Defiant Health Radio with Dr. William Davis

40 Episodes
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By: William Davis, MD

William Davis, MD, cardiologist and author of the #1 New York Times bestselling Wheat Belly books, as well as Undoctored and, most recently, Super Gut, brings the unvarnished truth about many health conditions. So much information in health is crafted by industry, bent to the benefit of healthcare systems, delivered by willfully ignorant physicians. Yet a critical mass of truly useful, safe, effective health information has been reached--but someone has to deliver it to you. That is Dr. Davis' intention. Among the topics the Defiant Health Podcast covers are:--Microbiome health--The key to so many health conditions, as well as preservation...

What's better than probiotics?
Yesterday at 11:00 PM

Many people take probiotics in the hopes that it will help reduce gastrointestinal struggles with excessive gas, bloating, diarrhea, constipation and other common complaints. Sometimes they help, sometimes they don’t. But why? Just what are probiotics and how are they created? 

In this episode of the Defiant Health podcast, let’s discuss the ups and downs of commercial probiotics, why they are really little more than haphazard collections of microbes assembled without rhyme or reason. Then let’s discuss how you can do better than taking some random commercial probiotic off the shelf. 


Sup...


My Conversation with JJ Flizanes: Conquering Your Life Obstacles
11/10/2025

JJ Flizanes has worn a number of hats over the years as actress, physical trainer, and most recently what she calls an “empowerment strategies.” Her most recent focus is to therefore counsel people to identify obstacles to success. Having worked with thousands of clients and a source of prolific advice and learning resources, JJ works to pinpoint why people fail to achieve their goals in health, weight loss, love, careers and other spheres of life. 

JJ is host of an impressive five podcasts including People’s Choice Awards nominee Spirit, Purpose & Energy, Fit 2 Love, and Nutrition and Alterna...


Pushback against GLP-1 agonists
11/05/2025

Millions of people have been persuaded that the GLP-1 agonist drugs are the answer to their weight loss prayers. While they do work well in the near-term for weight loss, the long-term health price you pay is substantial with a future of increased risk for frailty, loss of independence, and premature death. 

A better way is to manage the amount and location of muscle and fat, i.e., shape and body composition. And you can do so easily, naturally, and inexpensively. 

Support the show

YouTube channel: https://www.youtube.com/@WilliamDavisMD

Bl...


Why Weight Loss Can Be Harmful to Your Health
10/22/2025

Yes, you can lose weight by reducing calories whether through a calorie-cutting diet, bariatric procedure, or pharmaceutical. But the effect is almost always temporary and followed by a return of weight followed by significant downturn in health. You were also likely not advised that losing weight by cutting calories, we now know through tracking of large numbers of people over many years, likely abbreviates your life by several years. 

In this and future podcasts, I will be introducing concepts that block these effects, concepts that I shall be exploring in even greater depth in my new book, S...


Oxalate Hysteria
10/15/2025

There are a number of people advocating a diet low in oxalates, essentially eliminating many green leafy vegetables, Brussels sprouts, asparagus, celery, most nuts, berries, cocoa, and numerous otherwise healthy foods. Unfortunately, this advice is misguided and based on an incomplete understanding of the evidence. While there is no harm in reducing dietary oxalates beyond inconvenience, lack of variety, and the absence of many genuinely healthy foods, reducing oxalate exposure is not the primary problem, just a Band-Aid. 

Oxalate hyperabsorption is due to disruption of the gastrointestinal microbiome: loss of the many species that metabolize oxalates but w...


What happens when you deprive yourself of blue light?
09/24/2025

Science journalist Lynne Peeples did something extraordinary: She spent 10 days in a nuclear bunker exposed only to dim red light but no blue or other visible wavelength of light. She also rid the space of all clocks or other time-indicating devices and even avoided having any human contact. What she learned opened up numerous questions on how to best manage our day-to-day light exposure, wavelengths, and the implications they have on the quality of sleep, our moods, even various aspects of health and performance. After these sorts of unique experiences, along with discussions on circadian rhythms with numerous scientists...


