Brain Inspired

40 Episodes
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By: Paul Middlebrooks

Neuroscience and artificial intelligence work better together. Brain inspired is a celebration and exploration of the ideas driving our progress to understand intelligence. I interview experts about their work at the interface of neuroscience, artificial intelligence, cognitive science, philosophy, psychology, and more: the symbiosis of these overlapping fields, how they inform each other, where they differ, what the past brought us, and what the future brings. Topics include computational neuroscience, supervised machine learning, unsupervised learning, reinforcement learning, deep learning, convolutional and recurrent neural networks, decision-making science, AI agents, backpropagation, credit assignment, neuroengineering, neuromorphics, emergence, philosophy of mind, consciousness, general AI...

BI 215 Xiao-Jing Wang: Theoretical Neuroscience Comes of Age
Yesterday at 2:24 PM

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The Transmitter is an online publication that aims to deliver useful information, insights and tools to build bridges across neuroscience and advance research. Visit thetransmitter.org to explore the latest neuroscience news and perspectives, written by journalists and scientists.

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Sign up for Brain Inspired email alerts to be notified every time a new Brain Inspired episode is released.

To explore more neuroscience news and perspectives, visit thetransmitter.org.

Xiao-Jing Wang i...


BI 214 Nicole Rust: How To Actually Fix Brains and Minds
06/18/2025

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The Transmitter is an online publication that aims to deliver useful information, insights and tools to build bridges across neuroscience and advance research. Visit thetransmitter.org to explore the latest neuroscience news and perspectives, written by journalists and scientists.

Read more about our partnership.

Check out this story:

What, if anything, makes mood fundamentally different from memory?

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BI 213 Representations in Minds and Brains
06/04/2025

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The Transmitter is an online publication that aims to deliver useful information, insights and tools to build bridges across neuroscience and advance research. Visit thetransmitter.org to explore the latest neuroscience news and perspectives, written by journalists and scientists.

Read more about our partnership.

Check out this series of essays about representations:

What are we talking about? Clarifying the fuzzy concept of representation in neuroscience and beyond

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BI 212 John Beggs: Why Brains Seek the Edge of Chaos
05/21/2025

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The Transmitter is an online publication that aims to deliver useful information, insights and tools to build bridges across neuroscience and advance research. Visit thetransmitter.org to explore the latest neuroscience news and perspectives, written by journalists and scientists.

Read more about our partnership.

Sign up for Brain Inspired email alerts to be notified every time a new Brain Inspired episode is released.

To explore more neuroscience news and perspectives, visit thetransmitter.org.

You may h...


BI 211 COGITATE: Testing Theories of Consciousness
05/07/2025

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The Transmitter is an online publication that aims to deliver useful information, insights and tools to build bridges across neuroscience and advance research. Visit thetransmitter.org to explore the latest neuroscience news and perspectives, written by journalists and scientists.

Read more about our partnership.

Sign up for Brain Inspired email alerts to be notified every time a new Brain Inspired episode is released.

To explore more neuroscience news and perspectives, visit thetransmitter.org.

Rony Hirschhorn, A...


BI 210 Dean Buonomano: Consciousness, Time, and Organotypic Dynamics
04/22/2025

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Dean Buonomano runs the Buonomano lab at UCLA. Dean was a guest on Brain Inspired way back on episode 18, where we talked about his book Your Brain is a Time Machine: The Neuroscience and Physics of Time, which details much of his thought and research about how centrally important time is for virtually everything we do, different conceptions of time in philosophy, and how how brains might tell time. That was almost 7 years ago, and his work on time and dynamics in computational n...


BI 209 Aran Nayebi: The NeuroAI Turing Test
04/09/2025

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The Transmitter is an online publication that aims to deliver useful information, insights and tools to build bridges across neuroscience and advance research. Visit thetransmitter.org to explore the latest neuroscience news and perspectives, written by journalists and scientists.

Read more about our partnership.

Sign up for the “Brain Inspired” email alerts to be notified every time a new “Brain Inspired” episode is released.

To explore more neuroscience news and perspectives, visit thetransmitter.org.

Aran Nayebi is...


