Longevity Optimization with Kayla Barnes-Lentz

What if aging wasn’t just something that happens to us, but something science could actually slow down? That’s the question at the heart of today’s conversation with Dr. Matt Kaeberlein, who’s a leading scientist and longevity researcher at the University of Washington.

Dr. Kaeberlein has spent decades decoding the biology of aging, from cellular mechanisms to practical strategies that could extend not just how long we live, but how well we live. In this episode, we talked about surprising connections between aging and brain health, and looked into the research around lithium and Alzhe...

What if aging wasn’t just something that happens to us, but something science could actually slow down? That’s the question at the heart of today’s conversation with Dr. Matt Kaeberlein, who’s a leading scientist and longevity researcher at the University of Washington.

Dr. Kaeberlein has spent decades decoding the biology of aging, from cellular mechanisms to practical strategies that could extend not just how long we live, but how well we live. In this episode, we talked about surprising connections between aging and brain health, and looked into the research around lithium and Alzhe...

Join us in this powerful episode as we sit down with Dr. Natalie Crawford, a double board-certified OB/GYN and reproductive endocrinologist. We explore her personal journey with recurrent pregnancy loss, the rising rates of infertility, and the impact of inflammation, toxins, and lifestyle on reproductive health. Discover how Dr. Crawford is reshaping fertility care and empowering women to understand their bodies, advocate for their health, and make informed choices about their future.

Chapters:

00:00 – Introduction

02:15 – Dr. Crawford’s personal fertility journey & miscarriages

07:07 – Discovering inflammation, toxins & celiac c...

Today I’m joined by Dr. Bill Rawls, a board-certified physician and bestselling author, for a wide-ranging conversation on chronic illness, healing, and what it really takes to protect long-term health. We dive into the challenges people face when conventional medicine falls short, the role of lifestyle and environment in recovery, and the surprising power of natural approaches to restore balance in the body.Dr. Rawls also shares insights on resilience, aging, and why true wellness depends on going deeper than symptom management.

If you’ve ever struggled with confusing health issues or wondered why the body some...

Join us in this insightful episode as we sit down with Dr. Janaye Duane, a behavioral scientist, futurist, and bestselling author. We delve into the intersection of exponential technology, human systems, and the future of health. Discover how Dr. Duane's journey from opera singer to futurist informs her mission to improve life for a billion people.

Chapters:

Introduction to Dr. Janaye Duane (0:00 - 2:30)

From Opera Singer to Futurist (2:31 - 10:00)

The Im...

Today I’m joined by Dr. Brooke Stubbs, a double board-certified physician in internal and lifestyle medicine, for a deep dive into inflammation, what drives it, how it shows up in the body, and why so many women are silently affected by it. We explore how gut dysfunction, hormone imbalances, poor sleep, and emotional stress contribute to chronic symptoms like fatigue, bloating, brain fog, and burnout. Dr. Stubbs shares why inflammation is often overlooked in conventional care—and how a functional, root-cause approach can lead to lasting healing.She also explains how food, movement, stress management, and environment can eith...

In this conversation, I sit down with Nick to unpack the deeper science behind GLP-1s and metabolic health. We explore how compounds like Tirzepatide and GLP-1 agonists go beyond weight loss, influencing everything from cardiovascular elasticity and neuroinflammation to mood, cognition, and gut-brain signaling. We also discuss lesser-known drivers of real change, like adiponectin, MPO, and the surprising effects of statins on inflammation.But the conversation doesn’t stop with human health. We dive into the behavioral power of the microbiome, how dogs might reduce childhood allergies, and whether AI can actually translate what your pet is thinking. If...

In this conversation, Kayla and Dr. Amy Killen discuss the critical aspects of women's hormonal health, emphasizing the importance of estrogen, the impact of menopause, and the need for accurate information regarding hormone therapy. She highlights the significance of bone health, the role of lifestyle in hormonal balance, and emerging treatments that can enhance women's health. The discussion also touches on the intersection of women's health and environmental policy, as well as the evolving relationship between doctors and patients in the age of technology.

Dr. Amy Killen, MD is a leading expert in anti-aging a...

