The Wine Lab
A sciency podcast series about wine, chemistry, flavor, smell and everything in between hosted by wine and sensory scientist, book worm and food aficionado, Andreea Botezatu.
Why Wine Sometimes Smells Like Vinegar: The Science of Volatile Acidity
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Why does a wine sometimes smell like vinegar, or even nail polish remover?
In this episode of The Wine Lab, Andreea explores the science behind volatile acidity, one of the most confusing aspects of wine aroma. While small amounts can add brightness and complexity, higher levels can shift a wineâs character dramatically.
Youâll learn how volatile acidity forms, from grape damage in the vineyard to oxygen exposure in the cellar, and why microbes known as acetic acid bacteria play such...
Fault or Style? Understanding Oxidation in Wine
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Is that wine flawed⊠or just different?
In this episode of The Wine Lab, Andreea explores the difference between wine faults and flaws before turning to one of the most powerful forces in wine chemistry: oxidation.
What causes the bruised apple aroma in oxidized wine? What role does sulfur dioxide play in protection? Why did certain white Burgundies suffer from premature oxidation, known as âpremox,â in the 1990s and early 2000s? And why are wines like Sherry and Madeira intentionally oxidative?
This episode blends...
When Wine Labels Play Mind Games
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Have you ever stood in the wine aisle holding a bottle and thought, âAm I overthinking this?â
In this episode of The Wine Lab, Andreea unpacks why wine labels can feel so confusing, even to people who work in wine.
Why do some bottles list the grape, while others only name a place? What does Burgundy actually mean? Why does Bordeaux rarely tell you the grape outright?Â
We explore how grape varieties work (think apples: Granny Smith vs. Honeycrisp), how geography compre...
Second Round Wine: Piquette, Then and Now
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Piquette is one of wineâs oldest ideas and one of its newest obsessions. Made by fermenting grape pomace with water, this light, often sparkling wine has roots in ancient Roman practices, European vineyard culture, and everyday resourcefulness. Once known as a drink for workers and families - sometimes simply called âsecond round wineâ - piquette has reemerged as a symbol of sustainability, moderation, and creativity.
In this episode of The Wine Lab, we explore what piquette is, how itâs made, and why it resonates so strongly...
Between Valpolicella and Amarone: The Science of Ripasso
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Ripasso wines are made by giving a finished Valpolicella wine a second pass through fermentation, pouring it over the grape skins left behind from Amarone or Recioto and allowing renewed microbial activity and extraction to take place. In this episode of The Wine Lab, we walk through what that second pass actually does: how refermentation can restart, how phenolics and color are re-extracted from appassimento-treated skins, and how the chemistry of Ripasso differs depending on whether the pomace comes from sweet Recioto or dry Amarone. Along the way, we...
Appassimento and the Art of Waiting
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What happens when grapes are asked to wait?
In this episode of The Wine Lab, we explore appassimento, the traditional practice of drying grapes before fermentation, and how it reshapes wine long before yeast ever gets involved. From ancient Roman preservation methods to modern Amarone and passito wines, we look at how dehydration concentrates sugars, alters acidity, and transforms texture and aroma.
Along the way, we meet Corvina, the grape at the heart of Valpolicellaâs most iconic wines and trace ho...
Clay, Skins, and Time: Orange Wine in Georgia
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Orange wine often feels contemporary, even radical, yet its roots stretch back thousands of years. In this episode of The Wine Lab, we travel to Georgia, widely considered one of the birthplaces of wine, to explore qvevri winemaking, extended skin contact, and the historical foundations of what we now call orange wine. Along the way, we unpack how this style bridges white and red winemaking, why it pairs so naturally with food, and how ancient clay vessels continue to shape modern wine conversations. This is a story of time...
Marsala And The Reputation It Did Not Choose
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Welcome back to The Wine Lab. In this episode, we take a closer look at Marsala, one of the most misunderstood fortified wines in the world.
Often dismissed as a cooking ingredient, Marsala has a long history as a serious wine shaped by fortification, oxidative aging, and deliberate patience. We explore how Marsala is made, the grape varieties that define it, and why oxygen plays such a central role in its aroma and structure. Along the way, we unpack the classification system, from Secco to Vergine, and...
Vermouth and the Logic of Botanicals
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Vermouth is everywhere, yet rarely examined on its own.
