Base by Base - Music

This release contains only the music track from Base by Base Episode 390.

Song title: Mutual Destruction
Original Base by Base episode: 390: Daunorubicin, Mutual Destruction, and Layered Antiphage Defense

Article metadata:
Article title: DNA-intercalating antiphage molecules trigger abortive infection through mutual destruction and synergize with bacterial immunity
Journal: PNAS
DOI: https://doi.org/10.1073/pnas.2602073123
Reference: Gätgens C., Rackow B., Ernst L., et al. DNA-intercalating antiphage molecules trigger abortive infection through mutual destruction and synergize with bacterial immunity. PNAS. 2026;123(23):e2602073123. https://doi.org/10.1073/pnas.2602073123

Lyrics:
Verse 1
Bright s...

This release contains only the music track from Base by Base Episode 389.

Song title: Crotonylation, Hold the Line
Original Base by Base episode: 389: Crotonylation impedes c-Myc oncogenic activity

Article metadata:
Article title: Crotonylation impedes c-Myc oncogenic activity
Journal: PNAS
DOI: 10.1073/pnas.2530020123
Reference: https://doi.org/10.1073/pnas.2530020123

Lyrics:
Verse 1
Under white lights, the signals start to spark,
A switch on a protein in the dark.
A tiny mark where the messages align,
And suddenly the noise learns how to decline.

Pre-Chorus
...

This release contains only the music track from Base by Base Episode 388.

Song title: Borrowed Time, Brand-New Liver
Original Base by Base episode: 388: Base by Base | Episode 388 — In situ CAR‑macrophage alleviates liver fibrosis

Article metadata:
Article title: mRNA‑laden LNP‑enabled in situ CAR‑macrophage alleviates liver fibrosis via inhibiting activated HSCs and modulating the immune microenvironment
Journal: Proceedings of the National Academy of Sciences (PNAS)
DOI: 10.1073/pnas.2534673123
Reference: Huang X, Wang J, Hao J, et al. mRNA‑laden LNP‑enabled in situ CAR‑macrophage alleviates liver fibrosis via inhibiting activ...

This release contains only the music track from Base by Base Episode 387.

Song title: When the Shield Gets Thin
Original Base by Base episode: 387: Homotypic Dengue Reinfections and Long-Term Antibody Decay

Article metadata:
Article title: Long-term antibody dynamics challenge the paradigm of lifelong homotypic immunity to dengue virus
Journal: PNAS
DOI: 10.1073/pnas.2606206123
Reference: Andrade J, Mitard de Girardie A, Huang AT, et al. Long-term antibody dynamics challenge the paradigm of lifelong homotypic immunity to dengue virus. PNAS. 2026;123(22):e2606206123. doi:10.1073/pnas.2606206123

Lyrics:
Verse 1
We thought the lightning...

This release contains only the music track from Base by Base Episode 386.

Song title: Double the Light
Original Base by Base episode: 386: Genome Doubling and the Bioeconomy

Article metadata:
Article title: Polyploidy: A macromutational force pushing bioeconomic developments
Journal: Proceedings of the National Academy of Sciences (PNAS)
DOI: 10.1073/pnas.2522065123
Reference: Peeters MKR & Van de Peer Y (2026). Polyploidy: A macromutational force pushing bioeconomic developments. Proc. Natl. Acad. Sci. U.S.A. 123:e2522065123. https://doi.org/10.1073/pnas.2522065123

Lyrics:
Verse 1
In the lab glow, we tilt the dice of...

This release contains only the music track from Base by Base Episode 385.

Song title: Double the Light, Double the Shadow
Original Base by Base episode: 385: Growth under Pressure: Polyploidy Induced by Stress

Article metadata:
Article title: Growth under pressure: The pros and cons of polyploidy induced by stress
Journal: PNAS
DOI: 10.1073/pnas.2522063123
Reference: Sarabia Olivera L, Belato PB, Silva J, Selmecki A, Fox DT, Roeder AHK. Growth under pressure: The pros and cons of polyploidy induced by stress. PNAS. 2026;123(22):e2522063123. doi:10.1073/pnas.2522063123

Lyrics:
Verse 1
Under the...

