Biohacking Beauty: The Anti-Aging Skincare Podcast

Skincare trends are moving fast, and it can be hard to tell what is actually worth your attention. One day everyone is talking about red light masks, then peptide lip balms, at-home microneedling, men’s skincare, acne protocols, or another product claiming to be the next thing your skin needs.

The problem is that some of these tools can be useful, but the way they are marketed often leaves out the context that matters most. A red light device is not just about wavelength. Acne is not just about bacteria. Peptides in skincare are not automatically effective ju...

Peptides are being treated like the missing piece in recovery, skin longevity, fat loss, performance, and aging. The usual belief is that if you find the right compound, the right dose, or the right stack, the body will finally respond the way you want it to. But what if the protocol is not the first thing that needs to be fixed?

In this episode of Biohacking Beauty, I sit down with Chris Duffin to unpack what most peptide conversations skip: the state of the body receiving the signal. They get into why cellular terrain matters, what happens...

If you have been thinking about buying a LED mask, the hardest part is knowing what actually matters. The price range is all over the place, every brand seems to have some version of “FDA cleared” on the page, and a lot of the buying advice sounds scientific enough to trust. But none of that automatically tells you whether the device is strong enough to do anything meaningful for your skin.

That is why we wanted to take a closer look at an Allure post called So You Wanna Buy a LED Mask. The guide brings up the...

We have been getting the same question in our DMs for months now. Peptides are everywhere. Everyone is talking about them. But what actually has evidence behind it, what is hype, and where do hormones fit into all of this? So we went and found someone who has been living this conversation for 35 years, not just talking about it.

Dr. Jennifer Berman is a urologist, New York Times bestselling author, and one of the leading voices in female sexual and menopausal health. She pioneered the field at UCLA, runs the Berman Women's Wellness Center in Beverly Hills...

Creatine has been boxed in as a gym-bro supplement for decades, but the latest research shows it's doing far more than building muscle. It buffers brain energy under sleep deprivation, supporting bone density and mood stability through perimenopause, and freeing up methyl groups for detoxification and DNA repair.

We dive deeper into this in the Biohacking Beauty Podcast with Dr. Dan Pardi. We also chat about why the bloating myth is backwards, how creatine and NAD work synergistically to support mitochondrial energy, and what topical creatine could mean for the future of skincare.

Dr. Dan...

When summer skin starts looking dull, congested, tired, or slower to recover, it is easy to blame the obvious things: heat, sweat, sunscreen, long days outside, or the wrong moisturizer. So the conversation usually stays on the surface. Use SPF. Cleanse better. Switch to lighter products. Add antioxidants. But before we treat summer skin like another product problem, there is a deeper question worth asking: what is the sun doing to the cell before you ever see the damage in the mirror?

In this episode of Biohacking Beauty, I want to take the sun conversation past burns...

Every fibroblast inside your dermis right now is asking 200 to 2,000 mitochondria to power its work in real time, and those mitochondria are descendants of a free-living bacterium swallowed by a larger cell 2 billion years ago. As you age, those mitochondria run slower and your cells build fewer of them to replace the ones that fail.

In this solo episode, Young Goose co-founder Amitay Eshel breaks down the two sides of mitochondrial decline that drive skin aging and explains why the science-led skincare category has spent the last decades addressing only one of them.

The first...

Roughly 25% to 30% of the population carries slow variants in the MAOA or COMT genes, the two enzymes responsible for clearing adrenaline, dopamine, and serotonin from the brain.

For these individuals, common polyphenols marketed for inflammation and longevity, including curcumin, act as weak MAOA inhibitors that further slow neurotransmitter breakdown. The result is a quiet buildup of stimulation that gets misread as anxiety, insomnia, or unexplained agitation, with no obvious connection to the supplement bottle that caused it.

In this episode of Biohacking Beauty, Dr. Tyler Panzner joins us to translate exactly this kind of pharmacological...