BI 208 Gabriele Scheler: From Verbal Thought to Neuron Computation
03/26/2025

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Gabriele Scheler co-founded the Carl Correns Foundation for Mathematical Biology. Carl Correns was her great grandfather, one of the early pioneers in genetics. Gabriele is a computational neuroscientist, whose goal is to build models of cellular computation, and much of her focus is on neurons.

We discuss her theoretical work building a new kind of single neuron model. She, like Dmitri Chklovskii a few episodes ago, believes we've been stuck with essentially the same family of models for a neuron for a...


BI 207 Alison Preston: Schemas in our Brains and Minds
03/12/2025

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The Transmitter is an online publication that aims to deliver useful information, insights and tools to build bridges across neuroscience and advance research. Visit thetransmitter.org to explore the latest neuroscience news and perspectives, written by journalists and scientists.

Read more about our partnership.

Sign up for the “Brain Inspired” email alerts to be notified every time a new “Brain Inspired” episode is released.

To explore more neuroscience news and perspectives, visit thetransmitter.org.

The concept o...


Quick Announcement: Complexity Group
03/05/2025

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Complexity Group Email List.


BI 206 Ciara Greene: Memories Are Useful, Not Accurate
02/26/2025

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Ciara Greene is Associate Professor in the University College Dublin School of Psychology. In this episode we discuss Ciara's book Memory Lane: The Perfectly Imperfect Ways We Remember, co-authored by her colleague Gillian Murphy. The book is all about how human episodic memory works and why it works the way it does. Contrary to our common assumption, a "good memory" isn't necessarily highly accurate - we don't store memories like files in a filing cabinet. Instead our memories evolved to help us function i...


BI 205 Dmitri Chklovskii: Neurons Are Smarter Than You Think
02/12/2025

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The Transmitter is an online publication that aims to deliver useful information, insights and tools to build bridges across neuroscience and advance research. Visit thetransmitter.org to explore the latest neuroscience news and perspectives, written by journalists and scientists.

Read more about our partnership.

Sign up for the “Brain Inspired” email alerts to be notified every time a new “Brain Inspired” episode is released:

To explore more neuroscience news and perspectives, visit thetransmitter.org.

Since the 1940s...


BI 204 David Robbe: Your Brain Doesn’t Measure Time
01/29/2025

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The Transmitter is an online publication that aims to deliver useful information, insights and tools to build bridges across neuroscience and advance research. Visit thetransmitter.org to explore the latest neuroscience news and perspectives, written by journalists and scientists.

Read more about our partnership.

Sign up for the “Brain Inspired” email alerts to be notified every time a new “Brain Inspired” episode is released:

To explore more neuroscience news and perspectives, visit thetransmitter.org.

When you play...


BI 203 David Krakauer: How To Think Like a Complexity Scientist
01/14/2025

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The Transmitter is an online publication that aims to deliver useful information, insights and tools to build bridges across neuroscience and advance research. Visit thetransmitter.org to explore the latest neuroscience news and perspectives, written by journalists and scientists.

Read more about our partnership.

Sign up for the “Brain Inspired” email alerts to be notified every time a new “Brain Inspired” episode is released.

David Krakauer is the president of the Santa Fe Institute, where their mission is offici...


BI 202 Eli Sennesh: Divide-and-Conquer to Predict
01/03/2025

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The Transmitter is an online publication that aims to deliver useful information, insights and tools to build bridges across neuroscience and advance research. Visit thetransmitter.org to explore the latest neuroscience news and perspectives, written by journalists and scientists.

Read more about our partnership.

Sign up for the “Brain Inspired” email alerts to be notified every time a new Brain Inspired episode is released.

Eli Sennesh is a postdoc at Vanderbilt University, one of my old stomping groun...


BI 201 Rajesh Rao: From Predictive Coding to Brain Co-Processors
12/18/2024

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Today I'm in conversation with Rajesh Rao, a distinguished professor of computer science and engineering at the University of Washington, where he also co-directs the Center for Neurotechnology. Back in 1999, Raj and Dana Ballard published what became quite a famous paper, which proposed how predictive coding might be implemented in brains. What is predictive coding, you may be wondering? It's roughly the idea that your brain is constantly predicting incoming sensory signals, and it generates that prediction as a top-down signal that meets t...