This release contains only the music track from Base by Base Episode 384.

Song title: CisR on the Switch
Original Base by Base episode: 384: RNA Brake on Cholera Phage: CisR Controls CTXϕ

Article metadata:
Article title: A 3’UTR-derived small RNA modulates the life cycle of the cholera toxin–encoding filamentous phage, CTXϕ
Journal: PNAS
DOI: 10.1073/pnas.2535142123
Reference: Haycocks JRJ, O’Driscoll E, Sprenger M, Thriene K, Jung E-M, Siemers M, Lippegaus A, Krautwurst S, Grainger DC, Papenfort K. A 3’UTR-derived small RNA modulates the life cycle of the cholera toxin–encoding filamentous...

This release contains only the music track from Base by Base Episode 383.

Song title: Trans Signals in the Bloodlight
Original Base by Base episode: 383: Genetics of the Circulating Proteome: pQTLs, Pathways, and Disease Links

Article metadata:
Article title: Multi-cohort proteogenomic analyses reveal genetic effects across the proteome and diseasome
Journal: Cell
DOI: 10.1016/j.cell.2026.03.049
Reference: Koprulu M., Smith-Byrne K., Ferolito B.R., et al., 2026. Multi-cohort proteogenomic analyses reveal genetic effects across the proteome and diseasome. Cell 189, 3339–3357. https://doi.org/10.1016/j.cell.2026.03.049

Lyrics:
Verse 1
Late-night screens and a...

This release contains only the music track from Base by Base Episode 382.

Song title: Old Codes, New Blood
Original Base by Base episode: 382: How animal blood cells evolved from unicellular ancestors

Article metadata:
Article title: Animals have expanded the evolutionary legacy of unicellular ancestors in blood cells
Journal: PNAS
DOI: 10.1073/pnas.2528110123
Reference: Nagahata Y, Ishidae T, Satou Y, Nishimura Y, Kaitani R, Leong JCK, Oda-Ishiie I, Carmona-Rivas M, Najle SR, Ruiz-Trillo I, Kohtsuka H, Abeg S, Ikuta K, Miura T, Kawamoto H, Casacuberta E, Ogasawara M, Irieda N. Animals have...

This release contains only the music track from Base by Base Episode 381.

Song title: Light Writes the Map
Original Base by Base episode: 381: Light-written spatial barcodes enable tunable multiomic sequencing (BALI)

Article metadata:
Article title: Spatially tuneable multiomic sequencing using light-driven combinatorial barcoding of molecules in tissues
Journal: PNAS
DOI: 10.1073/pnas.2527896123
Reference: Battistoni G, Torres-Garcia S, Sia CY, Corriero S, Boquetale C, Williams E, et al. Spatially tuneable multi-omics sequencing using light-driven combinatorial barcoding of molecules in tissues. Proc Natl Acad Sci U S A. 2026;123(21):e2527896123. doi:10.1073/pnas.2527896123

...

This release contains only the music track from Base by Base Episode 380.

Song title: Barcode the Breakthrough
Original Base by Base episode: 380: Prime-SGE maps drug-resistance variants at scale

Article metadata:
Article title: A multiplex, prime editing framework for identifying drug resistance variants at scale
Journal: Cell Genomics
DOI: 10.1016/j.xgen.2026.101167
Reference: Abadie FMC, Suiter CC, Smith NT, et al. A multiplex, prime editing framework for identifying drug resistance variants at scale. Cell Genomics. 2026;6:101167. doi:10.1016/j.xgen.2026.101167

Lyrics:
Verse 1
Long nights under white-blue screens
We redraw...

This release contains only the music track from Base by Base Episode 379.