Your skin has a biological age and for most people, it's not the same as their chronological one. Mayo Clinic published the SkinSpan framework this year specifically to quantify it, and the 12 Hallmarks of Aging now have a direct application to dermal tissue.

This raises an uncomfortable question: if you're already optimizing everything below the neck with NAD IVs, peptides, and red light, why is the skincare on your face still operating on a paradigm from 1987?

In this new episode of the Biohacking Beauty Podcast, we give you a preview of the keynote we're delivering...

The melanocytes giving pigment to your skin right now might be older than your car. They have been sitting in your dermis for decades, and unlike the cells on your skin's surface, they do not get replaced. They have to keep themselves clean which happens through autophagy.

In Part 2 of our autophagy deep dive, we get specific about how skin handles autophagy differently from other parts of the body. We unpack why long-lived cells like fibroblasts and melanocytes depend on this cleanup process, what happens when it fails, and how it ties directly to gray hair, hyperpigmentation...

What if your skin could literally rebuild itself from the inside out? In this episode, we break down one of the most powerful and misunderstood biological processes in the human body: autophagy.

From its Nobel Prize-winning discovery to the molecular machinery that drives it, we walk you through exactly what autophagy is, how it works at the cellular level, and why it matters far more than most people realize for skin aging.

We explore the two master switches that control autophagy, mTOR and AMPK, and how the constant tug of war between them determines whether...

Most of what the supplement and skincare industry sells for aging targets one pathway at a time. But your biology does not age that way. It declines across 12 interconnected processes simultaneously, and by the time one of them shows up on your skin, the others have already been running for years.

We at Young Goose believe that skin longevity is not a topical problem. It is a whole biology problem, and the ingredients you choose, how they interact, and whether anyone has actually tested them together matters more than any single molecule ever could.

In...

Most of what goes viral on SkinTok is missing one thing. The part where someone actually checks if it works.

In this bonus episode, Amitay and Anastasia break down three of the most viral skincare trends circulating today, red light therapy wands, at-home dermarolling, and tretinoin, and run each one through a biohacker's lens. Not to dismiss them outright. But to ask the questions the original videos never do.

What is actually happening at the cellular level? What are the real risks? And where does the marketing stop and the science start?

What’s...

Mothers sacrifice so much of themselves to carry another human being in their body for nine months. Even after childbirth, there's a phase called the fourth trimester because babies are still heavily dependent on moms for their survival.

Motherhood looks different for every woman. For Anastasia, who is a first-time mom, motherhood looked particularly different since her family is overseas and she's also running Young Goose with Amitay. Yet, there's something unique when a biohacker becomes a mom that new moms can learn from.

In this Young Goose Mother's Day Special, we celebrate every mother...

Most of the NAD+ skincare on shelves right now is built on a misunderstanding. And if you've been trusting niacinamide to do the heavy lifting, this episode is going to change how you read a label.

This episode is Part 2 of our NAD+ deep dive. Here, we get into what actually works to raise NAD+ in the skin, the real precursors, the delivery technology that gets them where they need to go, and the mitochondrial support system most brands leave out. We also walk through the lifestyle levers that move the needle, and why one of them...

A lot of us treat hair loss the way skincare treats wrinkles, as a cosmetic problem to cover up. But almost every case of thinning, recession, or shedding has something deeper driving it, and by the time it shows up in the mirror, a significant amount of density is already gone.

We at Young Goose believe that beauty is whole body care, and hair is one of the most metabolically active tissues in the body. It is also one of the first places systemic stress, hormone shifts, nutrient deficiencies, and inflammation show up.

In this...

Most people know NAD+ as a supplement trend. But very few understand what's actually happening inside their skin cells when it runs out or what's stealing it in the first place.

By the time you're 45, you've lost half of the molecule that powers virtually every function keeping your skin young. Sadly, it only gets worse from there.

