Dr. Brendan McCarthy
Dr. Brendan McCarthy founded Protea Medical Center in 2006. In his role as Chief Medical Officer, Protea has grown and evolved into a dynamic medical center serving not only the Phoenix Valley, but also central Arizona. Dr. McCarthy is the author of, Jump Off The Mood Swing, A Sane Woman’s Guide To Her Crazy Hormones. He’s also internationally recognized as an expert in hormone replacement therapy. He has lectured physicians and pharmacists on topics such as weight loss, infertility, hormone replacement therapy, nutritional therapy and more. Through a growing referral network, individual patients have helped grow Protea Medical Center into...
Testosterone in Women: FSH, Hair Loss & Real Questions Answered
Welcome to the podcast with Dr. Brendan McCarthy!
In this episode, I’ll be responding to your questions and comments. As always, thank you for being part of this community. Your questions fuel these episodes — and I’m honored to keep showing up for you. 🧪 Have questions about your labs? Drop them in the comments — I may cover them in the next episode. 💬 Yes, I do read them (even in movie previews).
Dr. Brendan McCarthy founded Protea Medical Center in 2002. While he’s been the chief medical officer, Protea has grown and evolved into a...
What We’re Learning About TRT and Breast Cancer Risk
Welcome to the podcast with Dr. Brendan McCarthy!
In this episode, he dives deep into the powerful potential, and the necessary precautions, of testosterone replacement therapy (TRT) in women. He shares why this once-taboo treatment is gaining traction, how it may reduce the risk of breast cancer by up to 50%, and why lab testing and clinical nuance are absolutely non-negotiable. Dr. McCarthy also addresses medical betrayal, the rise of influencer-driven misinformation, and what it means to receive care rooted in science, safety, and trust. If you've ever been confused, dismissed, or overwhelmed by hormone therapy c...
Why I Always Run Labs Before Hormone Therapy: The Real Risks of Skipping FSH
Welcome to the podcast with Dr. Brendan McCarthy!
In this deeply personal episode, he shares why lab work—especially testing FSH (Follicle Stimulating Hormone)—is non-negotiable in hormone replacement therapy.
This is not about gatekeeping. It’s about understanding. It’s about caring. Dr. McCarthy recounts a formative memory of meeting a woman who underwent surgical menopause and was never told what would happen to her body afterward. That moment shaped his lifelong mission to treat women with comprehensive, individualized care—not cookie-cutter patches or “blind firing” estrogen without context.
In this episod...
Why Perimenopausal Hormone Labs Do Matter — Debunking Dangerous Myths
Welcome to the podcast with Dr. Brendan McCarthy!
In this video, Dr. Brendan McCarthy breaks down common misconceptions about hormone testing and treatment during perimenopause — including why many influencers and physicians get it wrong. From the misuse of expensive boutique tests like the Dutch test, to the dangers of suppressive hormone therapies without proper lab monitoring, Dr. McCarthy explains the science behind hormone fluctuations, why labs do provide valuable insights, and the importance of individualized care.
Learn why ignoring hormone labs isn’t just lazy — it’s harmful — and how true, affordable care should prio...
Should You Get HRT Without Lab Work? Why I Always Test First
Welcome to the podcast with Dr. Brendan McCarthy!
Can you start hormone replacement therapy (HRT) or bioidentical hormones without lab testing? Technically—yes. But should you? In this episode, Dr. Brendan McCarthy, Chief Medical Officer of Protea Medical Center, shares his medical perspective on why skipping labs could put your health at risk.
Responding to viral videos that suggest lab work is unnecessary, Dr. McCarthy walks you through:
✅ Why objective data matters—especially for hormone care
✅ The dangers of prescribing hormones without testing
✅ How HRT can be safely and affordably...
Testosterone in Women: Dosing, Labs & What Most Doctors Miss
Welcome to the podcast with Dr. Brendan McCarthy!
This episode takes you deep into the real-world practice of prescribing testosterone therapy for women.
This is not a high-level overview—this is a nuts and bolts breakdown:
✅ Who it's for
✅ How it's dosed
✅ What labs to run
✅ What delivery methods are safest
✅ Why it's often done wrong—and how to get it right
With over 20 years of clinical experience, Dr. McCarthy shares the insights no seminar or textbook can offer, including the em...