Song title: Long Reads, Clearer Roads
Original Base by Base episode: 379: Long reads reveal hidden structural and repeat variation in autism

Article metadata:
Article title: Long-read genome sequencing improves detection and functional interpretation of structural and repeat variants in autism
Journal: Cell Genomics
DOI: https://doi.org/10.1016/j.xgen.2026.101186
Reference: Mortazavi M., Guevara J., Diaz J., et al., 2026. Long-read genome sequencing improves detection and functional interpretation of structural and repeat variants in autism. Cell Genomics 6, 101186. https://doi.org/10.1016...

This release contains only the music track from Base by Base Episode 378.

Song title: Assembly Line of Light
Original Base by Base episode: 378: Dominant-negative PSMB8 variants stall immunoproteasome assembly

Article metadata:
Article title: Monoallelic PSMB8 variants cause PRAAS with immunodeficiency through impaired immunoproteasome assembly
Journal: The American Journal of Human Genetics
DOI: 10.1016/j.ajhg.2026.04.015
Reference: Wijngaard R., van der Made C.I., Kalkan Uçar S., et al. Monoallelic PSMB8 variants cause PRAAS with immunodeficiency through impaired immunoproteasome assembly. Am J Hum Genet. 2026;113:1–19. doi:10.1016/j.ajhg.2026.04.015

Lyrics:
Ver...

This release contains only the music track from Base by Base Episode 377.

Song title: Attention Turns to Steel
Original Base by Base episode: 377: ProteomeLM — proteome-scale language modeling for interactomes and essential genes

Article metadata:
Article title: ProteomeLM: A proteome-scale language model enables accurate and rapid prediction of protein–protein interactions and gene essentiality across taxa
Journal: Proceedings of the National Academy of Sciences (PNAS)
DOI: 10.1073/pnas.2524201123
Reference: Malbranke C, Zalaffi GP, Bitbol A-F. ProteomeLM: A proteome-scale language model enabling accurate and rapid prediction of protein–protein interactions and gene essentiality across...

This release contains only the music track from Base by Base Episode 376.

Song title: Slide Back, Strike Again
Original Base by Base episode: 376: Pfh1's Balancing Act: Unwinding, Rewinding, and the Role of Mitochondrial SSB

Article metadata:
Article title: Regulation of Pfh1 helicase activity by nucleic acid interactions and mitochondrial SSB
Journal: Proceedings of the National Academy of Sciences (PNAS)
DOI: 10.1073/pnas.2602528123
Reference: Ortiz-Rodríguez M, Singh SP, Cao-García FJ, Galletto R, Ibarra B. Regulation of Pfh1 helicase activity by nucleic acid interactions and mitochondrial SSB. PNAS. 2026;123(21):e2602528123. doi:10.1073/pn...

This release contains only the music track from Base by Base Episode 375.

Song title: Wired for the Light
Original Base by Base episode: 375: Biallelic DSCAM LoF: a syndromic NDD with nystagmus and cone-pathway retinal dysfunction

Article metadata:
Article title: Biallelic loss-of-function variants in DSCAM cause a neurodevelopmental syndrome with nystagmus and retinal dysfunction
Journal: Human Genetics and Genomics Advances
DOI: https://doi.org/10.1016/j.xhgg.2026.100622
Reference: Douzgou Houge S., Bredrup C., Wivestad Jansson R., Bojovic O., Aljamal B.M., Al-Otaibi M., Plomp A.S., Motazacker M.M., van Genderen M...

This release contains only the music track from Base by Base Episode 374.

Song title: DNA Keys, RNA Doors
Original Base by Base episode: 374: DNA-guided Cas12a reprogrammed to target RNA

Article metadata:
Article title: DNA-guided CRISPR–Cas12a effectors for programmable RNA recognition and cleavage
Journal: Nature Biotechnology
DOI: 10.1038/s41587-026-03120-5
Reference: Wu X., Lam W.H., Zhao Z., Feng X., Zhai Y., Hsing I.-M. DNA-guided CRISPR–Cas12a effectors for programmable RNA recognition and cleavage. Nature Biotechnology (2026). doi:10.1038/s41587-026-03120-5

Lyrics:
Vers...