The enzyme your skin uses for DNA repair can wipe out up to 90% of what's left after a single afternoon in the sun. This isn't a slow, graceful decline. It's a collapse happening beneath the surface long before...

Most people treat their skin like a surface problem. But almost every persistent skin issue, from rosacea to eczema to accelerated aging, has something deeper driving it.

That deeper driver is almost always the gut, the liver, or a backed-up detox pathway. We at Young Goose, always believe that skincare is whole body care and we want our community to identify the deeper causes of skin issues that products alone can’t fix.

In this episode, functional nutrition practitioner Dani Conway joins us to break down why the skin is not the origin of the pr...

Most people think that the stinging feeling, redness or tightness are always good signs of skin detoxification. Tricky enough, it can look like ‘glass skin’ or skin renewal. However, almost always the temporary tight and bright skin is a skin barrier issue in disguise.

Skin barrier damage is one of the most misread signals in skincare. It looks like purging but it is actually your skin telling you it has been pushed past its limit.

It’s easy to think there’s no damage at all because overexfoliation can temporarily give a satisfying baby skin at the c...

Did you know that the most powerful anti-aging protocol isn't about how long you sleep? It's about when. Getting eight hours of sleep for skincare feels like a tough feat to achieve especially when life gets in the way.

By understanding how your skin begins its optimal repair time, it’s still possible to achieve the best skin results without the guilt of not sleeping enough.

In our quest in finding the best skincare ingredient for our products, we discovered that hours of sleep do matter, but best skin results happen by following the skin’s op...

Molecular hydrogen is often described as a selective antioxidant, but that framing is incomplete. In this episode, we explore hydrogen as a mitochondrial hormetic signal that can influence redox balance, inflammatory regulation, and adaptive stress pathways. The key distinction is that delivery route changes mechanism. Oral, inhaled, and topical hydrogen act differently in the body, with different kinetics, tissue distribution, and biological implications.

We dive deeper into this in the Biohacking Beauty Podcast with Alex Tarnava. We discuss why topical hydrogen is gaining attention for skin outcomes, how gut-mediated signaling may drive systemic effects, and why interpreting...

Chronic stress isn’t just a mental or emotional burden. It creates a biological cascade that disrupts mitochondrial function, accelerates inflammation, and shows up visibly in the skin long before deeper symptoms appear.

We dive deeper into this in the Biohacking Beauty Podcast with Dr. Scott Sherr. We also talk about the sympathetic spiral of doom, why skin reflects mitochondrial decline before other symptoms appear, and why sequencing interventions matter more than intensity.

Dr. Scott Sherr is a board-certified internal medicine physician certified in Health Optimization Medicine (HOMe) and a specialist in Hyperbaric Oxygen Therapy. He...

Fascia is one of the most overlooked conversations in skin aging. We spend so much time thinking about collagen, serums, injectables, and trending tools, but very few people are talking about the structural system underneath the skin that influences how we actually age.

If you are dealing with under-eye puffiness, jaw tension, posture changes, facial asymmetry, or feeling like your face looks more tired than it should, this episode explores a deeper layer of the conversation. We dive into fascia, fluid movement, breathing patterns, and why your neck and jaw may be playing a much bigger role...

Being told your labs are “normal” and your cycle is still regular does not mean your metabolism and hormones are stable. Early insulin resistance can quietly increase inflammation, drive midsection fat gain, and accelerate skin aging years before menopause is officially diagnosed.

In this Biohacking Beauty episode with Dr. Jila Senemar, we break down why regular periods do not rule out perimenopause, why building muscle is one of the most powerful metabolic tools in midlife, and how early testing like DEXA scans can reveal hidden bone loss long before standard guidelines would ever check.

Dr. Jila...

Advanced skincare routines are more popular than ever, yet dryness, laxity, and visible aging still persist. The issue isn’t effort or discipline. It’s that skin aging is being treated as a surface-level problem instead of a cellular and structural one.

