The Skin Real ®

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Dr. Mary Alice Mina sits down with oral and maxillofacial surgeon Dr. Erin Sheffield to explore a part of facial aging most people never think about: the mouth. They dig into why tooth loss drives bone loss in the jaw, why flossing (done correctly) is one of the highest-impact, lowest-cost things anyone can do for their whole-body health, and why teeth keep shifting throughout life even without braces history. The conversation also covers grinding and mouth guards, the risks behind the veneer and cro...

In this episode, Dr. Mary Alice Mina answers the internet's most asked questions about testosterone, topical estrogen, and perimenopause. Pulled straight from the comments section, she covers who can actually prescribe testosterone, whether estradiol and estriol can be used together on the face, what swollen eyelids might really mean, what lab work matters before starting testosterone therapy, how topical estrogen interacts with birth control pills, the correct way to apply topical estrogen, whether birth control suppresses testosterone, and whether estrogen levels need to be monitored while using topical treatments. She closes with a detailed answer on facial estradiol, hair...

🔗 Scan your skin for free with my Skin Analysis app: https://realskin.theskinreal.com

Filler has had its moment, and for years the look was to go bigger: fuller lips, bigger cheeks, an almost caricature version of the face. Dr. Mary Alice Mina breaks down why the pendulum is swinging back toward natural results and what that means for anyone rethinking their filler. She walks through what hyaluronic acid filler actually is, how it compares to older options like silicone and collagen, and the three main reasons patients ask to have their filler dissolved, including the rare but...

Head lice might be one of the most stomach-turning phrases a parent can hear, but Dr. Mary Alice Mina wants everyone to take a breath before reaching for the clippers. In this episode of The Skin Real, she breaks down what head lice actually are, why they have nothing to do with hygiene, and how they really spread through close head-to-head contact rather than jumping from scalp to scalp. She walks through exactly how to check for lice and nits at home, the step-by-step protocol for using permethrin and pyrethrin shampoos correctly, including the treatment mistake most people make...

In this episode of The Skin Real, Dr. Mary Alice Mina sits down with dermatologist and Skinfluence Podcast host Dr. Dustin Portela to break down the skincare trends flooding social media right now. From DIY sunscreen and beef tallow moisturizer to at-home chemical peels and tanmaxxing, they separate real dermatology from viral misinformation. The conversation covers red flags to watch for in skincare influencers, the science behind sunscreen safety, why skin cycling can work when done right, age-appropriate routines for kids and teens, and what medical grade skincare actually means. It is a practical, no-nonsense guide to protecting your...

Basal cell carcinoma is the most common cancer on the planet, yet most people have never heard of it until they're sitting in a dermatologist's chair hearing the word cancer for the first time. In this episode, Dr. Mary Alice Mina walks through what these lesions actually look like, and it's rarely what people expect. Sometimes it's a pink, shiny bump that bleeds without warning. Other times it hides as a stubborn scar-like patch or a dry spot that gets mistaken for eczema for months.

She covers how a diagnosis actually comes together, from the dermatoscope exam...

Exosomes are one of the most talked about ingredients in skincare right now, but most people buying them have no idea what they are actually paying for. In this episode, Dr. Mary Alice Mina sits down with Alisa Lask, CEO of Rion Aesthetics and lead of Plated Skin Science, to break down what exosomes really are, why the source they come from matters more than the word on the label, and how platelet-derived exosomes differ from plant and stem cell versions. They cover how exosomes penetrate the skin, whether microneedling helps or hurts them, realistic timelines for seeing results...

In Part 2 of this mini series on Collagen Loss, Dr. Mary Alice Mina moves from biology to action: the exact morning and evening skincare routine that makes sense for post-menopausal skin, which ingredients actually have evidence behind them, and which in-office treatments are worth the money. She walks through why a routine built for oily 20-something skin works against you later, then breaks down a simple AM routine (gentle cleanse, antioxidant/vitamin C serum, moisturizer, sunscreen) and PM routine (cleanse, retinol/retinoid as the cornerstone anti-aging ingredient, moisturizer), plus how to exfoliate without damaging the skin barrier. She then...

