How God Works: The Science Behind Spirituality

40 Episodes
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By: PRX

While religion and science often seem at odds, there’s one thing they can agree on: people who take part in spiritual practices tend to live longer, healthier, and happier lives. The big question is: Why? In How God Works, professor Dave DeSteno takes us on a journey to find out how spirituality impacts our minds and bodies, as well as the world in which we live. He speaks to leading scientists and philosophers, religious thinkers, and thought leaders to explore what we can learn from the world’s faith traditions to help us meet some of life’s biggest challe...

DIY Spirituality?
#1
Last Sunday at 9:00 AM

About 70% of all Americans consider themselves spiritual in some way, whether it be a belief in the soul, spirits or just the idea that something's going on beyond the natural world and what science can prove. But that doesn't mean they're ordering off the menu of organized religion. 

In this episode, we’ll talk to religion professor Liz Bucar, about this “spiritual salad bar” approach: where people pick and choose ingredients from various religions. What’s lost if we take these traditions out of their intended context?  And could it even be causing harm? 

We’ll explore th...


Season 10 Trailer
03/08/2026

Join us for Season 10 of How God Works, starting next week!


Uniter or Divider? Explore Religion in Modern America. A How God Works Live Event (From the Archive)
02/22/2026

We’ll be back on March 15 with an all-new season of How God Works! In the meantime, we’re excited to share one of our favorite episodes — our very first live event.

If you ask people what they think about religion, you often get one of two answers: Religion is the source of war, violence, abuse, and hypocrisy OR a route to love, kindness, tolerance, and mercy.

Put another way, it’s either what divides us or it’s the thing that can actually bring us together. In a country deeply divided over social, political, and moral...


The Spiritual (and Political) Crisis in the US (From the Archive)
02/08/2026

A brand-new season of How God Works returns March 15! In the meantime, we’re revisiting a powerful episode from our archive that feels particularly relevant today. 

Anger, loneliness, and despair are hitting record levels in the US. Our social and political fabrics are fraying. Is the turn away from religion in the US part of the problem? And if so, might a spiritual renaissance (even among the secular left) help us find new ways to flourish? Join Dave as he talks with podcast host Krista Tippett and US Senator Chris Murphy about the role spirituality (or the lac...


Mattering
#8
01/25/2026

Feeling that our life is meaningful - that we add value to the world and are valued by the people around us, isn’t just a good feeling, it's a fundamentally necessary one. In fact, the need to matter is a universal human motive, second only to the needs of food and shelter.  On this episode we'll talk to author Jennifer Wallace about her new book on the topic of mattering, why we’re in a “mattering deficit,” the worrying impact this is having on our physical and emotional health, and what we can do to change that. And Duke rese...


Rethinking Sin (From the Archive)
01/11/2026

For many people, the word “sin” is associated with harsh judgment and shame. Or, it’s used to talk about guilty pleasures like consuming decadent desserts... But is this concept as harmful or outdated as it seems?

Join Dave as he talks with Elizabeth Oldfield about Christianity’s Seven Deadly Sins, and how reconceptualizing them for modern life can offer a science-backed user’s manual of sorts to find joy and connection in this world, whatever your beliefs.  

Elizabeth Oldfield is host of The Sacred podcast and author of the book Fully Alive: Tending to the Soul in...


The End of the World As We Know It
#7
12/28/2025

These days, it feels like the end of the world is always just around the corner. From RaptureTok to climate doom and geopolitical upheaval, someone always seems to be predicting an impending apocalypse. But how does believing in The End affect how we are in the world? And is there a healthier way to navigate living in uncertain times?

On this episode, we’ll talk to writer Dina Nayeri about growing up in a community that saw the apocalypse as right around the corner, and what she now sees as the dangers of that worldview. We’ll also...


Dream Yoga
#6
12/14/2025

 We spend about a third of our lives sleeping and yet the question of why we sleep and dream has remained a mystery for much of human existence. But recently scientists have developed the tools to begin to reveal some astonishing insights into lucid dreaming and its uses. 

