AJT Highlights

Hosts Roz and Dr. Sanchez-Fueyo discuss the key articles of the September issue of the American Journal of Transplantation.

[03:30] Blunted cardiac reserve as a marker of cirrhotic cardiomyopathy—Cardiac outcomes following liver transplantation and comparison to the existing guidelines

[14:18] Back-table intra-arterial administration of C1 esterase inhibitor to deceased donor kidney allografts improves posttransplant allograft function: Results of a randomized double-blind placebo-controlled clinical trial

[25:55] Donor-derived cell-free DNA is associated with the degree of immunosuppression in lung transplantation

[36:24] A two-threshold algorithm using donor-derived cell-free DNA fraction and quantity to detect acute rejection after he...

In this Specialty Podcast, Dr. Dami Ko is joined by Dr. Katherine Rizzolo, and Dr. Leonela Villegas to discuss kidney transplantation for undocumented immigrants in the United States, particularly the challenges they face and ethical considerations.

Dr. Dami Ko is an assistant professor at Northeastern University, specializing in post-transplant care and quality of life.

Dr. Katherine Rizzolo is a nephrologist in Boston, MA.

Dr. Leonela Villegas is a Pediatric Nephrologist at Hartford, CT

References:

Long-term impact of immigration status on outcomes in pediatric kidney transplant recipients. 

Successful p...

Hosts Roz and Alberto are joined by new Editorial Fellow Dr. Sofia Bin to discuss the key articles of the August issue of the American Journal of Transplantation.

Dr. Sofia Bin is an assistant professor of medical and surgical sciences at the University of Bologna.

[02:46] Gut microbiome alterations precede graft rejection in kidney transplantation patients

[10:31] Molecular diagnosis of kidney allograft rejection based on the Banff Human Organ Transplant gene panel: a multicenter international study

Editorial: Graft biopsy reimagined: Integrating morphology and molecular maps

[22:20] Does a changing donor p...

Hosts Roz and Alberto discuss the key articles of the July issue of the American Journal of Transplantation.

[03:48] Liver transplantation for hepatitis D virus/hepatitis B virus coinfection in Italy: an intention-to-treat analysis of long-term outcomes

[13:42] 10 degree C static storage of porcine donation after circulatory death livers improves biliary viability and mitigates ischemia-reperfusion injury

[22:20] Fewer medullary pyramids in the living kidney donor are associated with graft failure in the recipient

[33:35] Microvascular inflammation in kidney allografts: New directions for patient management

MOMOT (Mouse Models in Transplant) articles:

Can...

Host Roz is joined by new co-host Alberto Sanchez-Fueyo, MD, PhD to discuss the key articles of the June issue of the American Journal of Transplantation.

Dr. Sanchez-Fueyo is a Professor of Hepatology, and the Academic Director of the Institute of Liver Studies, King's College, London.

[02:51] Recipient toll-like receptor 4 determines the outcome of ischemia-reperfusion injury in steatotic liver transplantation in mice

[10:47] Association between everolimus combination therapy and cancer risk after liver transplantation: A nationwide population-based quasi-cohort study

[21:35] Balancing equity and human leukocyte antigen matching in deceased-donor kidney allocation with eplet mismatch<...

In this specialty podcast, Dr. Alissar El Chediak is joined by Dr. Jon Odorico and Dr. Ron Parsons to discuss the current state of pancreas transplantation, identify barriers and strategies for referral and candidate selection, and discuss solutions to address the decline in procedures.

Alissar El Chediak, MD is a transplant nephrologist at UT Southwestern Medical Center.

Jon Odorico, MD is a transplant surgeon at the University of Wisconsin.

Ron Parsons, MD is a transplant surgeon at the University of Pennsylvania.

References:

Generating strategies for a national c...

In this Specialty Podcast, Dr. Alejandra Mendoza is joined by Dr. Cameron Wolfe, infectious diseases specialist at Duke University, to discuss the growing concern of avian influenza (H5N1) in transplant recipients. Together, they explore the latest epidemiologic developments, potential risks to immunocompromised patients, and key considerations for clinicians managing solid organ and stem cell transplant recipients in the face of this evolving threat.