Often encountered through classic cocktails rather than the glass itself, vermouth plays a defining role in balance, aroma, and structure while remaining largely unacknowledged. In this episode of The Wine Lab, we slow down and treat vermouth as what it truly is: wine, shaped by fortification, bitterness, and deliberate design.
We explore vermouthâs foundations in neutral grape varieties, the use of grape spirit for stability and extraction, and the careful construction of botanical profiles built ar...
Madeira - From Ocean Voyages to Attic Barrels
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Madeira is one of the most resilient wines ever produced. Fortified during fermentation, intentionally heated, and slowly oxidized, it defies many of the rules that govern wine aging and thrives because of it.
In this episode of The Wine Lab, we explore how Madeiraâs unique production methods developed through long ocean voyages, how fortification with highly rectified grape spirit shapes sweetness and stability, and why heating methods like estufagem and canteiro create such extraordinary longevity. Along the way, we trace Madeiraâs chemical evolution, its role in h...
Fortified by the Douro: The Story of Port Wine
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Step into the steep, sunlit terraces of Portugalâs Douro Valley and explore how landscape, law, chemistry, and culture shaped one of the worldâs most distinctive wines.Â
In this episode of The Wine Lab, host Dr. Andreea Botezatu traces the story of Port from the Douroâs historic demarcation in 1756 to the precise moment fermentation is stopped with grape spirit.Â
Follow the evolution of styles, from rubyâs vibrant fruit to the layered depth of long-aged tawnies, and learn how traditional lagares, the BenefĂcio vineyar...
Under the Flor: The Science and Soul of Sherry
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In this episode of The Wine Lab, host Dr. Andreea Botezatu explores the scientific brilliance and cultural heritage of Sherry. From AndalucĂaâs luminous albariza soils to the flor yeasts that sculpt its aromatic identity, Sherry emerges as a wine shaped by geology, microbiology, and centuries of human expertise. We examine how fortification, performed after fermentation, determines whether a wine will age biologically as a Fino or oxidatively as an Oloroso, and how the solera system maintains continuity acro...
Winter in a Glass: The Story and Science of Icewine
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Icewine is one of the most challenging and extraordinary wines ever produced,a liquid born from winter itself. In this episode of The Wine Lab, Dr. Andreea Botezatu explores how a frozen accident in 1794 became one of the modern wine worldâs most coveted styles. We travel from Germany to Canadaâs Niagara Peninsula, through vineyards picked at â10°C, and into fermenters battling extreme osmotic stress, soaring Brix, and yeast pushed to its limits.
From the brutal harvest nights to the chemistry of freezing, from osmotol...
Pét-Nat: Ancient Method, Modern Mood
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Before Champagne perfected the art of bubbles, there was pétillant naturel or pét-nat - the ancestral, gracefully imperfect way to make sparkling wine. In this episode of The Wine Lab, we explore the chemistry, the history, and the somewhat controlled chaos that defines this naturally effervescent style.
Why does pét-nat fizz differently? What actually happens when fermentation finishes inside a sealed bottle? And why are winemakers, from the Loire to California, falling back in love with this centuries-old technique?
From carbo...
Steel, Bubbles, and Fruit: Inside the Making of Prosecco
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What makes Prosecco so different from Champagne or Cava?
 In this episode, Andreea takes you inside the tanks (almost literally) to explore the Charmat method, the clever bit of winemaking engineering that gives Prosecco its bright, floral personality.
Weâll look at how Glera grapes, stainless-steel pressure tanks, and precise temperature control create a wine built on freshness rather than aging. Youâll learn what âtirageâ and âdosageâ mean in Prosecco, why it skips lees aging, and how its chemistry translates into texture, aroma, and food pair...
Champagne & Cava: Two Ways to Catch a Bubble (or proof that joy can be engineered - one tiny bubble at a time)
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Across Europe, bubbles tell stories. In this episode of The Wine Lab, we explore two sparkling legends - Champagne and Cava - both born from the same meticulous process yet shaped by different lands, grapes, and histories.
Weâll uncover how the traditional method transforms still wine into a storm of fine bubbles, why the same Brut label can taste drier in Champagne than in Cava, and how yeast, sugar, and time create that signature creamy texture and brioche aroma...
