The Lancet Respiratory Medicine in conversation with
Editors at The Lancet Respiratory Medicine, in conversation with the journal’s authors, explore their latest research and its impact on people’s health, healthcare, and health policy.A monthly audio companion to the journal, this podcast covers a broad range of topics, from long COIVD outcomes to tobacco control, the management of uncontrolled asthma to intensive care medicine, and more.
Lorenzo Guglielmetti parla del trial clinico ENDTB-Q (in Italian)
This episode is in Italian. For the English version, please see the main feed.
Lorenzo Guglielmetti sul trial clinico ENDTB-Q per valutare l’efficacia e la sicurezza di un regime di farmaci per curare la tubercolosi in individui con tubercolosi pre-estesa farmaco-resistente.
Leggi l'articolo completo:
https://www.thelancet.com/journals/lanres/article/PIIS2213-2600(25)00194-8/fulltext?dgcid=buzzsprout_icw_podcast_July_25_lanres
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Carole Mitnick & Lorenzo Guglielmetti on the ENDTB-Q trial
Carole Mitnick & Lorenzo Guglielmetti join Ari Colosio, deputy editor of The Lancet Respiratory Medicine, to discuss the ENDTB-Q trial to evaluate the efficacy and safety of a drug regiment to treat TB in individuals with pre-extensively drug-resistant tuberculosis.
Read the full article:
https://www.thelancet.com/journals/lanres/article/PIIS2213-2600(25)00194-8/fulltext?dgcid=buzzsprout_icw_podcast_July_25_lanres
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Laura Garriga-Grimau on bronchiectasis in children and young people
Deputy editor Ari Colosio speaks with Dr. Laura Garriga-Grimau of the Val d’Hebron Hospital, Autonomous University of Barcelona. Dr. Garriga-Grimau discusses the first multi-country cohort study to describe the clinical features and standards of care for children and young people with bronchiectasis, drawing on data from the International Pediatric Bronchiectasis Registry.
Together, they examine key findings on regional differences in diagnosis, co-morbidities, clinical severity, and treatment practices across eight countries. Dr. Garriga-Grimau highlights the significant burden of bronchiectasis on patients and health systems, as well as the urgent need for earlier diagnosis, harmonised international guidelines, and mo...
Marcus J Schultz and Prashant Nasa on defining and subphenotyping ARDS
Bianca Brandon is joined by Professor Marcus Schultz and Dr Prashant Nasa to discuss their recent Position Paper reporting insights from an international Delphi expert panel on defining and subphenotyping ARDS. The findings underscore the need to refine the ARDS definition to better address heterogeneity of the condition and improve diagnostic precision, with use of subphenotyping where appropriate.
Read the full article:
https://www.thelancet.com/journals/lanres/article/PIIS2213-2600(25)00115-8/fulltext?dgcid=buzzsprout_icw_podcast_Jun_25_lanres
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Hjalmar Bouma on sepsis in patients who are immunocompromised
Bianca Brandon, Senior Editor at The Lancet Respiratory Medicine, is joined by Professor Hjalmar Bouma to discuss a new review on sepsis in immunocompromised patients, exploring the diagnostic challenges, complexities of immune status, and future directions for targeted therapies. The episode also analyses the increased vulnerability of specific patient groups, the importance of biomarker-driven personalised medicine, and the need for improved representation of immunosuppressed patients in clinical trials.
Read the full article:
https://www.thelancet.com/journals/lanres/article/PIIS2213-2600(25)00124-9/fulltext?dgcid=buzzsprout_icw_podcast_May_25_lanres
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Simon Wolf on pulmonary embolism in children and adolescents in the US during 2016 and 2019
Deputy Editor of The Lancet Respiratory Medicine Ari Colosio discusses the critical findings of a new epidemiological study on pulmonary embolism in children and adolescents with Simon Wolf from the University Hospital of Zurich.
This episode delves into the prevalence, risk factors, and clinical implications of this rare but serious condition, highlighting the need for increased awareness and further research.