Dr. Alejandra Mendoza is a transplant infectious diseases physician at the University of Utah. Dr. Cameron Wolfe is a professor of medicine in the division of infectious diseases at Duke University.

...

Host Roz is joined by Timucin Taner, MD, PhD and Dami Ko, PhD to discuss the key articles of the May issue of the American Journal of Transplantation.

Dr. Timucin Taner is a professor of surgery at Mayo Clinic, Rochester, MN. Dr. Dami Ko is an assistant professor at the School of Nursing at Northeastern University.

[02:51] Development and validation of the Neuro-Score: a specific scale to detect and monitor cognitive impairment in kidney or liver transplant recipients

Editorial: Cognitive impairment after liver and kidney transplant: An easy way to check

[14:16] Randomized...

Host Roz is joined by Rene Bermea, MD and Gonzalo Sapisochin, MD, PhD to discuss the key articles of the April issue of the American Journal of Transplantation.

Dr. Rene Bermea is an instructor at Harvard Medical School, and a transplant pulmonologist and intensivist. Dr. Gonzalo Sapisochin is an associate professor of surgery, abdominal transplant and surgical oncology at the University of Toronto, Canada.

[04:31] Generalizability of kidney transplant data in electronic health records — The Epic Cosmos database vs the Scientific Registry of Transplant Recipients

Editorial: Finding actionable information in the universe of data

Host Roz is joined by Ross Doyle, PhD to discuss the key articles of the March issue of American Journal of Transplantation.

Dr. Ross Doyle is a consultant nephrologist at Mater Hospital in Dublin, Ireland.

(Mentioned) A blood-based PT-LIFE (Pediatric Liver Transplantation-LIver Fibrosis Evaluation) biomarker panel for noninvasive evaluation of pediatric liver fibrosis after liver transplantation: A prospective derivation and validation study

Editorial: Are we closer to abandoning protocol graft biopsies after pediatric liver transplantation?

(Mentioned) Deceased donor urinary Dickkopf-3 associates with future allograft function following kidney transplantation

[04:08] Cure...

Hosts Roz and Josh are joined by Dr. Adam Stewart to discuss the key articles of the February issue of the American Journal of Transplantation.

[00:02:38] A competing risks model to estimate the risk of graft failure and patient death after kidney transplantation using continuous donor-recipient age combinations

[00:09:00] Donor-derived bartonellosis in solid organ transplant recipients from unhoused donors in Alberta

[00:16:54] Contemporary prevalence and practice patterns of out-of-sequence kidney allocation

Editorial: Out-of-sequence allocation: a necessary innovation or a new inequity in transplantation?

Editorial: Ethical implications of prioritizing utility at a...

Hosts Roz and Josh are joined by Sergio Acuna, MD to discuss the key articles of the January issue of American Journal of Transplantation.

Dr. Sergio Acuna is a clinical instructor in abdominal transplant surgery at the University of Alabama at Birmingham

[03:21] The dangerous precedent of censoring scientific dissemination

[08:45] Long-term ex situ normothermic machine perfusion allows regeneration of human livers with severe bile duct injury

Editorial: Time will tell: Employing long-term normothermic machine perfusion to gain new insight into bile duct regeneration

[14:00] Probable antibody-mediated rejection in kidney t...

Hosts Roz and Josh are joined by Abraham Matar, MD to discuss the key articles of the December issue of American Journal of Transplantation.

Dr. Abraham ‘Abe’ Matar is a Transplant Surgery Fellow at the University of Minnesota

[02:15] Economic Evaluation of Weight Loss and Transplantation Strategies for Kidney Transplant Candidates with Obesity

Editorial: Selecting Weight Loss Strategies for Kidney Transplant Candidacy: Weighty decisions

[11:44] Electrostimulation suppresses allograft rejection via promoting lymphatic regulatory T cell migration mediated by lymphotoxin (LT)-LTb receptor signaling

[18:57] Ischemia Reperfusion Responses in Human Lung Trans...