In the first half of a two-part episode on midlife skin, Dr. Mary Alice Mina breaks down the biology behind one of the most alarming stats in dermatology: women can lose up to 30% of their skin's collagen in the first five years after menopause. She explains why collagen decline actually starts as early as your 20s (about 1% a year), why estrogen loss accelerates that process dramatically at menopause, and why "collagen banking" earlier in life matters so much.

Rather than jumping straight to products and procedures, Dr. Mina makes the case that skincare is whole-body care — walking th...

In this episode of The Skin Real, Dr. Mary Alice Mina sits down with fellow board-certified dermatologist Dr. Amaris Geisler, a specialist in vulvar dermatoses based in Atlanta, to break the silence around a body part most women can't even name correctly — the vulva. They cover what the vulva actually is (versus the vagina), the most common conditions dermatologists see there (lichen sclerosis, eczema, psoriasis, and even skin cancer), and why so many women get dismissed with a yeast infection diagnosis instead of a real workup. Dr. Geisler explains the lifelong treatment path for lichen sclerosis, the risks of le...

Salmon sperm in your skincare? It sounds wild, but PDRN (polydeoxyribonucleotide) is everywhere right now — on your For You page, in Korean skincare hauls, and yes, Kim Kardashian had it injected into her face. In this episode, Dr. Mary Alice Mina cuts through the hype and gives you the full, unfiltered picture on what PDRN actually is, where it comes from, and what the science really says.

Dr. Mina breaks down the two proposed mechanisms behind PDRN — the adenosine A2A receptor pathway and the salvage pathway — and explains why the concept is genuinely exciting on paper. But sh...

Fungal acne is everywhere on social media, but most people are treating it completely wrong. In this episode of The Skin Real, Dr. Mary Alice Mina breaks down what fungal acne actually is: an overgrowth of malassezia yeast, not bacteria, and not true acne at all. She explains why standard acne treatments often fail, who's most at risk (think sweaty workouts, humid climates, tight clothing, and recent antibiotic use), and how to tell it apart from regular acne by looking at itch, uniformity, and the absence of blackheads or whiteheads. Dr. Mina walks through her go-to over-the-counter arsenal, including...

Sunscreen is the single most impactful thing you can do for your skin — and in this episode of The Skin Real, Dr. Mary Alice Mina breaks down exactly what to look for, what to skip, and which sunscreens she's personally stocking up on for summer 2026. Dr. Mina explains why UV radiation is responsible for the majority of premature aging and skin cancers, and why the U.S. has fallen behind the rest of the world in UV filter technology — plus the exciting news that a new UVA filter is finally on its way. She walks through the difference between mine...

Your skincare routine might be missing its most important ingredient — and it's not in any bottle. In this episode of The Skin Real, Dr. Mary Alice Mina breaks down the powerful (and often overlooked) connection between protein and skin health. She explains the four root causes of skin aging — collagen depletion, chronic inflammation, oxidative stress, and cellular waste buildup — and why what's on your plate directly impacts how your skin looks and ages.

Dr. Mina gets personal about her own journey from vegetarian to protein-conscious eater, why her body started craving chicken in her early 40s, and what t...

Topical estrogen is everywhere right now — but if you have melasma, rosacea, or acne, should you be worried? In this episode, Dr. Mary Alice Mina cuts through the fear-based noise and breaks down what the science actually says about topical estrogen and skin conditions like melasma and rosacea. She shares her own personal experience with melasma, explains why estrogen alone isn't enough to trigger it, and walks through what the current research — including a systematic review in Dermatologic Surgery — actually shows. She also covers who might want to proceed with caution, how to do a proper test spot, why sun pr...

In this episode of The Skin Real, Dr. Mary Alice Mina breaks down two of the most talked-about biostimulators in aesthetic medicine — Sculptra and Radiesse — and explains why they are not interchangeable, despite both building collagen. She covers how each product works at a cellular level, what to realistically expect after treatment (including the swelling that disappears in the first week), how long results last, which areas each product is best suited for, and the real risks like nodule formation. Dr. Mina also discusses hyperdilute Radiesse, the "rule of fives" massage protocol for Sculptra, injection technique, and how to comb...