Read the full article:
https://www.thelancet.com/journals/lanres/article/PIIS2213-2600(24)00412-0/fulltext?dgcid=buzzsprout_icw_podcast_generic_lanres
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Sandeep Sahay and Franck Rahaghi on future treatment paradigms in pulmonary arterial hypertension
Dr Sandeep Sahay and Professor Franck Rahaghi discuss their Personal View on future treatment paradigms in pulmonary arterial hypertension.
Read the full paper, Future treatment paradigms in pulmonary arterial hypertension: a personal view from physicians, health authorities, and patients, here: https://www.thelancet.com/journals/lanres/article/PIIS2213-2600(24)00425-9/fulltext
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Sergio Harari on the treatment of lymphangioleiomyomatosis (LAM)
Professor Sergio Harari joins us to discuss the results of a phase 2 clinical trial evaluating activity and safety of nintedanib in people with lymphangioleiomyomatosis (LAM).
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Sergio Harari sul trattamento della linfangioleiomiomatosi (LAM) (in Italian)
Il Professor Sergio Harari commenta i risultati di un trial clinico di fase 2 volto a valutare l’attivita’ e la sicurezza del farmaco nintedanib come trattamento in pazienti affetti da linfangioleiomiomatosi (LAM).
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Robert Kullberg on empirical antibiotics for Sepsis
Dr Robert Kullberg joins us to discuss his Viewpoint on empiric antibiotic therapy for sepsis and the importance of reducing unnecessary use of anti-anaerobic antibiotics.
Read the full article:
https://www.thelancet.com/journals/lanres/article/PIIS2213-2600(24)00257-1/fulltext?dgcid=buzzsprout_icw_podcast_generic_lanres
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Heather Zar on early-life RSV disease and long-term respiratory health
Professor Heather Zar joins The Lancet Respiratory Medicine to discuss early-life RSV disease and long-term respiratory health. This topic will be covered in one of four Series papers in a cross-journal Series with The Lancet.
You can read the Series of papers at:
https://www.thelancet.com/series/respiratory-syncytial-virus?dgcid=buzzsprout_icw_podcast_generic
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Margaux Mesle on lives saved by COVID-19 vaccination
Dr Margaux Mesle discusses estimates of lives directly saved by COVID-19 vaccination programs in the WHO European Region in the period from 2020 to 2023 and public health implications.
Read the full article:
https://www.thelancet.com/journals/lanres/article/PIIS2213-2600(24)00179-6?dgcid=buzzsprout_icw_podcast_generic_lanres
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James Hull on protecting the respiratory health of athletes
Professor James Hull joins us to discuss his recent Spotlight on protecting the respiratory health of athletes ahead of the Summer Olympics and Paralympics.
Read the full article:
https://www.thelancet.com/journals/lanres/article/PIIS2213-2600(24)00183-8?dgcid=buzzsprout_icw_podcast_generic_lanres
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Eric Lim on treatments for pleural mesothelioma
Professor Eric Lim discusses the outcomes after extended pleurectomy decortication plus chemotherapy versus chemotherapy alone for pleural mesothelioma.
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Anne Chang on the burden of chronic respiratory diseases in Indigenous people
Dr Anne Chang discusses the burden of chronic respiratory diseases in Indigenous people.
Read the full article:
https://www.thelancet.com/journals/lanres/article/PIIS2213-2600(24)00008-0/fulltext?dgcid=buzzsprout_icw_podcast_generic_lanres
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Daniel Steinfort and Shankar Siva on radiotherapy field planning in patients with NSCLC
Professor Daniel Steinfort and Professor Shankar Siva discuss the effect of systematic endoscopic mediastinal staging on radiotherapy field planning in patients with locally advanced non-small-cell lung cancer.