Description:  Hosts Roz and Josh are joined by Sharon Weeks Groh, MD to discuss the key articles of the November issue of American Journal of Transplantation.

Dr. Sharon Weeks Groh is a transplant surgeon at Walter Reed

[02:08] Robotic living donor hepatectomy is associated with superior outcomes for both the donor and the recipient compared to laparoscopic or open - A single center prospective registry study of 3,448 cases

[09:34] Public Attitudes to Xenotransplantation: A National Survey in the United States

[18:09] Non-clinical and clinical characterization of MAU868, a novel human-derived monoclonal neutralizing an...

Hosts Roz and Josh are joined by Frances Lee, MD to discuss the key articles of the October issue of American Journal of Transplantation.

[00:02:31] Pre-transplant Use of Immune Checkpoint Inhibitors for Hepatocellular Carcinoma: A Multicenter, Retrospective Cohort Study

Editorial: Integrating immune check inhibitors in liver transplantation for hepatocellular carcinoma: The right time and the right patient

[00:11:46] Association of Procurement Technique with Organ Yield and Cost Following Donation After Circulatory Death

Editorial: Dawn Has Arrived, Illuminating Thrilling Opportunities and Fresh Challenges in a New Era of U.S. Transplantation

...

Hosts Roz and Josh are joined by Alissar El Chediak, MD to discuss the key articles of the September issue of the American Journal of Transplantation.

Alissar El Chediak, MD is a transplant nephrologist at UT Southwestern

[02:55] – Liver Machine Perfusion Technology: Expanding the Donor Pool to Improve Access to Liver Transplantation

[08:01] – Editorial: Machine perfusion and liver transplant center behavior: Answers or more questions?

[11:01] - Obesity, Organ Failure, and Transplantation: A Review of the Role of Metabolic and Bariatric Surgery in Transplant Candidates and Recipients.

[18:48] – Virus Specific T Cell Th...

Description:  Hosts Roz and Josh are joined by Maria Alejandra Mendoza, MD to discuss the key articles of the August issue of American Journal of Transplantation.

[01:57] Impact of deceased organ donor marijuana use on donor culture positivity and solid organ transplant recipient outcomes https://doi.org/10.1016/j.ajt.2024.02.022

[13:11] China Issued Rules on Human Organ Donation and Transplantation https://doi.org/10.1016/j.ajt.2024.04.002

[21:10] Advancing Mouse Models for Transplantation Research https://doi.org/10.1016/j.ajt.2024.01.006

[30:05] Differential induction of donor-reactive Foxp3+ Treg via blockade of CD154 vs. CD40 https://doi.org/10.1016/j.ajt...

Hosts Roz and Josh are joined by Mack Morris, MD to discuss the key articles of the July issue of American Journal of Transplantation.

[03:33] Biliary complications after adult-to-adult living-donor liver transplantation: An international multicenter study of 3633 cases https://doi.org/10.1016/j.ajt.2024.02.023 

[13:07] The impact of time to death in donors after circulatory death on recipient outcome in simultaneous pancreas-kidney transplantation https://doi.org/10.1016/j.ajt.2024.02.008 

[24:30] Should advanced perfusion be the standard of care for donation after circulatory death liver transplant? https://doi.org/10.1016/j.ajt.2024.03.021 

[32:20] Immunosuppression Withdrawal in Living-donor Renal Transplant Rec...

In this specialty podcast, AJT Fellow and host David Cron is joined by Jesse Schold and Joel Adler to provide an overview policy evaluation in transplantation, including analytical approaches, pitfalls, and best practices.

References

Stewart et al. “Does anyone really know what (the kidney median waiting) time is?”  

Noreen et al. “Augmenting the United States transplant registry with external mortality data: A moving target ripe for further improvement”

Shifman et al. “Association of state Medicaid expansion policies with pediatric liver transplant outcomes”

Host Roz is joined by AJT Associate Editor Orla Morrissey, MD (Monash University) and AJT Editorial Fellow Elena-Bianca Barbir, MD (Mayo Clinic-Rochester).

