Docs Who Lift
Drs. Spencer and Karl Nadolsky talk about nutrition, medicine, and fitness through the lens of two physicians who lift weights. Both doctors are former NCAA division 1 wrestlers who have gone into medicine. Dr. Spencer Nadolsky is a board certified family physician specialized in obesity medicine and lipidology. Dr. Karl Nadolsky is a board certified endocrinologist also specialized in obesity medicine.
Current State of Nutrition Research and MAHA
Takeaways:
The MAHA report aims to address public health issues but lacks actionable policies.Historical context is crucial for understanding current dietary guidelines.Funding for nutrition research has been inadequate, impacting the quality of data.Public perception of nutrition often outpaces scientific evidence.The evolution of dietary guidelines reflects political and social influences.There is a need for more rigorous nutrition science to inform policy.The dietary guidelines have not significantly improved population health metrics.Political will is essential for implementing effective nutrition policies.Nutrition science faces challenges in funding and research infrastructure.The MAHA report's recommendations may...Joy Prescriptions
Click to read Joy Prescriptions
Drs. Karl and Spencer talk to Dr. Tiffany Moon all about Joy Prescriptions. Learn how to stop chasing perfection and embrace connection.
00:00Introduction to Dr. Tiffany Moon
02:02Journey to Reality TV: The Real Housewives of Dallas
05:58Life After Reality TV: Finding Joy and Purpose
09:59The Joy Prescription: A New Approach to Life
17:01Work-Life Integration: Balancing Career and Family
22:09Empowering Women: The Lead Her Summit
22:33Tiffany's Journey: From Childhood to Medical Success
24:43The Quest for Joy: Breaking t...
Zepbound versus Wegovy
Tirzepatide is more effective for weight loss than semaglutide.Cost-effectiveness is crucial in prescribing weight loss medications.Patients with severe obesity should receive more expensive medications for better outcomes.Both medications show significant benefits for obesity-related conditions.Long-term studies indicate sustained weight loss with both drugs.Gender differences affect weight loss outcomes with these medications.Safety profiles show tirzepatide may be better tolerated than semaglutide.The need for affordable drug pricing is emphasized.Clinical benefits extend beyond weight loss to include metabolic health.Future studies are needed to confirm cardiovascular benefits of tirzepatide.
Click here to see the study<...
Semaglutide for metabolic dysfunction associated steatotic liver disease (MASH).
Takeaways
MASH is a significant obesity-related complication.Semaglutide shows promise in treating MASH.Weight loss is crucial for improving liver health.Bariatric surgery remains the most effective treatment.The Essence trial indicates a 63% resolution of NASH.New medications are being developed for obesity treatment.Early intervention is key to preventing severe liver damage.Accessibility of medications is a major concern.Comparative studies are essential for evaluating new treatments.Future treatments may include innovative delivery methods.Chapters
00:00 Introduction to MASH and Semaglutide Study
04:29 Understanding Metabolic Dysfunction and Its Implications
08:02 Essence Trial: Semaglutide's...
Top 5 Women's Fitness Myths
Drs. Karl and Spencer chat with return guest Dr. Lauren Semple about creatine, protein, cortisol, fasting exercise, and training in women.
Follow Dr. Lauren's instagram
Join Dr. Spencer's online clinic
GLP-1 and metabolism and depression
Drs. Karl and Spencer discuss a new study looking at tirzepatide and metabolic rate. They also discuss a patient case of tirzepatide induced anhedonia.
Here is the tirzepatide study
If interested in joining Dr. Spencer's clinic Vineyard - Click Here
Do GLP-1 meds cause more fat cells?
Drs. Karl and Spencer discuss the claim that GLP-1 meds cause more fat cells.
Learn about if and how GLP-1 meds increase fat cells and what that means along with other claims about these medicine.
Join Dr. Spencer's online clinic that specializes in GLP-1 medicines
Future of medicine - Direct Care
Drs. Karl and Spencer talk to Dr. Kenneth Qiu all about direct medical care - the future of medicine.
Learn about how bypassing insurance and creating a relationship directly with a doctor can improve your health and save money in the long run.
Follow Dr. Qiu on Linked in
See Dr. Spencer's direct care model with Vineyard
Tirzepatide and Muscle Loss with Dr. Grant Tinsley
Drs. Karl and Spencer discuss with Dr. Grant Tinsley all about the new analysis of how much "lean mass" is lost with tirzepatide, the most powerful medicine available for weight loss.
Learn:
The difference between fat free mass and lean mass and lean soft tissue and muscle.
If GLP-1 medicines cause muscle loss specifically
How to minimize muscle loss when taking these medicines
Our new study together.
