The Human Upgrade: Biohacking for Longevity & Performance

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Multivitamin Mistakes, MTHFR Genetics, B Vitamins, Creatine & Prescription Drug Risks 

Host Dave Asprey sits down with Phil Cowley, a pharmacist, founder of Cache Valley Pharmacy, and creator of Phil's My Pharmacist, to explore multivitamins, prescription medications, supplement effectiveness, MTHFR genetics, methylated B vitamins, creatine, and the hidden problems within modern healthcare. 

After opening his pharmacy in Logan, Utah, in 2001, Phil spent two decades serving patients and dispensing millions of prescriptions. By 2021, declining insurance reimbursements threatened his business de...

I've tried every controversial focus drug I could get my hands on. Modafinil, LSD, psilocybin, mescaline, DMT, ketamine, MDMA, amphetamine, ephedrine, the racetams, and a shelf of Russian compounds most people have never heard of. I've spent 20 years and millions of dollars testing this on my own brain, and here's what I found: some of them work, most don't do what you've been told, and none of them are free.

But the one I'd crown above all of them is legal, costs almost nothing, and you can buy it this afternoon. You've just been...

Placebos Improved IBS Symptoms Even When Patients Knew the Pills Were Inactive

In a randomized trial of 80 adults with irritable bowel syndrome, participants who knowingly took placebo pills reported greater symptom improvement than those receiving no treatment. After three weeks, 59% of the placebo group reported adequate relief compared with 35% of controls. A larger follow-up study also found that openly prescribed placebos improved reported IBS symptoms more than a no-pill control. Host Dave Asprey explores how conditioning, expectations, and the ritual of taking a treatment may influence symptoms without deception. He explains why these findings do not mean...

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How Hops Extract Suppresses Hunger, Reduces Cravings, Supports Weight Loss, and Makes Intermittent Fasting Easier

Host Dave Asprey sits down with Sarah Kennedy, CEO of Calocurb, to explore the surprising science of hunger suppression, natural GLP-1 activation, intermittent fasting, weight loss, visceral fat reduction, and a patented hops extract that may help people eat less without relying on willpower. 

The conversation centers on Amarasate, a natural compound derived from New Zealand hops, the same plant used to make beer...

Explore House of Evolution: https://daveasprey.com/house-of-evolution/ 

Host Dave Asprey sits down with Dr. Tim Cook, a physician and longevity medicine expert who previously served as personal physician to two Governors General of Canada, to explore experimental gene therapy, biological age reversal, stem cell re-education, immune rejuvenation, muscle growth, and the emerging science of extending human lifespan. 

Recorded in the Amazon rainforest in Ecuador, the conversation explores three advanced longevity treatments Dave and Tim are working with through House of Evolution, their venture focused on expanding access to exper...

I have spent $2.5 million on this body, and Bryan Johnson spends about $5,400 a day on his. But does it need to be that expensive to biohack? So I gave myself a challenge: build a complete anti-aging protocol for $5/day, where every single thing on it has to be validated in humans, not mice. I could not spend the five dollars. In this video I'll show you the entire list and the two most powerful things I found… which cost nothing at all.

You'll Learn:

We just had to bring this one back for you. Today, we’re digging once again into specifics about food that you haven’t heard on the show before. This one may very well influence you to rethink your “healthy” diet and change how you feel about food completely. To get there, I’m excited to welcome back Teri Cochrane, an integrative practitioner and pioneer in personalized healthcare. 

Teri is the founder of the Global Sustainable Health Institute® and developer of The Cochrane Method®, a future-facing algorithm for decoding the human body. Teri is also one of the world’s l...

The Neuroscience of Flow, Peak Performance, Psychedelics, Trauma, Intuition & Consciousness with Steven Kotler

Host Dave Asprey sits down with Steven Kotler, New York Times bestselling author and leading researcher in the neuroscience of flow, to explore how altered states of consciousness influence peak performance, mental health, creativity, intuition, and our perception of reality.

Steven Kotler is a bestselling author of 17 books, including The Art of Impossible and We Are as Gods, and the founder of the Flow Research Collective. For decades, he has studied the neurobiology of peak performance...

The Miracle Morning, Visualization, Affirmations, Meditation, Morning Routines, Productivity & the Psychology of Success with Hal Elrod

Host Dave Asprey sits down with Hal Elrod, bestselling author of The Miracle Morning and personal development expert, to explore morning routines, visualization, affirmations, meditation, productivity, circadian rhythms, habit formation, and the psychology of success.

Hal Elrod is the creator of The Miracle Morning, a bestselling book and personal development method that has helped millions improve their daily habits. After surviving a devastating car accident at age 20 and later battling life-threatening cancer, Hal...