Dr. Mary Alice Mina breaks down the top five tretinoin mistakes she sees her patients make — and admits she's made herself. From the dreaded purge to layering too many actives, she explains why so many people quit this powerhouse ingredient right before it starts working, and exactly how to use it correctly. She covers the difference between purging and irritation, the right amount to apply, how often to use it, why it's not a spot treatment, and which products to avoid pairing it with. Dr. Mina also answers a listener's question about her teeth — and shares her own Invisalign and...

In this episode, Dr. Mary Alice Mina breaks down everything you need to know about your skin barrier — what it is, how you know it's damaged, and exactly what's causing the damage. She then walks through eight practical, zero-cost steps to repair it fast. From doing a hard skincare reset to applying moisturizer the right way, Dr. Mina cuts through the noise and reminds listeners that when it comes to a damaged skin barrier, less is always more.

In this episode: 

0:00 — Introduction & Why the Skin Barrier Is Trending

1:45 — What Is the Skin Barrier? (Stratum...

In this episode, Dr. Mary Alice Mina breaks down one of her most frequently asked questions: should you be putting topical estrogen on your face? She explains what estrogen loss actually does to the skin during perimenopause and menopause — from collagen collapse to barrier breakdown — and why these changes are hormonal, not just "normal aging." Dr. Mina walks through the two main forms of topical estrogen (estriol and estradiol), what makes them different, and which one is more commonly used for facial skin. She also covers who should be cautious, including those with melasma or a history of estrogen-sensitive canc...

LED face masks are having a major moment — but are they actually worth the hype?

In this episode, Dr. Mary Alice Mina breaks down the real science behind LED light therapy and why so many people are spending hundreds of dollars on devices that simply don't work.

She explains the concept of photobiomodulation, which wavelengths of light actually have clinical evidence behind them (blue, red, and near-infrared), and which colors are total gimmicks. Dr. Mina walks through exactly what to look for when buying an LED mask — from FDA clearance to bulb distribution to device desi...

Bed bugs. Just the phrase is enough to make your skin crawl — but Dr. Mary Alice Mina is breaking down everything you actually need to know about these tiny, relentless pests. In this episode of The Skin Real, she covers what bed bugs are, how they spread, why not everyone reacts to bites the same way, and — most importantly — how to protect yourself before, during, and after travel. You'll learn exactly how to inspect a hotel room like a pro, what to do if you think you brought them home, and how to treat the itchy welts on your skin w...

You've probably Googled "how to remove a skin tag at home" at least once. Before you reach for the dental floss, you need to hear this. In this episode of The Skin Real, Dr. Mary Alice Mina covers everything you need to know about skin tags — from what they actually are and why you get them, to what they might be revealing about your metabolic health, and how she safely removes them in her office.

In This Episode:

0:00 — Is That Dental Floss Around Your Skin Tag?
0:45 — What Are Skin Tags?
2:00 — Why You Get Skin Tag...

Think you know what's causing your under-eye bags? You might be wrong — and that's exactly why nothing you've tried has worked. In this solo episode, Dr. Mary Alice Mina breaks down the four distinct types of under-eye concerns: puffiness, fat pad herniation, volume loss/hollowing, and dark circles from pigment or vascularity. She explains how to identify which type you're dealing with, because the biggest mistake most people make is treating the wrong problem.

Dr. Mina walks through exactly what works for each type — from caffeine eye products and cold therapy for puffiness, to lower blepharoplasty for true...

***Apple audio issue fixed!

NAD is having a major moment — from IV drips and supplements to wellness clinics and now skincare. But is the science real, or is it just the next CBD? In this episode, Dr. Mary Alice Mina sits down with Melisse Shaban, CEO of Aramore and veteran beauty executive (Revlon, Aveda, The Beauty Shop), to break down exactly what NAD is, why your skin cells need it, and whether the new wave of NAD skincare products is worth your money.

They dig into the cellular biology of aging skin, why most moisturizers ar...