The Truth About Testosterone in Women: What Your Doctor May Not Be Telling You
Welcome to the podcast with Dr. Brendan McCarthy!
In this episode we dive deep into one of the most misunderstood and debated topics in hormone health: testosterone replacement therapy (TRT) for women. You may have heard horror stories—or glowing reviews. But what’s the truth?
Dr. McCarthy discusses:
- Why testosterone matters for women’s health
- How it affects brain chemistry, mood, bone density, and even breast tissue
- Its role after estrogen-suppressing breast cancer treatments
- The difference between safe and unsafe TRT
...Testosterone Therapy for Women: Breaking the Stigma
Welcome to the podcast with Dr. Brendan McCarthy!
Today’s episode is all about testosterone therapy in women—a topic that’s often misunderstood, highly debated, and rarely taught in depth. I’m sharing what I’ve learned over my years of clinical experience, how I approach testosterone use in women safely, and why the conversation around it needs to evolve.
Dr. Brendan McCarthy founded Protea Medical Center in 2002. While he’s been the chief medical officer, Protea has grown and evolved into a dynamic medical center serving the Valley and Central Arizon...
Progesterone Delivery Methods Explained: How It Actually Works in Your Body
Welcome to the podcast with Dr. Brendan McCarthy!
Explore how progesterone travels through the body depending on the method of delivery—oral, transdermal, or injection. Dr. McCarthy explains why certain forms may not be effective for all patients and discusses how the body metabolizes progesterone, influencing its therapeutic impact. This episode is essential for anyone considering or currently on hormone replacement therapy.
Dr. Brendan McCarthy founded Protea Medical Center in 2002. While he’s been the chief medical officer, Protea has grown and evolved into a dynamic medical center serving the Valley and Ce...
Answering Your Hormone Questions: Progesterone Reactions, MTHFR, Estrogen Detox & More
Welcome to the podcast with Dr. Brendan McCarthy!
Today’s episode is all about answering YOUR submitted questions — real concerns from real women — about hormone therapy, reverse responses to progesterone, MTHFR, estrogen detoxification, and more. This episode is packed with insights to help you better understand your body and your options.
Dr. Brendan McCarthy founded Protea Medical Center in 2002. While he’s been the chief medical officer, Protea has grown and evolved into a dynamic medical center serving the Valley and Central Arizona. A nationally recognized as an expert in hormone replacement...
Progesterone, Testosterone & HRT Questions You’re Afraid to Ask
Welcome to the podcast! In this deeply personal Q&A episode, Dr. Brendan McCarthy—Chief Medical Officer at Protea Medical Center—responds to your most powerful and vulnerable questions about hormone replacement therapy, including:
- Why some women reverse-respond to progesterone
- What to do when testosterone creams trigger migraines
- How to safely navigate HRT with MTHFR or methylation issues
- The emotional toll of being dismissed by doctors
- Why libido and vitality matter at every age
- How to advocate for yourself in a brok...
When Progesterone Backfires: Understanding Reverse Responders
Welcome to the podcast with Dr. Brendan McCarthy! Welcome to Part 3. In this episode, Dr. McCarthy dives deep into the complex world of reverse responders—women who experience increased anxiety or worsened symptoms from progesterone instead of the calming effects it typically provides.
If you’ve felt forgotten or unsupported in your hormone journey—this episode is for you.
Dr. Brendan McCarthy founded Protea Medical Center in 2002. While he’s been the chief medical officer, Protea has grown and evolved into a dynamic medical center serving the Valley and Central Arizona. A national...
When Progesterone Backfires: The Hidden Link Between Hormones, Anxiety & Trauma
Welcome to the podcast with Dr. Brendan McCarthy!
While progesterone is often prescribed for its calming and hormone-balancing effects, some women experience the exact opposite—increased anxiety, depression, and emotional instability. This phenomenon, known as reverse responding, is more common than many realize.