In this episode, we explore the intersection of ovarian health, menopause, and AI technology with Kiran, the founder of TimelessBioTech. The conversation delves into the importance of ovarian longevity for women's health, the predictive tools being developed to forecast menopause timing, and the various interventions that can support ovarian health. Kiran shares insights on hormonal balance, the role of lifestyle factors, and the future of personalized health strategies for women. The discussion emphasizes the need for targeted solutions and the potential for AI to revolutionize women's health care.

Timeless Biotech Website

Kiran's...

Meet my new doctor, Dr. Sara Szal Gottfried.

I am so excited about our new duo! This conversation explores various topics including medical gaslighting, hormonal health, Kayla's labs including genetic testing, nutrition, inflammation, and the impact of environmental toxins. Sara and Kayla emphasize the need for personalized care and proactive health strategies for women, aiming to empower listeners with knowledge and actionable insights.

Chapters

00:00 Introduction to Women's Health Podcast

02:53 Exploring Longevity and Women's Health

05:30 The Impact of Medical Gaslighting on Women

08:18 Understanding Hormonal Health...

Today I am speaking with Vania LACASCADE, Chief Innovation Officer at L'Oréal Groupe!

I joined L'Oréal Groupe in Paris recently to learn more about all of their new longevity initiatives! I was so impressed by their commitment to understanding the science of Longevity. They have over 4,000researchers on their team and are investing over 1B annually in R&I!

They've also recently become invested in some great longevity companies that you're heard me mention such as Trudiagnostics, and Timeline Nutrition to further their longevity efforts. They are rolling o...

In this episode of the Longevity Optimization Podcast, Dr. Aimee Eyvazzadeh shares her journey into OB-GYN and her passion for helping people conceive. The conversation delves into innovative treatments for fertility, including ovarian PRP, hyperbaric oxygen therapy, and the potential of stem cells. Dr. Dr. Aimee Eyvazzadeh discusses the importance of supplements, lifestyle changes, and comprehensive fertility workups, including the TUSHY method. The episode also highlights the significance of addressing PCOS and the future of fertility medicine, emphasizing education and access to treatments.

About Dr. Aimee Eyvazzadeh

Dr. Aimee Eyvazzadeh—affectionately known as “...

In this episode of the Longevity Optimization Podcast, Dr. Martin shares his approach to individualized medicine, emphasizing the importance of a personalized healthcare strategy focused on prevention and addressing the root causes of diseases. He discusses his experiences in preventive medicine, highlighting the value of comprehensive health assessments and lifestyle interventions as essential tools for effective health management.

The conversation covers critical topics such as cardiovascular health, lipid markers, and the use of advanced imaging techniques to assess disease risk. Dr. Martin explains the significance of correctly interpreting test results, warning of potential risks linked to direct-to-consumer...

In this episode of the Longevity Optimization Podcast, Dr. Staci Whitman explores the vital link between oral health and overall longevity. She shares her professional journey transitioning from traditional dentistry to a holistic, prevention-focused approach, with special attention to the importance of education in pediatric dental care.

The conversation delves into the core principles of biological dentistry, emphasizing the powerful impact of diet and the oral microbiome on dental and systemic health. Dr. Whitman discusses the significance of testing for oral dysbiosis and offers practical insights into managing common oral health problems through nutrition and supplementation.

In this episode of the Longevity Optimization Podcast, Dr. Carolina Reis Oliveira, co-founder and CEO of OneSkin, shares her journey in stem cell biology and the development of innovative products focused on skin and hair health. With a PhD in immunology and a background in stem cell and tissue engineering, Dr. Carolina leads OneSkin’s research and development efforts to create molecules that target cellular aging, including the groundbreaking OS-01 peptide.OneSkin is a biotechnology company founded in 2016 and based in Silicon Valley, focused on developing anti-aging skin and hair products. Under Dr. Carolina Reis Oliveira’s leadership, OneSkin aims...

Today I'm speaking with Pita Navarro from EVVY on the Longevity Optimization Podcast. In this conversation, we delve into the complexities of the vaginal microbiome and its crucial role in women’s health. Pita discusses the prevalence of vaginitis, the impact of the vaginal microbiome on fertility, and the importance of understanding and optimizing vaginal health through advanced testing and treatment. We also explore lifestyle factors that influence vaginal health and highlight the urgent need for more research and education in this field. The episode looks ahead to the future of vaginal microbiome testing and how it can empower wo...