[3:16] The respiratory syncytial virus vaccines are here: Implications for solid organ transplantation

[19:14] Association between cytomegalovirus viremia and long-term outcomes in lung transplant recipients

[35:40] Genetic versus self-reported African ancestry of the recipient and neighborhood predictors of kidney transplantation outcomes in 2 multiethnic urban cohorts

[EDITORIAL] Untangling genetic and environmental risks in kidney transplant outcomes: The interplay of self-identified race, genetic ancestry, monogenic risk alleles, and socioeconomic factors

[45:15] Low-affinity CD8+...

In this AJT specialty podcast, Luise Holzhauser, hosts Shelley Hall and Marie Budev to discuss the impact of the 2018 change in heart allocation and what the heart community can learn from experiences with continuous distribution of lung.

Host Roz is joined by AJT Executive Guest Editor Nadim Mahmud, MD, MPH (University of Pennsylvania) and AJT Editorial Fellow Tina Marinelli, MBBS, MPH&TM,  FRACP (Royal Prince Alfred Hospital).

Host Roz is joined by AJT Editor-in-Chief Emeritus Allan Kirk, MD, PhD, (Duke University) and AJT Editorial Fellow Laura Binari, MD (Vanderbilt University).

[2:34] Abdominal computed tomography measurements of body composition and waitlist mortality in kidney transplant candidates

[14:09] A2/A2B to B deceased donor kidney transplantation in the Kidney Allocation System era

[24:01] Xenotransplantation Papers

[25:07] Xenotransplantation experiments in brain-dead human subjects–A critical appraisal

[28:11] The decedent model: A new paradigm for de-risking high stakes clinical trials like xenotransplantation

[32:45] Exploring the single-cell immune landscape of kidney allograft inflammation using im...

Host Roz is joined by AJT Editorial Board Member Alexandre Loupy, MD, PhD (Necker Hospital) and AJT Editorial Fellow Thiago J Borges, PhD (Massachusetts General Hospital).

[2:39] Transplanting old organs promotes senescence in young recipients

[11:33] The Banff 2022 Kidney Meeting Report: Reappraisal of microvascular inflammation and the role of biopsy-based transcript diagnostics

[15:45] The Banff 2022 Kidney Meeting Work Plan: Data-driven refinement of the Banff Classification for renal allografts

(Editorial) [18:12] The Banff process—Reloaded: A joint initiative from the Banff Foundation for Allograft Pathology and the American Journal of Transplantation

[20:25] Antiobesity pharmacotherapy to fa...

Host Roz is joined by AJT Editorial Board Member John Greenland, MD, PhD (University of California, San Francisco) and AJT Editorial Fellow David Cron, MD, MS (Massachusetts General Hospital).

[2:53] Pure laparoscopic donor hepatectomy: Experience of 556 cases at Seoul National University Hospital

[11:26] Smoking exposure-induced bronchus-associated lymphoid tissue in donor lungs does not prevent tolerance induction after transplantation & Aging exacerbates murine lung ischemia-reperfusion injury by excessive inflammation and impaired tissue repair response

[20:28] Augmenting the Unites States transplant registry with external mortality data: A moving target ripe for further improvement

(Editorial) How hard are...

The podcast discusses the impact and implications the kidney allocation system (KAS 250) has had over kidney allocation in the United States, focusing on the effect on operational challenges, cold ischemic times, delayed graft function, and organ discard rates.

Guest speakers include Joel Adler (Dell Medical School, University of Texas in Austin) and John Friedewald (Northwestern Memorial Hospital).

Host Roz is joined by AJT Editorial Board Member Michael Mengel, MD (University of Alberta) and AJT Editorial Fellow Kazem Fallahzadeh, MD (Emory University).