In this episode we explore:
The neurological effects of progesterone and why it can backfire
The role of allopregnanolone and the GABA receptor
How trauma, PTSD, and adverse childhood experiences impact hormonal response
Safer and more personalized treatment options—including transrectal delivery, low-d...
Why Progesterone Doesn’t Work for Everyone
Welcome to the podcast with Dr. Brendan McCarthy!
Today he addresses a topic many women have been waiting to hear more about: why some people don't tolerate progesterone well.
Often overlooked in both conventional and alternative medicine, "reverse responders" experience heightened anxiety, insomnia, or mood shifts when taking progesterone — a reaction that defies the standard approach. Dr. McCarthy explores the science behind these responses, the emotional toll of being dismissed, and why deeper investigation and individualized care are essential.
This episode is the first in a multi-part series where Dr. McCarthy shares:
• What...
Migraine Series Q&A
Welcome to the podcast with Dr. Brendan McCarthy! In this episode we're wrapping up our migraine series by answering your most frequently asked questions. Dr. Brendan McCarthy, Chief Medical Officer at Protea Medical Center, dives deep into the science behind progesterone, its effects on the brain, and why some people experience negative reactions. He also discusses estrogen therapy, common side effects, and why personalized medicine is key.
Dr. Brendan McCarthy founded Protea Medical Center in 2002. While he’s been the chief medical officer, Protea has grown and evolved into a dynamic medical center serving the Val...
Triptans and Beyond: Understanding the True Causes of Migraines
Welcome to the podcast with Dr. Brendan McCarthy! In this episode, we dive into the complexities of migraines, particularly the role of triptans in treating them. Dr. McCarthy addresses a common misconception about migraine pathophysiology, discusses the importance of lifestyle and genetic factors, and explains why understanding the root causes of migraines is crucial for effective treatment. He emphasizes the importance of a comprehensive approach, going beyond just using medications like triptans and considering factors such as serotonin levels, magnesium deficiency, and food sensitivities. Tune in to learn more about the intricate science behind migraines and the personalized strategies...
Unlocking the Root Cause of Migraines: The Role of Progesterone and GABA
Welcome to the podcast with Dr. Brendan McCarthy! In this episode we dive deep into the root causes of migraines in women, with a focus on the powerful role of progesterone and the GABA pathway. Learn why simply treating symptoms with medication isn’t enough and how understanding hormone balance can lead to long-term relief. This is part two of our migraine series, where we explore how estrogen and progesterone fluctuations impact brain chemistry and neural inflammation. If you’re tired of being dismissed by doctors and want to better advocate for your health, this episode is for you.
<...The Role of Estrogen in Migraines: Understanding the Link & Treatment Options
Welcome to the podcast with Dr. Brendan McCarthy! In this episode we go over the connection between estrogen and migraines. He explores how hormone fluctuations can trigger migraines, the role of serotonin, and how proper medical testing can lead to better treatment options. Dr. McCarthy also addresses common failures in traditional medicine, the importance of a full neurological workup, and why balancing estrogen is key to overall health.
Dr. Brendan McCarthy founded Protea Medical Center in 2002. While he’s been the chief medical officer, Protea has grown and evolved into a dynamic medical center serving the...
Understanding Headaches
Welcome to the podcast with Dr. Brendan McCarthy! In this episode we dive into headaches—particularly how women suffer from them more frequently than men. If you’ve been dealing with headaches that no one seems to understand, you’re not alone. This series is designed to offer insight and actionable advice, empowering you with the information you need to address the root causes of your pain.
Dr. Brendan McCarthy founded Protea Medical Center in 2002. While he’s been the chief medical officer, Protea has grown and evolved into a dynamic medical center serving the Valley an...
Your Voice Matters—Let’s Talk Menopause
Welcome to the podcast with Dr. Brendan McCarthy, Chief Medical Officer of Protea Medical Center in Tempe, Arizona. Your feedback and comments shape the discussions we have here—because your voice matters.
In this episode, Dr. McCarthy addresses some of the most common questions and misconceptions about menopause and hormone replacement therapy (HRT). He breaks down the science, clears up misunderstandings, and emphasizes the importance of personalized care—whether you choose HRT or not.