BI 200 Grace Hwang and Joe Monaco: The Future of NeuroAI
12/04/2024

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Joe Monaco and Grace Hwang  co-organized a recent workshop I participated in, the 2024 BRAIN NeuroAI Workshop. You may have heard of the BRAIN Initiative, but in case not, BRAIN is is huge funding effort across many agencies, one of which is the National Institutes of Health, where this recent workshop was held. The BRAIN Initiative began in 2013 under the Obama administration, with the goal to support developing technologies to help understand the human brain, so we can cure brain based diseases.

BR...


BI 199 Hessam Akhlaghpour: Natural Universal Computation
11/26/2024

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The Transmitter is an online publication that aims to deliver useful information, insights and tools to build bridges across neuroscience and advance research. Visit thetransmitter.org to explore the latest neuroscience news and perspectives, written by journalists and scientists.

Read more about our partnership.

Sign up for the “Brain Inspired” email alerts to be notified every time a new “Brain Inspired” episode is released: https://www.thetransmitter.org/newsletters/

To explore more neuroscience news and perspectives, visit thetransm...


BI 198 Tony Zador: Neuroscience Principles to Improve AI
11/11/2024

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The Transmitter is an online publication that aims to deliver useful information, insights and tools to build bridges across neuroscience and advance research. Visit thetransmitter.org to explore the latest neuroscience news and perspectives, written by journalists and scientists.

Read more about our partnership.

Sign up for the “Brain Inspired” email alerts to be notified every time a new “Brain Inspired” episode is released: https://www.thetransmitter.org/newsletters/

To explore more neuroscience news and perspectives, visit thetransm...


BI 197 Karen Adolph: How Babies Learn to Move and Think
10/25/2024

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The Transmitter is an online publication that aims to deliver useful information, insights and tools to build bridges across neuroscience and advance research. Visit thetransmitter.org to explore the latest neuroscience news and perspectives, written by journalists and scientists.

Read more about our partnership.

Sign up for the “Brain Inspired” email alerts to be notified every time a new “Brain Inspired” episode is released.

To explore more neuroscience news and perspectives, visit thetransmitter.org.

Karen Adolph ru...


BI 196 Cristina Savin and Tim Vogels with Gaute Einevoll and Mikkel Lepperød
10/11/2024

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The Transmitter is an online publication that aims to deliver useful information, insights and tools to build bridges across neuroscience and advance research. Visit thetransmitter.org to explore the latest neuroscience news and perspectives, written by journalists and scientists. 

This is the second conversation I had while teamed up with Gaute Einevoll at a workshop on NeuroAI in Norway. In this episode, Gaute and I are joined by Cristina Savin and Tim Vogels. Cristina shares how her lab uses recurrent neural ne...


BI 195 Ken Harris and Andreas Tolias with Gaute Einevoll and Mikkel Lepperød
10/08/2024

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The Transmitter is an online publication that aims to deliver useful information, insights and tools to build bridges across neuroscience and advance research. Visit thetransmitter.org to explore the latest neuroscience news and perspectives, written by journalists and scientists.

This is the first of two less usual episodes. I was recently in Norway at a NeuroAI workshop called Validating models: How would success in NeuroAI look like? What follows are a few recordings I made with my friend Gaute Einevoll. Gaute h...


BI 194 Vijay Namboodiri & Ali Mohebi: Dopamine Keeps Getting More Interesting
09/27/2024

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https://youtu.be/lbKEOdbeqHo

The Transmitter is an online publication that aims to deliver useful information, insights and tools to build bridges across neuroscience and advance research. Visit thetransmitter.org to explore the latest neuroscience news and perspectives, written by journalists and scientists. 

The Transmitter has provided a transcript for this episode.

Vijay Namoodiri runs the Nam Lab at the University of California San Francisco, and Ali Mojebi is an assistant professor at the University of Wisconsin-Madison. Ali as be...