If you are using a GLP-1 medication and noticing hair shedding, brittle nails, or dull, dry skin, your body is signaling a nutrient gap. In this episode, Dr. Mary Alice Mina breaks down what is really happening beneath the surface and why these changes often appear before lab results do. She explains how appetite suppression can lead to low protein, vitamin deficiencies, and dehydration, all of which directly impact your skin, hair, and nails.

You will learn the key deficiencies to watch for, including B12, iron, folate, and vitamin D, and the exact signs your body shows...

📲 Download The Skin Real app for science backed routines, dermatologist guidance, and product recommendations you can trust. https://linktr.ee/theskinreal

TikTok and Instagram may have made Slugging famous, but dermatologists have relied on this technique for decades. In this episode, board certified dermatologist Dr. Mary Alice Mina breaks down what slugging really is, how it works, and why most people do it wrong.

Slugging uses a simple occlusive layer such as petrolatum to seal the skin barrier and reduce transepidermal water loss. The result is stronger hydration and improved barrier repair. While social media fra...

📲 Download The Skin Real app for science backed routines, dermatologist guidance, and product recommendations you can trust. https://linktr.ee/theskinreal

Botox is one of the most misunderstood tools in aesthetics. In this episode, Dr. Mary Alice Mina breaks down what Botox really is, how it works, and why so many people confuse it with filler. She explains the difference between basic injection patterns and advanced Botox placement, then walks through the lesser-known ways neuromodulators can be used for facial balance, symmetry, prevention, and subtle refinement.

You will hear how Botox can be used far bey...

📲 Download The Skin Real app for science backed routines, dermatologist guidance, and product recommendations you can trust. https://linktr.ee/theskinreal

If you use Tretinoin, get chemical peels, or are planning on a laser treatment, you are already doing skin cancer prevention. In this episode of The Skin Real, Dr. Mary Alice Mina sits down with board-certified dermatologist Dr. Dara Spearman, founder of Radiant Dermatology Associates in Fort Wayne, Indiana. She treats high volumes of skin cancer and precancers, plus cosmetic and procedural patients, so she brings a grounded view of what keeps skin healthy for decades.

📲 Download The Skin Real app for science backed routines, dermatologist guidance, and product recommendations you can trust. https://linktr.ee/theskinreal

Radio frequency treatments are everywhere. Med spas, dermatology offices, social feeds. But do they work and are they worth your money?

In this episode, Dr. Mary Alice Mina breaks down exactly how radio frequency works at the cellular level. She explains how electrical energy heats the dermis to stimulate collagen induction, what makes it different from lasers and ultrasound, and why precision matters more than intensity.

She also addresses the real risks. Inc...

Lip lines. Barcode lines. Smoker’s lines.

They frustrate patients more than almost any other wrinkle because they can age the face fast and they are not simple to fix.

In this episode of The Skin Real, Dr. Mary Alice Mina breaks down why upper lip lines form, why they are harder to treat than frown lines, and why there is no single magic solution. She explains the role of the orbicularis oris muscle, repetitive motion, collagen loss, menopause, bone resorption, and sun damage in accelerating these vertical lines.

Dr. Mina walks through wh...

Testosterone is known as THE male hormone, yet women carry more of it than estrogen across their lifespan. In this episode, Dr. Mary Alice Mina breaks down why testosterone matters for women and how imbalances show up in skin, hair, and nails. You learn the visible signs of low and high testosterone, how aging differs from menopause-related hormone shifts, and why blood work alone misses the full picture. The episode also covers risks of pellet therapy, smarter prescribing approaches, and practical dermatology-first steps you can take while waiting for medical evaluation. This is a clear, evidence-based guide to hormone...

Injectables can feel intimidating for many people. This episode of The Skin Real removes the fear. Dr. Mary Alice Mina walks you through the exact injectables she uses on her own face and why. You hear how her approach shifted in midlife and perimenopause. You learn how she thinks about balance, harmony, and long term skin health. She explains toxins, fillers, and biostimulants in plain language. She also shares where subtle treatments matter most as you age. This episode focuses on natural results, realistic expectations, and choosing the right injector for a long term plan.

In This...