This episode is part of an ongoing series on menopause treatment, driven by the real concerns and questions from listeners like you...
Menopause & Hormone Therapy: Treatment Pt. 2
Welcome to the podcast with Dr. Brendan McCarthy! We continue our menopause series as we dive into the treatment segment! Struggling with menopause symptoms like hot flashes, mood swings, or sleep issues? Hormone therapy (HRT) could be the solution! In this video, we break down how hormone treatment works, its benefits, risks, and who it’s best for. Learn the facts and take control of your health during menopause!
This is Part 2 of 2 for Treatment
Dr. Brendan McCarthy founded Protea Medical Center in 2002. While he’s been the chief medical officer, Protea has grown...
Menopause & Hormone Therapy: Treatment Pt. 1
Welcome to the podcast with Dr. Brendan McCarthy! We continue our menopause series as we dive into the treatment segment! Struggling with menopause symptoms like hot flashes, mood swings, or sleep issues? Hormone therapy (HRT) could be the solution! In this video, we break down how hormone treatment works, its benefits, risks, and who it’s best for. Learn the facts and take control of your health during menopause!
This is Part 1 of 2 for Treatment
Dr. Brendan McCarthy founded Protea Medical Center in 2002. While he’s been the chief medical officer, Protea has grown...
How to Recognize the Signs of Menopause: Symptoms & Diagnosis Explained
Welcome to the podcast with Dr. Brendan McCarthy! Are you experiencing changes in your body and wondering if it might be menopause? I’ll guide you through the key signs and symptoms of menopause, the role of hormonal changes, lab values and how to approach an accurate diagnosis. Understanding your body is the first step to managing this transition effectively.
This is Part 2 of 4
Dr. Brendan McCarthy founded Protea Medical Center in 2002. While he’s been the chief medical officer, Protea has grown and evolved into a dynamic medical center serving the Valley and C...
Menopause Explained: An Introduction to Understanding the Journey
Welcome to the podcast with Dr. Brendan McCarthy! In this video, I'm giving a brief overview of what women experience during menopause and trying to find proper treatment. From common symptoms to the changes your body goes through, this is the first step in understanding this natural phase of life. Stay tuned for more episodes where we’ll dive deeper into symptoms, diagnosis, and treatment options.
- This is Part 1 of 4 -
Dr. Brendan McCarthy founded Protea Medical Center in 2002. While he’s been the chief medical officer, Protea has grown and evolved into...
Why Is Treating Autoimmune Diseases So Challenging?
Welcome to the podcast with Dr. Brendan McCarthy! Autoimmune diseases can be complex and unpredictable, making treatment a significant challenge. From managing symptoms to addressing root causes, we uncover the hurdles in combating these conditions. How doctors should truly be helping YOU. Join me as we shed light on this crucial topic. Don’t forget to like, subscribe, and share your thoughts in the comments below!
This is a continuation to my Autoimmunity series, Part 5 of 5
Dr. Brendan McCarthy founded Protea Medical Center in 2002. While he’s been the chief medical officer, Protea has g...
Answering YOUR Questions About PMS | Everything You Need to Know! (Part 4)
Welcome to the podcast with Dr. Brendan McCarthy! Got questions about PMS? I'm here to help! In this Q&A, we’re going over the most common (and some not-so-common) questions from our viewers about premenstrual syndrome during this series. Don’t forget to like, comment, and subscribe for more content like this!
Dr. Brendan McCarthy founded Protea Medical Center in 2002. While he’s been the chief medical officer, Protea has grown and evolved into a dynamic medical center serving the Valley and Central Arizona. A nationally recognized as an expert in hormone replacement therapy, Dr McCa...
Balancing Hormones to Treat PMS: Effective Strategies Explained! (Part 3)
Welcome to the podcast with Dr. Brendan McCarthy! This episode brings you Part 3, the treatment segment. Hormonal imbalances might be the key to understanding and managing them effectively. In this video, we explore how hormonal treatments can help alleviate common PMS symptoms like mood swings, bloating, and fatigue. Learn about the types of hormones used, their benefits, and what to expect during treatment. Whether you're considering hormonal therapy or just curious about your options, this guide provides clear and practical insights. Don’t forget to like, subscribe, and hit the bell for more health and wellness tips!