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Daniel Prieto-Alhambra, Annika Jödicke, and Martí Català on vaccination to prevent Long COVID
Prof Daniel Prieto-Alhambra, Dr Annika Jödicke, and Dr Martí Català discuss the effectiveness of COVID-19 vaccines to prevent Long COVID, estimated to affect up to 20% of those infected with SARS-CoV-2.
Read the full article:
https://www.thelancet.com/journals/lanres/article/PIIS2213-2600(23)00414-9/fulltext?dgcid=buzzsprout_icw_podcast_generic_lanres
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Sarah Gorst and Tim Nicholson on long COVID outcomes
Dr Tim Nicholson and Dr Sarah Gorst discuss the development of an international Delphi consensus study on a core outcome measurement set for long COVID and how it will be used to inform future research and clinical care.
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Betty Raman on multiorgan MRI abnormalities after hospitalisation with COVID-19
Dr Betty Raman discusses multiorgan MRI findings in patients after hospitalisation with COVID-19.
Read the full article:
https://www.thelancet.com/journals/lanres/article/PIIS2213-2600(23)00262-X/fulltext?dgcid=buzzsprout_icw_podcast_generic_lanres
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Keith Chappell on a bivalent recombinant vaccine for COVID-19
Dr Keith Chappell discusses the bivalent recombinant vaccine for COVID-19 following the study by Dayan and colleagues, with focus on vaccine access, variants and boosters, tolerability and side effects, as well as hopes for future trials.
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James Chalmers on bronchiectasis across Europe
Prof. James Chalmers discusses the characteristics of patients with bronchiectasis across Europe, the differences between countries, and possible differences in clinical outcomes, based on data from the EMBARC registry.
Read the full article:
https://www.thelancet.com/journals/lanres/article/PIIS2213-2600(23)00093-0/fulltext?dgcid=buzzsprout_tlv_episode-notes_general_general
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Richard Costello on management of uncontrolled asthma
Prof Richard Costello discusses the use of digital measurements of medication adherence and lung function to guide management of uncontrolled asthma.
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Keiju Aokage on segmentectomy for ground-glass-dominant lung cancer
Dr Keiju Aokage discusses segmentectomy for ground-glass-dominant lung cancer with a tumour diameter of 3 cm or less.
Read the full article:
Segmentectomy for ground-glass-dominant lung cancer with a tumour diameter of 3 cm or less including ground-glass opacity (JCOG1211): a multicentre, single-arm, confirmatory, phase 3 trial
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Carol Hodgson on post-discharge outcomes for ECMO patients
Carol Hodgson discusses recent advances in our understanding of in-hospital and post-discharge outcomes in critically ill patients who receive ECMO.
Read the full article:
Comparative outcomes of extracorporeal membrane oxygenation for COVID-19 delivered in experienced European centres during successive SARS-CoV-2 variant outbreaks (ECMO-SURGES)
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Emma Grainger on 10 years of The Lancet Respiratory Medicine
Emma Grainger, Editor-in-Chief of The Lancet Respiratory Medicine, discusses the January issue and plans to celebrate the 10-year anniversary of the journal.
Read the Editorial from the 10th anniversary issue:
Past learnings and new beginnings in the digital age
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Vivienne Kahlmann and Catharina Moor on the TIRED study
Vivienne Kahlmann and Catharina Moor discuss a study looking at online mindfulness-based cognitive behaviour treatment to address fatigue associated with sarcoidosis.
Read the full article:
Online mindfulness-based cognitive therapy for fatigue in patients with sarcoidosis (TIRED)
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Yves Lacasse on long-term oxygen therapy for COPD
Yves Lacasse joins The Lancet Respiratory Medicine to discuss a meta-analysis on the effectiveness of home oxygen use for patients with COPD.
Read the full article:
Home oxygen for moderate hypoxaemia in chronic obstructive pulmonary disease: a systematic review and meta-analysis
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Rachael Evans on living with long COVID
Rachael Evans discusses the needs of people with long COVID and the latest findings from the PHOSP-COVID study.