This release contains only the music track from Base by Base Episode 373.

Song title: Stop Signs Turn to Lyrics
Original Base by Base episode: 373: Base by Base 373 — A ciliate rewrites UAA and UAG

Article metadata:
Article title: Identification of a non-canonical ciliate nuclear genetic code where UAA and UAG code for different amino acids
Journal: PLOS Genetics
DOI: https://doi.org/10.1371/journal.pgen.1010913
Reference: McGowan J, Kilias ES, Alacid E, Lipscombe J, Jenkins BH, Gharbi K, et al. (2023) Identification of a non-canonical ciliate nuclear genetic code where UAA and UAG co...

This release contains only the music track from Base by Base Episode 372.

Song title: Threads That Pull Us Forward
Original Base by Base episode: 372: Genes, IQ and Socioeconomic Outcomes in Emerging Adults

Article metadata:
Article title: Longitudinal associations between cognitive ability and socioeconomic status are partially genetic in nature
Journal: Scientific Reports
DOI: 10.1038/s41598-026-37786-3
Reference: Kajonius PJ. Longitudinal associations between cognitive ability and socioeconomic status are partially genetic in nature. Scientific Reports. 2026;16:4315. doi:10.1038/s41598-026-37786-3

Lyrics:
Verse 1
We start with the...

This release contains only the music track from Base by Base Episode 371.

Song title: Open the Switches in the Dark
Original Base by Base episode: 371: Glial epigenomic dysregulation and genetic risk in tauopathies

Article metadata:
Article title: Single-nucleus epigenomic dysregulation unmasks genetic risk-associated neurodegenerative glia states
Journal: Nature Communications
DOI: 10.1038/s41467-026-73007-1
Reference: Han, X., Rosenberg, G.M., Kisling, V.M. et al. Single-nucleus epigenomic dysregulation unmasks genetic risk-associated neurodegenerative glia states. Nat Commun (2026). https://doi.org/10.1038/s41467-026-73007-1

Lyrics:
Verse 1
In...

This release contains only the music track from Base by Base Episode 370.

Song title: Methyl to the Membrane
Original Base by Base episode: 370: ICMT and INPP5E enable BRAFV600E tumor growth

Article metadata:
Article title: ICMT supports BRAF
V600E
-driven tumor growth by membrane targeting of the CAAX protein INPP5E
Journal: Proceedings of the National Academy of Sciences
DOI: 10.1073/pnas.2601795123
Reference: Yang X, Qiao X, Schmidt S, et al. ICMT supports BRAFV600E-driven tumor growth by membrane targeting of the CAAX protein INPP5E. PNAS. 2026;123(20...

This release contains only the music track from Base by Base Episode 369.

Song title: Break the Efflux
Original Base by Base episode: 369: NEK2 drives EBV-positive NHL pathogenesis

Article metadata:
Article title: NEK2 drives pathogenesis, drug resistance, and LMP1 expression in EBV-positive non-Hodgkin lymphoma
Journal: PNAS
DOI: 10.1073/pnas.2535550123
Reference: White MC, Lange PT, Stewart J, Damania B. NEK2 drives pathogenesis, drug resistance, and LMP1 expression in EBV-positive non-Hodgkin lymphoma. Proc Natl Acad Sci U S A. 2026;123:e2535550123. doi:10.1073/pnas.2535550123

Lyrics:
Verse 1
Midnight in the lab, bright screen...

This release contains only the music track from Base by Base Episode 368.

Song title: Cut the Static, Save the Signal
Original Base by Base episode: 368: PARP1 and Amyloid: Protecting Neurons in a Familial AD Model

Article metadata:
Article title: PARP1 deficiency mitigates amyloid pathology, neurodegeneration, and cognitive decline in a familial Alzheimer’s disease model
Journal: PNAS
DOI: 10.1073/pnas.2525028123
Reference: Jhaldiyal A., Kumari M., Guttman L. C., et al. PARP1 deficiency mitigates amyloid pathology, neurodegeneration, and cognitive decline in a familial Alzheimer’s disease model. PNAS (2026). DOI: 10.1073/pnas.2525028123

Lyri...