 In this episode, we'll talk to neuroscientist Ken Paller about the science of Lucid dreaming. Whether it's something any of us can learn to do and what benefits it might offer. 

And while the science of lucid dreaming and its possible uses is still in its infancy, Tibe...


Shamanism
#5
11/30/2025

When life feels uncertain, who do you turn to? Across cultures and throughout history, many of us have looked to people who seemed to have a special set of abilities and knowledge… shamans.

On this episode, we’ll talk to anthropologist Manvir Singh about what shamanism actually is, how it works, and why its appeal is both timeless and universal. From a remote island in Indonesia to American Pentecostal churches, we’ll explore how shamans harness ritual, empathy, and performance to help people find meaning and relief in times of need.

Manvir Singh directs the Integr...


Give Us This Day our Daily Kale
#4
11/16/2025

For most of human history, religion guided people’s choices about health and food. Then with the rise of modern nutritional science in the 19th century, people began to favor scientific advice over religious ideas about how to eat. 

But lately, a new generation of Christian diet influencers are putting the God back in nutritional guidance, sometimes at the expense of science altogether. And this messaging might not be creating healthier or holier people.

 We'll talk to New York Times writer Jessica Grose and historian Catherine Newell about the long, complex history of food, faith, and...


Becoming Wise
#3
11/02/2025

We often think of wisdom as something that comes with age, or as a gift reserved for a chosen few. But what if wisdom is more like a muscle… one that becomes stronger with practice?

On this episode, we’re exploring the true meaning of wisdom. We’ll talk to psychologist Igor Grossmann and Jesuit priest Barton Geger about how science and spirituality have come to many of the same conclusions about what wisdom looks like in practice and what we can all do to train our hearts and minds to see more clearly and make choices that a...


Seeking the Spiritual Life
#2
10/19/2025

If you want to grow spiritually, should you go to a monastery and withdraw from the world, or look for greater meaning, connection, and purpose in the loud messiness of life?  In other words, do you heal the world by working in it or praying for it? Philosophers and spiritual thinkers have debated it for centuries, but perhaps finding the right balance is the answer. 

On this episode of How God Works, we’ll talk with journalist Sigal Samuel, about the centuries old debate over the spiritual life and how best to pursue it - through contemplation or a...


The Friendship Cure
#1
10/05/2025

We say friends are what make life worth living. But if that’s true, why are so many of us struggling to find and keep them these days? And what can we do to cultivate better friendships?

Join us as we talk to psychiatrist  Robert Waldinger about the importance of friendship to our health and happiness, and to philosopher Samuel Kimbriel about the keys to forming meaningful friendships and the helpful advice spiritual traditions offer. Along the way, we’ll also ask what it means to be a good friend… and what that means for society as a whole...


Season 9 Trailer
09/28/2025

Join us for Season 9 of How God Works, starting next week!


Healing Rituals: There's Power in Belief (From the Archive)
09/14/2025

We will be back with a whole new season of How God Works on October 5th. In the meantime, we wanted to share some of our favorite episodes from the archives. 

A majority of people in the US believe that faith can heal. And while there isn’t any strong scientific data backing the idea of faith healing by divine intervention, there is a growing recognition that faith in the power of a person, religious ritual, or even medicine to heal can play a role in recovery via the placebo effect. Join Dave and his guests science wri...


Midlife: Leaning Into the Change (From the Archive)
09/02/2025

We'll be back with a whole new season of How God Works on October 5th. But in the meantime, we wanted to share some of our favorite episodes from the archives.

Data shows that for many people, happiness takes a big dip around 50. But aging doesn’t have to be a crisis if we can figure out how to embrace who we’re becoming rather than hanging on to who we used to be. If done right, midlife can actually be a time of deepening joy and satisfaction. Join Dave as he talks to The Atlantic columnist Arth...