[2:43] Recurrent atypical antiglomerular basement membrane nephritis in the kidney transplant

[14:26] Pretransplantation coronavirus disease 2019 vaccination requirements: A matched case-control study of factors associated with waitlist inactivation

(Editorial) Coronavirus disease 2019 vaccine mandates and the Owl of Minerva

[21:45] Incomplete tissue product tracing during an investigation of a tissue-derived tuberculosis outbreak

[29:48] Risk for graft loss in pediatric and young adult kidney transplant recipients due to recurrent IgA nephropathy

Host Roz is joined by AJT Editorial Board Member Emily Blumberg, MD (University of Pennsylvania) and AJT Editorial Fellow Dempsey Hughes, MD (Northwestern Medicine).

[03:03] Predicting post–liver transplant outcomes in patients with acute-on-chronic liver failure using Expert-Augmented Machine Learning

[10:34] Clinical features, treatment, and outcomes of mpox in solid organ transplant recipients: A multicenter case series and literature review

[14:05] First case of rapidly fatal mpox from secondary (household) transmission in a kidney transplant recipient

[15:28] A joint program of antimicrobial stewardship and hospital-acquired infection control to reduce healthcare-associated infections after kidney transplantation: The Hi...

In this specialty podcast, Arielle Cimeno, hosts Raymond Lynch and Amit Mathur to discuss recent trends and new initiatives to assess kidney utilization and organ procurement organization performance.  

Host Roz is joined by Ramsey Hachem, MD (Washington University School of Medicine in Saint Louis) and AJT Editorial Fellow Helen Tsai, MD (Montefiore Medical Center) 

[03:30] Disseminated vaccine-induced varicella infection in a kidney transplant recipient

[06:50] Safety and Immunogenicity of the Live-Attenuated Varicella Vaccine in Pediatric Solid Organ Transplant Recipients: A Systematic Review and Meta-Analysis

[10:34] (Editorial) Balancing the live virus vaccine scales: protection vs risk

[14:22] Outcomes after flow cytometry crossmatch-positive lung transplants managed with perioperative desensitization

[19:25] Lung transplantation despite preformed donor-specific anti-HLA antibodies: 9-year single-center experience

[23:00] (Editorial) What i...

Host Roz is joined by AJT Editorial Fellow Salil Kumar, MD (incoming Assistant Professor at MD Anderson Medical Center)

[2:24] Importance of social vulnerability on long-term outcomes after heart transplantation

[12:51] Microbiota-dependent and -independent effects of obesity on transplant rejection and hyperglycemia

[21:26] Memory T follicular helper cells drive donor-specific antibodies independent of memory B cells and primary germinal center and alloantibody formation

[28:52] Validation of a prediction system for risk of kidney allograft failure in pediatric kidney transplant recipients: An international observational study

[36:44] Qualifying a novel clinical trial endpoint (iBOX) predictive of...

Host Roz is joined by AJT Editorial Board Member Kenneth Newell, MD, PhD (Emory University) and AJT Editorial Fellow Kyle Jackson, MD, PhD (Emory University)

[2:45] Identifying and understanding variation in population-based access to liver transplantation in the United States

[12:44] Intra-graft B cell differentiation during the development of tolerance to kidney allografts is associated with a regulatory B cell signature revealed by single cell transcriptomics

[18:21] Single-cell RNA sequencing reveals peripheral blood mononuclear immune cell landscape associated with operational tolerance in a kidney transplant recipient

[22:20] Impact of allele-specific anti-HLA class I antibodies on...

In this specialty podcast, Carrie Thiessen, MD, PhD (University of Wisconsin-Madison) hosts Robert Montgomery, MD, PhD, (NYU Langone) and Muhammad Mohiuddin, MBBS, (University of Maryland) to discuss ethical issues related to informed authorization and informed consent for decedent kidney and human cardiac xenotransplants.