Today I'm speaking with Dr. Sasha Hakman on the Longevity Optimization Podcast. In this conversation, we discuss endometriosis, a condition affecting approximately 10% of women, characterized by the presence of endometrial cells outside the uterus. Dr. Hakman explains the definition, symptoms, and prevalence of the condition, as well as the challenges involved in diagnosing it. She also explores potential causes, including genetic and environmental factors, and discusses various treatment options. The conversation emphasizes the importance of understanding endometriosis, its impact on fertility, and the need for increased awareness and proactive care.Dr. Sasha Hakman is a respected expert in women’s...

Today I'm speaking with Ara Katz, the co-founder of Seed, on the Longevity Optimization Podcast. In this episode, Ara shares her personal journey and the inspiration behind founding Seed. She emphasizes the vital role of the microbiome in human health and explains how nutrition shapes gut health from early life through adulthood. Our conversation explores what exactly constitutes a microbiome, how it develops (the “seeding” process), and why a diverse diet is essential for maintaining a healthy gut. Seed Probiotics is an innovative company dedicated to advancing microbiome science and optimizing human health through next-generation probiotics. Their flagship product, DS-0...

In this engaging conversation, Dr. Claudia Aguirre, a neuroscientist and mind-body expert, discusses the intricate connections between the brain and skin, the differences between male and female brains, and the impact of stress on health. She emphasizes the importance of neuroplasticity, the role of AI in cognitive function, and offers practical techniques for stress reduction, highlighting the significance of touch and emotional processing in our lives. In this conversation, the speakers delve into various aspects of health, focusing on longevity, the importance of touch, sleep differences between genders, the role of hormones in brain health, and strategies for healthy...

Today I'm speaking with Siim Land on the Longevity Optimization Podcast. In this episode, Siim shares his inspiring journey into preventive health and highlights the critical role of biological age testing in understanding and improving longevity. We explore key biomarkers that can help track health progress and discuss how to strike a balance between following strict health protocols and still enjoying life to its fullest. Additionally, Siim offers fascinating insights into how AI is shaping the future of health optimization.Siim Land is a dedicated advocate for longevity and preventive healthcare, focusing on practical strategies to extend healthy lifespan...

Today I'm speaking with Kevin Ferber from American Cell Technology on the Longevity Optimization Podcast. In this episode, we dive into the exciting world of stem cell therapy. We discuss the process of harvesting and banking autologous stem cells, exploring the regulatory landscape surrounding stem cell therapy and its various applications in regenerative medicine and aesthetics.

Kevin shares valuable insights into the mechanisms of action of mesenchymal stem cells, emphasizing the importance of proper culturing techniques for their effectiveness. Our conversation also touches on current advancements in stem cell research, potential future applications, and how these therapies...

Today I'm speaking with Dr. Kara Fitzgerald on the Longevity Optimization Podcast. In this conversation, we explore her journey into functional medicine and longevity, emphasizing the importance of dietary and lifestyle interventions in reversing biological age. Dr. Fitzgerald highlights the role of diagnostic tests in understanding health status, the impact of technology on health monitoring, and the significance of epigenetics in influencing gene expression.

Throughout our discussion, we cover various dietary patterns and protein requirements essential for optimal health. Dr. Kara also addresses the accessibility of health interventions for individuals from diverse backgrounds, advocating for inclusive approaches...

Today I'm speaking with Danny Grannick from Bristle Health on the Longevity Optimization Podcast. In this conversation, we delve into the significance of oral microbiome testing and its implications for dental health and overall well-being. Danny shares insights into the differences between good and bad bacteria, highlighting the connection between oral health and systemic diseases. We also discuss the barriers to mainstream acceptance of oral microbiome testing and the importance of raising awareness about its benefits.

Danny Grannick is a passionate advocate for oral health and the role of the microbiome in overall wellness. Throughout our discussion...

Today I'm speaking with Dr. Stephanie Venn-Watson on the Longevity Optimization Podcast. In this episode, we discuss the intriguing concept of longevity molecules, with a particular focus on C15 fatty acid and its implications for health and aging. Our conversation explores various longevity molecules, their mechanisms, and the surprising findings from research on dolphins that led to the discovery of C15 as a key factor in healthy aging. We emphasize the importance of understanding dietary sources of C15 and its role in promoting longevity and overall health.

Dr. Stephanie Venn-Watson is a leading researcher...