We dive deeper into this in the latest Biohacking Beauty Podcast with Jess Kane. We also chat about how cell membrane health shapes visible aging, why omega fats are widely misunderstood, and how most “liposomal” supplements never reach the cell.

Jessica Kane is the Co-Owner and Chief Marketing Officer of BodyBio, a third-generation wellness...

It’s Valentine’s Day, and while we don’t usually shape our work around holidays, this one felt different because we’re not just co-founders of Young Goose, we’re life partners. For us, care has always shown up in daily choices and consistency, the same philosophy behind how we think about skin longevity.

In this special episode, we flip the format and recommend ingredients to each other based on real-time skin needs. We get into methylene blue, NAD support, ectoin, retinol, and repair-focused actives through the lens of cellular energy, inflammation control, repair, and long-term resilience...

Skin problems are often the body’s earliest warning sign that detoxification, inflammation control, and nutrient absorption are already compromised. When detox demand rises and recovery systems can’t keep up, skin changes and aging-related signs become more pronounced.

In this episode of the Biohacking Beauty Podcast, we sit down with Marina Moiseyeva to explore why medications and aggressive topicals increase detox load, how sweating and lymphatic movement support skin longevity, and why “Ozempic face” is driven by muscle, bone, and nutrient loss rather than fat alone.

Marina Moiseyeva is a Functional Medicine Practitioner and Board Ce...

Advanced skin treatments often underperform for a reason rarely addressed: regeneration cannot occur in a chronically stressed or under-resourced system. Elevated cortisol, inflammation, and metabolic imbalance weaken collagen signaling and tissue repair before any device, injectable, or modality has a chance to work.

In this episode of the Biohacking Beauty Podcast, we sit down with Joe Radich from R3 Health to unpack why physiological preparation determines treatment outcomes. 

We explore how internal factors like stress, hormones, micronutrients, and metabolic health shape skin regeneration, and why modalities like peptides, hyperbaric oxygen, and exosomes only work as w...

Skin sagging, crepiness, and loss of bounce are often blamed on collagen loss, yet the real driver sits elsewhere in the skin’s architecture. Elastin degradation accumulates quietly over time, shaping how skin functions long before changes fully register in the mirror.

In this Biohacking Beauty episode, we unpack why rebuilding elastin is largely a myth, how elastin breakdown differs fundamentally from collagen loss, and how even a single period of stress can influence skin integrity for decades.

We also examine how collagen is over-credited in conversations about sagging and how lasers and radiofrequency treatments ca...

Most conversations about advanced skin treatments stay at the surface, particularly around regenerative approaches, overlooking why lasting results are so hard to achieve.

We dive deeper into this in the latest Biohacking Beauty episode with Dylan Gemelli. We explore why oral peptides often fall short, and how BPC-157 relates to gut healing, inflammation resolution, and collagen repair. We also unpack the real mechanism behind PRP facials, and how neuromodulating peptides compare to Botox over the long term.

Dylan Gemelli is a prominent figure in the fitness and biohacking space and the host of the Dylan...

Ever wonder why your skin changes so much in winter?

In this episode of Biohacking Beauty, we explain what actually happens when humidity drops, TEWL rises and indoor heating pulls moisture from the skin. We also talk about UVA exposure in cold months, lifestyle shifts that increase oxidative stress and why winter puts more pressure on your skin’s repair systems.

We break down the winter ingredients that matter most, like ceramides, barrier lipids, vitamin F, beta glucan, hyaluronic acid, peptides, NAD precursors and exosomes, and how to use them in a routine that supports ba...

What if fine lines, breakouts, and flare-ups are not just skin issues, but the body replaying old experiences it never got to resolve? In this episode, we explore how nervous system patterns, unresolved emotion, and the way we hold stress in the body can quietly shape how our skin ages over time. We look at the skin as a boundary, a canvas, and a reflection of how safe we feel in the world.