Why are you no longer hungry?
09/17/2025

People who were previously ravenously hungry, struggling to be satisfied and tending to overeat, can find themselves miraculously back in control of appetite just by adopting a number of basic dietary strategies that begin with elimination of gliadin-derived opioid peptides that come from the partial digestion of wheat and grains. 

Add a handful of other strategies and you will be freed from abnormal and perverse appetite stimulation that comes from consumption of several foods, nonsensical dietary advice, and a disrupted gastrointestinal microbiome. 

Support the show

YouTube channel: https://www.youtube.com/@WilliamDavisMD

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There's a 50:50 chance that you have this epidemic condition
09/09/2025

There is a non-infectious epidemic occurring right beneath our noses. The likelihood that you are affected is around 50%. It's the epidemic of small intestinal bacterial overgrowth, or SIBO. In this episode of Defiant Health, I run through the rationale that reveals that, even conservatively estimated, more than 100 million Americans have this condition.

Because of the natural permeability of the small intestine designed for nutrient absorption, invading fecal microbes that have ascended from the colon yield a phenomenon called "endotoxemia," or the entry of bacterial breakdown products into the bloodstream. This is how a disrupted small intestinal microbiome...


Here's a microbe you should know about: Bacillus subtilis
09/03/2025

My original recipe for SIBO Yogurt included three microbes chosen for their ability to colonize or germinate in the small intestine and produce bacteriocins, natural peptide antibiotics effective in killing the species of SIBO. The original formulation therefore specified L. reuteri, L. gasseri, and B. coagulans. 

However, B. coagulans proved to be unreliable in generating the high microbial counts we desire to overcome the trillions of invading fecal microbial species of SIBO. I therefore replaced it with B. subtilis, a virtual powerhouse of a bacteriocin producer, producing up to 7 bacteriocins, thereby giving you greater power in pushing b...


Yogurt That's Not Yogurt: My Accidental Sleep Cure
08/29/2025

I’ve personally struggled with insomnia for years, unable to sleep more than a few hours at a time, experiencing frequent awakenings, sometimes awakening at 3 or 4 in the morning and unable to get back to sleep. And I tried almost everything short of prescription sedatives: tryptophan, 5-HTP, megadose melatonin, GABA, theanine, the antihistamine diphenhydramine, self-hypnosis, YouTube videos that claim to help you sleep within minutes. The few that worked left me feeling drugged the next day and, if they did not work, I was often left irritable and fatigued. 

All this changed when I began experimenting with mic...


Misplaced blame
08/28/2025

You’re walking down the street, minding your own business, just out to run some errands. You’re wearing a black jacket, running shoes, a baseball cap. You pass the doors of a bank. Suddenly, the bank’s doors fly open and a man runs out, a man wearing a black jacket and a baseball cap. You see him running at top speed, disappearing around a corner. Moments later, two policemen burst through the bank’s doors, spot you, roughly spin you around, handcuff and arrest you. 

It’s a clear case of mistaken identify, of blaming you for som...


Microbiome Madness
08/17/2025

It’s truly an exciting time. The information and science surrounding the microbiome is exploding. It seems that a day doesn’t pass without some new, interesting insight emerges on microbiome questions,  providing us with unprecedented insights and strategies to get better control over health, weight management, aging, etc. Look at what we are accomplishing, for example, with our cultivation of L. reuteri and L. crispatus. 

But it also means that misinformation, misinterpretation, and sometimes misrepresentation are becoming more common, leading you to make mistakes that could yield ineffective or even harmful results. 

In this episode...


What was this Wheat Belly thing all about?
08/05/2025

When the first Wheat Belly book was released in 2011, it quickly leapt to centerstage, gaining a huge worldwide following. Millions of copies of the book were sold in 37 countries, the conversation was featured in major media from network news to Dr. Oz to . I don’t believe that this was due to my personal charm or charisma, but because it worked: people experienced unexpected and substantial health and weight loss benefits even if such things had eluded them for years. 