Inside the Barrel: Where Wine Meets Oak, Fire, and Time
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In this episode of The Wine Lab, Andreea takes you inside one of winemakingâs most iconic tools â the oak barrel. From Celtic craftsmanship to modern coopering, weâll explore how fire, oxygen, and time turn simple wood into a vessel of transformation.
Discover why oak became the gold standard, what happens during toasting, and how micro-oxygenation softens tannins and stabilizes color. Learn about the differences between French, American, and Hungarian oak, the chemistry behind aging, and even the future of sustainable cooperage â including experimental ideas like biochar...
From Leather to Cabernet: The Story of Tannins
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In this episode of The Wine Lab, we explore the science and story of tannins: what they are, where they come from, and why some wines feel silky while others grip your gums.
From the ancient craft of leather tanning to modern barrel aging, we trace how these polyphenolic compounds shape wineâs structure, color, and longevity. Weâll look at how fermentation temperature, pH, and rising alcohol shift what gets extracted from skins and seeds â and how acidity changes the way tannins feel on your palate.
Y...
Wine with Spirit: The World of Fortified Wines
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What do Port, Sherry, Madeira, Marsala, and Vermouth all have in common? Theyâre wines with an extra ingredient â spirit. In this episode of The Wine Lab, Dr. Andreea Botezatu explores how fortification began as a practical solution for preserving wine on long sea voyages and evolved into a craft that shaped trade, taste, and culture.
From Shakespeareâs Falstaff praising âsackâ to George Washingtonâs love for Madeira, weâll travel through history and a little chemistry to understand what makes fortified wines so endur...
Dom Perignon - The Monk Who Didnât Invent Champagne
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Everyone knows the story of Dom PĂ©rignon â the monk who invented Champagne and declared he was âtasting the stars.â But history tells a very different tale. In this episode of The Wine Lab, we uncover the truth behind one of wineâs most enduring myths.
Dom PĂ©rignon didnât create sparkling wine at all! In fact, he spent much of his life trying to eliminate bubbles from the Abbey of Hautvillersâ wines. Yet his innovations in grape selection, blending, and cellar practices laid the foundation for the Champa...
Roots of Disaster: The Phylloxera Story. A tiny insect nearly erased wine from history â discover how science, stubbornness, and a Texan saved it.
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In the late 1800s, an almost invisible insect began destroying Europeâs vineyards. This episode of The Wine Lab takes you inside the phylloxera crisis â from the first mysterious vine deaths in France to the desperate experiments, scientific breakthroughs, and global collaboration that saved wine from near extinction. Along the way, we meet the heroes of the story, including Texan horticulturist T.V. Munson, whose work with American rootstocks helped rescue French viticulture. Discover how this tiny pest reshaped winemaking traditions, why grafted vines are now the global standard, and...
From Bark to Bottle: The Cork Chronicles
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Cork is everywhere in the world of wine, from the quiet of a cellar to the noise of a celebration. But how did this small stopper come to influence the way wines age, the rituals of opening a bottle, and even the way we think about quality? In this episode of The Wine Lab, we explore the science, the history, and the culture wrapped up in every cork, and ponder why it remains central to wine today.Â
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Sweet Lies and Dry Truths: Sugar in Wine
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 Is wine really âfull of sugarâ? What about those âzero sugarâ labels, or the idea that wine is keto-friendly? In this episode of The Wine Lab, Andreea breaks down what you need to know about sugar in wine â from grapes on the vine to yeast in the tank, from chaptalization in Burgundy to back-sweetening in Riesling, and from Champagne dosage to carbs and calories. Along the way, weâll uncover whatâs legal, whatâs marketing, and what really ends up in your glass.Â
Glossary
Glucose & Fru...Wine in Art â From Ancient Gods to Pop Culture
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 Wine shimmers across the history of art: painted on Egyptian tomb walls, poured into Greek amphorae, celebrated in Roman mosaics, lifted in Renaissance chalices, and glowing in Impressionist picnics. In this episode of The Wine Lab, we follow its journey through image, poetry, and song, tracing how wine has carried sacred meanings, earthly joys, and artistic inspiration across millenniaâending with Pablo Nerudaâs luminous Ode to Wine.
đ· Glossary of Lesser-Known Terms
Amphora
A tall, two-handled clay vessel used in ancie...