Click here for the tirzepatide paper
Click here to see Dr. Grant Tinsely's Instagram
Click here...
The Super Bowl Hims and Hers Ad
Drs. Karl and Spencer discuss how bad the Hims and Hers ad was.
From an outside perspective, the ad may have seemed good.
But when you dig deeper, it was actually really bad.
Listen to learn.
Join Dr. Spencer's new online clinic - Vineyard.
NAD and NMN with Dr. Charles Brenner
Drs. Karl and Spencer chat with NMN and NAD expert Dr. Charles Brenner all about these supposed longevity supplements.
Learn about NAD metabolism
Whether it's worth supplementing or not with NAD or NMN
Follow Dr. Brenner on Twitter
The 60 Minutes Obesity Doctor - Dr. Fatima Cody Stanford
Drs. Karl and Spencer chat with Dr. Fatima Cody Stanford all about obesity, genetics, and her appearance on 60 minutes.
Does Dr. Sanford believe lifestyle doesn't matter for obesity?
Find out by listening!
Watch Dr. Stanford's 60 minute clip
Join Dr. Spencer's Obesity Clinic
New Obesity Definition and Higher Wegovy Dose
Drs. Karl and Spencer chat about the new Lancet Commission's report on Clinical Obesity along with the new study on high dosed Wegovy.
Learn:
How 7.2 mg of Wegovy (semaglutide) compares to 2.4 mg
What the proposed definitions of clinical and preclinical obesity are
Click here to join Dr. Spencer's new online clinic
The Ozempic Revolution - with Dr. Sowa
Drs. Karl and Spencer chat with Dr. Sowa about her book The Ozempic Revolution.
Learn:
Why she wrote the book.
The top 3 things to know when starting a GLP-1 medicine.
Also hear the top criticism from Drs. Karl and Spencer. You will laugh.
Click here to get the book
If you're on a GLP-1 currently and want to switch to Dr. Spencer's new clinic, Click Here
Microdosing GLP-1 and Cagrisema headlines
Drs. Karl and Spencer discuss the concept of "microdosing" GLP-1 receptor agonists along with talk about the new top line results from REDEFINE which studied the new drug CagriSema.
Changing your workouts based on your menstrual cycle
Drs. Karl and Spencer chat with Dr. Lauren Colenso-Semple all about how the menstrual cycle and how it should affect your workout programming.
Should you change your workouts around your menstrual cycle?
Find out by listening!
Check out her instagram
Read her paper on exercise and menstrual cycles
Read her paper on protein synthesis throughout the menstrual cycle
Zepbound vs Wegovy trial and compounded GLP-1s
Drs. Karl and Spencer discuss the topline results from Surmount 5 which put Zepbound (tirzepatide) against Wegovy (semaglutide) for weight loss. They also discuss some news around compounded GLP-1s.
Learn:
Weight loss and glycemic differences between tirzepatide and semaglutide
What the FDA is thinking for compounded GLP-1s
If you're not on Dr. Spencer's virtual clinic waitlist, click here
Types of Diabetes, CGMs, and More
Drs. Karl and Spencer chat with Dr. Shivani Misra, a metabolic specialist physician researcher from the UK, all about the various forms of diabetes mellitus.
Learn:
The types of diabetes mellitusThe monogenic forms (some what refer to as MODY)The differences within type 2 diabetesWhether CGMs (continuous glucose monitors) are usefulIf low carb could help someFollow Dr. Misra on X/Twitter
A new way of delivering healthcare - Direct Primary Care
Drs. Karl and Spencer chat with AtlasMD - Dr. Josh Umbehr all about making healthcare cheaper using direct primary care.
Learn:
How cheap labs and and meds should beHow cutting out the middlemen can help healthcare and decrease costsFind AtlasMD here
1st longer term tirzepatide study (3 years)
Drs. Karl and Spencer discuss the brand new 3 year study of tirzepatide in those with prediabetes along with a discussion on semaglutide treating osteoarthritis.
Learn:
If people lose weight and keep it off with tirzepatideHow many people regain weight after stopping the medicineLong-term side effectsIf semaglutide helps with osteoarthritisClick here to read the tirzepatide study
Click here to read the semaglutide study
Making America Healthy Again - Joe Rogan Podcast Review
Drs. Karl and Spencer invite Dr. Andrea Love back to the podcast to discuss a recent Joe Rogan podcast with Calley and Casey Means along with the concept of Make America Healthy Again and RFK jr.
Learn:
What the docs agree with.
What they don't agree with.
Is raw milk okay?
Are cancer rates rising?
and more
Follow Dr. Andrea here
https://www.instagram.com/dr.andrealove
Cortisol 101
Drs. Karl and Spencer discuss all things cortisol and poke fun at the influencers who try to fear monger exercise due to cortisol increases.