Well, over those 15 years, memories have faded and, sadly, some people have gradually gravitated back to consuming thi...


10 things you may not know about your CT heart scan and coronary calcium score
07/25/2025

While CT heart scans are becoming increasingly popular to generate a coronary calcium score as a gauge of coronary atherosclerotic plaque and thereby risk for heart attack, there is actually a treasure trove of other useful information provided by the scan—but often not reported to you. 

In this episode of the Defiant Health podcast, I therefore help make you aware of the wealth of information provided by a CT heart scan that can empower you further in maintaining health and preventing heart disease. 


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How to use inulin to map the location of microbes in your GI tract
07/07/2025

Inulin is a common fiber, the fiber found in root vegetables like onions, garlic, shallots, asparagus, jicama and many other foods. Humans lack the digestive enzymes, however, for metabolizing inulin, but microbes living in your gastrointestinal track are able to metabolize it. When beneficial microbes metabolize inulin, they convert it to fatty acids with numerous beneficial effects on gastrointestinal, brain, and metabolic health. But, when undesirable microbes metabolize inulin, bad things can happen and cause you to experience symptoms such as excessive bloating, abdominal discomfort, diarrhea, mental effects such as anxiety, depression, suicidal thoughts, worsening joint pain or skin...


The Guardrails of Diet
06/24/2025

Here are what I call "The Guardrails of Diet,' i.e.., metabolic markers that tell you whether your diet is genuinely healthy or not. Too many people put too much stock in either a single marker like blood glucose, or the wrong marker like LDL cholesterol that takes you down the path of health disruptions: weight gain, visceral fat expansion, protein glycation, insulin resistance, formation of VLDL particles, cause you to rely on unhealthy foods, even increased risk for heart disease and other conditions. 

In this episode of the Defiant Health podcast, Let’s therefore discuss how...


Managing high blood pressure without drugs
06/20/2025

Conventional healthcare and dietary advice are, unfortunately, virtually useless in providing effective strategies on how to manage blood pressure naturally and nutritionally. They have, for instance, the DASH diet that can reduce systolic and diastolic blood pressure by a few millimeters but not more. They provide bland advice like lose weight or move more. Yet there are effective strategies that you can adopt that powerfully reduce and typically normalize blood pressure. Such strategies may sound unconventional but are really efforts to restore your physiology to mimic that of populations who enjoy lifelong normal blood pressure. 

In this e...


Ten Unexpected Signs of SIBO
06/16/2025

Small intestinal bacterial overgrowth, or SIBO, is now rampant, a virtual nationwide epidemic, a condition now carried by around 50% of the population. If you have food intolerances, fibromyalgia, restless leg syndrome, are overweight or obese, have irritable bowel syndrome, an autoimmune condition, atrial fibrillation or numerous other common conditions, it is highly likely that SIBO is either the original cause or at least an exacerbating factor. You can take all the antiinflammatory drugs, biologics, weight loss drugs or numerous other pharmaceutical “fixes” but, unless the SIBO is dealt with, you will lose this battle and more health problems are in y...


The Lies Being Spread About Sourdough Bread
05/30/2025

Bakers, breadlovers, even purported health information authorities such as the Mayo Clinic all spread the claim that all the problems associated with consumption of foods made of wheat are eliminated or significantly reduced by sourdough fermentation. Is this true?

In this episode of the Defiant Health podcast, Let’s take each of those claims made, one by one, and examine the evidence to see if there is any truth behind them. 

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A 15% discount is available for Defiant Health podcast listeners by entering dis...


Hyaluronic acid: Most important DIETARY fiber of all?
05/15/2025

We’ve been urged to include plenty of dietary fiber in our daily routines, fibers that come from vegetables, legumes, grains and other plant sources. But there is an animal-sourced fiber that has nearly disappeared from the modern human diet: hyaluronic acid. 

