label “ACLF” to a deteriorating patient truly alters clinical decisions, or if focusing on the specifics of organ failure and reversibility is more useful. Experts debate the real-world utility of prognostic scores, the clarity (or confusion) created by multiple definitions, and whether the ACLF concept drives urgency, facilitates transplant access, or improves outcomes. A thought-provoking look at where terminology meets bedside care.
Moderator: Tom Marjot
Speakers: Paolo Angeli and Julia Wendon
This EASL Studio is supported by GENFIT. EASL has received no input from...
EASL Studio Podcast: The Clinical Blind Spot: Are We Neglecting Alcohol?
This EASL Studio explores the discrepancy between the huge burden of patients hospitalised with, and dying from, alcohol-related liver disease (ALD) or MetALD, versus the same disease’s near non-existence from population data. The panel will discuss whether current classification systems (heavily favoring metabolic causes) misrepresent the true burden of ALD and MetALD, and what clinicians can do to better map the role of alcohol in liver patients.
Moderator: Maja Thiele
Speakers: Brian Lee, Mzamo Mbelle, Elisa Pose
All EASL Studio Podcasts are available on EASL Campus.
Cl...
EASL Studio Podcast: Hepatitis C, Re-infection or Failure of Treatment in People Engaging in High Risk Practices – Do These Labels Matter in 2025?
What do we call it when someone with high-risk practices becomes viraemic again after treatment? In this episode, experts discuss the challenges of managing Hepatitis C in people who inject drugs (PWID) and other high-risk groups. Topics include SVR confirmation rates, DAA prescribing practices, acute vs. chronic infection, and real-world reinfection data. Are traditional labels still meaningful or do we need new frameworks for 2025?
Moderator: Ahmed Elsharkawy
Speakers: Ashley Brown, Tatyana Kushner and Sabela Lens
All EASL Studio Podcasts are available on EASL Campus.
Click here to...
EASL Studio Podcast: What Matters Most? The questions every hepatologist should ask their patients
In hepatology, effective care goes beyond diagnostics and treatment. This episode explores the crucial questions hepatologists should ask to truly understand their patients’ needs, values, and priorities. By focusing on communication and patient-centred care, our experts highlight how listening carefully can improve adherence, enhance quality of life, and ultimately lead to better outcomes.
Moderator: Pierre-Emmanuel Rautou
Speakers: Agnès Dumas, Maria Hjorth, José Willemse, Zobair Younossi
All EASL Studio Podcasts are available on EASL Campus.
Click here to see all EASL Video Podcasts on Apple Podcasts.
COVID-19 vaccination in patients with liver disease
In this episode, Professor Markus Cornberg is joined by Dr Christiane Eberhardt and Professor Daniel Shouval to answer a range of questions raised by EASL’s Patient Synergies regarding the recently approved COVID-19 vaccinations.
They address topics including the reasons for the rapid development of the vaccines, whether immunocompromised liver transplant patients should receive the vaccine, real-world data from vaccination programmes worldwide and the potential duration of immunity.
Discover on our website more educational materials on COVID-19 and the liver.