...
Is It PMS or Something Else? Diagnosing PMS Symptoms (Part 2)
Welcome to the podcast with Dr. Brendan McCarthy! Are you experiencing mood swings, bloating, fatigue, or irritability and wondering if it's PMS — or something more? In this video, I break down the symptoms of Premenstrual Syndrome (PMS) and how to identify it accurately. As a hormone replacement specialist, I’ll explain how your hormones fluctuate during your cycle, what causes PMS, and how it can be managed effectively. Next episode we will also explore treatment options, including natural remedies, lifestyle changes, and when hormone therapy might be the right solution for you.
Dr. Brendan McCarthy found...
Understanding PMS: An Intro to Symptoms, Causes, and Management (Introduction, Part 1)
Welcome to the podcast with Dr. Brendan McCarthy! In this video, we dive into everything you need to know about PMS (Premenstrual Syndrome). An introduction into the a 4 part series.
1. Introduction
2. Diagnosis
3. Treatment
4. Q&A
Whether you're experiencing PMS or want to better understand it, this introduction will provide helpful insights and tips. Make sure to come back to see the rest of the series!
Dr. Brendan McCarthy founded Protea Medical Center in 2002. While he’s been the chief medical officer, Protea has grown and evo...
The Truth About Prostate Cancer & Testosterone: What Every Man Needs to Know
Welcome to the podcast with Dr. Brendan McCarthy! Are testosterone and prostate cancer connected? In this video, we dive into the science and myths surrounding testosterone therapy and its potential impact on prostate health. Learn what research really says about testosterone levels, prostate cancer risks, and what every man should know to make informed health decisions. Don't let misinformation guide your choices—get the facts here.
📌 Key Topics Covered:
Does testosterone cause prostate cancer?
The role of testosterone in men's health Common myths and misconceptions Latest research and expert insights
👉 Su...
The Evolution of Testosterone Replacement Therapy (TRT)
Welcome to the podcast with Dr. Brendan McCarthy! Testosterone Replacement Therapy (TRT) has undergone a remarkable transformation over the years. Recently i received an email regarding new available TRT here in my local area. In this video, we dive into the goal behind their email and if its worth trusting these large medical establishments. Whether you're considering TRT or just curious about the latest developments, this video provides a comprehensive overview of where the therapy stands now—and where it's headed in the future!
Dr. Brendan McCarthy founded Protea Medical Center in 2002. While he’s been...
Ways for Managing Autoimmune Diseases Naturally & Effectively (Part 3)
Welcome to the podcast with Dr. Brendan McCarthy! Struggling with autoimmune symptoms? In this video, we dive into the most effective ways to manage and treat autoimmune diseases. Learn about lifestyle changes, dietary adjustments, natural remedies, and medical treatments that can help reduce inflammation, boost your immune system, and improve your quality of life. Whether you’re dealing with rheumatoid arthritis, lupus, or another autoimmune condition, these tips could make a big difference.
Don’t forget to like, share, and subscribe for more health insights!
💬 Got questions or tips? Share them in the comments...
Understanding Autoimmunity: A Guide to Diagnosis and Early Detection (Part 2.2)
Welcome to the podcast with Dr. Brendan McCarthy! Autoimmune diseases affect millions worldwide, yet many struggle to get a timely diagnosis. In this video, we dive into the world of autoimmunity, exploring what triggers these conditions and common symptoms. Whether you’re experiencing symptoms or just want to learn more, we’ll break down steps in identifying autoimmune diseases and why early detection is crucial for effective management. Join me to understand the complexities of autoimmunity and empower yourself with knowledge on this often misunderstood topic! (Part 2 of 2)
Dr. Brendan McCarthy founded Protea Medical Center in 20...
Understanding Autoimmunity: A Guide to Diagnosis and Early Detection (Part 2.1)
Welcome to the podcast with Dr. Brendan McCarthy! Autoimmune diseases affect millions worldwide, yet many struggle to get a timely diagnosis. In this video, we dive into the world of autoimmunity, exploring what triggers these conditions and common symptoms. Whether you’re experiencing symptoms or just want to learn more, we’ll break down steps in identifying autoimmune diseases and why early detection is crucial for effective management. Join me to understand the complexities of autoimmunity and empower yourself with knowledge on this often misunderstood topic!