Read the full article:
Physical, cognitive, and mental health impacts of COVID-19 after hospitalisation (PHOSP-COVID)
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Daniel Munblit and Dale Needham on core outcomes post-COVID-19
Daniel Munblit and Dale Needham discuss the importance of developing a core outcome set for post-COVID-19 condition.
Read the full Position Paper:
A core outcome set for post-COVID-19 condition in adults for use in clinical practice and research: an international Delphi consensus study
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Daiana Stolz on antibiotic stewardship in pneumonia
Daiana Stolz discusses antibiotic stewardship in patients hospitalised with pneumonia and at risk of Gram-negative bacterial infection.
Read the full article:
Fast multiplex bacterial PCR of bronchoalveolar lavage for antibiotic stewardship in hospitalised patients with pneumonia at risk of Gram-negative bacterial infection (Flagship II)
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Ablo Wachinou on sleep disordered breathing in Benin
Dr Ablo Wachinou discusses the prevalence of sleep disordered breathing in Benin and how awareness and treatment might be improved.
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Peter Openshaw and Felicity Liew on corticosteroids in the early in the treatment of COVID
Professor Peter Openshaw and Dr Felicity Liew discuss the use of inhaled corticosteroids in the early treatment of COVID and the involvement of the respiratory mucosa in response to viral infection.
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Dinh Bui on preterm birth and lung function deficits
Dr Dinh Bui discusses the association between very-to-moderate preterm birth and lung function deficits and COPD at age 53.
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Ruvim Izĭckson on a joint flu and COVID-19 vaccine
Ruvim Izĭckson discusses the safety and immunogenicity of administering a high-dose quadrivalent influenza vaccine together with a third dose of the Moderna COVID-19 vaccine in adults aged 65 years and older.
Read the full article:
Safety and immunogenicity of a high-dose quadrivalent influenza vaccine administered concomitantly with a third dose of the mRNA-1273 SARS-CoV-2 vaccine in adults aged ≥65 year
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Wisia Wedzicha on a vaccine for COPD
Wisia Wedzicha discusses findings of a trial of a vaccine for the prevention of COPD exacerbations and provides her insights for future research.
Read the full article:
Non-typeable Haemophilus influenzae–Moraxella catarrhalis vaccine for the prevention of exacerbations in chronic obstructive pulmonary disease
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Eileen Rubin on patient-centered ARDS
Eileen Rubin, author of a paper on advancing precision medicine for acute respiratory distress syndrome discusses her delayed diagnosis and how clinician and researcher goals can differ from those of patients.
Read the full article:
Advancing precision medicine for acute respiratory distress syndrome
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Daniel Altmann on COVID boosters
Daniel Atlmann discusses the duration of immune protection from COVID vaccination and the crucial implications for the implementation of booster vaccination programmes.
Read the full article:
Waning immunity to SARS-CoV-2: implications for vaccine booster strategies - The Lancet Respiratory Medicine
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Michael Kreuter on interstitial lung disease
Comment author Michael Kreuter discusses a series of papers published in The Lancet and The Lancet Respiratory Medicine on interstitial lung disease.
Read the full article:
https://www.thelancet.com/journals/lanres/article/PIIS2213-2600(21)00403-3/fulltext
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Bairbre McNicholas and Jie Li on awake prone positioning and COVID-19
Bairbre McNicholas and Jie Li discuss an open label superiority meta-trial looking at the efficacy of awake prone positioning for patients with COVID-19 acute hypoxaemic respiratory failure.
Read the full article:
https://www.thelancet.com/journals/lanres/article/PIIS2213-2600(21)00356-8/fulltext
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Charles Sprung and authors on end-of-life practices in ICUs globally
Charles Sprung and fellow co authors Christiane Hartog, Joseph Nates, and Gavin Joynt discuss the Ethicus-II study, which looked at differences in end-of-life care in nearly 200 ICUs across 36 countries.
Read the full article:
https://www.thelancet.com/journals/lanres/article/PIIS2213-2600(21)00261-7/fulltext
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