📲 Download The Skin Real app for science backed routines, dermatologist guidance, and product recommendations you can trust. https://linktr.ee/theskinreal

Hair loss in women feels frightening and personal. You see it in the shower. On your pillow. In the mirror. In this episode of The Skin Real, Dr. Mary Alice Mina explains why female hair loss happens and what truly helps.

You learn how dermatologists classify hair loss. Scarring versus non scarring. Shedding versus thinning. You hear why menopause, stress, weight loss, medications, nutrition, and styling habits all matter. Dr. Mina walks through evidence-based tre...

Retinoids confuse a lot of people. This episode removes the guesswork. Dr. Mary Alice Mina breaks down every form of retinoid in clear terms. You learn the difference between retinol, retinaldehyde, Adapalene, Tretinoin, Tazarotene, and oral isotretinoin. She explains who should start slow, who should go straight to prescription strength, and why skin type matters more than age. The episode walks through acne treatment, pigment control, collagen support, and long term skin health. You also get exact instructions for nighttime use, dosing, frequency, product layering, and how to prevent irritation, flaking, and purging. This is a step by step...

Sagging jowls tend to sneak up on you. One day your jawline feels sharp and familiar. Then slowly, definition softens and the lower face starts to feel heavier. 

In this episode, Dr. Mina breaks down what is really happening when jowls form. She explains how bone changes, fat pad movement, muscle pull, collagen loss, genetics, and how daily habits can shape the lower face over time. She walks through what supports skin health at home, what looks promising but falls short, and which in office treatments deliver meaningful improvement when used strategically.

You will learn h...

There comes a point when you start to notice patterns. Your skin flares after certain meals, bloating lingers through the week, and your body feels a little more reactive than it used to. Especially in midlife, it is easy to wonder: Is it hormones, stress, aging, or something deeper happening in the gut?

Dr. Mina sits down with Dr. Pia Prakash, a board-certified gastroenterologist and passionate educator on gut health. Together, they unpack the science behind the gut microbiome, inflammation, leaky gut, SIBO, diet patterns, perimenopause, and why conditions like acne, rosacea, psoriasis, and hidradenitis often flare...

If you’ve ever delayed scheduling your mammogram because of fear, discomfort, or sheer overwhelm, you’re not alone. Many midlife women quietly carry anxiety about breast health, balancing busy lives while putting their own care on the back burner. 

In this episode of The Skin Real, Dr. Mary Alice Mina sits down with Dr. Anjali Malik, a breast imaging and interventional radiologist and passionate advocate for women’s health. Together, they break down what mammograms actually involve, why annual screening starting at age 40 matters, and how misinformation has unnecessarily scared women away from a life-saving test. This co...

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If your skin suddenly feels unpredictable during pregnancy, it is not your imagination and it is not your fault. Hormones shift rapidly, collagen stretches, pigment deepens, and routines that once worked may no longer feel effective.

In this episode, Dr. Mina sits down with integrative dermatologist Dr. Mamina Turegano for an honest, evidence-based conversation on skincare during pregnancy. Together, they break down the most common concerns dermatologists see at this stage, from acne and hyperpigmentation to melasma, stretch marks, and sunscreen safety.

They clarify which ingredients are best...

In this week's episode, Dr. Mary Alice Mina welcomes Dr. Kandace Kichler to talk about what liposuction actually is today. Together they explore why this procedure, once considered aggressive and intimidating, has become a favorite for targeted contouring, especially in midlife.

From safety and anesthesia to expectations and recovery, they lay out what’s possible with awake liposuction, and why it can help women feel more comfortable and more confident in their clothes and their skin.

Key Takeaways:

There comes a point in midlife when you look in the mirror and realize your skin feels different. Maybe it is suddenly drier, more reactive, or simply not bouncing back the way it used to!

In this episode, Dr. Mina explains the powerful role estrogen plays in collagen, hydration, elasticity, and the overall strength of your skin. She walks through what declining estrogen in perimenopause and postmenopause really means, what the research shows about topical estrogen, and how it compares to systemic hormone therapy.

She also shares practical advice on when topical estrogen might be...