Learn:
What is cortisol and what does it do?
Is cortisol bad?
Should you worry about cortisol increases with exercise?
Should you take supplements to lower cortisol?
and more
New Healthcare Service
Drs. Karl and Spencer discuss their ideal healthcare delivery system.
Learn:
Spencer's journey building and selling Sequence and what he wants to do next.
How Dr. Karl believes healthcare should be and what he's doing next.
Click here to get on Dr. Spencer's waitlist
Obesity medicine updates and Kardashian supplements
Drs. Karl and Spencer discuss BS supplements claiming to be like Ozempic along with discuss some new obesity drugs coming down the pipeline that were announced in phase 1 and 2 trials.
Are there any supplements that can mimic Ozempic?
What is amylin and how does it help with weight and sugars?
What is this new oral drug "amycretin" in phase 1 trials?
and more
Menopause 101
Drs. Karl and Spencer chat with Dr. Jen Gunter all about menopause.
Learn:
How it's diagnosed.
When and when not to treat.
The various treatment.
If it is indicated for cardiovascular disease prevention or body composition.
Whether or not you should get labs.
See more at Dr. Gunter's website
Olympic controversies and GLP-1 for Alzheimer's and Heart Failure
Drs. Karl and Spencer talk about the top line results from study showing liraglutide may have some benefit in Alzheimer's along with top line results from the Summit trial showing heart failure benefits with tirzepatide.
They also discuss the women's boxing controversy and BMI in athletes.
New Vitamin D Guidelines
Drs. Karl and Spencer chat with return guest and bone expert endocrinologist Dr. Rachel Pessah-Pollack all about the new Vitamin D guidelines.
Should healthy people even check a vitamin D level?
Should they supplement with vitamin D?
What people should check or supplement?
Click here for the new guidelines
Semaglutide and Blindness
Does semaglutide cause blindness?
What is NAION (nonarteritic anterio ischemic optic neuropathy)?
What about worsening of diabetic retinopathy with semaglutide?
What can you do to minimize the risk of NAION and retinopathy?
Get the full study here
Read Dr. Brugger's blog
Tirzepatide for Obstructive Sleep Apnea
Tirzepatide may be a good option if you have obesity and obstructive sleep apnea.
Click here to read the study
Stomach Ablation for Weight Loss
Click here to read about the gastric ablation and trial.
Click here to see Dr. McGowan's clinic
FLOW trial and GLP-1 cost rant
Drs. Karl and Spencer discuss the recent FLOW trial where semaglutide was found to be kidney protective. They also go off about the costs of these medicines and what to do (including compounding considerations).
Click here to see the study
South Park - The End of Obesity
Drs. Karl and Spencer discuss the most recent South Park episode where GLP-1 medicines are discussed along with the dysfunctions of our healthcare system among other issues.
Fallacies of Functional Medicine
Drs. Karl and Spencer discuss the fallacies of functional medicine.
You'll learn what functional medicine is and whether you should seek it out.
Another response to Jillian Michaels and Bill Maher
Drs. Karl and Spencer respond to Jillian Michaels on the Bill Maher show
Bariatric surgery through the mouth? Endoscopy gastroplasty 101
Drs. Karl and Spencer discuss with gastroenterologist Dr. McGowan all about endoscopic gastroplasty.
See recent study on cost effectiveness of endoscopic gastroplasty vs semaglutide
Check out his program
GLP-1 meds and Parkinson's and Heart Failure
Drs. Karl and Spencer discuss the new studies about GLP-1 medicines and Parkinson's and heart failure along with how these meds are not just weight loss drugs but health promoting medicines.
Click here to see the Parkinson's study
Click here to see the heart failure study
Lipedema Patient Journey
Drs. Karl and Spencer chat with Kasey Potts all about her journey with lipedema.
Learn more about how this condition is diagnosed and treated.
Check out her instagram
All about Lipedema - with Dr. Amron
Drs. Karl and Spencer chat with Dr. Amron all about lipedema. He is a specialized surgeon who treats lipedema daily. Learn about diagnosing and treating this condition that is commonly mistaken with obesity.
Check his sites
https://www.dramronconsultations.com/
https://www.advancedlipedematreatment.com/
GLP-1 Weight Loss Maintenance from Exercise
Drs. Karl and Spencer discuss a new study showcasing the importance of exercise during and after GLP-1 medicine use.
Click here to see the original study
Click here to see the extension study
Bustin' Hyman Myths - GLP-1 edition
Drs. Karl and Spencer discuss a recent Mark Hyman podcast where he perpetuated some myths about obesity and GLP-1 receptor agonist medicines.