Hyluronic acid has nearly disappeared from the diet because it is primarily sourced from animal products, especially organ meats like brain, skin, and tongue. But hyaluronic acid is a fiber crucial for the health of many human organs: skin, joints, uterus, cervix, vagina, arteries. It is also a fiber with significant benefits on the gastrointestinal mic...


The REAL way to stop or reverse heart disease
04/24/2025

LDL cholesterol, apoprotein B, saturated fat, TMAO, statin cholesterol drugs: Over the last 40 years, we have been inundated with misguided advice on how to reduce your risk for coronary heart disease, i.e., risk for such things as heart attack, need for heart procedures such as stent implantation or bypass surgery, or sudden cardiac death, serious and often life-threatening events. Has it worked? 80 million Americans now take statin drugs to reduce cholesterol yet there has been no meaningful reduction in such events and, in fact, I’ll bet some of your local hospitals have added multi-million dollar wings for ca...


Will eating yogurt change your life?
04/12/2025

Go to any supermarket and you will see the impressive variety of products in the dairy aisle labeled "yogurt." You have a mindboggling collection of choices: non-fat, low-fat, full-fat, flavored, unflavored. Single-serve cartons, quart containers, squeezable tubes, jars. Will consuming any of these products change your life in any significant way? Will you be heathier, have better bowel health, skin health, metabolic health, mental health? 

Let’s discuss why, no, you will not experience any dramatic life-altering effects from consuming these products. They may be tasty, but they will not change your life in any meaningful way. But...


Cold Water Immersion: Cardiac Russian Roulette
04/02/2025

The practice of immersing your body in ice water is growing in popularity based on claims of improved mood and well-being, muscle recovery after exercise, even longevity. But this ignores the well-established fact that sudden cardiac death is a real risk due to coronary spasm, causing heart attack, and unstable heart rhythms due to a situation called autonomic conflict. There are a growing number of lawsuits that have been filed for the many sudden cardiac deaths that have occurred. So let’s discuss what we know about this concept of cold water immersion and why it is such a da...


Why Cutting Calories is Dangerous
03/20/2025

Over 50% of Americans are, at any one time, trying to lose weight. So it’s understandable that the GLP-1 agonist drugs like Ozempic and Mounjaro have become so popular, given their spectacular upfront results. Others have used reduced calorie diets in their various forms: counting points, assigning foods red, yellow, or green lights, meal replacement products, etc. Or bariatric procedures like lap-band, jejunoileal bypass, or gastric bypass. But there is a lot that people are not told about these methods. The near-term prospect of losing weight is so enticing to people and so profitable to doctors, the healthcare system, an...


Dr. Eric Westman on the Power of Limiting Carbohydrates to Reverse Type 2 Diabetes; Cholesterol is not a disease
03/04/2025

I first met Dr. Eric Westman at a low-carbohydrate meeting a number of years ago where he discussed an extremely important and insightful human clinical trial he had conducted in which he counseled participants with type 2 diabetes to follow a very low-carbohydrate, essentially ketogenic, diet. He was almost prohibited from conducted the study because some colleagues felt it was too dangerous. Nonetheless, the study was completed and demonstrated that type 2 diabetic participants no longer needed insulin and most diabetes drugs while achieving improved blood glucose measures by engaging in a lifestyle that was the direct opposite of conventional dietary...


Are health coaches the future of healthcare?
02/05/2025

We all recognize that American healthcare is a badly broken system. Wildly overpriced, exploitative, with a focus on pharmaceuticals and medical procedures to the exclusion of basic issues such as nutrition, the role of nutrients, and the microbiome. Can we expect doctors, healthcare executives, pharma or medical device executives to find better solutions? 

I highly doubt it. One of the problems plaguing conventional delivery of healthcare is that doctors lack the time, knowledge, and frankly the interest in spending more time with their patients, hearing about their issues, then creating solutions that address their unique concerns. 

...