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I slept 8 hours a night and got 5 minutes of deep sleep, and no doctor could help me. Then I found a molecule that hits the same receptor as Valium but WITHOUT sedating you. 400 mg before bed, stacked with four things that cost nothing, took me from 5 minutes to 90. Here's all five, plus WHY it’s mission critical you get this precious deep sleep (hint: it has to do with your me...

The king is back! You probably recognize his name as the author of the famous book, Men Are From Mars, Women Are From Venus. 

But what's especially exciting is how John has evolved his insights to address the changing dynamics between men and women in the modern world, as he highlighted in his 2020 book, Beyond Mars and Venus: Relationship Skills for Today's Complex World.

Now, why is this episode a must-listen? Well, John isn't just a relationship expert; he's also a seasoned biohacker who understands the profound impact of our environment – including relationships – on our hormo...

Sleep Anxiety, Insomnia, Circadian Rhythms, Chronotypes, Sleep Trackers & How to Sleep Better with Dr. Michael Breus 

Host Dave Asprey sits down with Dr. Michael Breus, clinical psychologist, sleep specialist, and internationally recognized sleep expert known as The Sleep Doctor, to explore insomnia, sleep anxiety, circadian rhythms, chronotypes, nighttime awakenings, temperature regulation, sleep medications, wearable sleep trackers, and the science of improving sleep quality. 

The conversation challenges conventional thinking about sleep, including whether everyone needs eight hours, why trying harder to fall asleep can make insomnia worse, and how the body...

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Cartilage Regeneration, Joint Pain, Nitric Oxide, Blood Flow, Muscle Strength & Longevity with Kiran Krishnan 

Host Dave Asprey sits down with Kiran Krishnan, research microbiologist, systems biology researcher, and co-founder of Microbiome Labs, to explore cartilage regeneration, joint pain, osteoarthritis, nitric oxide, vascular health, inflammation, muscle growth, gut health, bone density, and the biological mechanisms that influence how the body ages. 

Kiran Krishnan is a research microbiologist, health...

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This video reveals that the brain has a documented neurological focus state driven by prefrontal cortex activation and norepinephrine signaling that most people access accidentally but can learn to trigger reliably. Dave explains the biological mechanism and the specific supplement and behavioral stack that activates this state within 20 minutes.

You'll Learn:

Infections Were Linked to About 1 in 8 Cancer Cases Worldwide 

A new global analysis estimates that infections were responsible for roughly 2.3 million new cancer cases in 2024, about 12% of all cancers worldwide. H. pylori and HPV were the largest contributors, followed by hepatitis B, Epstein-Barr virus, and hepatitis C. Host Dave Asprey explores how persistent infections can contribute to cancer through chronic inflammation, DNA damage, altered immune surveillance, and other biological pathways. He explains why this does not mean cancer is contagious or that infection inevitably leads to cancer, but argues that identifying, preventing, and treating i...

Get a free digital and audiobook copy of Angelic Attendants at https://askjulieryan.com/request-ebook/ 

Psychic Abilities, Medical Intuition, Energy Healing, Remote Viewing & What Happens When We Die with Julie Ryan 

Host Dave Asprey sits down with Julie Ryan, psychic, medical intuitive, inventor, author, entrepreneur, and host of the Ask Julie Ryan podcast, to explore intuition, consciousness, energetic healing, remote viewing, communication with spirits, past lives, dreams, and what Julie says happens as people approach death. 

Julie Ryan is a psychic and medical intuitive who says s...

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Clean Living, Stress Reduction, Sleep, Skincare & Simple Wellness Habits with Miranda Kerr 

Host Dave Asprey sits down with Miranda Kerr, founder of KORA Organics, entrepreneur, model, and longtime wellness advocate, to explore clean living, stress, sleep, skincare, meditation, parenting, and why her approach to health has become simpler over time. 

Miranda shares how her mother’s cancer diagnosis when she was 16 changed the way her family looked at everyday ingredients and helped s...

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I'm in the best shape of my life, and it has nothing to do with working harder. In this video, I break down the 5 unconventional hacks that helped me lose over 100 pounds, kill brain fog, and feel two decades younger, starting with something as simple as what I put in my morning coffee. If you're tired of doing everything 'right' and still feeling old, this one's for you.

<...

Vagus Nerve Stimulation Improves Cognitive Scores in a Small Trial 

In a 24-week trial involving people with mild cognitive impairment, participants assigned to electrical stimulation at vagus-innervated parts of the ear improved by an average of 3.2 points on a general cognitive test, compared with 0.3 points in a sham-stimulation group. Host Dave Asprey explores the proposed connection between the vagus nerve and the locus coeruleus, a brainstem region involved in attention and learning. He explains why an improved test score is intriguing but does not show that vagus nerve stimulation prevents Alzheimer’s disease—or that a consumer devic...

Visit https://www.younggoose.com/ and use code ASPREY10 to save on the skin longevity products discussed in this episode. 