BI 193 Kim Stachenfeld: Enhancing Neuroscience and AI
09/11/2024

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The Transmitter is an online publication that aims to deliver useful information, insights and tools to build bridges across neuroscience and advance research. Visit thetransmitter.org to explore the latest neuroscience news and perspectives, written by journalists and scientists. 

Read more about our partnership.

Check out this story:  Monkeys build mental maps to navigate new tasks

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To explore...


BI 192 Àlex Gómez-Marín: The Edges of Consciousness
08/28/2024

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Àlex Gómez-Marín heads The Behavior of Organisms Laboratory at the Institute of Neuroscience in Alicante, Spain. He's one of those theoretical physicist turned neuroscientist, and he has studied a wide range of topics over his career. Most recently, he has become interested in what he calls the "edges of consciousness", which encompasses the many trying to explain what may be happening when we have experiences outside our normal everyday experiences. For example, when we are under the influence of hallucinogens, when have...


BI 191 Damian Kelty-Stephen: Fractal Turbulent Cascading Intelligence
08/15/2024

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Damian Kelty-Stephen is an experimental psychologist at State University of New York at New Paltz. Last episode with Luis Favela, we discussed many of the ideas from ecological psychology, and how Louie is trying to reconcile those principles with those of neuroscience. In this episode, Damian and I in some ways continue that discussion, because Damian is also interested in unifying principles of ecological psychology and neuroscience. However, he is approaching it from a different perspective that Louie. What drew me originally to D...


BI 190 Luis Favela: The Ecological Brain
07/31/2024

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Luis Favela is an Associate Professor at Indiana University Bloomington. He is part philosopher, part cognitive scientist, part many things, and on this episode we discuss his new book, The Ecological Brain: Unifying the Sciences of Brain, Body, and Environment.

In the book, Louie presents his NeuroEcological Nexus Theory, or NExT, which, as the subtitle says, proposes a way forward to tie together our brains, our bodies, and the environment; namely it has a lot to do with the complexity sciences a...


BI 189 Joshua Vogelstein: Connectomes and Prospective Learning
06/29/2024

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Jovo, as you'll learn, is theoretically oriented, and enjoys the formalism of mathematics to approach questions that begin with a sense of wonder. So after I learn more about his overall approach, the first topic we discuss is the world's currently largest map of an entire brain... the connectome of an insect, the fruit fly. We talk about his role in this collaborative effort, what the heck a connectome is, why it's useful and what to do with it, and so on.


BI 188 Jolande Fooken: Coordinating Action and Perception
05/27/2024

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Jolande Fooken is a post-postdoctoral researcher interested in how we move our eyes and move our hands together to accomplish naturalistic tasks. Hand-eye coordination is one of those things that sounds simple and we do it all the time to make meals for our children day in, and day out, and day in, and day out. But it becomes way less seemingly simple as soon as you learn how we make various kinds of eye movements, and how we make various kinds of h...


BI 187: COSYNE 2024 Neuro-AI Panel
04/20/2024

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Recently I was invited to moderate a panel at the annual Computational and Systems Neuroscience, or COSYNE, conference. This year was the 20th anniversary of COSYNE, and we were in Lisbon Porturgal. The panel goal was to discuss the relationship between neuroscience and AI. The panelists were Tony Zador, Alex Pouget, Blaise Aguera y Arcas, Kim Stachenfeld, Jonathan Pillow, and Eva Dyer. And I'll let them introduce themselves soon. Two of the panelists, Tony and Alex, co-founded COSYNE those 20 years ago, and they c...


BI 186 Mazviita Chirimuuta: The Brain Abstracted
03/25/2024

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Mazviita Chirimuuta is a philosopher at the University of Edinburgh. Today we discuss topics from her new book, The Brain Abstracted: Simplification in the History and Philosophy of Neuroscience.

She largely argues that when we try to understand something complex, like the brain, using models, and math, and analogies, for example - we should keep in mind these are all ways of simplifying and abstracting away details to give us something we actually can understand. And, when we do science, every t...


BI 185 Eric Yttri: Orchestrating Behavior
03/06/2024

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As some of you know, I recently got back into the research world, and in particular I work in Eric Yttris' lab at Carnegie Mellon University.