HGW Presents: How Rituals Help Us Process Grief (The Science of Happiness)
08/17/2025

How God Works will be back with all new episodes this fall. In the meantime, we're taking the opportunity to share episodes from some of our favorite shows with you, our listeners. Today, we're excited to feature an episode from our friends at The Science of Happiness podcast, hosted by Dacher Keltner.

Summary: We investigate how Día de los Muertos, or Day of the Dead,  rituals strengthen family ties and cultural identity, and learn about its evolution from a 3,000 year old practice to a global celebration. We look at key elements like the ofrenda and explore ho...


HGW Presents: Kelly Corrigan Wonders (with Rainn Wilson)
08/03/2025

How God Works will be back with all new episodes this fall. In the meantime, we're taking the opportunity to share episodes from some of our favorite shows with you, our listeners. Today, we're excited to feature a conversation from the podcast Kelly Corrigan Wonders, featuring Rainn Wilson, creator of the book and podcast Soul Boom. 

"Going Deep with Rainn Wilson on Spirituality"

Rainn Wilson (who you might know as Dwight Schrute) is making a serious call for a spiritual revolution based on joy, acts of service and being honest about our mixed natures. This i...


Bonus: Losing Our Religion or Finding What Matters?
07/20/2025

As more Americans move away from organized religion, the moral and emotional needs once met by faith communities remain. What can secular society borrow from spiritual traditions — ritual, meaning, belonging and moral imagination — to nourish the human spirit and strengthen our shared civic life? In this conversation, recorded live at the 2025 Aspen Ideas Festival, Dave explores how sacred wisdom can still guide character, compassion, and community in a post-religious age with Krista Tippett, Father Greg Boyle, and Rabbi Shira Stutman.

Krista Tippet is the creator and host of the award winning podcast On Being and an awardee of t...


Speaking in Tongues
#8
06/29/2025

The spiritual practice of speaking in tongues –a form of communication with the divine through speaking words in an unknown or unrecognizable language– has invited a lot of speculation and skepticism over the years. To many, it seems like the stuff of horror movies, or old-timey religious revivals. But charismatic Christianity, for which speaking in tongues is a central practice, is one of the fastest growing Christian movements in modern history.  So why has it not only persisted, but recently gained momentum? What exactly is happening to the mind and body when people engage in this practice? 

We’ll...


The Soul and Science of Prayer
#7
06/15/2025

What is prayer? And why do it? People pray for all kinds of reasons, and in all kinds of ways: alone, together, aloud, in silence, from memory, or from instinct. But whatever form it takes, there’s a reason prayer has been part of just about every spiritual tradition out there: its effects run deep. 

On this episode, we’re digging into the science and spirit of prayer. We’ll talk to neuroscientist Andrew Newberg about what prayer does to our minds and bodies, and how it helps shape us as people. And friend of the show Rabbi S...


Of God and Men
#6
06/01/2025

There's a lot of talk these days about a crisis of masculinity. But is it a genuine problem or just another culture war talking point? 

In this special episode, we’ll talk to writer and researcher Richard Reeves about the real and worrying data around the male struggle for meaning and purpose, and what role community and ritual can play in helping men find answers. We’ll also hear from Dr. Russell Moore and Pastor Rasool Berry about how and why religion can help support men, but also the dangers it can pose if they follow it down...


Adolescence: How to Build an Adult (From the Archive)
05/18/2025

 Hey listeners, we'll be back in two weeks with a special episode looking at the multiple challenges facing men in America today. But while you wait, we wanted to share an episode from Season 2 of our show that feels especially relevant to that conversation. Think of it as a prequel or primer, because part of the problem, and possibly part of the solution, may have to do with how boys become men in the first place. We hope you enjoy!


When you’re a teenager, you’re kind of between two worlds. You’re leaving...


The Conscious Cosmos
#5
05/04/2025

For centuries, Western science and philosophy have struggled to explain what consciousness is and where it comes from. What if the answer to both those questions is: everything?