Skin Longevity, Cellular Repair, Red Light Therapy & the Biology of Younger Skin with Young Goose 

Host Dave Asprey sits down with Amitay Eshel and Anastasia Khodzhaeva, co-founders of Young Goose, to explore the emerging science of skin longevity, cellular aging, mitochondrial function, exosomes, NAD+, red light therapy, and what it may take to keep skin functioning younger for longer. 

Anastasia is a biologist, biohacker, and co-CEO...

Visit LoveYourLiver.com and use code DAVE7 to access the special offer from de-liver-ance mentioned in this episode. 

Fatty Liver, GLP-1s, Alcohol, Hormones, Brain Fog, Weight Gain & Longevity 

Host Dave Asprey sits down with Siggi Clavien, Founder and CEO of The Liver Clinic and de-liver-ance, to explore why the liver may be one of the most overlooked organs in metabolism, hormone health, detoxification, brain function, weight management, and longevity. 

Siggi explains why fatty liver can develop without obvious symptoms and why someone can appear lean...

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This video explains the most effective ways to lose visceral fat, escalating from least to most effective, like a caloric deficit & diet quality (high protein, cut alcohol), Aerobic exercise (cardio), resistance training, sleep optimization, and stress reduction.

If diet and exercise aren't melting stubborn belly fat, fix your sleep first with 300mg of Magnesium 101...

Novo Nordisk Eyes Hair-Loss Market in Consumer-Health Expansion 

Novo Nordisk, the company behind Ozempic and Wegovy, is exploring hair loss as one of several possible areas for future expansion, alongside menopause and addiction. The company has not announced a hair-loss drug, clinical trial, acquisition, or partnership, but Chief Scientific Officer Martin Holst Lange pointed to the category during the company's 2026 Capital Markets Day. Host Dave Asprey breaks down why hair loss makes strategic sense for a company already deeply involved in endocrine biology, how emerging treatments are moving beyond traditional options like minoxidil and finasteride, and why s...

Back again with one of the best episodes we've done on the channel. So good that we had to play it once more for you! Today you’ll meet Robert Waldinger, M.D., who leads an extraordinary scientific study on happiness that’s still going strong after eight decades. The study set out to understand human health by what made people thrive.

Since 1938, the Harvard Study of Adult Development has tracked two groups of men and their families with the goal of discovering what really makes for a good life. Along the way, thousands of questions were asked...

Catharine Arnston on Spirulina, Chlorella, Mitochondria, Detox, Brain Energy, and Longevity 

Visit https://energybits.com/ and use code HUMANUPGRADE for 20% off. 

Could one of the oldest foods on Earth also be one of the most overlooked tools for mitochondrial health, brain function, detoxification, and longevity? 

Host Dave Asprey sits down with Catharine Arnston, founder of ENERGYbits and author of Love Your Health to Bits with Algae, to explore the biology of spirulina and chlorella and why these microscopic organisms have been studied for decades as unusua...

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If you're waking up exhausted, foggy, or inflamed and nothing seems to fix it, the answer might be hiding in your walls. This deep dive walks through how toxic mold and mycotoxins settle into your brain, nerves, and mitochondria, how to properly test your home and body for exposure, and the exact order of operations, environment first, then detox...

Back with another all-time classic. Teal's is one of those episodes I keep going back to because it was just that good. Now more than ever, we need to ask ourselves: what is the role of Ego? Do we need to worry about AI killing us? Is there hope for the future of our species?

These are just a few of the big questions you’ll tackle in this enlightening and esoteric episode re-run. I’m joined by Teal Swan, a thought leader, bestselling author, and international speaker who is on a mission to redu...

Dr. Michael Leon on Smell Training, Memory, Sleep, Alzheimer’s Risk, and Brain Longevity 

Your sense of smell may reveal more about your brain health than you realize, and stimulating it while you sleep may improve memory, sleep quality, and cognitive function. 

**Visit https://memoryair.com/ and use code DAVE15 for 15% off. **

Host Dave Asprey sits down with Dr. Michael Leon, Professor Emeritus of Neurobiology and Behavior at UC Irvine and one of the world’s most cited scientists, to explore why smell may be one of th...

**Visit https://www.gatlan.com/ and use cod ‘DAVE’ to unlock a free consultation!**

At 53, Josh Duhamel says he feels better than he did in his 30s. 

Host Dave Asprey sits down with actor and Gatlan Health founder Josh Duhamel to talk testosterone, peptides, nootropics, brain health, fatherhood, and what it takes to stay strong as you age. 

Josh shares why he started TRT in his early 40s, what changed once he began tracking his hormones, and why he decided to build a health compan...

Carolina Reis de Oliveira on Reversing Skin Age, Menopause, GLP-1 Skin, and the Science of Senescent Cells 

Your skin is likely biologically older than you are, but new research suggests some of that aging may be reversible. 