This release contains only the music track from Base by Base Episode 367.

Song title: Old Notes, New Bites
Original Base by Base episode: 367: Ancestral Splice Variation Fuels Cichlid Jaw Diversification

Article metadata:
Article title: Ancestral splice variation is a key substrate for rapid diversification in African cichlids
Journal: PNAS
DOI: 10.1073/pnas.2516477123
Reference: Singh P., Ahi E.P., Duenser A., Durdevic M., Gessl W., Schaeffer S., Gall J., Seehausen O., Sturmbauer C. Ancestral splice variation is a key substrate for rapid diversification in African cichlids. PNAS. 2026;123(20):e2516477123. doi:10.1073/pnas.2516477123

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This release contains only the music track from Base by Base Episode 366.

Song title: Circle in the Static
Original Base by Base episode: 366: BRCA1P1 suppresses antiviral and antitumor immunity

Article metadata:
Article title: Regulation of antiviral and antitumor immunity by the BRCA1 pseudogene in human cancers
Journal: Proceedings of the National Academy of Sciences (PNAS)
DOI: 10.1073/pnas.2528911123
Reference: Han YJ, Zhang J, Shariff M, Wu S, Khramtsova G, Nguyen LC, Peiffer DS, Li N, Lewicka A, Moore M, Piccirilli JA, Olopade OI. Regulation of antiviral and antitumor immunity by...

This release contains only the music track from Base by Base Episode 366.

Song title: Circle in the Static
Original Base by Base episode: 366: BRCA1P1 suppresses antiviral and antitumor immunity

Article metadata:
Article title: Regulation of antiviral and antitumor immunity by the BRCA1 pseudogene in human cancers
Journal: Proceedings of the National Academy of Sciences (PNAS)
DOI: 10.1073/pnas.2528911123
Reference: Han YJ, Zhang J, Shariff M, Wu S, Khramtsova G, Nguyen LC, Peiffer DS, Li N, Lewicka A, Moore M, Piccirilli JA, Olopade OI. Regulation of antiviral and antitumor immunity by...

This release contains only the music track from Base by Base Episode 365.

Song title: Pocket Full of Proof
Original Base by Base episode: 365: MEN1 mutations and menin inhibitor resistance

Article metadata:
Article title: CRISPR base editor screening identifies spectrum of MEN1 mutations impacting menin inhibitors in clinical trials
Journal: Nature Communications
DOI: 10.1038/s41467-026-72685-1
Reference: Bourgeois, W., Rice, H.E., Wenge, D.V. et al. CRISPR base editor screening identifies spectrum of MEN1 mutations impacting menin inhibitors in clinical trials. Nat Commun (2026). https://doi.org/10.1038/s41467-026-72685...

This release contains only the music track from Base by Base Episode 365.

Song title: Pocket Full of Proof
Original Base by Base episode: 365: MEN1 mutations and menin inhibitor resistance

Article metadata:
Article title: CRISPR base editor screening identifies spectrum of MEN1 mutations impacting menin inhibitors in clinical trials
Journal: Nature Communications
DOI: 10.1038/s41467-026-72685-1
Reference: Bourgeois, W., Rice, H.E., Wenge, D.V. et al. CRISPR base editor screening identifies spectrum of MEN1 mutations impacting menin inhibitors in clinical trials. Nat Commun (2026). https://doi.org/10.1038/s41467-026-72685...

This release contains only the music track from Base by Base Episode 364.

Song title: C4 Under the Skin
Original Base by Base episode: 364: Peripheral C4 and Schizophrenia: A Neutrophil Gene–Protein Link

Article metadata:
Article title: Peripheral complement C4 protein in schizophrenia: Association with gene copy number and immune cell subtypes
Journal: PNAS
DOI: 10.1073/pnas.2536376123
Reference: Kalinowski A., Macaubas C., Guo H., et al. Peripheral complement C4 protein in schizophrenia: Association with gene copy number and immune cell subtypes. PNAS. 2026;123(20):e2536376123. doi:10.1073/pnas.2536376123

Lyrics:
Verse 1
White co...