On this episode, we dive into panpsychism: the idea that consciousness may not be limited to humans, or even living beings, but could be a basic property of reality itself. We’ll talk to philosopher Philip Goff about why this idea is gaining attention in academic circles, and to theologian Joanna Leidenhag about how panpsychism aligns with spiritual traditions from across cultures and throughout history. We’ll also ask: coul...


Found By Faith
#4
04/20/2025

People find faith or change faiths for many reasons: marriage, raising a family, dealing with  grief or crisis. But sometimes it happens the other way around… faith finds you. A believing takes hold, a sense that something divine is there. And maybe not in the way or role that you might have expected. 

It’s not uncommon. Data show that these types of experiences happen to about 30% of people. On this episode we’ll talk to one of these people –New York Times columnist and best selling author David Brooks– about his unexpected encounter with faith and what came af...


Fasting for the Soul
#3
04/06/2025

Many would agree there are few things better than sharing a delicious meal with the people you love, which is one reason why breaking bread together is a cornerstone of religions the world over. But so too is the opposite - going without food.  From Ramadan to Yom Kippur to Lent, fasting is an important ritual in many faiths. But why do so many religions periodically take away the very thing that nourishes our bodies and souls?  

On this episode we'll talk with Khalil-Abdur Rashid about the role fasting plays in Islam, and why not eating and dri...


Origins of Belief
#2
03/23/2025

We often think of belief as a religious or cultural idea that is a hallmark of modern humans. But what if the early sparks of belief burned in our ancestors’ minds long before modern humans walked the earth? What if beliefs about some of the biggest questions out there, like what happens after death, weren’t just pondered by Homo sapiens?

On this episode, evolutionary anthropologist Agustín Fuentes takes us on a journey spanning millions of years, from our primate relatives in the deep past to the complex spiritual and cultural traditions we know today. Along the w...


Marriage, Monogamy and the Modern Mind
#1
03/09/2025

When it comes to finding happiness, many religions see marriage as the gold standard: a path to love, stability, and fulfillment. But is that really true? And if so, why are marriage rates plummeting in so many parts of the world?

In this episode, we’ll talk to anthropologist Joseph Henrich about the surprising history of marriage and monogamy, including how these institutions helped lay the groundwork for much of our modern way of life. We’ll also speak with psychologist Geoff MacDonald about what it means to live a happy, single life in a world that ofte...


Season 8 Trailer
03/02/2025

Join us for Season 8 of How God Works, starting next week!


Every Breath You Take (From the Archive)
02/23/2025

We'll be back with a whole new season of How God Works on March 9th. But in the meantime, we wanted to share shows from our archives that speak to some of the most pressing challenges we're all facing today. It’s only February, and already this has been an intense year. So if you’re feeling stressed today, how about… a breather?

It’s no accident that the Hebrew word for breath is the same as the word for spirit (ruach). Breath doesn’t just give us life: it helps regulate everything from vital organ functions to cogniti...


Moving Beyond Us vs Them (From the Archive)
02/09/2025

We'll be back with a whole new season of How God Works starting in early March. But in the meantime, we wanted to share a few shows from our archives that speak to some of the most pressing challenges we're all facing today.

Hate and prejudice based on ethnicity, religion, gender and sexual orientation are all too common in our world. But are we doomed to be this way? Or is it possible to create a world where cooperation and peace are the norm?

Join Dave as he talks to NYU professor Jay van Bavel...


Religion and Robots and AI … Oh My! (From the Archive)
01/26/2025

Artificial Intelligence, and its possible applications to religion, have been in the news a lot lately, so while we're busy working on Season 8, we thought we'd share this episode from 2022 with you.

Can you pray with a robot? Will people worship AI like a god? It’s not science fiction. It’s starting to happen now. But what does it mean if robots become priests, or AIs start offering ethical advice? And how do we know when to trust them?

We’ll talk to MIT social roboticist Cynthia Breazeal about how technology can manipulate our minds...