Today I'm speaking with Robin Berzin, MD, on the Longevity Optimization Podcast. In this conversation, we delve into the principles of functional medicine, emphasizing its focus on treating the root causes of health issues rather than just symptoms. We discuss the importance of preventive care, particularly for women, and the need for comprehensive testing to understand metabolic health, blood sugar levels, and hormonal balance. Our conversation highlights the significance of dietary interventions, lifestyle changes, and the crucial role of sleep in overall health.

Dr. Robin Berzin is a leading advocate for functional medicine, dedicated to transforming healthcare...

Today I'm speaking with Whitney Tingle, the founder of Sakara Life, on the Longevity Optimization Podcast. In this engaging conversation, we explore the realms of wellness, nutrition, and the journey of creating Sakara, a healthy meal delivery service. Whitney shares her personal health struggles and emphasizes the importance of gut health, discussing how nutrition profoundly impacts overall well-being. Our dialogue delves into the science behind food, the significance of hydration, and the challenges of sourcing quality ingredients, all while reflecting on the unique health landscape of New York City.

Whitney Tingle is a passionate advocate for holistic...

Today I'm speaking with Liz Parrish, the founder and CEO of BioViva, on the Longevity Optimization Podcast. In this episode, we explore groundbreaking advancements in gene therapy and its potential to cure age-related diseases. Liz shares her personal journey that led to the creation of BioViva, providing insights into the mechanisms of gene therapy and the current landscape of approved therapies. Our conversation delves into the hallmarks of aging, the role of specific genes like follistatin and telomerase, and the future of gene therapy as a preventative measure for health optimization.

Liz Parrish is a pioneering figure...

Today I'm speaking with Dr. Kay Linker on the Longevity Optimization Podcast. In this episode, we delve into the intricate relationship between neuroscience, nutrition, and longevity. Together, we explore the differences between male and female brains, the importance of brain health, and how diet and exercise play crucial roles in cognitive function. The conversation highlights the impact of neurotoxins, the significance of the blood-brain barrier, and the vital connection between gut health and brain function. We also discuss the detrimental effects of alcohol on the brain and the benefits of walking for cognitive performance.

Dr. Kay Linker...

Today I'm speaking with Dr. Sasha Hakman, a fertility expert, on the Longevity Optimization Podcast. In this episode, we discuss the rising trends in infertility, the impact of environmental toxins, and the critical importance of lifestyle factors such as nutrition and exercise on fertility. Dr. Hakman shares insights into the role of hormones, particularly progesterone, and how thyroid and autoimmune conditions can affect fertility outcomes. The conversation emphasizes the need for awareness and proactive measures to optimize fertility.

Dr. Sasha Hakman is a renowned fertility specialist dedicated to helping individuals and couples navigate the complexities of reproductive...

Today I'm speaking with @HarperCarrollAI  an AI and ML software engineer, on the Longevity Optimization Podcast. In this episode, we explore the fascinating intersection of artificial intelligence and health optimization. Harper shares insights into the concept of AI as the ultimate polymath, detailing her journey into the field and the transformative potential of AI in revolutionizing health diagnostics and treatments, particularly in cancer care. The conversation delves into the implications of AI in personalized medicine and how technology can shape the future of health optimization.Harper Carroll is an AI/ML engineer, advisor and educator focused on making AI co...

Today I'm speaking with Julian Mitchell from Life Cykel. In this episode, we delve into the fascinating world of functional mushrooms, particularly focusing on Lion's Mane, Reishi, and Cordyceps. Julian shares insights into the origins of Life Cykel and the extensive research supporting the benefits of these mushrooms for cognitive health, sleep optimization, and gut health. The conversation emphasizes the importance of biohacking and how mushrooms can enhance overall well-being and longevity.

Julian Mitchell is a passionate advocate for the health benefits of functional mushrooms and the co-founder of Life Cykel, a company dedicated to harnessing the...

Today I'm speaking with Dr. Paziotopoulos on the Longevity Optimization Podcast. In this episode, we explore his unique journey into the field of medicine and longevity, focusing on the integration of AI in health monitoring and the innovative concept of medical maintenance engineering. The conversation delves into the importance of imaging, the role of supplements, and the critical significance of compliance in health programs. Dr. Paziotopoulos highlights key compounds for longevity, emphasizing the essential role of vitamin D in overall health and its importance in cancer prevention.