Host Roz is joined by AJT Editorial Board Member Sanjay Kulkarni, MD, (Yale School of Medicine) and AJT Editorial Fellow Luise Holzhauser, MD (University of Pennsylvania)

[2:40] In a real-life setting, risk factors, Coronary artery calcium score and coronary stenosis at Computed Tomography Angiography are associated with MACE and all-cause mortality among kidney transplant candidates

[16:00] The minimum weight and age of kidney donors: En bloc kidney transplantation from preterm neonatal donors weighing less than 1.2kg to adult recipients

[24:35] Increased volume of organ offers and decreased efficiency of kidney placement under circle-based kidney allocation

In this AJT specialty podcast, Aly Strauss, hosts Allison Kwong and Manuel Rodriguez-Peralvarez to discuss MELD 3.0,  Gender-Equity Model for Liver Allocation (GEMA), and international efforts to eliminate gender disparities in allocation of liver transplants. 

Bernards et al. AJT: https://pubmed.ncbi.nlm.nih.gov/35871752/

Kim et al. Meld 3.0: https://pubmed.ncbi.nlm.nih.gov/34481845/

Meld 3.0 calculator: https://medcalculators.stanford.edu/meld

Rodriguez-Peralvarez et al. GEMA: https://pubmed.ncbi.nlm.nih.gov/36528041/

GEMA calculator: http://gema-transplant.com/

Host Roz is joined by AJT Editorial Board Member Seth Karp, MD (Vanderbilt University Medical Center) and AJT Editorial Fellow Thiago Borges, PhD (Massachusetts General Hospital)

[2:33] Xenorecognition and costimulation of porcine endothelium-derived extracellular vesicles in initiating human porcine-specific T cell immune responses

[11:28] The tele-liver frailty index (TeLeFI): development of a novel frailty tool in patients with cirrhosis via telemedicine

[21:18] The 20-year paradigm shift toward organ recovery centers: 2500 donors at Mid-America Transplant and broader adoption across the United States

[33:13] Outcomes of lung and liver transplantation after simultaneous recovery using abdominal normothermic regional...

Hosts Roz and Josh discuss the key articles of the June issue of American Journal of Transplantation.

[1:30] The evolving use of biomarkers in heart transplantation: Consensus of an expert panel

[9:49] Effects of in vivo CXCR4 Blockade and Proteasome Inhibition on Bone Marrow Plasma Cells in HLA Sensitized Kidney Transplant Candidates

[16:50] An ethical analysis of obesity as a contraindication to pediatric liver transplant candidacy

[23:53] Racial and ethnic disparities in psychosocial evaluation and liver transplant waitlisting

Host Roz and Josh are joined by AJT Editorial Fellow Scott Krummey, MD, PhD, to discuss the key articles of the May issue of American Journal of Transplantation.

[01:59] Genetic evaluation of living kidney donor candidates: A review and recommendations for best practices

[11:36] Mutations In Latent Membrane Protein 1 of Epstein-Barr Virus are Associated with Increased Risk for Post-Transplant Lymphoproliferative Disorder in Children

[23:13] Impacts of removing race from the calculation of the Kidney Donor Profile Index

[31:49] The Association of Donor Hepatitis C Virus Infection with Three-Yea...

Host Roz and Josh are joined by AJT Editorial Fellow Daniel Galvez Lima, MD, to discuss the key articles of the April issue of American Journal of Transplantation.

[02:01] Successful pathways to liver transplant for undocumented immigrants, Kerznerman et al

[10:30] Effect of vitamin K supplementation on serum calcification propensity and arterial stiffness in vitamin K-deficient kidney transplant recipients: A double-blind, randomized, placebo-controlled clinical trial, Eelderink et al

[18:07] ABO Genotyping finds more A2 to B kidney transplant opportunities than lectin-based subtyping, Joseph et al

[29:15] Oxidative stress and related metabolic alterations are induced in...

Host Roz is joined by AJT Editorial Fellow Aly Strauss, MD, to discuss the key articles of the March issue of American Journal of Transplantation.

[2:57] Milestones on the path to clinical pig organ xenotransplantation, Cooper & Pierson.

[12:45] Infection and clinical xenotransplantation: Guidance from the Infectious Disease Community of Practice of the American Society of Transplantation, Mehta et al.

[20:30] Addressing sex-based disparities in solid organ transplantation in the United States – a conference report, Sawinski et al.

[33:45] A comparison of deprivation indices and application to transplant populations, Park et al.