**For Dave’s listeners only, visit oneskin.co/Dave  for exclusive early access to the OS-01 Face Rich Cream!**

Host Dave Asprey sits down with Carolina Reis de Oliveira, PhD, CEO and co-founder of OneSkin. Carolina holds a PhD in stem cell biology and tissue engineering, is a co-i...

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This video walks you through the complete biological timeline of a 36-hour sugar fast, from insulin dropping and liver glycogen draining to fat burning, ketone production, lower inflammation, and sharper mental clarity. You’ll see how quickly your metabolism can start switching back to the fuel system it was built to use.

Thank you to...

Sea Squirt Plasmalogens Show Brain And Aging Benefits In Old Mice 

Aged mice given purified plasmalogen supplements showed better memory performance, healthier synaptic structure, lower neuroinflammation, and increased signaling tied to neurite growth and synapse development, with treated mice even growing thicker, darker, glossier hair. Plasmalogens are specialized lipids concentrated in cell membranes and the brain that tend to decline with age and neurodegenerative disease, making them an intriguing target for cognitive longevity. Host Dave Asprey breaks down why membrane composition matters for brain signaling, mitochondrial function, and inflammation, while stressing that this remains mouse research from 2022 a...

Dr. Karan Rajan on Fiber Fermentation, Sodium Myths, and What Your Poop Reveals About Disease Risk 

Your poop is more predictive than almost any other health signal, and you are flushing that data away every single day without a second look. 

Watch this episode on YouTube for the full video experience: 

https://www.youtube.com/@DaveAspreyBPR 

Host Dave Asprey sits down with Dr. Karan Rajan, a practicing NHS gastrointestinal surgeon, best-selling author, and Chief Science Officer at Throne, who has built a foll...

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Most people fail to lose weight because they have a metabolic block nobody told them about. In this video, I’ve shared the three golden rules for losing 50 pounds fast, and why everything you've been told about weight loss is working directly against you.

You'll also learn:

Raw Garlic "Ultimate Biohack" Trend Faces Scientific Scrutiny 

Raw garlic has gone viral as a morning ritual, with fans crushing a clove, mixing it with honey, and crediting it with everything from lower cholesterol and better insulin sensitivity to cleared acne, eliminated brain fog, and colds cured within 24 hours. The biochemistry behind the trend is real: garlic contains no allicin until it's crushed or chopped, which mixes an enzyme with a sulfur compound to form the active compound, and letting it sit for ten to fifteen minutes before cooking preserves more of that activity. Host Dave Asprey s...

Jenny McCarthy on Reversing Autism, Healing Mold Toxicity, and the Biohacking Protocol Big Pharma Doesn't Want You to Know 

Back with another long one! Autism, mold poisoning, and cognitive decline share more root causes than most doctors admit, and this episode hands you the biohacking playbook to reverse all three. 

Want to try Jenny's makeup and skincare line? Visit https://bit.ly/Formless-Beauty and use code DAVE to unlock a discount. 

Host Dave Asprey sits down with Jenny McCarthy Wahlberg, a New York Times bests...

The 3 "Longevity Drugs" That Fail the Data, and 4 Repurposed Ones Worth Considering 

Back with another solo episode, this one on Big Pharma! Metformin, rapamycin, and statins are three of the most trusted names in longevity, and none of them hold up the way you've been told. This episode breaks down the human data behind the drugs everyone assumes are safe, and reveals four lesser-known repurposed pharmaceuticals that might do more for your metabolism, mitochondria, and lifespan. 

Watch this episode on YouTube for the full video experience: https://www.youtube.com/@Dav...

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The most powerful energy compounds aren't in your local supplement store. They're sitting in Eastern European science, and Thai herbal medicine, completely ignored by an industry that only profits from what it can patent. In this video I break down 7 compounds that have transformed my energy, sharpened my focus, and kept my brain performing like it did decades ago. 

Starting your weekend off right, with the king of mindset. We had to replay this one because it's too goo not to!

Meet a man who makes miracles happen. Today, I’m joined in the studio by Hal Elrod, author of the international bestseller The Miracle Morning and his newest book, The Miracle Equation. After overcoming multiple near-death experiences and financial hardships, Hal channeled his adversity into helping others overcome their own challenges. His Miracle Morning approach has impacted millions of lives.

On today’s episode, Hal tells us all about his upda...

Jonny Miller on Nervous System Mastery, Grief, and Why High Performers Can't Afford to Stay Stuck in Their Heads 

Your nervous system is running every decision, relationship, and reaction in your life, and you won't notice how much it's costing you until something breaks. This episode gives you the exact framework for building real nervous system mastery instead of running on autopilot until it fails. 

Watch this episode on YouTube for the full video experience: https://www.youtube.com/@DaveAspreyBPR 

Host Dave Asprey sits down with...