We talk with practitioner Eva Hooft about psychosomatics, face mapping, and the cell danger response, and how a chronically dysregulated system keeps inflammation and...

Everyone is chasing the next skincare hack, yet true beauty begins far deeper than a product. It grows through awareness, alignment, and how we move through life.

In this episode, we sit down with beauty expert and coach Liz Kennedy to explore how biohacking, mindset, and consciousness work together to create what she calls magnetic beauty. We discuss how affirmations, community, and daily rituals strengthen your energy, as well as how outer practices such as peptides, NAD, and red light therapy enhance results when your inner world is balanced.

Liz explains her approach to conscious...

Many listeners asked us to go deeper into exosomes, and this episode expands on everything that most brands avoid talking about: count, consistency, purity, and microRNA composition. We explain why exosomes on a label don’t mean much without verified numbers, and how dose shapes whether the skin actually receives a biologically meaningful message.

We walk through why platelet-derived exosomes offer the clearest communication to human skin, why microRNAs matter more than growth factors alone, and how publishing full sequencing data creates a new standard for transparency in longevity skincare. We also explore the synergy between exosomes an...

Many listeners have been curious about exosomes, and this episode offers a simple, science-based foundation for understanding them. We explore what exosomes are, how they act as communication packets between cells, and why they play such an important role in skin rejuvenation.

We walk through the three main categories of exosomes found in skincare, plant, stem cell, and platelet-derived,  and discuss how each behaves differently inside the skin. We explain what happens when cellular signals weaken with age, what we’ve learned through PRP and regenerative medicine, and why not every exosome speaks the same biological language. We...

We have seen face taping explode across social media, yet very few people understand what real Japanese face taping actually does for the skin. Most viral videos show shortcuts or stickers that never interact with fascia, muscle tension, or lymphatic flow. In this episode, we explore the method behind true face taping and why the right tape, placement, and technique can support healthier aging at a biological level.

In this episode of Biohacking Beauty, we sit down with Olga from Natural Face Bible to unpack how Japanese medical grade tape lifts the upper tissue layers, boosts blood...

We’ve always said that healthy skin starts from within, but few people understand how deeply skin and longevity are connected. Every wrinkle, blemish, or loss of elasticity begins with inflammation and cellular stress that ripple throughout the body.

In this episode, we sit down with world-renowned dermatologist Dr. Doris Day to explore how the skin doesn’t just reflect your health, it drives it. From managing inflammation to restoring collagen through sleep, nutrition, and resistance training, Dr. Day reveals why true skin longevity starts at the cellular level.

We also discuss the rise of prej...

We’ve always believed that data drives better health, but even we were surprised by how powerful hormone data can be. Hormones influence everything from how we age to how our skin repairs itself, yet most people only test them once a year, if at all.

In this episode, we sit down with Fady and Marina from Eli Health to explore how real-time hormone testing is changing the way we understand health optimization. Their saliva-based technology tracks cortisol and progesterone with over 90 percent lab-comparable accuracy, while their AI-powered app translates results into actionable lifestyle insights.

We...

Everyone online is talking about peptides like they’re the next collagen powder, but most people are skipping the most important part: is your body even in a state to heal?

In this episode, we sit down with longevity expert Nat Niddam to get clear on what peptides actually are, how they work in the body, and where people are getting this conversation dangerously wrong. We talk about the difference between signaling peptides and bioregulator peptides, why inflammation and gut integrity determine whether you’ll see real results, and why “anti-aging for skin” is not as simple as injec...

What if the secret to better skin isn’t another serum or laser, but lowering inflammation from the inside out?

In this episode, I sit down with Karin Adoni, a certified holistic nutritionist, to talk about how food, sleep, and everyday toxins shape the way we age. Karin shares how she turned her own recovery from eating disorders into a mission to help women rebuild their metabolism and hormone balance naturally. 

We break down why ultra-processed foods and seed oils accelerate aging, how gut health drives skin health, and why sustainable change starts with real foo...