Why Spirituality is Important in our Increasingly Secular World (Dave on the How to Be a Better Human Podcast)
01/12/2025

Faith has always been a strong force in human history – but in modern times, it may feel antiquated to have it. This is an episode of the How to Be a Better Human podcast in which Dave talks about his research exploring questions of faith, his findings, and why we shouldn’t leave spiritual wisdom behind, even in the age of science. 

Hosted by comedian Chris Duffy, How to Be a Better Human features conversations that uncover sharp insights and give clear takeaways on how you can improve your life.  From your work to your home and your h...


Finding Holiday Happiness
#8
12/15/2024

The holidays are supposed to be a time of joy. But all too often, the darker, colder days of winter, and even the stress of preparing for the holidays themselves, can lead people to feel something else: rushed, stressed, lonely, or even hopeless. How can you make sure this year is bright? Science shows that there's a wisdom to parts of traditional winter celebrations – a wisdom that's been honed over centuries to help us all find light, joy, and connection during the darkest and coldest time of the year. 

Join Dave as he chats with Laurie Santos abo...


Finding Hope in Dark Times (From the Archive)
#7
12/08/2024

This episode from 2023 is one of our all-time listener favorites. We're sharing it again for anyone who may have missed it, or could do with a refresher, especially at the holiday season! 

Surveys show feelings of sadness and despair peaked in 2023. So as we look to the new year, it’s understandable why any of us might be feeling pessimistic, even hopeless. But these feelings aren’t written in stone. We always have a choice. It’s in these darkest of times, when all feels lost, that hope helps us find our way … not just to heal ourselves...


The Bad Place
11/24/2024

Lots of religions embrace the idea of hell – a place of eternal punishment for wrong doers. But where did that idea come from? How has it changed through time? And how does a belief in it (or not) affect us while we’re alive? 

We’ll talk with Bart Ehrman about the history of beliefs in hell from ancient Mesopotamia through modern Christianity. And with Shadi Hamid about why he thinks it can be a good thing for people to believe in hell, and how that belief shapes our political and social lives.  


Bart E...


Near Death Experiences
#5
11/10/2024

People have been having Near-Death Experiences (NDEs) all over the world for as long as we can look back into history. And the strange thing is… these experiences seem to have a lot in common. Why? Is it a look into the afterlife? Is it just our neurons firing in weird ways as the brain dies? 

We’ll talk to psychiatrist Bruce Greyson, one of the world’s leading experts on Near-Death Experiences, about the research that led him to rethink his understanding of the nature of life, death, and the continuity of consciousness. We’ll explore the scien...


So You say You’re a Cynic
10/27/2024

There’s no question we’re living in difficult times that lead many of us to adopt a cynical outlook. But while cynicism might feel smart, science shows it’s corrosive not only to our own wellbeing, but to society as a whole. We’ll talk to Stanford Professor of Psychology Jamil Zaki about the surprising benefits that a willingness to trust in the goodness of others can offer, and how to build this skill in a wise way through habits of mind and action.

We’ll also speak with political writer Peter Wehner about how cynicism leads to t...


Succeeding Without Trying
#3
10/13/2024

We spend a lot of time on How God Works talking about how spirituality can offer tools to become better versions of ourselves.  And while learning to be happier, healthier and more resilient are all positive things to strive for, they can also lead us down a different path - an obsession with productivity and self-optimization… which can lead to a culture of trying to grind or life-hack our way through everything.

But what if the secret to success lies in doing less, not more? On this episode, we’ll explore the Chinese concept of wu wei, effor...


Rethinking Regret
#2
09/29/2024

Regret can be a double-edged sword.  It can be painful, and enduring, but we can also learn important lessons from it - IF we treat it right. Most religions speak of forgiveness and compassion, not only toward others but also toward oneself. Still, letting go can be difficult to do at times. So how do we learn from regret and start anew?

Dave speaks with best selling author Daniel Pink, and renowned Buddhist teacher Sharon Salzberg to learn about the science of regret and how some spiritual wisdom and practices can help us move beyond it and b...