Headaches, Hipsters, and the Myth of Sulfite-Free Natural Wine
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 In this episode of The Wine Lab, host Andreea Botezatu unpacks the misunderstood world of sulfites in wine â what they are, what they do, and why that warning label exists. From antioxidant chemistry to ancient winemaking tricks, we look at how sulfur dioxide protects wine, explore common myths - like the one about sulfites and headaches - and even dive into the science of those rare sulfite sensitivities. Expect a splash of history, a little rock ânâ roll, and a few nerdy detours into redox chemistry.Â
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The Oldest Wines Ever Discovered â Stories from the Ancient World
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From Neolithic pottery shards to golden amphorae sealed for millennia, the worldâs oldest wines tell us more than just what ancient people drank â they reveal how wine shaped trade, ritual, and daily life across civilizations. In this episode, we journey through some of the most remarkable archaeological wine finds, explore the science used to identify them, and imagine what these ancient vintages might have tasted like.
Glossary
Qvevri (also spelled Kvevri)
Large, egg-shaped clay vessels used in Geor...
Under Pressure: The Craft and Chemistry of Sparkling Wine. How do the worldâs finest bubbles get into your glass? We explore the science, regions, and traditions of sparkling wine.
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 From royal courts in 17th-century France to todayâs celebrations around the world, sparkling wine has captured attention for centuries. In this episode of The Wine Lab, host Andreea Botezatu explains how sparkling wines are made, from traditional Champagne techniques to Proseccoâs Charmat method and beyond. Weâll look at the role of secondary fermentation, explore different sweetness levels, highlight the major regions producing sparkling wine, and share the story of La Veuve Clicquot, the woman who changed sparkling wine production forever.Â
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Native Rebels and Cultured Icons: Yeast in the Cellar - How yeast drives complexity, unpredictability, and style in winemaking.
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In this episode of The Wine Lab, we explore the unseen world of yeastâthe microscopic winemakers transforming grape juice into wine.Â
From lab-selected commercial strains to wild, spontaneous fermentations and even wineries culturing their own native yeasts, we uncover how these tiny organisms shape wineâs flavor, texture, and identity.Â
Along the way, we touch on yeastâs long history in human cultureâfrom bread to beer to Bordeaux.Â
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Smells Like Wine Spirit: The Science of Aroma
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Why does a glass of wine smell like blackberries, jasmine, or freshly cut herbsâwhen itâs made entirely from grapes?Â
In this episode, we explore the complex and fascinating science of wine aroma.
 From compounds naturally found in grapes and flowers to the transformative role of fermentation and microbes, we trace how scent molecules form, evolve, and interact with our senses.Â
Weâll also examine how genetics, memory, and culture shape the way we experience wine, and why no two noses interpret it quite...
Malolactic: Magic or Mayhem?
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In this episode of The Wine Lab, we swirl through the science of malolactic fermentation (MLF), the process that can soften wine and elevate complexity, but also invite spoilage and instability, especially in high pH wines. We break down what MLF actually is, why winemakers use it, when they avoid it, and how to manage its benefits and risks with precision.
Perfect for winemakers, wine students, and curious wine lovers.
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Sour Grapes, Sweet Solutions: How Verjus Could Help Winemakers Beat the Heat
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Can a splash of sour grape juice make wines better in a warming world?Â
In this episode, we explore how verjusâjuice from unripe grapesâcan improve wine chemistry, reduce alcohol, and enhance sustainability in hot-climate winemaking. Based on research from Texas A&M University.
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Uncorking Haloanisoles in Wine
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Weâve all heard of âcorkedâ wine â but what if that wet dog smell isnât the corkâs fault at all? In this episode of The Wine Lab, we explore the fascinating and frustrating world of haloanisoles: TCA, TBA, TeCA, PCA, and their highly aromatic footprint in wine.
These powerful compounds can travel through the air, cling to barrels and insulation, and even sabotage stainless steel tanks. Learn about their origins, their impact on sensory perception, the limits of closures like screwcaps and synthetic corks, and t...
Cluster Thinning and Wine Quality: Myth, Method, or Must?
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Can fewer grapes mean better wine? In this episode of The Wine Lab, Dr. Andreea Botezatu explores the science behind cluster thinning, a time-honored but hotly debated vineyard practice. Drawing from a recent narrative systematic review, we break down what the research really says about its impact on wine aroma, phenolics, sensory quality, and economic viability. Whether youâre managing a vineyard or just love wine science, this episode offers practical insights to help you make informed decisions.
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