Eric's lab studies the relationship between various kinds of behaviors and the neural activity in a few areas known to be involved in enacting and shaping those behaviors, namely the motor cortex and basal ganglia.  And study that, he uses tools like optogentics, neuronal recordings, and stimulations, while mice perform certain tasks, or, in my ca...


BI 184 Peter Stratton: Synthesize Neural Principles
02/20/2024

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Peter Stratton is a research scientist at Queensland University of Technology.

I was pointed toward Pete by a patreon supporter, who sent me a sort of perspective piece Pete wrote that is the main focus of our conversation, although we also talk about some of his work in particular - for example, he works with spiking neural networks, like my last guest, Dan Goodman.

What Pete argues for is what he calls a sideways-in approach. So a bottom-up approach i...


BI 183 Dan Goodman: Neural Reckoning
02/06/2024

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You may know my guest as the co-founder of Neuromatch, the excellent online computational neuroscience academy, or as the creator of the Brian spiking neural network simulator, which is freely available. I know him as a spiking neural network practitioner extraordinaire. Dan Goodman runs the Neural Reckoning Group at Imperial College London, where they use spiking neural networks to figure out how biological and artificial brains reckon, or compute.

All of the current AI we use to do all the impressive t...


BI 182: John Krakauer Returns… Again
01/19/2024

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Check out my free video series about what's missing in AI and Neuroscience

John Krakauer has been on the podcast multiple times (see links below). Today we discuss some topics framed around what he's been working on and thinking about lately. Things like

Whether brains actually reorganize after damage The role of brain plasticity in general The path toward and the path not toward understanding higher cognition How to fix motor problems after strokes AGI Functionalism, consciousness, and much more.

BI 181 Max Bennett: A Brief History of Intelligence
12/25/2023

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Check out my free video series about what's missing in AI and Neuroscience

By day, Max Bennett is an entrepreneur. He has cofounded and CEO'd multiple AI and technology companies. By many other countless hours, he has studied brain related sciences. Those long hours of research have payed off in the form of this book, A Brief History of Intelligence: Evolution, AI, and the Five Breakthroughs That Made Our Brains.

Three lines of research formed the basis for how M...


BI 180 Panel Discussion: Long-term Memory Encoding and Connectome Decoding
12/11/2023

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Welcome to another special panel discussion episode.

I was recently invited to moderate at discussion amongst 6 people at the annual Aspirational Neuroscience meetup. Aspirational Neuroscience is a nonprofit community run by Kenneth Hayworth. Ken has been on the podcast before on episode 103. Ken helps me introduce the meetup and panel discussion for a few minutes. The goal in general was to discuss how current and developing neuroscience technologies might be used to decode a nontrivial memory from a static connectome - w...


BI 179 Laura Gradowski: Include the Fringe with Pluralism
11/27/2023

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Laura Gradowski is a philosopher of science at the University of Pittsburgh. Pluralism is roughly the idea that there is no unified account of any scientific field, that we should be tolerant of and welcome a variety of theoretical and conceptual frameworks, and methods, and goals, when doing science. Pluralism is kind of a buzz word right now in my little neuroscience world, but it's an old and w...


BI 178 Eric Shea-Brown: Neural Dynamics and Dimensions
11/13/2023

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Eric Shea-Brown is a theoretical neuroscientist and principle investigator of the working group on neural dynamics at the University of Washington. In this episode, we talk a lot about dynamics and dimensionality in neural networks... how to think about them, why they matter, how Eric's perspectives have changed through his career. We discuss a handful of his specific research findings about dynamics and dimensionality, like how dimensionality changes w...


BI 177 Special: Bernstein Workshop Panel
10/30/2023

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I was recently invited to moderate a panel at the Annual Bernstein conference - this one was in Berlin Germany. The panel I moderated was at a satellite workshop at the conference called How can machine learning be used to generate insights and theories in neuroscience? Below are the panelists. I hope you enjoy the discussion!

Program: How can machine learning be used to generate insights and theories in neuroscience? Panelists: Katrin Franke Lab website. Twitter: @kfrankelab. Ralf Haefner Haefner lab. Twitter: @h...