This release contains only the music track from Base by Base Episode 363.

Song title: Entropy Between the Beats
Original Base by Base episode: 363: cfDNA size deconvolution reveals a 159‑bp nucleosomal pivot and tumor fragmentomic signatures

Article metadata:
Article title: Cell-free DNA size deconvolution resolves nucleosomal origins and reveals tumor-associated fragmentomic alterations
Journal: Nature Communications
DOI: 10.1038/s41467-026-72925-4
Reference: Zhou Z, Cooper WN, Cheng Z, et al. Cell-free DNA size deconvolution resolves nucleosomal origins and reveals tumor-associated fragmentomic alterations. Nat Commun (2026). https://doi.org/10.1038/s41467-026-72925-4

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This release contains only the music track from Base by Base Episode 362.

Song title: When the Bridge Breaks
Original Base by Base episode: 362: D614G Reshapes Spike Allostery and Speeds RBD Opening

Article metadata:
Article title: D614G reshapes allosteric networks and opening mechanisms of SARS - CoV - 2 spikes
Journal: PNAS
DOI: 10.1073/pnas.2504793123
Reference: Kearns FL, Bogetti AT, Calvó-Tusell C, et al. D614G reshapes allosteric networks and opening mechanisms of SARS-CoV-2 spikes. PNAS. 2026;123(19):e2504793123. doi:10.1073/pnas.2504793123

Lyrics:
Verse 1
Long nights, white light, and a...

This release contains only the music track from Base by Base Episode 361.

Song title: Mirror-Hands on the Backbone
Original Base by Base episode: 361: Chiral Inversion Mutagenesis Reveals Structured Hotspots in LCDs

Article metadata:
Article title: Chiral inversion mutagenesis identifies geometrically constrained residues within self - associating low - complexity domains
Journal: PNAS
DOI: 10.1073/pnas.2535888123
Reference: Beckner RL, Kim L, Carter C, Walterscheid A, Liszczak G. Chiral inversion mutagenesis identifies geometrically constrained residues within self-associating low-complexity domains. Proc Natl Acad Sci U S A. 2026;123(19):e2535888123. doi:10.1073/pnas.2535888123

Lyrics:
...

This release contains only the music track from Base by Base Episode 361.

Song title: Mirror-Hands on the Backbone
Original Base by Base episode: 361: Chiral Inversion Mutagenesis Reveals Structured Hotspots in LCDs

Article metadata:
Article title: Chiral inversion mutagenesis identifies geometrically constrained residues within self - associating low - complexity domains
Journal: PNAS
DOI: 10.1073/pnas.2535888123
Reference: Beckner RL, Kim L, Carter C, Walterscheid A, Liszczak G. Chiral inversion mutagenesis identifies geometrically constrained residues within self-associating low-complexity domains. Proc Natl Acad Sci U S A. 2026;123(19):e2535888123. doi:10.1073/pnas.2535888123

Lyrics:
...

This release contains only the music track from Base by Base Episode 360.

Song title: Entropy in the Quiet
Original Base by Base episode: 360: An inverse correlation between structural linguistic and human genetic diversity

Article metadata:
Article title: An inverse correlation between structural linguistic and human genetic diversity
Journal: PNAS
DOI: 10.1073/pnas.2526762123
Reference: Graff A., Ringen E.J., Zakharko T., Stoneking M., Shimizu K.K., Bickel B., Barbieri C. An inverse correlation between structural linguistic and human genetic diversity. Proc. Natl. Acad. Sci. U.S.A. 2026;123(18):e2526762123. doi:10.1073/pnas.2526762123

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This release contains only the music track from Base by Base Episode 359.