Is blue light damaging your eyesight?
01/22/2025

Over the past decade, most of us have converted our home lighting to light-emitting diode (LED) bulbs, as they save a significant amount of energy, requiring 75-90% less energy than older incandescent lights. Personally, I converted the 50 or lightbulbs in my house to nearly all LEDs.

Most current LEDs emit, of course, visible light. But they also emit a significant amount of blue light and very little red and infrared (IR), in contrast to old-fashioned incandescent bulbs that emit some blue and a lot of red and IR. Remember when you had to change an incandescent bulb...


Managing Endotoxemia: Key to SO Many Aspects of Health
01/04/2025

I’ve touched on the topic of endotoxemia in past episodes of the Defiant Health podcast. In this episode, let’s dive deeper into this topic that is absolutely crucial to understanding and managing SO many aspects of health, from subduing anxiety and panic, to depressive, to joint pain and skin rashes, to gastrointestinal conditions, even weight management. 

What is endotoxemia? Fecal microbes, so-called Gram-negative species because of the way these microbes take up stain for examination under a microscope, species such as E. coli and Salmonella, have something called lipopolysaccharide endotoxin in their cells walls. Other speci...


Why managing skin pH is crucial for skin health and appearance
12/13/2024

I’ve been showing thousands of people how to restore this microbe lost by the majority of modern people, Lactobacillus reuteri. But, of all the spectacular improvements in health we can gain by managing our microbiomes, such as an increase in empathy and generosity, reduction in anxiety and depression, deeper sleep, increased libido, restored youthful musculature and strength, the females in my audience have repeatedly said something like, “Well, that’s all well and good, but I’m mostly interested in the skin benefits.” So I’ve spent a good deal of time, energy, and resources in exploring this question, in...


The curious phenomenon of bacterial translocation that is key to so many health conditions
12/06/2024

I’ve spent some time reflecting back on all my years practicing in hospitals, often not sleeping for extended periods, sometimes days, covering hospitals floors and ICUs, resuscitating people who experienced cardiac arrests, taking them to the cath lab to open arteries, but also witnessing people with all sorts of other health conditions: cancers, wound infections, sepsis, delirium, the various stages of dementia, and hundreds of other debilitating disease. 

I now recognize that, looking back, so many health conditions can be better understood in light of the contribution of the microbiome, i.e., the trillions of microbes occ...


Seven Reasons to NEVER Eat Wheat Again
11/20/2024

Those of you who follow my discussions that started with the Wheat Belly series of books already know that there is a long list of reasons why humans made an enormous blunder when we first resorted to the consumption of the seeds of grasses, meaning wheat and related grains. We know this from the anthropological record of human disease, we know this from modern science that has exposed the many problems that arise with their consumption from tooth decay to arthritis.

But in my many conversations with people, I find that, because we are all bombarded with...


The myth of “optimal medical therapy”
11/03/2024

Over 30 years ago, I help set up the first CT heart scan device in Wisconsin, one of the first in the entire midwest. This was so long ago that it was really an electron beam tomogrraphy, or EBT, device that predated the more recently developed CT devices. The point is that these devices acquired images quickly, about 1/10th of a second. This is important because the heart is perpetually in motion through various cycles of its beating rhythm, with motion also provided by breathing. But these devices allowed us to precisely quantify calcium in the coronary arteries of the...


Unlocking Wellness: Reed Davis on Environmental Toxins and Holistic Health Solutions
10/18/2024

“Everyone coming in the door were sick and had already been to 8 or 10 healthcare practitioners and weren’t better yet. This is all wrong.”

“It’s not just what you eat. It’s the air you breathe and the water you drink, the personal care products you use, household cleaning products. . .” 

Here is a conversation I had recently with with Reed Davis, a board-certified Holistic Health Practitioner (HHP) and Certified Nutritional Therapist (CNT). Over many years of experience, Reed has developed expertise in applying functional lab testing to pinpoint environmental, hormonal, nutritional, and other health disruptions and...


