Changing a Leopard's Spots: Science, Data/AI, & Strategy
Join John F. Conway (creator of Rock Stars of R&D) from 20/15 Visioneers and Dr. Raminderpal Singh (from HitchhikersAI) as they dive into the evolving world of science, artificial intelligence, and strategic innovation. Through insightful discussions, they challenge assumptions and uncover new perspectives on technology and decision-making.Podcast: Changing a Leopard's Spots | 20/15Visioneers | HitchhikersAI
Technical Debt in R&D Organizations: A Conversation with John F. Conway and Raminderpal Singh

Technical Debt in R&D Organizations: A Conversation with John F. Conway and Raminderpal Singh
Overview
John F. Conway and Raminderpal Singh explore how technical debt accumulates within R&D organizations — particularly in pharma and life sciences — and why it often goes unaddressed. They share real-world stories, practical solutions, and leadership lessons for managing the growing complexity of scientific and technical systems.
đź’ˇ Key Topics Covered:
How technical debt arises in well-funded vs. resource-constrained organizationsThe hidden challenges of integrating outdated and redundant systemsWh...The Multiple Ways to Fund a Scientific Business Endeavor
Funding Science Startups & Avoiding Failure | Changing a Leopard’s Spots - Ep. 2
In this episode of Changing a Leopard’s Spots, hosts John Conway (20/15 Visioneers) and Raminderpal Singh (HitchhikersAI.org) dive into the challenges of funding scientific businesses and the key strategies for building sustainable organizations.
đź’ˇ Key Topics Covered:
🔹 Alternative funding options beyond venture capital – grants, angel investors, IPOs & more
🔹 The reality of VC funding: high stakes, pressure, and low success rates
🔹 Bootstrapping vs. raising capital – when to choose what
🔹 Building a strong company culture and avoiding toxic competition
🔹 The e...
Can AI Save the Data Culture Challenge?
In the inaugural episode of Changing a Leopard’s Spots, John Conway (20/15 Visioneers) and Raminderpal Singh (HitchhikersAI) discuss the intricate relationship between AI, data culture, and organizational transformation. They explore historical parallels, current challenges, and future implications for businesses navigating a data-driven world.
The Evolution of Culture and Data
The discussion begins with how culture has driven major shifts, from early civilizations to today’s digital revolution. Culture isn’t just policies—it’s the unwritten behaviors that shape progress. Conway and Singh emphasize that fostering a data culture is distinct from traditional knowledge...