Song title: MB11 at the Door
Original Base by Base episode: 359: Ultrapotent PDCoV Miniprotein MB11

Article metadata:
Article title: Computational design of an ultrapotent deltacoronavirus miniprotein inhibitor
Journal: PNAS
DOI: 10.1073/pnas.2533456123
Reference: Avery NG, Yoshiyama CN, Taylor AL, Park Y-J, Asarnow D, Perruzza L, Brown JT, Corti D, Benigni F, Starr TN, Veesler D. Computational design of an ultrapotent deltacoronavirus miniprotein inhibitor. PNAS. 2026;123:e2533456123. doi:10.1073/pnas.2533456123

Lyrics:
Verse 1
In the quiet lab where the...

This release contains only the music track from Base by Base Episode 358.

Song title: Import the Light Back In
Original Base by Base episode: 358: CHCHD4 and a Pediatric OXPHOS Collapse

Article metadata:
Article title: Biallelic variants in CHCHD4 are associated with combined OXPHOS defect leading to mitochondrial disease
Journal: Human Genetics and Genomics Advances
DOI: 10.1016/j.xhgg.2026.100615
Reference: Mantecon M, Chhuon C, Roger K, et al. Biallelic variants in CHCHD4 are associated with combined OXPHOS defect leading to mitochondrial disease. Human Genetics and Genomics Advances. 2026;7:100615. doi:10.1016/j.xhgg.2026.100615

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This release contains only the music track from Base by Base Episode 356.

Song title: Phased in the Dark
Original Base by Base episode: 356: Recessive Coding Associations Across Six Biobanks

Article metadata:
Article title: Meta-analysis across six global biobanks identifies recessive coding associations with complex traits and diseases
Journal: The American Journal of Human Genetics
DOI: 10.1016/j.ajhg.2026.04.005
Reference: Lassen F.H. et al., 2026. Meta-analysis across six global biobanks identifies recessive coding associations with complex traits and diseases. The American Journal of Human Genetics 113, 1–17. https://doi.org/10.1016/j.ajhg.2026.04.005

Ly...

This release contains only the music track from Base by Base Episode 355.

Song title: Quiet in the Sirens
Original Base by Base episode: 355: Influenza D replicates in the human airway — zoonotic risk

Article metadata:
Article title: Efficient replication of influenza D virus in the human airway underscores zoonotic potential
Journal: PNAS
DOI: 10.1073/pnas.2530325123
Reference: Sanders CG et al., Efficient replication of influenza D virus in the human airway underscores zoonotic potential. PNAS (2026) Vol. 123 No. 17 e2530325123. doi:10.1073/pnas.2530325123

Lyrics:
Verse 1
Out where the rails and fences end,

This release contains only the music track from Base by Base Episode 354.

Song title: Two Marks, One Map
Original Base by Base episode: 354: How Cohesin Acetylation and ATPase Shape Chromatin Loops and Cohesion

Article metadata:
Article title: Cohesin acetylation and ATPase activity control cohesion and loop architecture through distinct mechanisms
Journal: PNAS
DOI: 10.1073/pnas.2531218123
Reference: Costantino L, Ye T, Boardman K, Xiang S, Luo J, Mu Y, Ma W, Koshland D. Cohesin acetylation and ATPase activity control cohesion and loop architecture through distinct mechanisms. PNAS. 2026;123(17):e2531218123. doi:10.1073/pnas.2531218123.

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This release contains only the music track from Base by Base Episode 353.

Song title: After the Crossover
Original Base by Base episode: 353: Masculinization Reverses Sex Differences in Fertility

Article metadata:
Article title: Masculinization of populations reverses sex differences in fertility
Journal: PNAS
DOI: 10.1073/pnas.2533317123
Reference: Schubert HA, Spoorenberg T, Dudel C, Skirbekk VF. Masculinization of populations reverses sex differences in fertility. Proc Natl Acad Sci U S A. 2026;123:e2533317123. doi:10.1073/pnas.2533317123

Lyrics:
Verse 1
On bright screens, the numbers lean like weather
A quiet shift you...