Omega-3 Fatty Acids: Facts and Controversies
10/16/2024

Over the last 30 years, the question over whether omega-3 fatty acids from fish has been the subject of controversy, swinging from exuberance over its potential benefits to skepticism over whether they provide any benefit at all. It seems that one day we hear that fish oil reduces risk for heart attack, while the next day we hear that there is no such benefit, even harm. We’ve also been subjected to numerous marketing claims for competing products with claims such as “40 times more potent than fish oil” or “You can’t buy this in a health food store” that further mudd...


How NOT to have atrial fibrillation
09/30/2024

Atrial fibrillation, or A fib for short, is the most common heart rhythm issue that plagues people. About 30% of people will experience this rhythm disorder at some time in their lives, an issue that becomes more and more likely as we age. 

The rhythm is typically experienced as the sudden onset of breathlessness and lightheadedness, and sometimes chest pain, even while you are sitting or relaxing. This is because, with A fib, the heart rate is typically in the range of 150-220 beats per minute, way above the normal resting heart rate of 60-70 beats per minute. I...


The Powerful Influence of the GI Microbiome on Sleep
09/14/2024

Sleep issues represent a major struggle for millions of people: too little sleep, trouble falling asleep, trouble staying asleep, early morning awakenings followed by difficulty falling back asleep. Some people complain that, despite having a full night of sleep, they awake feeling like they didn’t sleep at all, struggling with sleepiness, fog, and fatigue all through waking hours. There are also known associations of health conditions such as irritable bowel syndrome and Parkinson’s disease with disruptions of sleep. 

The science that explores the role of gastrointestinal microbes in sleep are yielding new and exciting lessons. Recen...


The GLP-1 Agonist Weight Loss Disaster
08/25/2024

You’ve likely heard the headlines gushing about the weight loss effects of the GLP-1 agonist class of drugs, agents that go by names like Wegovy, Mounjaro, Rebelsus and others. Doctors are declaring these drugs as breakthroughs or even magical, witnessing the rapid and dramatic weight loss they can achieve. 

People appear willing to accept the side-effects of nausea, vomiting, even bowel obstruction, a catastrophic complication, or thyroid cancer, or pancreatitis that can irreversibly damage your pancreas and make you a type 1 diabetic. They also accept the costs that vary widely, depending on who dispenses it, but not...


How much of your personal health begins in the mouth?
08/10/2024

The oral microbiome is second only to the colon in the density of microbes living there. The mouth is really a collection of varied ecosystems that differ in composition. For instance, the microbiome of the teeth is different from that of the tongue that is, in turn, different from the microbiome of the gumline. The oral cavity is therefore teeming with hundreds, perhaps thousands, of species of bacteria, fungi, Archaea, and viruses. It is a virtual tropical jungle of life. 

But what is especially remarkable is that the oral microbiome is an ecosystem of life that plays a...


Common Myths and Misconceptions About Wheat
07/29/2024

Despite having written 7 books in the Wheat Belly series pointing out the harms that this “food” has inflicted on people, harms that doctors nearly always misdiagnose as an opportunity to “treat” with pharmaceuticals and procedures, questions and ideas to the contrary continue to crop up. Some of these ideas are simply due to the barrage of advertising that comes from Big Food and Big Agribusiness, industries that continue to make a lot of money by propagating fictitious claims that grains are healthy. Some of it is due to the continued repeated urgings by the U.S. government, insisting that grains s...


The Finer Points of Vitamin D Supplementation
07/16/2024

Achieving an optimal level of vitamin D provides numerous health advantages, from relief from winter blues to reduction in cardiovascular risk to reduced risk for several forms of cancer. It’s one of the most important nutrients to get right, i.e., achieve an ideal blood level of the primary blood marker for vitamin D, 25-OH vitamin D. 

But, even after many years of I and others discussing the importance of vitamin D, I still see plenty of people getting it wrong, often on the advice of their doctors. Sadly, you would think that doctors would be cha...