Dr. Brendan McCarthy founded Protea Medical Center in 2002. While he’s...
Autoimmunity Explained: Understanding the Body's Defense Gone Wrong (Introduction, Part 1)
Welcome to the podcast with Dr. Brendan McCarthy! In this video, we introduce the basics of autoimmunity, specifically focusing on how it affects women. In this series you will learn how the immune system, which is designed to protect your body, sometimes turns against your healthy cells, leading to autoimmune diseases. We’ll break down why women are more prone to conditions like lupus, rheumatoid arthritis, and Hashimoto’s thyroiditis, and what signs to look for. If you're curious about how your body works or want to better understand autoimmune disorders, this introduction video is 1 of 4 of the series. Subs...
Endometriosis Q&A: Doctor Answers to Your Most Asked Questions! (Part 4)
Welcome to the podcast with Dr. Brendan McCarthy! Welcome to our Q&A session for the Endometriosis Awareness series! 🎥
In this episode, we dive into your most pressing questions about endometriosis, a condition affecting millions of women worldwide. We’ll cover key topics like diagnosis, symptoms, treatment options, lifestyle management, and how to support loved ones living with this condition. 💬
Got more questions? Drop them in the comments! 🔔 Don’t forget to like, subscribe, and hit the bell icon to stay updated with more episodes and Dr. Brendan McCarthy's insights.
Dr. Brendan McCarthy founded Prote...
Understanding and Treating Endometriosis (Part 3)
Welcome to the podcast with Dr. Brendan McCarthy! In this video, we dive deep into endometriosis, a common but often misunderstood condition affecting millions of women worldwide. If you've been experiencing chronic pelvic pain, painful periods, or fertility issues, this video will help you better understand the condition and explore the best treatment options.
Dr. Brendan McCarthy founded Protea Medical Center in 2002. While he’s been the chief medical officer, Protea has grown and evolved into a dynamic medical center serving the Valley and Central Arizona. A nationally recognized as an expert in hormone replacement therapy, Dr Mc...
How to Diagnose Endometriosis: Symptoms, Tests, and What to Expect (Part 2)
Welcome to the podcast with Dr. Brendan McCarthy! In this video, we dive into the process of diagnosing endometriosis, a condition that affects millions of women worldwide. Learn about common symptoms to look out for, the various tests and procedures doctors use to confirm a diagnosis, and what you can expect during the process. Whether you're experiencing symptoms or just want to be informed, this guide will provide you with valuable insights. Don't forget to like, subscribe, and share if you found this helpful!
Dr. Brendan McCarthy founded Protea Medical Center in 2002. While he’s been the ch...
Endometriosis 101: Understanding Symptoms, Causes, and Treatment (Introduction, Part 1)
Welcome to the podcast with Dr. Brendan McCarthy! In this video, I provide an introduction to endometriosis, a common but often misunderstood condition affecting millions of women worldwide. Learn about the symptoms, causes, and potential treatment options for managing this chronic illness. Whether you're seeking to understand more about your own health or supporting a loved one, this video offers valuable insights to help you navigate endometriosis.
Dr. Brendan McCarthy founded Protea Medical Center in 2002. While he’s been the chief medical officer, Protea has grown and evolved into a dynamic medical center serving the Valley and Ce...
Does Vitamin D Prevent Infection from Surgery? 🦠💊
Welcome to the podcast with Dr. Brendan McCarthy! In this video, we explore whether Vitamin D can help prevent infections after surgery. Vitamin D is known for its role in bone health and immune system support, but can it reduce the risk of surgical site infections? We'll dive into the latest research, uncover how this essential vitamin impacts recovery, and discuss whether supplementing Vitamin D before surgery could be beneficial.
Dr. Brendan McCarthy founded Protea Medical Center in 2002. While he’s been the chief medical officer, Protea has grown and evolved into a dynamic medical center serving th...