Dr. Paziotopoulos is a distinguished physician and researcher with a...

Today I'm speaking with Jeff Krasno on the Longevity Optimization Podcast. In this episode, we explore his transformative journey from the music industry to the wellness space, where he shares the profound impact of 9/11 on his life, the founding of Wanderlust, and a personal health crisis that ignited his passion for metabolic health and the concept of good stress. The conversation also touches on the launch of a female health community and the challenges of modern living, emphasizing the need to reconnect with our ancestral roots for better health.Jeff Krasno is a visionary entrepreneur and wellness advocate, best...

Today I'm speaking with ‪@susannasoeberg‬ on the Longevity Optimization Podcast. In this episode, we delve into the fascinating interplay between cold and heat therapies, exploring their profound effects on metabolism and the crucial role of brown fat in overall health. Dr. Soeberg is a renowned expert in the field of metabolic health, with a focus on the physiological impacts of temperature exposure. With extensive research on the benefits of cold exposure, she has contributed significantly to our understanding of how these therapies can enhance insulin sensitivity and mental well-being. Throughout the conversation, we discuss practical advice for beginners interested in c...

Today I'm speaking with Forrest Smith from Kineon, exploring the transformative potential of red light therapy, also known as photobiomodulation. We discuss the mission behind this innovative technology, its applications in pain management, and the significant benefits it offers for both male and female health. Our conversation delves into the science of wavelengths, the systemic effects of targeted therapy, and the exciting future of light therapy products.

Forrest Smith is a leading figure at Kineon, a company at the forefront of developing cutting-edge light therapy products. With a focus on optimizing health and well-being...

Today I'm speaking with Jennifer Garrison, PhD, about her groundbreaking research on ovarian aging and its implications for female health. She emphasizes the importance of understanding the brain-ovary connection and how ovarian health impacts overall health span. Our conversation highlights the need for more research in female physiology, the challenges faced in the field, and the exciting innovations on the horizon for women's health.

Jennifer Garrison, PhD, is a renowned scientist specializing in the study of aging and female reproductive health. Her work focuses on uncovering the intricate connections between the brain and ovaries, aiming to improve...

Today I'm speaking with Dr. Yvonne Burkart about the critical issue of environmental toxins and their impact on health. We discuss the alarming number of chemicals in our environment, the regulatory failures surrounding them, and specific toxins to avoid, including PFAS and microplastics. Our conversation also highlights the dangers of fragrances and beauty products, emphasizing the need for consumer awareness and corporate responsibility in addressing these health risks.

Dr. Yvonne Burkart is an expert in toxicology with a passion for educating the public about environmental health. With years of experience in the field, she has dedicated her...

Today I’m speaking with Dr. Tyna Moore about the importance of individualized medicine in modern healthcare. In this episode, we discuss her insights on metabolic health, GLP-1 agonists, and the challenges practitioners face in a landscape dominated by influencers and generalized protocols. Dr. Moore emphasizes the value of tailoring medical approaches to meet individual needs and creating meaningful, patient-centered solutions. Dr. Tyna Moore is a naturopathic physician and chiropractor with a strong focus on metabolic health and resilience. Known for her science-based and practical perspectives, she is a leading advocate for personalized medicine and proactive healthcare strategies. Timestamps 00:00 Fo...

Today I’m speaking with Dr. Stacy Sims, a leading expert in exercise physiology and nutrition science, to delve into the unique physiological differences between men and women. In this episode, we explore how the menstrual cycle impacts women’s training and performance, and the critical need for personalized exercise regimens tailored to different stages of a woman’s life. Dr. Sims shares her groundbreaking insights on optimizing health and performance for women through science-backed strategies.

Dr. Stacy Sims is an acclaimed researcher, author, and speaker specializing in women’s health and performance. Known for her mantra, “Women are...

Today I’m speaking with Dr. Jeffrey Bland, often referred to as the "father of functional medicine," to explore the transformative principles of this healthcare approach. In this episode, we dive into the root causes of health issues, focusing on autoimmunity in women and the critical role of rejuvenating the immune system. Dr. Bland shares actionable insights on how dietary choices and lifestyle changes can redefine our approach to health and wellness.

Dr. Jeffrey Bland is a world-renowned biochemist, educator, and the founder of the functional medicine movement. With decades of experience, he has dedicated his career to...